Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: Evidence for independent roles of age and sex

Diabetologia

Volumn 46, Issue 4, 2003, Pages 459-469

  Cnop, M ^a,e   Havel, P J ^b   Utzschneider, K M ^a   Carr, D B ^c   Sinha, M K ^d   Boyko, E J ^a   Retzlaff, B M ^a   Knopp, R H ^a   Brunzell, J D ^a   Kahn, S E ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^d Linco Research Inc   (United States)

^e UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

Acrp30; Adiponectin; AdipoQ; Cardiovascular disease; Central obesity; Hepatic lipase; Insulin sensitivity; Intra abdominal fat; Leptin; Lipids; Subcutaneous fat

Indexed keywords

ADIPONECTIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LEPTIN; LIPOPROTEIN; LIVER TRIACYLGLYCEROL LIPASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ABDOMEN; ADULT; AGE; AGED; ARTICLE; ATHEROGENESIS; BODY FAT; BODY MASS; BODY SIZE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; FEMALE; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MULTIPLE REGRESSION; OBESITY; PRIORITY JOURNAL; SEX DIFFERENCE; SUBCUTANEOUS FAT;

EID: 0038293399     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-003-1074-z     Document Type: Article

References (70)

1. Kolterman OG, Insel J, Saekow M, Olefsky JM (1980) Mechanisms of insulin resistance in human obesity: evidence for receptor and postreceptor defects. J Clin Invest 65:1272-1284
2. Lillioja S, Bogardus C (1988) Obesity and insulin resistance: lessons learned from the Pima Indians. Diabetes Metab Rev 4:517-540
3. Bjorntorp P (1993) Visceral obesity: a "civilization syndrome". Obes Res 1:206-222
4. Peiris AN, Mueller RA, Smith GA, Struve MF, Kissebah AH (1986) Splanchnic insulin metabolism in obesity. Influence of body fat distribution. J Clin Invest 78:1648-1657
5. Vague J (1956) The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. Am J Clin Nutr 4:20
6. Fujioka S, Matsuzawa Y, Tokunaga K, Tarui S (1987) Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. Metabolism 36:54-59
7. Despres JP, Nadeau A, Tremblay A et al. (1989) Role of deep abdominal fat in the association between regional adipose tissue distribution and glucose tolerance in obese women. Diabetes 38:304-309
8. Fujimoto WY, Abbate SL, Kahn SE, Hokanson JE, Brunzell JD (1994) The visceral adiposity syndrome in Japanese-American men. Obes Res 2:364-371
9. Goodpaster BH, Kelley DE, Wing RR, Meier A, Thaete FL (1999) Effects of weight loss on regional fat distribution and insulin sensitivity in obesity. Diabetes 48:839-847
10. Purnell JQ, Kahn SE, Albers JJ, Nevin DN, Brunzell JD, Schwartz RS (2000) Effect of weight loss with reduction of intra-abdominal fat on lipid metabolism in older men. J Clin Endocrinol Metab 85:977-982
11. Cnop M, Landchild MJ, Vidal J et al. (2002) The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations: distinct metabolic effects of two fat compartments. Diabetes 51:1005-1015
12. Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG (2000) Central nervous system control of food intake. Nature 404:661-671
13. Havel PJ (2000) Role of adipose tissue in body-weight regulation: mechanisms regulating leptin production and energy balance. Proc Nutr Soc 59:359-371
14. Gordon ES (1960) Non-esterified fatty acids in blood of obese and lean subjects. Am J Clin Nutr 8:740-747
15. Boden G (1997) Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 46:3-10
16. Shulman GI (2000) Cellular mechanisms of insulin resistance. J Clin Invest 106:171-176
17. Arner P (1995) Differences in lipolysis between human subcutaneous and omental adipose tissues. Ann Med 27:435-438
18. Rebrin K, Steil GM, Getty L, Bergman RN (1995) Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin. Diabetes 44:1038-1045
19. Boden G, Cheung P, Stein TP, Kresge K, Mozzoli M (2002) FFA cause hepatic insulin resistance by inhibiting insulin suppression of glycogenolysis. Am J Physiol 283:E12-E19
20. Fisher EA, Ginsberg HN (2002) Complexity in the secretory pathway: the assembly and secretion of apolipoprotein B-containing Lipoproteins. J Biol Chem 277:17377-17380
21. Fruebis J, Tsao TS, Javorschi S et al. (2001) Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci USA 98:2005-2010
22. Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K (1996) cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem Biophys Res Commun 221:286-289
23. Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF (1995) A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 270:26746-26749
24. Nakano Y, Tobe T, Choi-Miura NH, Mazda T, Tomita M (1996) Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma. J Biochem (Tokyo) 120:803-812
25. Hu E, Liang P, Spiegelman BM (1996) AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 271:10697-10703
26. Saltiel AR (2001) You are what you secrete. Nat Med 7:887-888
27. Havel PJ (2002) Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin. Curr Opin Lipidol 13:51-59
28. Arita Y, Kihara S, Ouchi N et al. (1999) Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 257:79-83
29. Hotta K, Funahashi T, Arita Y et al. (2000) Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 20:1595-1599
30. Weyer C, Funahashi T, Tanaka S et al. (2001) Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 86:1930-1935
31. Zoccali C, Mallamaci F, Tripepi G et al. (2002) Adiponectin, metabolic risk factors, and cardiovascular events among patients with end-stage renal disease. J Am Soc Nephrol 13:134-141
32. Ouchi N, Kihara S, Arita Y et al. (1999) Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation 100:2473-2476
33. Stefan N, Vozarova B, Funahashi T et al. (2002) Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans. Diabetes 51:1884-1888
34. Kazumi T, Kawaguchi A, Sakai K, Hirano T, Yoshino G (2002) Young men with high-normal blood pressure have lower serum adiponectin, smaller LDL size, and higher elevated heart rate than those with optimal blood pressure. Diabetes Care 25:971-976
35. Maeda N, Takahashi M, Funahashi T et al. (2001) PPAR-gamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes 50:2094-2099
36. Yang WS, Jeng CY, Wu TJ et al. (2002) Synthetic peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, increases plasma levels of adiponectin in type 2 diabetic patients. Diabetes Care 25:376-380
37. Hotta K, Funahashi T, Bodkin NL et al. (2001) Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 50:1126-1133
38. Kubota N, Terauchi Y, Yamauchi T et al. (2002) Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem 277:25863-25866
39. Maeda N, Shimomura I, Kishida K et al. (2002) Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 17 (online)
40. Knopp RH, Retzlaff BM, Walden CE et al. (1999) Effects of insulin resistance and obesity on the LDL response to egg ingestion. Circulation 100 (Suppl 1):I-116
41. Krotkiewski M, Bjorntorp P, Sjostrom L, Smith U (1983) Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution. J Clin Invest 72:1150-1162
42. Shuman WP, Newell Morris LL, Leonetti DL et al. (1986) Abnormal body fat distribution detected by computed tomography in diabetic men. Invest Radiol 21:483-487
43. Schwartz RS, Shuman WP, Larson V et al. (1991) The effect of intensive endurance exercise training on body fat distribution in young and older men. Metabolism 40:545-551
44. Bergman RN, Ider YZ, Bowden CR, Cobelli C (1979) Quantitative estimation of insulin sensitivity. Am J Physiol 236:E667-E677
45. Beard JC, Bergman RN, Ward WK, Porte D Jr (1986) The insulin sensitivity index in man: correlation between clamp-derived and IVGTT-derived values. Diabetes 35:362-369
46. Prigeon RL, Kahn SE, Porte D Jr (1994) Reliability of error estimates from the minimal model: implications for measurements in physiological studies. Am J Physiol 266:E279-E286
47. Abbate SL, Fujimoto WY, Brunzell JD, Kahn SE (1993) Effect of heparin on insulin-glucose interactions measured by the minimal model technique: implications for reproducibility using this method. Metabolism 42:353-357
48. Morgan DR, Lazarow A (1963) Immunoassay of insulin: two antibody system: plasma insulin levels of normal, sub-diabetic, and diabetic rats. Diabetes 12:115-126
49. Ma Z, Gingerich RL, Santiago JV, Klein S, Smith CH, Landt M (1996) Radioimmunoassay of leptin in human plasma. Clin Chem 42:942-946
50. Marcovina SM, Albers JJ, Kennedy H, Mei JV, Henderson LO, Hannon WH (1994) International Federation of Clinical Chemistry standardization project for measurements of apolipoproteins A-I and B. IV. Comparability of apolipoprotein B values by use of International Reference Material. Clin Chem 40:586-592
51. Purnell JQ, Marcovina SM, Hokanson JE et al. (1995) Levels of lipoprotein(a), apolipoprotein B, and lipoprotein cholesterol distribution in IDDM. Results from follow-up in the Diabetes Control and Complications Trial. Diabetes 44:1218-1226
52. Berg AH, Combs TP, Du X, Brownlee M, Scherer PE (2001) The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 7:947-953
53. Combs TP, Berg AH, Obici S, Scherer PE, Rossetti L (2001) Endogenous glucose production is inhibited by the adipose-derived protein Acrp30. J Clin Invest 108:1875-1881
54. Motoshima H, Wu X, Sinha MK et al. (2002) Differential regulation of adiponectin secretion from cultured human omental and subcutaneous adipocytes: effects of insulin and rosiglitazone. Diabetes 51 (Suppl 2):A-88
55. Nishizawa H, Shimomura I, Kishida K et al. (2002) Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein. Diabetes 51:2734-2741
56. Comuzzie AG, Funahashi T, Sonnenberg G et al. (2001) The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome. J Clin Endocrinol Metab 86:4321-4325
57. DeFronzo RA (1979) Glucose intolerance of aging. Evidence for tissue insensitivity to insulin. Diabetes 28:1095-1101
58. Chen M, Bergman RN, Pacini G, Porte D Jr (1985) Pathogenesis of age-related glucose intolerance in man: insulin resistance and decreased β-cell function. J Clin Endocrinol Metab 60:13-20
59. Schwartz RS, Shuman WP, Bradbury VL et al. (1990) Body fat distribution in healthy young and older men. J Gerontol 45:M181-M185
60. Colman E, Katzel LI, Rogus E, Coon P, Muller D, Goldberg AP (1995) Weight loss reduces abdominal fat and improves insulin action in middle-aged and older men with impaired glucose tolerance. Metabolism 44:1502-1508
61. Combs TP, Berg AH, Rajala MW et al. (2003) Sexual differentiation, pregnancy, caloric restriction, and aging affect the adipocyte-specific secretory protein adiponectin. Diabetes 52:268-276
62. Lindsay RS, Funahashi T, Hanson RL et al. (2002) Adiponectin and development of type 2 diabetes in the Pima Indian population. Lancet 360:57-58
63. Brunzell JD (2003) Dyslipidemia of the metabolic syndrome. In: Eckel RH (eds) Obesity: mechanism and clinical management. Lippincott, Williams and Wilkins, Philadelphia
64. Matsubara M, Maruoka S, Katayose S (2002) Decreased plasma adiponectin concentrations in women with dyslipidemia. J Clin Endocrinol Metab 87:2764-2769
65. Despres JP, Ferland M, Moorjani S et al. (1989) Role of hepatic-triglyceride lipase activity in the association between intra-abdominal fat and plasma HDL cholesterol in obese women. Arteriosclerosis 9:485-492
66. Carr MC, Hokanson JE, Deeb SS, Purnell JQ, Mitchell ES, Brunzell JD (1999) A hepatic lipase gene promoter polymorphism attenuates the increase in hepatic lipase activity with increasing intra-abdominal fat in women. Arterioscler Thromb Vasc Biol 19:2701-2707
67. Iverius PH, Brunzell JD (1985) Human adipose tissue lipoprotein lipase: changes with feeding and relation to post-heparin plasma enzyme. Am J Physiol 249:E107-E114
68. Ouchi N, Kihara S, Arita Y et al. (2000) Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation 102:1296-1301
69. Ouchi N, Kihara S, Arita Y et al. (2001) Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages. Circulation 103:1057-1063
70. Halleux CM, Takahashi M, Delporte ML et al. (2001) Secretion of adiponectin and regulation of apM1 gene expression in human visceral adipose tissue. Biochem Biophys Res Commun 288:1102-1107