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Volumn 90, Issue 5, 2008, Pages

The apelinergic system: The role played in human physiology and pathology and potential therapeutic applications;O sistema apelinérgico: Papel na fisiologia e patologia humanas e potenciais aplicações terapêuticas

Author keywords

Apeline; Cardiac output, low; Diabetes mellitus; Hypertension; Peptides drug effects; Peptides Physiology

Indexed keywords

APELIN; APELIN RECEPTOR; INSULIN;

EID: 44849144176     PISSN: 0066782X     EISSN: 16784170     Source Type: Journal    
DOI: 10.1590/S0066-782X2008000500012     Document Type: Review
Times cited : (64)

References (67)
  • 1
    • 0027717002 scopus 로고
    • A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11
    • O'Dowd B, Heiber M, Chan A, Heng H, Tsui L, Kennedy J, et al. A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. Gene. 1993; 136 (1-2): 355-60.
    • (1993) Gene , vol.136 , Issue.1-2 , pp. 355-360
    • O'Dowd, B.1    Heiber, M.2    Chan, A.3    Heng, H.4    Tsui, L.5    Kennedy, J.6
  • 2
    • 0032552988 scopus 로고    scopus 로고
    • Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor
    • Tatemoto K, Hosoya M, Habata Y, Fujii R, Kakegawa T, Zou MX, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun. 1998; 251 (2): 471-6.
    • (1998) Biochem Biophys Res Commun , vol.251 , Issue.2 , pp. 471-476
    • Tatemoto, K.1    Hosoya, M.2    Habata, Y.3    Fujii, R.4    Kakegawa, T.5    Zou, M.X.6
  • 3
    • 0037341188 scopus 로고    scopus 로고
    • Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin
    • Medhurst AD, Jennings CA, Robbins MJ, Davis RP, Ellis C, Winborn KY, et al. Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J Neurochem. 2003; 84 (5): 1162-72.
    • (2003) J Neurochem , vol.84 , Issue.5 , pp. 1162-1172
    • Medhurst, A.D.1    Jennings, C.A.2    Robbins, M.J.3    Davis, R.P.4    Ellis, C.5    Winborn, K.Y.6
  • 4
    • 0034697792 scopus 로고    scopus 로고
    • Distribution of mRNA encoding B78/apj, the rat homologue of the human APJ receptor, and its endogenous ligand apelin in brain and peripheral tissues
    • O'Carroll AM, Selby TL, Palkovits M, Lolait SJ. Distribution of mRNA encoding B78/apj, the rat homologue of the human APJ receptor, and its endogenous ligand apelin in brain and peripheral tissues. Biochim Biophys Acta. 2000; 1492 (1): 72-80.
    • (2000) Biochim Biophys Acta , vol.1492 , Issue.1 , pp. 72-80
    • O'Carroll, A.M.1    Selby, T.L.2    Palkovits, M.3    Lolait, S.J.4
  • 5
    • 12344312427 scopus 로고    scopus 로고
    • Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells
    • Kleinz MJ, Skepper JN, Davenport AP. Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells. Regul Pept. 2005; 126 (3): 233-40.
    • (2005) Regul Pept , vol.126 , Issue.3 , pp. 233-240
    • Kleinz, M.J.1    Skepper, J.N.2    Davenport, A.P.3
  • 7
    • 28844479589 scopus 로고    scopus 로고
    • Apelin: A novel neurohumoral modulator of the cardiovascular system: pathophysiologic importance and potential use as a therapeutic target
    • Falcao-Pires I, Leite-Moreira AF. Apelin: a novel neurohumoral modulator of the cardiovascular system: pathophysiologic importance and potential use as a therapeutic target. Rev Port Cardiol. 2005; 24 (10): 1263-76.
    • (2005) Rev Port Cardiol , vol.24 , Issue.10 , pp. 1263-1276
    • Falcao-Pires, I.1    Leite-Moreira, A.F.2
  • 8
    • 21444455985 scopus 로고    scopus 로고
    • Emerging roles of apelin in biology and medicine
    • Kleinz MJ, Davenport AP. Emerging roles of apelin in biology and medicine. Pharmacol Ther. 2005; 107 (2): 198-211.
    • (2005) Pharmacol Ther , vol.107 , Issue.2 , pp. 198-211
    • Kleinz, M.J.1    Davenport, A.P.2
  • 9
    • 10444230360 scopus 로고    scopus 로고
    • Apelin signalling: A promising pathway from cloning to pharmacology
    • Masri B, Knibiehler B, Audigier Y. Apelin signalling: a promising pathway from cloning to pharmacology. Cell Signal. 2005; 17 (4): 415-26.
    • (2005) Cell Signal , vol.17 , Issue.4 , pp. 415-426
    • Masri, B.1    Knibiehler, B.2    Audigier, Y.3
  • 11
    • 33645992126 scopus 로고    scopus 로고
    • Unravelling the roles of the apelin system: Prospective therapeutic applications in heart failure and obesity
    • Lee DK, George SR, O'Dowd BF. Unravelling the roles of the apelin system: prospective therapeutic applications in heart failure and obesity. Trends Pharmacol Sci. 2006; 27 (4): 190-4.
    • (2006) Trends Pharmacol Sci , vol.27 , Issue.4 , pp. 190-194
    • Lee, D.K.1    George, S.R.2    O'Dowd, B.F.3
  • 13
    • 1542289804 scopus 로고    scopus 로고
    • Agonist-independent nuclear localization of the Apelin, angiotensin AT1, and bradykinin B2 receptors
    • Lee DK, Lanca AJ, Cheng R, Nguyen T, Ji XD, Gobeil F Jr., et al. Agonist-independent nuclear localization of the Apelin, angiotensin AT1, and bradykinin B2 receptors. J Biol Chem. 2004; 279 (9): 7901-8.
    • (2004) J Biol Chem , vol.279 , Issue.9 , pp. 7901-7908
    • Lee, D.K.1    Lanca, A.J.2    Cheng, R.3    Nguyen, T.4    Ji, X.D.5    Gobeil Jr., F.6
  • 14
    • 0032811273 scopus 로고    scopus 로고
    • Amino acid sequence and embryonic expression of msr/apj, the mouse homolog of Xenopus X-msr and human APJ
    • Devic E, Rizzoti K, Bodin S, Knibiehler B, Audigier Y. Amino acid sequence and embryonic expression of msr/apj, the mouse homolog of Xenopus X-msr and human APJ. Mech Dev. 1999; 84 (1-2): 199-203.
    • (1999) Mech Dev , vol.84 , Issue.1-2 , pp. 199-203
    • Devic, E.1    Rizzoti, K.2    Bodin, S.3    Knibiehler, B.4    Audigier, Y.5
  • 15
    • 0034647520 scopus 로고    scopus 로고
    • Molecular and functional characteristics of APJ: Tissue distribution of mRNA and interaction with the endogenous ligand apelin
    • Hosoya M, Kawamata Y, Fukusumi S, Fujii R, Habata Y, Hinuma S, et al. Molecular and functional characteristics of APJ: tissue distribution of mRNA and interaction with the endogenous ligand apelin. J Biol Chem. 2000; 275 (28): 21061-7.
    • (2000) J Biol Chem , vol.275 , Issue.28 , pp. 21061-21067
    • Hosoya, M.1    Kawamata, Y.2    Fukusumi, S.3    Fujii, R.4    Habata, Y.5    Hinuma, S.6
  • 16
    • 11144240956 scopus 로고    scopus 로고
    • Modification of the terminal residue of apelin-13 antagonizes its hypotensive action
    • Lee DK, Saldivia VR, Nguyen T, Cheng R, George SR, O'Dowd BF. Modification of the terminal residue of apelin-13 antagonizes its hypotensive action. Endocrinology. 2005; 146 (1): 231-6.
    • (2005) Endocrinology , vol.146 , Issue.1 , pp. 231-236
    • Lee, D.K.1    Saldivia, V.R.2    Nguyen, T.3    Cheng, R.4    George, S.R.5    O'Dowd, B.F.6
  • 17
    • 0032826034 scopus 로고    scopus 로고
    • Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum
    • Habata Y, Fujii R, Hosoya M, Fukusumi S, Kawamata Y, Hinuma S, et al. Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum. Biochim Biophys Acta. 1999; 1452 (1): 25-35.
    • (1999) Biochim Biophys Acta , vol.1452 , Issue.1 , pp. 25-35
    • Habata, Y.1    Fujii, R.2    Hosoya, M.3    Fukusumi, S.4    Kawamata, Y.5    Hinuma, S.6
  • 18
    • 0031662094 scopus 로고    scopus 로고
    • An orphan seven-transmembrane domain receptor expressed widely in the brain functions as a coreceptor for human immunodeficiency virus type 1 and simian immunodeficiency virus
    • Edinger A, Hoffman T, Sharron M, Lee B, Yi Y, Choe W, et al. An orphan seven-transmembrane domain receptor expressed widely in the brain functions as a coreceptor for human immunodeficiency virus type 1 and simian immunodeficiency virus. J Virol. 1998; 72 (10): 7934-40.
    • (1998) J Virol , vol.72 , Issue.10 , pp. 7934-7940
    • Edinger, A.1    Hoffman, T.2    Sharron, M.3    Lee, B.4    Yi, Y.5    Choe, W.6
  • 19
    • 18544378161 scopus 로고    scopus 로고
    • Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase
    • Vickers C, Hales P, Kaushik V, Dick L, Gavin J, Tang J, et al. Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase. J Biol Chem. 2002; 277 (17): 14838-43.
    • (2002) J Biol Chem , vol.277 , Issue.17 , pp. 14838-14843
    • Vickers, C.1    Hales, P.2    Kaushik, V.3    Dick, L.4    Gavin, J.5    Tang, J.6
  • 20
    • 33645299090 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme II in the heart and the kidney
    • Danilczyk U, Penninger J. Angiotensin-converting enzyme II in the heart and the kidney. Circ Res. 2006; 98: 463-71.
    • (2006) Circ Res , vol.98 , pp. 463-471
    • Danilczyk, U.1    Penninger, J.2
  • 21
    • 0037032005 scopus 로고    scopus 로고
    • Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility
    • Szokodi I, Tavi P, Foldes G, Voutilainen-Myllyla S, Ilves M, Tokola H, et al. Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility. Circ Res. 2002; 91 (5): 434-40.
    • (2002) Circ Res , vol.91 , Issue.5 , pp. 434-440
    • Szokodi, I.1    Tavi, P.2    Foldes, G.3    Voutilainen-Myllyla, S.4    Ilves, M.5    Tokola, H.6
  • 23
    • 0036289790 scopus 로고    scopus 로고
    • Apelin (65-77) activates extracellular signal-regulated kinases via a PTX-sensitive G protein
    • Masri B, Lahlou H, Mazarguil H, Knibiehler B, Audigier Y. Apelin (65-77) activates extracellular signal-regulated kinases via a PTX-sensitive G protein. Biochem Biophys Res Commun. 2002; 290 (1): 539-45.
    • (2002) Biochem Biophys Res Commun , vol.290 , Issue.1 , pp. 539-545
    • Masri, B.1    Lahlou, H.2    Mazarguil, H.3    Knibiehler, B.4    Audigier, Y.5
  • 24
    • 10044296019 scopus 로고    scopus 로고
    • Apelin (65-77) activates p70 S6 kinase and is mitogenic for umbilical endothelial cells
    • Masri B, Morin N, Cornu M, Knibiehler B, Audigier Y. Apelin (65-77) activates p70 S6 kinase and is mitogenic for umbilical endothelial cells. Faseb J. 2004; 18 (15): 1909-11.
    • (2004) Faseb J , vol.18 , Issue.15 , pp. 1909-1911
    • Masri, B.1    Morin, N.2    Cornu, M.3    Knibiehler, B.4    Audigier, Y.5
  • 25
    • 0035876612 scopus 로고    scopus 로고
    • The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism
    • Tatemoto K, Takayama K, Zou MX, Kumaki I, Zhang W, Kumano K, et al. The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism. Regul Pept. 2001; 99 (2-3): 87-92.
    • (2001) Regul Pept , vol.99 , Issue.2-3 , pp. 87-92
    • Tatemoto, K.1    Takayama, K.2    Zou, M.X.3    Kumaki, I.4    Zhang, W.5    Kumano, K.6
  • 26
    • 0041696762 scopus 로고    scopus 로고
    • The msr/apj gene encoding the apelin receptor is an early and specific marker of the venous phenotype in the retinal vasculature
    • Saint-Geniez M, Argence CB, Knibiehler B, Audigier Y. The msr/apj gene encoding the apelin receptor is an early and specific marker of the venous phenotype in the retinal vasculature. Gene Expr Patterns. 2003; 3 (4): 467-72.
    • (2003) Gene Expr Patterns , vol.3 , Issue.4 , pp. 467-472
    • Saint-Geniez, M.1    Argence, C.B.2    Knibiehler, B.3    Audigier, Y.4
  • 27
    • 0035084443 scopus 로고    scopus 로고
    • (125)I]-(Pyr(1))Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man
    • Katugampola SD, Maguire JJ, Matthewson SR, Davenport AP. [(125)I]-(Pyr(1))Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man. Br J Pharmacol. 2001; 132 (6): 1255-60.
    • (2001) Br J Pharmacol , vol.132 , Issue.6 , pp. 1255-1260
    • Katugampola, S.D.1    Maguire, J.J.2    Matthewson, S.R.3    Davenport, A.P.4
  • 28
    • 1542300876 scopus 로고    scopus 로고
    • Immunocytochemical localization of the endogenous vasoactive peptide apelin to human vascular and endocardial endothelial cells
    • Kleinz MJ, Davenport AP. Immunocytochemical localization of the endogenous vasoactive peptide apelin to human vascular and endocardial endothelial cells. Regul Pept. 2004; 118 (3): 119-25.
    • (2004) Regul Pept , vol.118 , Issue.3 , pp. 119-125
    • Kleinz, M.J.1    Davenport, A.P.2
  • 30
    • 19944373052 scopus 로고    scopus 로고
    • The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo
    • Ashley EA, Powers J, Chen M, Kundu R, Finsterbach T, Caffarelli A, et al. The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo. Cardiovasc Res. 2005; 65 (1): 73-82.
    • (2005) Cardiovasc Res , vol.65 , Issue.1 , pp. 73-82
    • Ashley, E.A.1    Powers, J.2    Chen, M.3    Kundu, R.4    Finsterbach, T.5    Caffarelli, A.6
  • 31
    • 2942711581 scopus 로고    scopus 로고
    • Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo
    • Ishida J, Hashimoto T, Hashimoto Y, Nishiwaki S, Iguchi T, Harada S, et al. Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo. J Biol Chem. 2004; 279 (25): 26274-9.
    • (2004) J Biol Chem , vol.279 , Issue.25 , pp. 26274-26279
    • Ishida, J.1    Hashimoto, T.2    Hashimoto, Y.3    Nishiwaki, S.4    Iguchi, T.5    Harada, S.6
  • 32
    • 33750301665 scopus 로고    scopus 로고
    • Down-regulation of cardiac apelin system in hypertrophied and failing hearts: Possible role of angiotensin II-angiotensin type 1 receptor system
    • Iwanaga Y, Kihara Y, Takenaka H, Kita T. Down-regulation of cardiac apelin system in hypertrophied and failing hearts: possible role of angiotensin II-angiotensin type 1 receptor system. J Mol Cell Cardiol. 2006; 41 (5): 798-806.
    • (2006) J Mol Cell Cardiol , vol.41 , Issue.5 , pp. 798-806
    • Iwanaga, Y.1    Kihara, Y.2    Takenaka, H.3    Kita, T.4
  • 33
    • 33746402829 scopus 로고    scopus 로고
    • Exercise training promotes expression of apelin and APJ of cardiovascular tissues in spontaneously hypertensive rats
    • Zhang J, Ren CX, Qi YF, Lou LX, Chen L, Zhang LK, et al. Exercise training promotes expression of apelin and APJ of cardiovascular tissues in spontaneously hypertensive rats. Life Sci. 2006; 79 (12): 1153-9.
    • (2006) Life Sci , vol.79 , Issue.12 , pp. 1153-1159
    • Zhang, J.1    Ren, C.X.2    Qi, Y.F.3    Lou, L.X.4    Chen, L.5    Zhang, L.K.6
  • 34
    • 0042165829 scopus 로고    scopus 로고
    • Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure
    • Foldes G, Horkay F, Szokodi I, Vuolteenaho O, Ilves M, Lindstedt KA, et al. Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure. Biochem Biophys Res Commun. 2003; 308 (3): 480-5.
    • (2003) Biochem Biophys Res Commun , vol.308 , Issue.3 , pp. 480-485
    • Foldes, G.1    Horkay, F.2    Szokodi, I.3    Vuolteenaho, O.4    Ilves, M.5    Lindstedt, K.A.6
  • 35
    • 33744816839 scopus 로고    scopus 로고
    • Plasma concentrations of the novel peptide apelin are decreased in patients with chronic heart failure
    • Chong KS, Gardner RS, Morton JJ, Ashley EA, McDonagh TA. Plasma concentrations of the novel peptide apelin are decreased in patients with chronic heart failure. Eur J Heart Fail. 2006; 8 (4): 355-60.
    • (2006) Eur J Heart Fail , vol.8 , Issue.4 , pp. 355-360
    • Chong, K.S.1    Gardner, R.S.2    Morton, J.J.3    Ashley, E.A.4    McDonagh, T.A.5
  • 36
    • 33751160364 scopus 로고    scopus 로고
    • Apelin increases contractility in failing cardiac muscle
    • Dai T, Ramirez-Correa G, Gao WD. Apelin increases contractility in failing cardiac muscle. Eur J Pharmacol. 2006; 553 (1-3): 222-8.
    • (2006) Eur J Pharmacol , vol.553 , Issue.1-3 , pp. 222-228
    • Dai, T.1    Ramirez-Correa, G.2    Gao, W.D.3
  • 37
    • 29244481551 scopus 로고    scopus 로고
    • Apelin protects myocardial injury induced by isoproterenol in rats
    • Jia YX, Pan CS, Zhang J, Geng B, Zhao J, Gerns H, et al. Apelin protects myocardial injury induced by isoproterenol in rats. Regul Pept. 2006; 133 (1-3): 147-54.
    • (2006) Regul Pept , vol.133 , Issue.1-3 , pp. 147-154
    • Jia, Y.X.1    Pan, C.S.2    Zhang, J.3    Geng, B.4    Zhao, J.5    Gerns, H.6
  • 38
    • 33745070050 scopus 로고    scopus 로고
    • Apelin and cardiac function in hemodialyzed patients: Possible relations?
    • Malyszko J, Malyszko JS, Kozminski P, Mysliwiec M. Apelin and cardiac function in hemodialyzed patients: possible relations? Am J Nephrol. 2006; 26 (2): 121-6.
    • (2006) Am J Nephrol , vol.26 , Issue.2 , pp. 121-126
    • Malyszko, J.1    Malyszko, J.S.2    Kozminski, P.3    Mysliwiec, M.4
  • 39
    • 33847367028 scopus 로고    scopus 로고
    • Cardiac resynchronization therapy increases plasma levels of the endogenous inotrope apelin
    • Francia P, Salvati A, Balla C, De Paolis P, Pagannone E, Borro M, et al. Cardiac resynchronization therapy increases plasma levels of the endogenous inotrope apelin. Eur J Heart Fail. 2007; 9 (3): 306-9.
    • (2007) Eur J Heart Fail , vol.9 , Issue.3 , pp. 306-309
    • Francia, P.1    Salvati, A.2    Balla, C.3    De Paolis, P.4    Pagannone, E.5    Borro, M.6
  • 40
    • 34249800363 scopus 로고    scopus 로고
    • Hypoxia inducible factor regulates the cardiac expression and secretion of apelin
    • Ronkainen VP, Ronkainen JJ, Hanninen SL, Leskinen H, Ruas JL, Pereira T, et al. Hypoxia inducible factor regulates the cardiac expression and secretion of apelin. Faseb J. 2007; 21 (8): 1821-30.
    • (2007) Faseb J , vol.21 , Issue.8 , pp. 1821-1830
    • Ronkainen, V.P.1    Ronkainen, J.J.2    Hanninen, S.L.3    Leskinen, H.4    Ruas, J.L.5    Pereira, T.6
  • 41
    • 34249058073 scopus 로고    scopus 로고
    • Ischemic heart failure enhances endogenous myocardial apelin and APJ receptor expression
    • Atluri P, Morine KJ, Liao GP, Panlilio CM, Berry MF, Hsu VM, et al. Ischemic heart failure enhances endogenous myocardial apelin and APJ receptor expression. Cell Mol Biol Lett. 2007; 12 (1): 127-38.
    • (2007) Cell Mol Biol Lett , vol.12 , Issue.1 , pp. 127-138
    • Atluri, P.1    Morine, K.J.2    Liao, G.P.3    Panlilio, C.M.4    Berry, M.F.5    Hsu, V.M.6
  • 42
    • 33748415221 scopus 로고    scopus 로고
    • Utility of amino-terminal pro-brain natriuretic peptide, galectin-3, and apelin for the evaluation of patients with acute heart failure
    • van Kimmenade RR, Januzzi JL Jr., Ellinor PT, Sharma UC, Bakker JA, Low AF, et al. Utility of amino-terminal pro-brain natriuretic peptide, galectin-3, and apelin for the evaluation of patients with acute heart failure. J Am Coll Cardiol. 2006; 48 (6): 1217-24.
    • (2006) J Am Coll Cardiol , vol.48 , Issue.6 , pp. 1217-1224
    • van Kimmenade, R.R.1    Januzzi Jr., J.L.2    Ellinor, P.T.3    Sharma, U.C.4    Bakker, J.A.5    Low, A.F.6
  • 43
    • 33947205566 scopus 로고    scopus 로고
    • Utility of plasma apelin and other indices of cardiac dysfunction in the clinical assessment of patients with dilated cardiomyopathy
    • Miettinen KH, Magga J, Vuolteenaho O, Vanninen EJ, Punnonen KR, Ylitalo K, et al. Utility of plasma apelin and other indices of cardiac dysfunction in the clinical assessment of patients with dilated cardiomyopathy. Regul Pept. 2007; 140 (3): 178-84.
    • (2007) Regul Pept , vol.140 , Issue.3 , pp. 178-184
    • Miettinen, K.H.1    Magga, J.2    Vuolteenaho, O.3    Vanninen, E.J.4    Punnonen, K.R.5    Ylitalo, K.6
  • 44
    • 30344482556 scopus 로고    scopus 로고
    • Reduced apelin levels in lone atrial fibrillation
    • Ellinor PT, Low AF, Macrae CA. Reduced apelin levels in lone atrial fibrillation. Eur Heart J. 2006; 27 (2): 222-6.
    • (2006) Eur Heart J , vol.27 , Issue.2 , pp. 222-226
    • Ellinor, P.T.1    Low, A.F.2    Macrae, C.A.3
  • 46
    • 0035015269 scopus 로고    scopus 로고
    • Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain
    • Reaux A, De Mota N, Skultetyova I, Lenkei Z, El Messari S, Gallatz K, et al. Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain. J Neurochem. 2001; 77 (4): 1085-96.
    • (2001) J Neurochem , vol.77 , Issue.4 , pp. 1085-1096
    • Reaux, A.1    De Mota, N.2    Skultetyova, I.3    Lenkei, Z.4    El Messari, S.5    Gallatz, K.6
  • 47
    • 0037008882 scopus 로고    scopus 로고
    • Distribution of apelin-synthesizing neurons in the adult rat brain
    • Reaux A, Gallatz K, Palkovits M, Llorens-Cortes C. Distribution of apelin-synthesizing neurons in the adult rat brain. Neuroscience. 2002; 113 (3): 653-62.
    • (2002) Neuroscience , vol.113 , Issue.3 , pp. 653-662
    • Reaux, A.1    Gallatz, K.2    Palkovits, M.3    Llorens-Cortes, C.4
  • 49
    • 18444364972 scopus 로고    scopus 로고
    • The effects of centrally administered apelin-13 on food intake, water intake and pituitary hormone release in rats
    • Taheri S, Murphy K, Cohen M, Sujkovic E, Kennedy A, Dhillo W, et al. The effects of centrally administered apelin-13 on food intake, water intake and pituitary hormone release in rats. Biochem Biophys Res Commun. 2002; 291 (5): 1208-12.
    • (2002) Biochem Biophys Res Commun , vol.291 , Issue.5 , pp. 1208-1212
    • Taheri, S.1    Murphy, K.2    Cohen, M.3    Sujkovic, E.4    Kennedy, A.5    Dhillo, W.6
  • 50
    • 33747346441 scopus 로고    scopus 로고
    • Effects of central and peripheral injections of apelin on fluid intake and cardiovascular parameters in rats
    • Mitra A, Katovich MJ, Mecca A, Rowland NE. Effects of central and peripheral injections of apelin on fluid intake and cardiovascular parameters in rats. Physiol Behav. 2006; 89 (2): 221-5.
    • (2006) Physiol Behav , vol.89 , Issue.2 , pp. 221-225
    • Mitra, A.1    Katovich, M.J.2    Mecca, A.3    Rowland, N.E.4
  • 51
    • 20144380036 scopus 로고    scopus 로고
    • Apelin, a newly identified adipokine up-regulated by insulin and obesity
    • Boucher J, Masri B, Daviaud D, Gesta S, Guigne C, Mazzucotelli A, et al. Apelin, a newly identified adipokine up-regulated by insulin and obesity. Endocrinology. 2005; 146 (4): 1764-71.
    • (2005) Endocrinology , vol.146 , Issue.4 , pp. 1764-1771
    • Boucher, J.1    Masri, B.2    Daviaud, D.3    Gesta, S.4    Guigne, C.5    Mazzucotelli, A.6
  • 52
    • 25844530179 scopus 로고    scopus 로고
    • The apj receptor is expressed in pancreatic islets and its ligand, apelin, inhibits insulin secretion in mice
    • Sorhede Winzell M, Magnusson C, Ahren B. The apj receptor is expressed in pancreatic islets and its ligand, apelin, inhibits insulin secretion in mice. Regul Pept. 2005; 131 (1-3): 12-7.
    • (2005) Regul Pept , vol.131 , Issue.1-3 , pp. 12-17
    • Sorhede Winzell, M.1    Magnusson, C.2    Ahren, B.3
  • 53
    • 22044453852 scopus 로고    scopus 로고
    • Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric banding
    • Heinonen MV, Purhonen AK, Miettinen P, Paakkonen M, Pirinen E, Alhava E, et al. Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric banding. Regul Pept. 2005; 130 (1-2): 7-13.
    • (2005) Regul Pept , vol.130 , Issue.1-2 , pp. 7-13
    • Heinonen, M.V.1    Purhonen, A.K.2    Miettinen, P.3    Paakkonen, M.4    Pirinen, E.5    Alhava, E.6
  • 54
    • 33846138616 scopus 로고    scopus 로고
    • Changes and relations of circulating visfatin, apelin, and resistin levels in normal, impaired glucose tolerance, and type 2 diabetic subjects
    • Li L, Yang G, Li Q, Tang Y, Yang M, Yang H, et al. Changes and relations of circulating visfatin, apelin, and resistin levels in normal, impaired glucose tolerance, and type 2 diabetic subjects. Exp Clin Endocrinol Diabetes. 2006; 114 (10): 544-8.
    • (2006) Exp Clin Endocrinol Diabetes , vol.114 , Issue.10 , pp. 544-548
    • Li, L.1    Yang, G.2    Li, Q.3    Tang, Y.4    Yang, M.5    Yang, H.6
  • 55
    • 33845682441 scopus 로고    scopus 로고
    • TNFalpha up-regulates apelin expression in human and mouse adipose tissue
    • Daviaud D, Boucher J, Gesta S, Dray C, Guigne C, Quilliot D, et al. TNFalpha up-regulates apelin expression in human and mouse adipose tissue. Faseb J. 2006; 20 (9): 1528-30.
    • (2006) Faseb J , vol.20 , Issue.9 , pp. 1528-1530
    • Daviaud, D.1    Boucher, J.2    Gesta, S.3    Dray, C.4    Guigne, C.5    Quilliot, D.6
  • 56
    • 34250812741 scopus 로고    scopus 로고
    • Apelin, an APJ receptor ligand, regulates body adiposity and favors the messenger ribonucleic acid expression of uncoupling proteins in mice
    • Higuchi K, Masaki T, Gotoh K, Chiba S, Katsuragi I, Tanaka K, et al. Apelin, an APJ receptor ligand, regulates body adiposity and favors the messenger ribonucleic acid expression of uncoupling proteins in mice. Endocrinology. 2007; 148 (6): 2690-7.
    • (2007) Endocrinology , vol.148 , Issue.6 , pp. 2690-2697
    • Higuchi, K.1    Masaki, T.2    Gotoh, K.3    Chiba, S.4    Katsuragi, I.5    Tanaka, K.6
  • 57
    • 34247876193 scopus 로고    scopus 로고
    • Apelin modulates aortic vascular tone via endothelial nitric oxide synthase phosphorylation pathway in diabetic mice
    • Zhong JC, Yu XY, Huang Y, Yung LM, Lau CW, Lin SG. Apelin modulates aortic vascular tone via endothelial nitric oxide synthase phosphorylation pathway in diabetic mice. Cardiovasc Res. 2007; 74 (3): 388-95.
    • (2007) Cardiovasc Res , vol.74 , Issue.3 , pp. 388-395
    • Zhong, J.C.1    Yu, X.Y.2    Huang, Y.3    Yung, L.M.4    Lau, C.W.5    Lin, S.G.6
  • 58
    • 0345714715 scopus 로고    scopus 로고
    • Intracerebroventricular injection of apelin-13 reduces food intake in the rat
    • Sunter D, Hewson AK, Dickson SL. Intracerebroventricular injection of apelin-13 reduces food intake in the rat. Neurosci Lett. 2003; 353 (1): 1-4.
    • (2003) Neurosci Lett , vol.353 , Issue.1 , pp. 1-4
    • Sunter, D.1    Hewson, A.K.2    Dickson, S.L.3
  • 59
    • 0037736658 scopus 로고    scopus 로고
    • Inhibitory effect of apelin-12 on nocturnal food intake in the rat
    • O'Shea M, Hansen MJ, Tatemoto K, Morris MJ. Inhibitory effect of apelin-12 on nocturnal food intake in the rat. Nutr Neurosci. 2003; 6 (3): 163-7.
    • (2003) Nutr Neurosci , vol.6 , Issue.3 , pp. 163-167
    • O'Shea, M.1    Hansen, M.J.2    Tatemoto, K.3    Morris, M.J.4
  • 60
    • 10744223499 scopus 로고    scopus 로고
    • Apelin, a new enteric peptide: Localization in the gastrointestinal tract, ontogeny, and stimulation of gastric cell proliferation and of cholecystokinin secretion
    • Wang G, Anini Y, Wei W, Qi X, AM OC, Mochizuki T, et al. Apelin, a new enteric peptide: localization in the gastrointestinal tract, ontogeny, and stimulation of gastric cell proliferation and of cholecystokinin secretion. Endocrinology. 2004; 145 (3): 1342-8.
    • (2004) Endocrinology , vol.145 , Issue.3 , pp. 1342-1348
    • Wang, G.1    Anini, Y.2    Wei, W.3    Qi, X.4    AM, O.C.5    Mochizuki, T.6
  • 61
    • 34250173089 scopus 로고    scopus 로고
    • Increased colonic apelin production in rodents with experimental colitis and in humans with IBD
    • Han S, Wang G, Qiu S, de la Motte C, Wang HQ, Gomez G, et al. Increased colonic apelin production in rodents with experimental colitis and in humans with IBD. Regul Pept. 2007; 142 (3): 131-7.
    • (2007) Regul Pept , vol.142 , Issue.3 , pp. 131-137
    • Han, S.1    Wang, G.2    Qiu, S.3    de la Motte, C.4    Wang, H.Q.5    Gomez, G.6
  • 62
    • 33846805814 scopus 로고    scopus 로고
    • Apelin stimulates proliferation and suppresses apoptosis of mouse osteoblastic cell line MC3T3-E1 via JNK and PI3-K/Akt signaling pathways
    • Tang SY, Xie H, Yuan LQ, Luo XH, Huang J, Cui RR, et al. Apelin stimulates proliferation and suppresses apoptosis of mouse osteoblastic cell line MC3T3-E1 via JNK and PI3-K/Akt signaling pathways. Peptides. 2007; 28 (3): 708-18.
    • (2007) Peptides , vol.28 , Issue.3 , pp. 708-718
    • Tang, S.Y.1    Xie, H.2    Yuan, L.Q.3    Luo, X.H.4    Huang, J.5    Cui, R.R.6
  • 63
  • 64
    • 17544397389 scopus 로고    scopus 로고
    • The orphan seven-transmembrane receptor apj supports the entry of primary T-cell-line-tropic and dualtropic human immunodeficiency virus type 1
    • Choe H, Farzan M, Konkel M, Martin K, Sun Y, Marcon L, et al. The orphan seven-transmembrane receptor apj supports the entry of primary T-cell-line-tropic and dualtropic human immunodeficiency virus type 1. J Virol. 1998; 72 (7): 6113-8.
    • (1998) J Virol , vol.72 , Issue.7 , pp. 6113-6118
    • Choe, H.1    Farzan, M.2    Konkel, M.3    Martin, K.4    Sun, Y.5    Marcon, L.6
  • 65
    • 0034715584 scopus 로고    scopus 로고
    • Expression and coreceptor function of APJ for primate immunodeficiency viruses
    • Puffer BA, Sharron M, Coughlan CM, Baribaud F, McManus CM, Lee B, et al. Expression and coreceptor function of APJ for primate immunodeficiency viruses. Virology. 2000; 276 (2): 435-44.
    • (2000) Virology , vol.276 , Issue.2 , pp. 435-444
    • Puffer, B.A.1    Sharron, M.2    Coughlan, C.M.3    Baribaud, F.4    McManus, C.M.5    Lee, B.6
  • 66
    • 0034468948 scopus 로고    scopus 로고
    • Apelin, the natural ligand of the orphan seven-transmembrane receptor APJ, inhibits human immunodeficiency virus type 1 entry
    • Cayabyab M, Hinuma S, Farzan M, Choe H, Fukusumi S, Kitada C, et al. Apelin, the natural ligand of the orphan seven-transmembrane receptor APJ, inhibits human immunodeficiency virus type 1 entry. J Virol. 2000; 74 (24): 11972-6.
    • (2000) J Virol , vol.74 , Issue.24 , pp. 11972-11976
    • Cayabyab, M.1    Hinuma, S.2    Farzan, M.3    Choe, H.4    Fukusumi, S.5    Kitada, C.6
  • 67
    • 0034604130 scopus 로고    scopus 로고
    • Apelin peptides block the entry of human immunodeficiency virus (HIV)
    • Zou MX, Liu HY, Haraguchi Y, Soda Y, Tatemoto K, Hoshino H. Apelin peptides block the entry of human immunodeficiency virus (HIV). FEBS Lett. 2000; 473 (1): 15-8.
    • (2000) FEBS Lett , vol.473 , Issue.1 , pp. 15-18
    • Zou, M.X.1    Liu, H.Y.2    Haraguchi, Y.3    Soda, Y.4    Tatemoto, K.5    Hoshino, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.