-
1
-
-
33751106653
-
New approaches to molecular cancer therapeutics
-
I. Collins, and P. Workman New approaches to molecular cancer therapeutics Nat Chem Biol 2 12 2006 689 700
-
(2006)
Nat Chem Biol
, vol.2
, Issue.12
, pp. 689-700
-
-
Collins, I.1
Workman, P.2
-
2
-
-
0036635291
-
Glivec (STI571), a rationally developed, targeted anticancer drug
-
R. Capdeville, E. Buchdunger, J. Zimmerman, and A. Matter Glivec (STI571), a rationally developed, targeted anticancer drug Nat Rev Drug Discov 1 7 2002 493
-
(2002)
Nat Rev Drug Discov
, vol.1
, Issue.7
, pp. 493
-
-
Capdeville, R.1
Buchdunger, E.2
Zimmerman, J.3
Matter, A.4
-
3
-
-
84869761071
-
The protein-folding problem, 50 years on
-
K.A. Dill, and J.L. MacCallum The protein-folding problem, 50 years on Science 338 6110 2012 1042 1046
-
(2012)
Science
, vol.338
, Issue.6110
, pp. 1042-1046
-
-
Dill, K.A.1
MacCallum, J.L.2
-
4
-
-
84863903065
-
Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: Progress and prognosis
-
S.L. Lindquist, and J.W. Kelly Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosis Cold Spring Harb Perspect Biol 3 12 2011 34
-
(2011)
Cold Spring Harb Perspect Biol
, vol.3
, Issue.12
, pp. 34
-
-
Lindquist, S.L.1
Kelly, J.W.2
-
5
-
-
33746099650
-
Protein aggregation in crowded environments
-
R.J. Ellis, and A.P. Minton Protein aggregation in crowded environments Biol Chem 387 5 2006 485 497
-
(2006)
Biol Chem
, vol.387
, Issue.5
, pp. 485-497
-
-
Ellis, R.J.1
Minton, A.P.2
-
6
-
-
0031873752
-
The 90-kDa molecular chaperone family: Structure, function, and clinical applications. A comprehensive review
-
P. Csermely, T. Schnaider, C. Soti, Z. Prohaszka, and G. Nardai The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review Pharmacol Ther 79 2 1998 129 168
-
(1998)
Pharmacol Ther
, vol.79
, Issue.2
, pp. 129-168
-
-
Csermely, P.1
Schnaider, T.2
Soti, C.3
Prohaszka, Z.4
Nardai, G.5
-
8
-
-
0031444238
-
Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
-
C. Prodromou, S.M. Roe, R. O'Brien, J.E. Ladbury, P.W. Piper, and L.H. Pearl Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone Cell 90 1 1997 65 75
-
(1997)
Cell
, vol.90
, Issue.1
, pp. 65-75
-
-
Prodromou, C.1
Roe, S.M.2
O'Brien, R.3
Ladbury, J.E.4
Piper, P.W.5
Pearl, L.H.6
-
9
-
-
0034663806
-
The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains
-
C. Prodromou, B. Panaretou, S. Chohan, G. Siligardi, R. O'Brien, and J.E. Ladbury The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains EMBO J 19 16 2000 4383 4392
-
(2000)
EMBO J
, vol.19
, Issue.16
, pp. 4383-4392
-
-
Prodromou, C.1
Panaretou, B.2
Chohan, S.3
Siligardi, G.4
O'Brien, R.5
Ladbury, J.E.6
-
10
-
-
0028064940
-
Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: Essential role for stress proteins in oncogenic transformation
-
L. Whitesell, E.G. Mimnaugh, B. De Costa, C.E. Myers, and L.M. Neckers Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation Proc Natl Acad Sci USA 91 18 1994 8324 8328
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, Issue.18
, pp. 8324-8328
-
-
Whitesell, L.1
Mimnaugh, E.G.2
De Costa, B.3
Myers, C.E.4
Neckers, L.M.5
-
11
-
-
0032959590
-
Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics Radicicol and Geldanamycin
-
S.M. Roe, C. Prodromou, R. O'Brien, J.E. Ladbury, P.W. Piper, and L.H. Pearl Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics Radicicol and Geldanamycin J Med Chem 42 2 1999 260 266
-
(1999)
J Med Chem
, vol.42
, Issue.2
, pp. 260-266
-
-
Roe, S.M.1
Prodromou, C.2
O'Brien, R.3
Ladbury, J.E.4
Piper, P.W.5
Pearl, L.H.6
-
12
-
-
0036718795
-
ATPases as drug targets: Learning from their structure
-
P. Chene ATPases as drug targets: learning from their structure Nat Rev Drug Discov 1 9 2002 665 673
-
(2002)
Nat Rev Drug Discov
, vol.1
, Issue.9
, pp. 665-673
-
-
Chene, P.1
-
13
-
-
37649024109
-
Development and application of Hsp90 inhibitors
-
D.B. Solit, and G. Chiosis Development and application of Hsp90 inhibitors Drug Discov Today 13 1-2 2008 38 43
-
(2008)
Drug Discov Today
, vol.13
, Issue.12
, pp. 38-43
-
-
Solit, D.B.1
Chiosis, G.2
-
14
-
-
84902071075
-
Exploiting Cancer Dependence on Molecular Chaperones: HSP90 Inhibitors Past, Present, and Future
-
S. Neidle, 2nd ed. Elsevier Inc London
-
S. Sharp, K. Jones, and P. Workman Exploiting Cancer Dependence on Molecular Chaperones: HSP90 Inhibitors Past, Present, and Future S. Neidle, Cancer Drug Design and Discovery 2nd ed. 2014 Elsevier Inc London 239 274
-
(2014)
Cancer Drug Design and Discovery
, pp. 239-274
-
-
Sharp, S.1
Jones, K.2
Workman, P.3
-
15
-
-
79952734485
-
A phase I study of the heat shock protein 90 inhibitor Alvespimycin (17-DMAG) given intravenously to patients with advanced solid tumors
-
S. Pacey, R.H. Wilson, M. Walton, M.M. Eatock, A. Hardcastle, and A. Zetterlund A phase I study of the heat shock protein 90 inhibitor Alvespimycin (17-DMAG) given intravenously to patients with advanced solid tumors Clin Cancer Res 17 6 2011 1561 1570
-
(2011)
Clin Cancer Res
, vol.17
, Issue.6
, pp. 1561-1570
-
-
Pacey, S.1
Wilson, R.H.2
Walton, M.3
Eatock, M.M.4
Hardcastle, A.5
Zetterlund, A.6
-
16
-
-
51449093764
-
Targeting Hsp90: Small-molecule inhibitors and their clinical development
-
T. Taldone, A. Gozman, R. Maharaj, and G. Chiosis Targeting Hsp90: small-molecule inhibitors and their clinical development Curr Opin Pharmacol 8 4 2008 370 374
-
(2008)
Curr Opin Pharmacol
, vol.8
, Issue.4
, pp. 370-374
-
-
Taldone, T.1
Gozman, A.2
Maharaj, R.3
Chiosis, G.4
-
17
-
-
80052330412
-
Multicenter phase II trial of the heat shock protein 90 inhibitor, retaspimycin hydrochloride (IPI-504), in patients with castration-resistant prostate cancer
-
W.K. Oh, M.D. Galsky, W.M. Stadler, S. Srinivas, F. Chu, and G. Bubley Multicenter phase II trial of the heat shock protein 90 inhibitor, retaspimycin hydrochloride (IPI-504), in patients with castration-resistant prostate cancer Urology 78 3 2011 626 630
-
(2011)
Urology
, vol.78
, Issue.3
, pp. 626-630
-
-
Oh, W.K.1
Galsky, M.D.2
Stadler, W.M.3
Srinivas, S.4
Chu, F.5
Bubley, G.6
-
18
-
-
33746377987
-
Inhibitors of the HSP90 molecular chaperone: Attacking the master regulator in cancer
-
E. McDonald, P. Workman, and K. Jones Inhibitors of the HSP90 molecular chaperone: attacking the master regulator in cancer Curr Top Med Chem 6 11 2006 1091 1107
-
(2006)
Curr Top Med Chem
, vol.6
, Issue.11
, pp. 1091-1107
-
-
McDonald, E.1
Workman, P.2
Jones, K.3
-
19
-
-
38349157746
-
4,5-Diarylisoxazole Hsp90 chaperone inhibitors: Potential therapeutic agents for the treatment of cancer
-
P.A. Brough, W. Aherne, X. Barril, J. Borgognoni, K. Boxall, and J.E. Cansfield 4,5-Diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer J Med Chem 51 2 2008 196 218
-
(2008)
J Med Chem
, vol.51
, Issue.2
, pp. 196-218
-
-
Brough, P.A.1
Aherne, W.2
Barril, X.3
Borgognoni, J.4
Boxall, K.5
Cansfield, J.E.6
-
20
-
-
34248166042
-
Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues
-
S.Y. Sharp, C. Prodromou, K. Boxall, M.V. Powers, J.L. Holmes, and G. Box Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues Mol Cancer Ther 6 4 2007 1198 1211
-
(2007)
Mol Cancer Ther
, vol.6
, Issue.4
, pp. 1198-1211
-
-
Sharp, S.Y.1
Prodromou, C.2
Boxall, K.3
Powers, M.V.4
Holmes, J.L.5
Box, G.6
-
21
-
-
20644448390
-
The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors
-
K.-M.J. Cheung, T.P. Matthews, K. James, M.G. Rowlands, K.J. Boxall, and S.Y. Sharp The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors Bioorg Med Chem Lett 15 14 2005 3338 3343
-
(2005)
Bioorg Med Chem Lett
, vol.15
, Issue.14
, pp. 3338-3343
-
-
Cheung, K.-M.J.1
Matthews, T.P.2
James, K.3
Rowlands, M.G.4
Boxall, K.J.5
Sharp, S.Y.6
-
22
-
-
33947210121
-
In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors
-
S.Y. Sharp, K. Boxall, M. Rowlands, C. Prodromou, S.M. Roe, and A. Maloney In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors Cancer Res 67 5 2007 2206 2216
-
(2007)
Cancer Res
, vol.67
, Issue.5
, pp. 2206-2216
-
-
Sharp, S.Y.1
Boxall, K.2
Rowlands, M.3
Prodromou, C.4
Roe, S.M.5
Maloney, A.6
-
23
-
-
84923109894
-
-
[Internet]
-
ClinicalTrials.gov [Internet]. Available from: http://www.clinicaltrials.gov/.
-
-
-
-
24
-
-
84866382273
-
Phase II study of the HSP90 inhibitor AUY922 in patients with previously treated, advanced non-small cell lung cancer (NSCLC)
-
E.B. Garon, T. Moran, F. Barlesi, L. Gandhi, L.V. Sequist, and S.-W. Kim Phase II study of the HSP90 inhibitor AUY922 in patients with previously treated, advanced non-small cell lung cancer (NSCLC) J Clin Oncol 30 15 2012
-
(2012)
J Clin Oncol
, vol.30
, Issue.15
-
-
Garon, E.B.1
Moran, T.2
Barlesi, F.3
Gandhi, L.4
Sequist, L.V.5
Kim, S.-W.6
-
25
-
-
84875533868
-
Phase IB/II study of the HSP90 inhibitor AUY922, in combination with trastuzumab, in patients with HER2+ advanced breast cancer
-
A. Kong, D. Rea, S. Ahmed, J.T. Beck, R.L. Lopez, and L. Biganzoli Abstract 530: Phase IB/II study of the HSP90 inhibitor AUY922, in combination with trastuzumab, in patients with HER2+ advanced breast cancer J Clin Oncol 30 15 2012 530
-
(2012)
J Clin Oncol
, vol.30
, Issue.15
, pp. 530
-
-
Kong, A.1
Rea, D.2
Ahmed, S.3
Beck, J.T.4
Lopez, R.L.5
Biganzoli, L.6
-
26
-
-
77955863827
-
Fragment-based drug discovery applied to Hsp90. Discovery of two lead series with high ligand efficiency
-
C.W. Murray, M.G. Carr, O. Callaghan, G. Chessari, M. Congreve, and S. Cowan Fragment-based drug discovery applied to Hsp90. Discovery of two lead series with high ligand efficiency J Med Chem 53 16 2010 5942 5955
-
(2010)
J Med Chem
, vol.53
, Issue.16
, pp. 5942-5955
-
-
Murray, C.W.1
Carr, M.G.2
Callaghan, O.3
Chessari, G.4
Congreve, M.5
Cowan, S.6
-
27
-
-
84859729014
-
The heat shock protein 90 inhibitor, AT13387, displays a long duration of action in vitro and in vivo in non-small cell lung cancer
-
B. Graham, J. Curry, T. Smyth, L. Fazal, R. Feltell, and I. Harada The heat shock protein 90 inhibitor, AT13387, displays a long duration of action in vitro and in vivo in non-small cell lung cancer Cancer Sci 103 3 2012 522 527
-
(2012)
Cancer Sci
, vol.103
, Issue.3
, pp. 522-527
-
-
Graham, B.1
Curry, J.2
Smyth, T.3
Fazal, L.4
Feltell, R.5
Harada, I.6
-
28
-
-
33746365169
-
Discovery and development of purine-scaffold Hsp90 inhibitors
-
G. Chiosis Discovery and development of purine-scaffold Hsp90 inhibitors Curr Top Med Chem 6 11 2006 1183 1191
-
(2006)
Curr Top Med Chem
, vol.6
, Issue.11
, pp. 1183-1191
-
-
Chiosis, G.1
-
29
-
-
3042637928
-
Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms
-
L. Wright, X. Barril, B. Dymock, L. Sheridan, A. Surgenor, and M. Beswick Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms Chem Biol 11 6 2004 775 785
-
(2004)
Chem Biol
, vol.11
, Issue.6
, pp. 775-785
-
-
Wright, L.1
Barril, X.2
Dymock, B.3
Sheridan, L.4
Surgenor, A.5
Beswick, M.6
-
30
-
-
0035071607
-
A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells
-
G. Chiosis, M.N. Timaul, B. Lucas, P.N. Munster, F.F. Zheng, and L. Sepp-Lorenzino A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells Chem Biol 8 3 2001 289 299
-
(2001)
Chem Biol
, vol.8
, Issue.3
, pp. 289-299
-
-
Chiosis, G.1
Timaul, M.N.2
Lucas, B.3
Munster, P.N.4
Zheng, F.F.5
Sepp-Lorenzino, L.6
-
31
-
-
3042553538
-
Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90
-
M. Vilenchik, D. Solit, A. Basso, H. Huezo, B. Lucas, and H. He Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90 Chem Biol 11 6 2004 787 797
-
(2004)
Chem Biol
, vol.11
, Issue.6
, pp. 787-797
-
-
Vilenchik, M.1
Solit, D.2
Basso, A.3
Huezo, H.4
Lucas, B.5
He, H.6
-
32
-
-
17444416142
-
Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90
-
L. Llauger, H. He, J. Kim, J. Aguirre, N. Rosen, and U. Peters Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90 J Med Chem 48 8 2005 2892 2905
-
(2005)
J Med Chem
, vol.48
, Issue.8
, pp. 2892-2905
-
-
Llauger, L.1
He, H.2
Kim, J.3
Aguirre, J.4
Rosen, N.5
Peters, U.6
-
33
-
-
30444447639
-
Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90
-
H. He, D. Zatorska, J. Kim, J. Aguirre, L. Llauger, and Y. She Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90 J Med Chem 49 1 2005 381 390
-
(2005)
J Med Chem
, vol.49
, Issue.1
, pp. 381-390
-
-
He, H.1
Zatorska, D.2
Kim, J.3
Aguirre, J.4
Llauger, L.5
She, Y.6
-
34
-
-
66449094961
-
BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90
-
K. Lundgren, H. Zhang, J. Brekken, N. Huser, R.E. Powell, and N. Timple BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90 Mol Cancer Ther 8 4 2009 921 929
-
(2009)
Mol Cancer Ther
, vol.8
, Issue.4
, pp. 921-929
-
-
Lundgren, K.1
Zhang, H.2
Brekken, J.3
Huser, N.4
Powell, R.E.5
Timple, N.6
-
35
-
-
84871563835
-
Phase II study of the HSP90-inhibitor BIIB021 in gastrointestinal stromal tumors
-
M.A. Dickson, S.H. Okuno, M.L. Keohan, R.G. Maki, D.R. D'Adamo, and T.J. Akhurst Phase II study of the HSP90-inhibitor BIIB021 in gastrointestinal stromal tumors Ann Oncol 24 1 2013 252 257
-
(2013)
Ann Oncol
, vol.24
, Issue.1
, pp. 252-257
-
-
Dickson, M.A.1
Okuno, S.H.2
Keohan, M.L.3
Maki, R.G.4
D'Adamo, D.R.5
Akhurst, T.J.6
-
36
-
-
84866309629
-
EC144 is a potent inhibitor of the heat shock protein 90
-
J. Shi, R. Van de Water, K. Hong, R.B. Lamer, K.W. Weichert, and C.M. Sandoval EC144 is a potent inhibitor of the heat shock protein 90 J Med Chem 55 17 2012 7786 7795
-
(2012)
J Med Chem
, vol.55
, Issue.17
, pp. 7786-7795
-
-
Shi, J.1
Van De Water, R.2
Hong, K.3
Lamer, R.B.4
Weichert, K.W.5
Sandoval, C.M.6
-
37
-
-
84884257315
-
Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series
-
T. Taldone, P.D. Patel, M. Patel, H.J. Patel, C.E. Evans, and A. Rodina Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series J Med Chem 56 17 2013 6803 6818
-
(2013)
J Med Chem
, vol.56
, Issue.17
, pp. 6803-6818
-
-
Taldone, T.1
Patel, P.D.2
Patel, M.3
Patel, H.J.4
Evans, C.E.5
Rodina, A.6
-
38
-
-
84886599750
-
Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2
-
P.D. Patel, P. Yan, P.M. Seidler, H.J. Patel, W. Sun, and C. Yang Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2 Nat Chem Biol 9 11 2013 677 684
-
(2013)
Nat Chem Biol
, vol.9
, Issue.11
, pp. 677-684
-
-
Patel, P.D.1
Yan, P.2
Seidler, P.M.3
Patel, H.J.4
Sun, W.5
Yang, C.6
-
39
-
-
84879098944
-
ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system
-
S. Polier, R.S. Samant, P.A. Clarke, P. Workman, C. Prodromou, and L.H. Pearl ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system Nat Chem Biol 9 5 2013 307 312
-
(2013)
Nat Chem Biol
, vol.9
, Issue.5
, pp. 307-312
-
-
Polier, S.1
Samant, R.S.2
Clarke, P.A.3
Workman, P.4
Prodromou, C.5
Pearl, L.H.6
-
40
-
-
77953576838
-
Targeting HSP70: The second potentially druggable heat shock protein and molecular chaperone?
-
M.V. Powers, K. Jones, C. Barillari, I. Westwood, R.L. van Montfort, and P. Workman Targeting HSP70: the second potentially druggable heat shock protein and molecular chaperone? Cell Cycle 9 8 2010 1542 1550
-
(2010)
Cell Cycle
, vol.9
, Issue.8
, pp. 1542-1550
-
-
Powers, M.V.1
Jones, K.2
Barillari, C.3
Westwood, I.4
Van Montfort, R.L.5
Workman, P.6
-
41
-
-
77958516062
-
ATPases as drug targets: Insights from heat shock proteins 70 and 90
-
A.J. Massey ATPases as drug targets: insights from heat shock proteins 70 and 90 J Med Chem 53 20 2010 7280 7286
-
(2010)
J Med Chem
, vol.53
, Issue.20
, pp. 7280-7286
-
-
Massey, A.J.1
-
42
-
-
57749188299
-
Targeting cancer with small molecule kinase inhibitors
-
J. Zhang, P.L. Yang, and N.S. Gray Targeting cancer with small molecule kinase inhibitors Nat Rev Cancer 9 1 2009 28 39
-
(2009)
Nat Rev Cancer
, vol.9
, Issue.1
, pp. 28-39
-
-
Zhang, J.1
Yang, P.L.2
Gray, N.S.3
-
43
-
-
0036527429
-
Protein kinases - The major drug targets of the twenty-first century?
-
P. Cohen Protein kinases-the major drug targets of the twenty-first century? Nat Rev Drug Discov 1 4 2002 309 315
-
(2002)
Nat Rev Drug Discov
, vol.1
, Issue.4
, pp. 309-315
-
-
Cohen, P.1
-
44
-
-
0037032835
-
The protein kinase complement of the human genome
-
G. Manning, D.B. Whyte, R. Martinez, T. Hunter, and S. Sudarsanam The protein kinase complement of the human genome Science 298 5600 2002 1912 1934
-
(2002)
Science
, vol.298
, Issue.5600
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
45
-
-
0037392444
-
Issues and progress with protein kinase inhibitors for cancer treatment
-
J. Dancey, and E.A. Sausville Issues and progress with protein kinase inhibitors for cancer treatment Nat Rev Drug Discov 2 4 2003 296 313
-
(2003)
Nat Rev Drug Discov
, vol.2
, Issue.4
, pp. 296-313
-
-
Dancey, J.1
Sausville, E.A.2
-
47
-
-
1642270826
-
Recent kinase and kinase inhibitor X-ray structures: Mechanisms of inhibition and selectivity insights
-
M. Cherry, and D.H. Williams Recent kinase and kinase inhibitor X-ray structures: mechanisms of inhibition and selectivity insights Curr Med Chem 11 6 2004 663 673
-
(2004)
Curr Med Chem
, vol.11
, Issue.6
, pp. 663-673
-
-
Cherry, M.1
Williams, D.H.2
-
48
-
-
33749238553
-
Discovery and development of sorafenib: A multikinase inhibitor for treating cancer
-
S. Wilhelm, C. Carter, M. Lynch, T. Lowinger, J. Dumas, and R.A. Smith Discovery and development of sorafenib: a multikinase inhibitor for treating cancer Nat Rev Drug Discov 5 10 2006 835 844
-
(2006)
Nat Rev Drug Discov
, vol.5
, Issue.10
, pp. 835-844
-
-
Wilhelm, S.1
Carter, C.2
Lynch, M.3
Lowinger, T.4
Dumas, J.5
Smith, R.A.6
-
49
-
-
84879360909
-
Ins and outs of kinase DFG motifs
-
K. Treiber Daniel, and Neil P. Shah Ins and outs of kinase DFG motifs Chem Biol 20 6 2013 745 746
-
(2013)
Chem Biol
, vol.20
, Issue.6
, pp. 745-746
-
-
Treiber Daniel, K.1
Shah, N.P.2
-
50
-
-
15744380263
-
Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition
-
J.F. Ohren, H. Chen, A. Pavlovsky, C. Whitehead, E. Zhang, and P. Kuffa Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition Nat Struct Mol Biol 11 12 2004 1192 1197
-
(2004)
Nat Struct Mol Biol
, vol.11
, Issue.12
, pp. 1192-1197
-
-
Ohren, J.F.1
Chen, H.2
Pavlovsky, A.3
Whitehead, C.4
Zhang, E.5
Kuffa, P.6
-
51
-
-
79953314480
-
The resurgence of covalent drugs
-
J. Singh, R.C. Petter, T.A. Baillie, and A. Whitty The resurgence of covalent drugs Nat Rev Drug Discov 10 4 2011 307 317
-
(2011)
Nat Rev Drug Discov
, vol.10
, Issue.4
, pp. 307-317
-
-
Singh, J.1
Petter, R.C.2
Baillie, T.A.3
Whitty, A.4
-
52
-
-
84891496533
-
Drug discovery considerations in the development of covalent inhibitors
-
R. Mah, J.R. Thomas, and C.M. Shafer Drug discovery considerations in the development of covalent inhibitors Bioorg Med Chem Lett 24 1 2014 33 39
-
(2014)
Bioorg Med Chem Lett
, vol.24
, Issue.1
, pp. 33-39
-
-
Mah, R.1
Thomas, J.R.2
Shafer, C.M.3
-
53
-
-
84923085602
-
-
Centerwatch. Available from http://centerwatch.com/drug-information/fda-approved-drugs/.
-
-
-
Centerwatch1
-
54
-
-
84868481873
-
Vemurafenib: The first drug approved for BRAF-mutant cancer
-
G. Bollag, J. Tsai, J. Zhang, C. Zhang, P. Ibrahim, and K. Nolop Vemurafenib: the first drug approved for BRAF-mutant cancer Nat Rev Drug Discov 11 11 2012 873 886
-
(2012)
Nat Rev Drug Discov
, vol.11
, Issue.11
, pp. 873-886
-
-
Bollag, G.1
Tsai, J.2
Zhang, J.3
Zhang, C.4
Ibrahim, P.5
Nolop, K.6
-
55
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
H. Davies, G.R. Bignell, C. Cox, P. Stephens, S. Edkins, and S. Clegg Mutations of the BRAF gene in human cancer Nature 417 6892 2002 949 954
-
(2002)
Nature
, vol.417
, Issue.6892
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
Clegg, S.6
-
56
-
-
0036654443
-
A genome-based strategy uncovers frequent BRAF mutations in melanoma
-
P.M. Pollock, and P.S. Meltzer A genome-based strategy uncovers frequent BRAF mutations in melanoma Cancer Cell 2 1 2002 5 7
-
(2002)
Cancer Cell
, vol.2
, Issue.1
, pp. 5-7
-
-
Pollock, P.M.1
Meltzer, P.S.2
-
57
-
-
33947101019
-
Patterns of somatic mutation in human cancer genomes
-
C. Greenman, P. Stephens, R. Smith, G.L. Dalgliesh, C. Hunter, and G. Bignell Patterns of somatic mutation in human cancer genomes Nature 446 7132 2007 153 158
-
(2007)
Nature
, vol.446
, Issue.7132
, pp. 153-158
-
-
Greenman, C.1
Stephens, P.2
Smith, R.3
Dalgliesh, G.L.4
Hunter, C.5
Bignell, G.6
-
58
-
-
12144289677
-
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
-
P.T.C. Wan, M.J. Garnett, S.M. Roe, S. Lee, D. Niculescu-Duvaz, and V.M. Good Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF Cell 116 6 2004 855 867
-
(2004)
Cell
, vol.116
, Issue.6
, pp. 855-867
-
-
Wan, P.T.C.1
Garnett, M.J.2
Roe, S.M.3
Lee, S.4
Niculescu-Duvaz, D.5
Good, V.M.6
-
59
-
-
42949149240
-
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
-
J. Tsai, J.T. Lee, W. Wang, J. Zhang, H. Cho, and S. Mamo Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity Proc Natl Acad Sci USA 105 8 2008 3041 3046
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.8
, pp. 3041-3046
-
-
Tsai, J.1
Lee, J.T.2
Wang, W.3
Zhang, J.4
Cho, H.5
Mamo, S.6
-
60
-
-
70349438995
-
A dimerization-dependent mechanism drives RAF catalytic activation
-
T. Rajakulendran, M. Sahmi, M. Lefrancois, F. Sicheri, and M. Therrien A dimerization-dependent mechanism drives RAF catalytic activation Nature 461 7263 2009 542 545
-
(2009)
Nature
, vol.461
, Issue.7263
, pp. 542-545
-
-
Rajakulendran, T.1
Sahmi, M.2
Lefrancois, M.3
Sicheri, F.4
Therrien, M.5
-
61
-
-
0033179479
-
Paradoxical activation of Raf by a novel Raf inhibitor
-
C.A. Hall-Jackson, P.A. Eyers, P. Cohen, M. Goedert, F.T. Boyle, and N. Hewitt Paradoxical activation of Raf by a novel Raf inhibitor Chem Biol 6 8 1999 559 568
-
(1999)
Chem Biol
, vol.6
, Issue.8
, pp. 559-568
-
-
Hall-Jackson, C.A.1
Eyers, P.A.2
Cohen, P.3
Goedert, M.4
Boyle, F.T.5
Hewitt, N.6
-
62
-
-
84856996617
-
The RAF inhibitor paradox revisited
-
A.D. Cox, and C.J. Der The RAF inhibitor paradox revisited Cancer Cell 21 2 2012 147 149
-
(2012)
Cancer Cell
, vol.21
, Issue.2
, pp. 147-149
-
-
Cox, A.D.1
Der, C.J.2
-
63
-
-
77956513286
-
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
-
G. Bollag, P. Hirth, J. Tsai, J. Zhang, P.N. Ibrahim, and H. Cho Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma Nature 467 7315 2010 596 599
-
(2010)
Nature
, vol.467
, Issue.7315
, pp. 596-599
-
-
Bollag, G.1
Hirth, P.2
Tsai, J.3
Zhang, J.4
Ibrahim, P.N.5
Cho, H.6
-
64
-
-
84886385231
-
Identification of multiple mechanisms of resistance to vemurafenib in a patient with BRAFV600E-mutated cutaneous melanoma successfully rechallenged after progression
-
E. Romano, S. Pradervand, A. Paillusson, J. Weber, K. Harshman, and K. Muehlethaler Identification of multiple mechanisms of resistance to vemurafenib in a patient with BRAFV600E-mutated cutaneous melanoma successfully rechallenged after progression Clin Cancer Res 19 20 2013 5749 5757
-
(2013)
Clin Cancer Res
, vol.19
, Issue.20
, pp. 5749-5757
-
-
Romano, E.1
Pradervand, S.2
Paillusson, A.3
Weber, J.4
Harshman, K.5
Muehlethaler, K.6
-
65
-
-
84863115580
-
Resistance to selective BRAF inhibition can be mediated by modest upstream pathway activation
-
F. Su, W.D. Bradley, Q. Wang, H. Yang, L. Xu, and B. Higgins Resistance to selective BRAF inhibition can be mediated by modest upstream pathway activation Cancer Res 72 4 2012 969 978
-
(2012)
Cancer Res
, vol.72
, Issue.4
, pp. 969-978
-
-
Su, F.1
Bradley, W.D.2
Wang, Q.3
Yang, H.4
Xu, L.5
Higgins, B.6
-
66
-
-
16844381831
-
Mechanisms of B-cell lymphoma pathogenesis
-
R. Kuppers Mechanisms of B-cell lymphoma pathogenesis Nat Rev Cancer 5 4 2005 251 262
-
(2005)
Nat Rev Cancer
, vol.5
, Issue.4
, pp. 251-262
-
-
Kuppers, R.1
-
67
-
-
73849145729
-
Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
-
R.E. Davis, V.N. Ngo, G. Lenz, P. Tolar, R.M. Young, and P.B. Romesser Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma Nature 463 7277 2010 88 92
-
(2010)
Nature
, vol.463
, Issue.7277
, pp. 88-92
-
-
Davis, R.E.1
Ngo, V.N.2
Lenz, G.3
Tolar, P.4
Young, R.M.5
Romesser, P.B.6
-
68
-
-
38049084406
-
Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase
-
Z. Pan, H. Scheerens, S.-J. Li, B.E. Schultz, P.A. Sprengeler, and L.C. Burrill Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase ChemMedChem 2 1 2007 58 61
-
(2007)
ChemMedChem
, vol.2
, Issue.1
, pp. 58-61
-
-
Pan, Z.1
Scheerens, H.2
Li, S.-J.3
Schultz, B.E.4
Sprengeler, P.A.5
Burrill, L.C.6
-
69
-
-
19744365702
-
A small molecule-kinase interaction map for clinical kinase inhibitors
-
M.A. Fabian, W.H. Biggs, D.K. Treiber, C.E. Atteridge, M.D. Azimioara, and M.G. Benedetti A small molecule-kinase interaction map for clinical kinase inhibitors Nat Biotechnol 23 3 2005 329 336
-
(2005)
Nat Biotechnol
, vol.23
, Issue.3
, pp. 329-336
-
-
Fabian, M.A.1
Biggs, W.H.2
Treiber, D.K.3
Atteridge, C.E.4
Azimioara, M.D.5
Benedetti, M.G.6
-
70
-
-
13144266690
-
Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor
-
D.W. Fry, A.J. Bridges, W.A. Denny, A. Doherty, K.D. Greis, and J.L. Hicks Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor Proc Natl Acad Sci USA 95 20 1998 12022 12027
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, Issue.20
, pp. 12022-12027
-
-
Fry, D.W.1
Bridges, A.J.2
Denny, W.A.3
Doherty, A.4
Greis, K.D.5
Hicks, J.L.6
-
71
-
-
19744364796
-
Structural bioinformatics-based design of selective, irreversible kinase inhibitors
-
M.S. Cohen, C. Zhang, K.M. Shokat, and J. Taunton Structural bioinformatics-based design of selective, irreversible kinase inhibitors Science 308 5726 2005 1318 1321
-
(2005)
Science
, vol.308
, Issue.5726
, pp. 1318-1321
-
-
Cohen, M.S.1
Zhang, C.2
Shokat, K.M.3
Taunton, J.4
-
72
-
-
77955625479
-
The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy
-
L.A. Honigberg, A.M. Smith, M. Sirisawad, E. Verner, D. Loury, and B. Chang The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy Proc Natl Acad Sci USA 107 29 2010 13075 13080
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.29
, pp. 13075-13080
-
-
Honigberg, L.A.1
Smith, A.M.2
Sirisawad, M.3
Verner, E.4
Loury, D.5
Chang, B.6
-
73
-
-
84883313959
-
Irreversible kinase inhibitors gain traction
-
K. Sanderson Irreversible kinase inhibitors gain traction Nat Rev Drug Discov 12 9 2013 649 651
-
(2013)
Nat Rev Drug Discov
, vol.12
, Issue.9
, pp. 649-651
-
-
Sanderson, K.1
-
74
-
-
84906092687
-
AZD9291: An irreversible, potent and selective third generation tyrosine kinase inhibitor (TKI) targeting EGFR activating (EGFRm +) and resistance (T790M) mutations in advanced lung adenocarcinoma
-
D. Cross, S. Ashton, C. Nebhan, C. Eberlein, M.R.V. Finlay, and G. Hughes Abstract A109: AZD9291: an irreversible, potent and selective third generation tyrosine kinase inhibitor (TKI) targeting EGFR activating (EGFRm +) and resistance (T790M) mutations in advanced lung adenocarcinoma Mol Cancer Ther 12 2013 A109
-
(2013)
Mol Cancer Ther
, vol.12
, pp. A109
-
-
Cross, D.1
Ashton, S.2
Nebhan, C.3
Eberlein, C.4
Finlay, M.R.V.5
Hughes, G.6
-
75
-
-
84908371107
-
Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor
-
M.R.V. Finlay, M. Anderton, S. Ashton, P. Ballard, P.A. Bethel, and M.R. Box Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor J Med Chem 57 20 2014 8249 8267
-
(2014)
J Med Chem
, vol.57
, Issue.20
, pp. 8249-8267
-
-
Finlay, M.R.V.1
Anderton, M.2
Ashton, S.3
Ballard, P.4
Bethel, P.A.5
Box, M.R.6
-
76
-
-
78650303507
-
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
-
R. Nazarian, H. Shi, Q. Wang, X. Kong, R.C. Koya, and H. Lee Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation Nature 468 7326 2010 973 977
-
(2010)
Nature
, vol.468
, Issue.7326
, pp. 973-977
-
-
Nazarian, R.1
Shi, H.2
Wang, Q.3
Kong, X.4
Koya, R.C.5
Lee, H.6
-
77
-
-
78650008177
-
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K
-
J. Villanueva, A. Vultur, J.T. Lee, R. Somasundaram, M. Fukunaga-Kalabis, and A.K. Cipolla Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K Cancer Cell 18 6 2010 683 695
-
(2010)
Cancer Cell
, vol.18
, Issue.6
, pp. 683-695
-
-
Villanueva, J.1
Vultur, A.2
Lee, J.T.3
Somasundaram, R.4
Fukunaga-Kalabis, M.5
Cipolla, A.K.6
-
78
-
-
84902183019
-
Resistance mechanisms for the Bruton's tyrosine kinase inhibitor Ibrutinib
-
J.A. Woyach, R.R. Furman, T.-M. Liu, H.G. Ozer, M. Zapatka, and A.S. Ruppert Resistance mechanisms for the Bruton's tyrosine kinase inhibitor Ibrutinib N Engl J Med 370 24 2014 2286 2294
-
(2014)
N Engl J Med
, vol.370
, Issue.24
, pp. 2286-2294
-
-
Woyach, J.A.1
Furman, R.R.2
Liu, T.-M.3
Ozer, H.G.4
Zapatka, M.5
Ruppert, A.S.6
-
79
-
-
84902137363
-
Ibrutinib resistance in chronic lymphocytic leukemia
-
R.R. Furman, S. Cheng, P. Lu, M. Setty, A.R. Perez, and A. Guo Ibrutinib resistance in chronic lymphocytic leukemia N Engl J Med 370 24 2014 2352 2354
-
(2014)
N Engl J Med
, vol.370
, Issue.24
, pp. 2352-2354
-
-
Furman, R.R.1
Cheng, S.2
Lu, P.3
Setty, M.4
Perez, A.R.5
Guo, A.6
-
80
-
-
33745102555
-
Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
-
M. Talpaz, N.P. Shah, H. Kantarjian, N. Donato, J. Nicoll, and R. Paquette Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias N Engl J Med 354 24 2006 2531 2541
-
(2006)
N Engl J Med
, vol.354
, Issue.24
, pp. 2531-2541
-
-
Talpaz, M.1
Shah, N.P.2
Kantarjian, H.3
Donato, N.4
Nicoll, J.5
Paquette, R.6
-
81
-
-
33745086350
-
Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL
-
H. Kantarjian, F. Giles, L. Wunderle, K. Bhalla, S. O'Brien, and B. Wassmann Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL N Engl J Med 354 24 2006 2542 2551
-
(2006)
N Engl J Med
, vol.354
, Issue.24
, pp. 2542-2551
-
-
Kantarjian, H.1
Giles, F.2
Wunderle, L.3
Bhalla, K.4
O'Brien, S.5
Wassmann, B.6
-
82
-
-
10444280878
-
Strategies to overcome resistance to targeted protein kinase inhibitors
-
H. Daub, K. Specht, and A. Ullrich Strategies to overcome resistance to targeted protein kinase inhibitors Nat Rev Drug Discov 3 12 2004 1001 1010
-
(2004)
Nat Rev Drug Discov
, vol.3
, Issue.12
, pp. 1001-1010
-
-
Daub, H.1
Specht, K.2
Ullrich, A.3
-
83
-
-
75149130051
-
Targeting the cancer kinome through polypharmacology
-
Z.A. Knight, H. Lin, and K.M. Shokat Targeting the cancer kinome through polypharmacology Nat Rev Cancer 10 2 2010 130 137
-
(2010)
Nat Rev Cancer
, vol.10
, Issue.2
, pp. 130-137
-
-
Knight, Z.A.1
Lin, H.2
Shokat, K.M.3
-
84
-
-
84907943686
-
Polypharmacology: Challenges and opportunities in drug discovery
-
A. Anighoro, J. Bajorath, and G. Rastelli Polypharmacology: challenges and opportunities in drug discovery J Med Chem 57 19 2014 7874 7887
-
(2014)
J Med Chem
, vol.57
, Issue.19
, pp. 7874-7887
-
-
Anighoro, A.1
Bajorath, J.2
Rastelli, G.3
-
85
-
-
54249162351
-
Targeted polypharmacology: Discovery of dual inhibitors of tyrosine and phosphoinositide kinases
-
B. Apsel, J.A. Blair, B. Gonzalez, T.M. Nazif, M.E. Feldman, and B. Aizenstein Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases Nat Chem Biol 4 11 2008 691 699
-
(2008)
Nat Chem Biol
, vol.4
, Issue.11
, pp. 691-699
-
-
Apsel, B.1
Blair, J.A.2
Gonzalez, B.3
Nazif, T.M.4
Feldman, M.E.5
Aizenstein, B.6
-
86
-
-
33847076849
-
Chromatin modifications and their function
-
T. Kouzarides Chromatin modifications and their function Cell 128 4 2007 693 705
-
(2007)
Cell
, vol.128
, Issue.4
, pp. 693-705
-
-
Kouzarides, T.1
-
87
-
-
78651162036
-
Acetylation and methylation of histones and their possible role in the regulation of RNA synthesis
-
V.G. Allfrey, R. Faulkner, and A.E. Mirsky Acetylation and methylation of histones and their possible role in the regulation of RNA synthesis Proc Natl Acad Sci USA 51 5 1964 786 794
-
(1964)
Proc Natl Acad Sci USA
, vol.51
, Issue.5
, pp. 786-794
-
-
Allfrey, V.G.1
Faulkner, R.2
Mirsky, A.E.3
-
88
-
-
36048958965
-
Histone deacetylase inhibitors: Overview and perspectives
-
M. Dokmanovic, C. Clarke, and P.A. Marks Histone deacetylase inhibitors: overview and perspectives Mol Cancer Res 5 10 2007 981 989
-
(2007)
Mol Cancer Res
, vol.5
, Issue.10
, pp. 981-989
-
-
Dokmanovic, M.1
Clarke, C.2
Marks, P.A.3
-
89
-
-
34547122494
-
HDAC inhibitors: Clinical update and mechanism-based potential
-
K.B. Glaser HDAC inhibitors: clinical update and mechanism-based potential Biochem Pharmacol 74 5 2007 659 671
-
(2007)
Biochem Pharmacol
, vol.74
, Issue.5
, pp. 659-671
-
-
Glaser, K.B.1
-
90
-
-
0037444803
-
Histone deacetylases (HDACs): Characterization of the classical HDAC family
-
A.J.M. de Ruijter, A.H. van Gennip, H.N. Caron, S. Kemp, and A.B.P. van Kuilenburg Histone deacetylases (HDACs): characterization of the classical HDAC family Biochem J 370 3 2003 737 749
-
(2003)
Biochem J
, vol.370
, Issue.3
, pp. 737-749
-
-
De Ruijter, A.J.M.1
Van Gennip, A.H.2
Caron, H.N.3
Kemp, S.4
Van Kuilenburg, A.B.P.5
-
91
-
-
1842578986
-
Molecular evolution of the histone deacetylase family: Functional implications of phylogenetic analysis
-
I. Gregoretti, Y.-M. Lee, and H.V. Goodson Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis J Mol Biol 338 1 2004 17 31
-
(2004)
J Mol Biol
, vol.338
, Issue.1
, pp. 17-31
-
-
Gregoretti, I.1
Lee, Y.-M.2
Goodson, H.V.3
-
92
-
-
78649905409
-
Histone deacetylase inhibitors: A chemical genetics approach to understanding cellular functions
-
P.A. Marks Histone deacetylase inhibitors: a chemical genetics approach to understanding cellular functions BBA-Gene Regul Mech 1799 10-12 2010 717 725
-
(2010)
BBA-Gene Regul Mech
, vol.1799
, Issue.10-12
, pp. 717-725
-
-
Marks, P.A.1
-
93
-
-
0033539092
-
Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors
-
M.S. Finnin, J.R. Donigian, A. Cohen, V.M. Richon, R.A. Rifkind, and P.A. Marks Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors Nature 401 6749 1999 188 193
-
(1999)
Nature
, vol.401
, Issue.6749
, pp. 188-193
-
-
Finnin, M.S.1
Donigian, J.R.2
Cohen, A.3
Richon, V.M.4
Rifkind, R.A.5
Marks, P.A.6
-
94
-
-
26444439216
-
Prospects: Histone deacetylase inhibitors
-
M. Dokmanovic, and P.A. Marks Prospects: histone deacetylase inhibitors J Cell Biochem 96 2 2005 293 304
-
(2005)
J Cell Biochem
, vol.96
, Issue.2
, pp. 293-304
-
-
Dokmanovic, M.1
Marks, P.A.2
-
95
-
-
33748451151
-
Anticancer activities of histone deacetylase inhibitors
-
J.E. Bolden, M.J. Peart, and R.W. Johnstone Anticancer activities of histone deacetylase inhibitors Nat Rev Drug Discov 5 9 2006 769 784
-
(2006)
Nat Rev Drug Discov
, vol.5
, Issue.9
, pp. 769-784
-
-
Bolden, J.E.1
Peart, M.J.2
Johnstone, R.W.3
-
96
-
-
0036527775
-
Histone-deacetylase inhibitors: Novel drugs for the treatment of cancer
-
R.W. Johnstone Histone-deacetylase inhibitors: novel drugs for the treatment of cancer Nat Rev Drug Discov 1 4 2002 287 299
-
(2002)
Nat Rev Drug Discov
, vol.1
, Issue.4
, pp. 287-299
-
-
Johnstone, R.W.1
-
97
-
-
70349100446
-
Histone deacetylase inhibitors: Current status and overview of recent clinical trials
-
X. Ma, H.H. Ezzeldin, and R.B. Diasio Histone deacetylase inhibitors: current status and overview of recent clinical trials Drugs 69 14 2009 1911 1934
-
(2009)
Drugs
, vol.69
, Issue.14
, pp. 1911-1934
-
-
Ma, X.1
Ezzeldin, H.H.2
Diasio, R.B.3
-
98
-
-
0030798245
-
Histone acetylation in chromatin structure and transcription
-
M. Grunstein Histone acetylation in chromatin structure and transcription Nature 389 6649 1997 349 352
-
(1997)
Nature
, vol.389
, Issue.6649
, pp. 349-352
-
-
Grunstein, M.1
-
99
-
-
0021145614
-
Sodium butyrate induction of milk-related antigens in human MCF-7 breast carcinoma cells
-
M. Abe, and D.W. Kufe Sodium butyrate induction of milk-related antigens in human MCF-7 breast carcinoma cells Cancer Res 44 10 1984 4574 4577
-
(1984)
Cancer Res
, vol.44
, Issue.10
, pp. 4574-4577
-
-
Abe, M.1
Kufe, D.W.2
-
100
-
-
0033740191
-
Histone deacetylase inhibitors decrease proliferation and modulate cell cycle gene expression in normal mammary epithelial cells
-
T. Davis, C. Kennedy, Y.-E. Chiew, C.L. Clarke, and A. deFazio Histone deacetylase inhibitors decrease proliferation and modulate cell cycle gene expression in normal mammary epithelial cells Clin Cancer Res 6 11 2000 4334 4342
-
(2000)
Clin Cancer Res
, vol.6
, Issue.11
, pp. 4334-4342
-
-
Davis, T.1
Kennedy, C.2
Chiew, Y.-E.3
Clarke, C.L.4
Defazio, A.5
-
101
-
-
0034634635
-
Rapid induction of histone hyperacetylation and cellular differentiation in human breast tumor cell lines following degradation of histone deacetylase-1
-
Q. Zhou, Z.K. Melkoumian, A. Lucktong, M. Moniwa, J.R. Davie, and J.S. Strobl Rapid induction of histone hyperacetylation and cellular differentiation in human breast tumor cell lines following degradation of histone deacetylase-1 J Biol Chem 275 45 2000 35256 35263
-
(2000)
J Biol Chem
, vol.275
, Issue.45
, pp. 35256-35263
-
-
Zhou, Q.1
Melkoumian, Z.K.2
Lucktong, A.3
Moniwa, M.4
Davie, J.R.5
Strobl, J.S.6
-
102
-
-
0035577768
-
The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces differentiation of human breast cancer cells
-
P.N. Munster, T. Troso-Sandoval, N. Rosen, R. Rifkind, P.A. Marks, and V.M. Richon The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces differentiation of human breast cancer cells Cancer Res 61 23 2001 8492 8497
-
(2001)
Cancer Res
, vol.61
, Issue.23
, pp. 8492-8497
-
-
Munster, P.N.1
Troso-Sandoval, T.2
Rosen, N.3
Rifkind, R.4
Marks, P.A.5
Richon, V.M.6
-
103
-
-
20444479514
-
Drug insight: Histone deacetylase inhibitors - Development of the new targeted anticancer agent suberoylanilide hydroxamic acid
-
W.K. Kelly, and P.A. Marks Drug insight: histone deacetylase inhibitors - development of the new targeted anticancer agent suberoylanilide hydroxamic acid Nat Rev Clin Oncol 2 3 2005 150 157
-
(2005)
Nat Rev Clin Oncol
, vol.2
, Issue.3
, pp. 150-157
-
-
Kelly, W.K.1
Marks, P.A.2
-
104
-
-
84874410182
-
Histone deacetylase inhibitors (HDACIs): Multitargeted anticancer agents
-
K. Ververis, A. Hiong, T.C. Karagiannis, and P.V. Licciardi Histone deacetylase inhibitors (HDACIs): multitargeted anticancer agents Biologics 7 2013 47 60
-
(2013)
Biologics
, vol.7
, pp. 47-60
-
-
Ververis, K.1
Hiong, A.2
Karagiannis, T.C.3
Licciardi, P.V.4
-
105
-
-
84907689730
-
A phase 2 study of belinostat (PXD101) in patients with relapsed or refractory acute myeloid leukemia or patients over the age of 60 with newly diagnosed acute myeloid leukemia: A California Cancer Consortium Study
-
M.H. Kirschbaum, K.A. Foon, P. Frankel, C. Ruel, B. Pulone, and J.M. Tuscano A phase 2 study of belinostat (PXD101) in patients with relapsed or refractory acute myeloid leukemia or patients over the age of 60 with newly diagnosed acute myeloid leukemia: a California Cancer Consortium Study Leuk Lymphoma 55 10 2014 2301 2304
-
(2014)
Leuk Lymphoma
, vol.55
, Issue.10
, pp. 2301-2304
-
-
Kirschbaum, M.H.1
Foon, K.A.2
Frankel, P.3
Ruel, C.4
Pulone, B.5
Tuscano, J.M.6
-
106
-
-
0015009308
-
Hemoglobin synthesis in murine virus-induced leukemic cells in vitro: Stimulation of erythroid differentiation by dimethyl sulfoxide
-
C. Friend, W. Scher, J.G. Holland, and T. Sato Hemoglobin synthesis in murine virus-induced leukemic cells in vitro: stimulation of erythroid differentiation by dimethyl sulfoxide Proc Natl Acad Sci USA 68 2 1971 378 382
-
(1971)
Proc Natl Acad Sci USA
, vol.68
, Issue.2
, pp. 378-382
-
-
Friend, C.1
Scher, W.2
Holland, J.G.3
Sato, T.4
-
107
-
-
0003019001
-
Induction of erythroid differentiation in murine virus infected eythroleukemia cells by highly polar compounds
-
M. Tanaka, J. Levy, M. Terada, R. Breslow, R.A. Rifkind, and P.A. Marks Induction of erythroid differentiation in murine virus infected eythroleukemia cells by highly polar compounds Proc Natl Acad Sci USA 72 3 1975 1003 1006
-
(1975)
Proc Natl Acad Sci USA
, vol.72
, Issue.3
, pp. 1003-1006
-
-
Tanaka, M.1
Levy, J.2
Terada, M.3
Breslow, R.4
Rifkind, R.A.5
Marks, P.A.6
-
108
-
-
0000317446
-
A new group of potent inducers of differentiation in murine erythroleukemia cells
-
R.C. Reuben, R.L. Wife, R. Breslow, R.A. Rifkind, and P.A. Marks A new group of potent inducers of differentiation in murine erythroleukemia cells Proc Natl Acad Sci USA 73 3 1976 862 866
-
(1976)
Proc Natl Acad Sci USA
, vol.73
, Issue.3
, pp. 862-866
-
-
Reuben, R.C.1
Wife, R.L.2
Breslow, R.3
Rifkind, R.A.4
Marks, P.A.5
-
109
-
-
0025954615
-
Potent cytodifferentiating agents related to hexamethylenebisacetamide
-
R. Breslow, B. Jursic, Z.F. Yan, E. Friedman, L. Leng, and L. Ngo Potent cytodifferentiating agents related to hexamethylenebisacetamide Proc Natl Acad Sci USA 88 13 1991 5542 5546
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, Issue.13
, pp. 5542-5546
-
-
Breslow, R.1
Jursic, B.2
Yan, Z.F.3
Friedman, E.4
Leng, L.5
Ngo, L.6
-
110
-
-
1542588471
-
Second generation hybrid polar compounds are potent inducers of transformed cell differentiation
-
V.M. Richon, Y. Webb, R. Merger, T. Sheppard, B. Jursic, and L. Ngo Second generation hybrid polar compounds are potent inducers of transformed cell differentiation Proc Natl Acad Sci USA 93 12 1996 5705 5708
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, Issue.12
, pp. 5705-5708
-
-
Richon, V.M.1
Webb, Y.2
Merger, R.3
Sheppard, T.4
Jursic, B.5
Ngo, L.6
-
111
-
-
0023137324
-
Induction of transformed cells to terminal differentiation and the modulation of gene expression
-
P.A. Marks, M. Sheffery, and R.A. Rifkind Induction of transformed cells to terminal differentiation and the modulation of gene expression Cancer Res 47 3 1987 659 666
-
(1987)
Cancer Res
, vol.47
, Issue.3
, pp. 659-666
-
-
Marks, P.A.1
Sheffery, M.2
Rifkind, R.A.3
-
112
-
-
0024996768
-
Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A
-
M. Yoshida, M. Kijima, M. Akita, and T. Beppu Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A J Biol Chem 265 28 1990 17174 17179
-
(1990)
J Biol Chem
, vol.265
, Issue.28
, pp. 17174-17179
-
-
Yoshida, M.1
Kijima, M.2
Akita, M.3
Beppu, T.4
-
113
-
-
12444321545
-
Phase I clinical trial of histone deacetylase inhibitor: Suberoylanilide hydroxamic acid administered intravenously
-
W.K. Kelly, V.M. Richon, O. O'Connor, T. Curley, B. MacGregor-Curtelli, and W. Tong Phase I clinical trial of histone deacetylase inhibitor: suberoylanilide hydroxamic acid administered intravenously Clin Cancer Res 9 10 2003 3578 3588
-
(2003)
Clin Cancer Res
, vol.9
, Issue.10
, pp. 3578-3588
-
-
Kelly, W.K.1
Richon, V.M.2
O'Connor, O.3
Curley, T.4
MacGregor-Curtelli, B.5
Tong, W.6
-
114
-
-
34249937594
-
Phase I trial of histone deacetylase inhibition by valproic acid followed by the topoisomerase II inhibitor Epirubicin in advanced solid tumors: A clinical and translational study
-
P. Münster, D. Marchion, E. Bicaku, M. Schmitt, J.H. Lee, and R. DeConti Phase I trial of histone deacetylase inhibition by valproic acid followed by the topoisomerase II inhibitor Epirubicin in advanced solid tumors: a clinical and translational study J Clin Oncol 25 15 2007 1979 1985
-
(2007)
J Clin Oncol
, vol.25
, Issue.15
, pp. 1979-1985
-
-
Münster, P.1
Marchion, D.2
Bicaku, E.3
Schmitt, M.4
Lee, J.H.5
Deconti, R.6
-
115
-
-
18044401469
-
Design and synthesis of a novel class of histone deacetylase inhibitors
-
R. Lavoie, G. Bouchain, S. Frechette, S.H. Woo, E.A. Khalil, and S. Leit Design and synthesis of a novel class of histone deacetylase inhibitors Bioorg Med Chem Lett 11 21 2001 2847 2850
-
(2001)
Bioorg Med Chem Lett
, vol.11
, Issue.21
, pp. 2847-2850
-
-
Lavoie, R.1
Bouchain, G.2
Frechette, S.3
Woo, S.H.4
Khalil, E.A.5
Leit, S.6
-
116
-
-
1642453460
-
Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histone deacetylase inhibitor PXD101
-
J.A. Plumb, P.W. Finn, R.J. Williams, M.J. Bandara, M.R. Romero, and C.J. Watkins Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histone deacetylase inhibitor PXD101 Mol Cancer Ther 2 8 2003 721 728
-
(2003)
Mol Cancer Ther
, vol.2
, Issue.8
, pp. 721-728
-
-
Plumb, J.A.1
Finn, P.W.2
Williams, R.J.3
Bandara, M.J.4
Romero, M.R.5
Watkins, C.J.6
-
117
-
-
1642490813
-
Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone B
-
L. Fuino, P. Bali, S. Wittmann, S. Donapaty, F. Guo, and H. Yamaguchi Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone B Mol Cancer Ther 2 10 2003 971 984
-
(2003)
Mol Cancer Ther
, vol.2
, Issue.10
, pp. 971-984
-
-
Fuino, L.1
Bali, P.2
Wittmann, S.3
Donapaty, S.4
Guo, F.5
Yamaguchi, H.6
-
118
-
-
81555228390
-
Belinostat: Clinical applications in solid tumors and lymphoma
-
L.R. Molife, and J.S. de Bono Belinostat: clinical applications in solid tumors and lymphoma Expert Opin Investig Drugs 20 12 2011 1723 1732
-
(2011)
Expert Opin Investig Drugs
, vol.20
, Issue.12
, pp. 1723-1732
-
-
Molife, L.R.1
De Bono, J.S.2
-
119
-
-
0022256150
-
Integration of a mutant c-Ha-ras oncogene into C3H/10 T1/2 cells and its relationship to tumorigenic transformation
-
T.H. Manoharan, J.A. Burgess, D. Ho, C.L. Newell, and W.E. Fahl Integration of a mutant c-Ha-ras oncogene into C3H/10 T1/2 cells and its relationship to tumorigenic transformation Carcinogenesis 6 9 1985 1295 1301
-
(1985)
Carcinogenesis
, vol.6
, Issue.9
, pp. 1295-1301
-
-
Manoharan, T.H.1
Burgess, J.A.2
Ho, D.3
Newell, C.L.4
Fahl, W.E.5
-
120
-
-
0028299638
-
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. II. Structure determination
-
N. Shigematsu, H. Ueda, S. Takase, H. Tanaka, K. Yamamoto, and T. Tada FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. II. Structure determination J Antibiot 47 1994 311 314
-
(1994)
J Antibiot
, vol.47
, pp. 311-314
-
-
Shigematsu, N.1
Ueda, H.2
Takase, S.3
Tanaka, H.4
Yamamoto, K.5
Tada, T.6
-
121
-
-
0032563871
-
Fungal metabolite FR901228 inhibits c-Myc and Fas ligand expression
-
R. Wang, T. Brunner, L. Zhang, and Y. Shi Fungal metabolite FR901228 inhibits c-Myc and Fas ligand expression Oncogene 17 12 1998 1503 1508
-
(1998)
Oncogene
, vol.17
, Issue.12
, pp. 1503-1508
-
-
Wang, R.1
Brunner, T.2
Zhang, L.3
Shi, Y.4
-
122
-
-
0031768386
-
Effects of a novel antitumor depsipeptide, FR901228, on human breast cancer cells
-
G. Rajgolikar, K. Chan, and H.-C. Wang Effects of a novel antitumor depsipeptide, FR901228, on human breast cancer cells Breast Cancer Res Treat 51 1 1998 29 38
-
(1998)
Breast Cancer Res Treat
, vol.51
, Issue.1
, pp. 29-38
-
-
Rajgolikar, G.1
Chan, K.2
Wang, H.-C.3
-
123
-
-
0344431240
-
FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor
-
H. Nakajima, Y.B. Kim, H. Terano, M. Yoshida, and S. Horinouchi FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor Exp Cell Res 241 1 1998 126 133
-
(1998)
Exp Cell Res
, vol.241
, Issue.1
, pp. 126-133
-
-
Nakajima, H.1
Kim, Y.B.2
Terano, H.3
Yoshida, M.4
Horinouchi, S.5
-
124
-
-
77954879663
-
Final results from a multicenter, international, pivotal study of Romidepsin in refractory cutaneous T-cell lymphoma
-
S.J. Whittaker, M.-F. Demierre, E.J. Kim, A.H. Rook, A. Lerner, and M. Duvic Final results from a multicenter, international, pivotal study of Romidepsin in refractory cutaneous T-cell lymphoma J Clin Oncol 28 29 2010 4485 4491
-
(2010)
J Clin Oncol
, vol.28
, Issue.29
, pp. 4485-4491
-
-
Whittaker, S.J.1
Demierre, M.-F.2
Kim, E.J.3
Rook, A.H.4
Lerner, A.5
Duvic, M.6
-
125
-
-
37849019672
-
Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors
-
N. Khan, M. Jeffers, S. Kumar, C. Hackett, F. Boldog, and N. Khramtsov Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors Biochem J 409 2 2008 581 589
-
(2008)
Biochem J
, vol.409
, Issue.2
, pp. 581-589
-
-
Khan, N.1
Jeffers, M.2
Kumar, S.3
Hackett, C.4
Boldog, F.5
Khramtsov, N.6
-
126
-
-
34547864236
-
Histone deacetylase inhibitors: Molecular mechanisms of action
-
W.S. Xu, R.B. Parmigiani, and P.A. Marks Histone deacetylase inhibitors: molecular mechanisms of action Oncogene 26 37 2007 5541 5552
-
(2007)
Oncogene
, vol.26
, Issue.37
, pp. 5541-5552
-
-
Xu, W.S.1
Parmigiani, R.B.2
Marks, P.A.3
-
128
-
-
0036402177
-
Basic pharmacology of Valproate
-
W. Löscher Basic pharmacology of Valproate CNS Drugs 16 10 2002 669 694
-
(2002)
CNS Drugs
, vol.16
, Issue.10
, pp. 669-694
-
-
Löscher, W.1
-
129
-
-
34447304130
-
Valproic acid (VPA) in patients with refractory advanced cancer: A dose escalating phase I clinical trial
-
A. Atmaca, S.E. Al-Batran, A. Maurer, A. Neumann, T. Heinzel, and B. Hentsch Valproic acid (VPA) in patients with refractory advanced cancer: a dose escalating phase I clinical trial Br J Cancer 97 2 2007 177 182
-
(2007)
Br J Cancer
, vol.97
, Issue.2
, pp. 177-182
-
-
Atmaca, A.1
Al-Batran, S.E.2
Maurer, A.3
Neumann, A.4
Heinzel, T.5
Hentsch, B.6
-
130
-
-
34548395116
-
A phase II study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors
-
M. Candelaria, D. Gallardo-Rincón, C. Arce, L. Cetina, J. Aguilar-Ponce, and Ó. Arrieta A phase II study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors Ann Oncol 18 9 2007 1529 1538
-
(2007)
Ann Oncol
, vol.18
, Issue.9
, pp. 1529-1538
-
-
Candelaria, M.1
Gallardo-Rincón, D.2
Arce, C.3
Cetina, L.4
Aguilar-Ponce, J.5
Arrieta Ó.6
-
131
-
-
45749142120
-
Isoform-selective histone deacetylase inhibitors
-
A.V. Bieliauskas, and M.K.H. Pflum Isoform-selective histone deacetylase inhibitors Chem Soc Rev 37 7 2008 1402 1413
-
(2008)
Chem Soc Rev
, vol.37
, Issue.7
, pp. 1402-1413
-
-
Bieliauskas, A.V.1
Pflum, M.K.H.2
-
132
-
-
21244464349
-
Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer
-
W.K. Kelly, O.A. O'Connor, L.M. Krug, J.H. Chiao, M. Heaney, and T. Curley Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer J Clin Oncol 23 17 2005 3923 3931
-
(2005)
J Clin Oncol
, vol.23
, Issue.17
, pp. 3923-3931
-
-
Kelly, W.K.1
O'Connor, O.A.2
Krug, L.M.3
Chiao, J.H.4
Heaney, M.5
Curley, T.6
-
133
-
-
0036301281
-
Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms
-
V. Sandor, S. Bakke, R.W. Robey, M.H. Kang, M.V. Blagosklonny, and J. Bender Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms Clin Cancer Res 8 3 2002 718 728
-
(2002)
Clin Cancer Res
, vol.8
, Issue.3
, pp. 718-728
-
-
Sandor, V.1
Bakke, S.2
Robey, R.W.3
Kang, M.H.4
Blagosklonny, M.V.5
Bender, J.6
-
134
-
-
51649110503
-
Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia
-
G. Garcia-Manero, S. Assouline, J. Cortes, Z. Estrov, H. Kantarjian, and H. Yang Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia Blood 112 4 2008 981 989
-
(2008)
Blood
, vol.112
, Issue.4
, pp. 981-989
-
-
Garcia-Manero, G.1
Assouline, S.2
Cortes, J.3
Estrov, Z.4
Kantarjian, H.5
Yang, H.6
-
135
-
-
38949096781
-
Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes
-
G. Garcia-Manero, H. Yang, C. Bueso-Ramos, A. Ferrajoli, J. Cortes, and W.G. Wierda Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes Blood 111 3 2008 1060 1066
-
(2008)
Blood
, vol.111
, Issue.3
, pp. 1060-1066
-
-
Garcia-Manero, G.1
Yang, H.2
Bueso-Ramos, C.3
Ferrajoli, A.4
Cortes, J.5
Wierda, W.G.6
-
136
-
-
35048856900
-
Depsipeptide (FK228) as a novel histone deacetylase inhibitor: Mechanism of action and anticancer activity
-
E. Lech-Maranda, E. Robak, A. Korycka, and T. Robak Depsipeptide (FK228) as a novel histone deacetylase inhibitor: mechanism of action and anticancer activity Mini-Rev Med Chem 7 10 2007 1062 1069
-
(2007)
Mini-Rev Med Chem
, vol.7
, Issue.10
, pp. 1062-1069
-
-
Lech-Maranda, E.1
Robak, E.2
Korycka, A.3
Robak, T.4
-
137
-
-
84897443073
-
Oncogenic protein interfaces: Small molecules, big challenges
-
T.L. Nero, C.J. Morton, J.K. Holien, J. Wielens, and M.W. Parker Oncogenic protein interfaces: small molecules, big challenges Nat Rev Cancer 14 2014 248 262
-
(2014)
Nat Rev Cancer
, vol.14
, pp. 248-262
-
-
Nero, T.L.1
Morton, C.J.2
Holien, J.K.3
Wielens, J.4
Parker, M.W.5
-
138
-
-
78649903089
-
Bcl-2 family proteins as therapeutic targets
-
P.E. Czabotar, and G. Lessene Bcl-2 family proteins as therapeutic targets Curr Pharm Des 16 2010 3132 3148
-
(2010)
Curr Pharm des
, vol.16
, pp. 3132-3148
-
-
Czabotar, P.E.1
Lessene, G.2
-
139
-
-
44849112219
-
ABT-263: A potent and orally bioavailable Bcl-2 family inhibitor
-
C. Tse, A.R. Shoemaker, J. Adickes, M.G. Anderson, J. Chen, and S. Jin ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor Cancer Res 68 2008 3421 3428
-
(2008)
Cancer Res
, vol.68
, pp. 3421-3428
-
-
Tse, C.1
Shoemaker, A.R.2
Adickes, J.3
Anderson, M.G.4
Chen, J.5
Jin, S.6
-
140
-
-
52649083344
-
Discovery of ABT-263, a Bcl-family protein inhibitor: Observations on targeting a large protein-protein interaction
-
M.D. Wendt Discovery of ABT-263, a Bcl-family protein inhibitor: observations on targeting a large protein-protein interaction Expert Opin Drug Discov 3 2008 1123 1143
-
(2008)
Expert Opin Drug Discov
, vol.3
, pp. 1123-1143
-
-
Wendt, M.D.1
-
141
-
-
31544467109
-
Discovery of a potent inhibitor of the antiapoptotic protein Bcl-xL from NMR and parallel synthesis
-
A.M. Petros, J. Dinges, D.J. Augeri, S.A. Baumeister, D.A. Betebenner, and M.G. Bures Discovery of a potent inhibitor of the antiapoptotic protein Bcl-xL from NMR and parallel synthesis J Med Chem 49 2006 656 663
-
(2006)
J Med Chem
, vol.49
, pp. 656-663
-
-
Petros, A.M.1
Dinges, J.2
Augeri, D.J.3
Baumeister, S.A.4
Betebenner, D.A.5
Bures, M.G.6
-
142
-
-
20444486559
-
An inhibitor of Bcl-2 family proteins induces regression of solid tumors
-
T. Oltersdorf, S.W. Elmore, A.R. Shoemaker, R.C. Armstrong, D.J. Augeri, and B.A. Belli An inhibitor of Bcl-2 family proteins induces regression of solid tumors Nature 435 2005 677 681
-
(2005)
Nature
, vol.435
, pp. 677-681
-
-
Oltersdorf, T.1
Elmore, S.W.2
Shoemaker, A.R.3
Armstrong, R.C.4
Augeri, D.J.5
Belli, B.A.6
-
143
-
-
0030614915
-
Structure of Bcl-xL-Bak peptide complex: Recognition between regulators of apoptosis
-
M. Sattler, H. Liang, D. Netesheim, R.P. Meadows, J.E. Harlan, and M. Eberstadt Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis Science 275 1997 983 986
-
(1997)
Science
, vol.275
, pp. 983-986
-
-
Sattler, M.1
Liang, H.2
Netesheim, D.3
Meadows, R.P.4
Harlan, J.E.5
Eberstadt, M.6
-
144
-
-
0035980337
-
Rational design of diflunisal analogues with reduced affinity for human serum albumin
-
H. Mao, P.J. Hajduk, R. Craig, R. Bell, T. Borre, and S.W. Fesik Rational design of diflunisal analogues with reduced affinity for human serum albumin J Am Chem Soc 123 43 2001 10429 10435
-
(2001)
J Am Chem Soc
, vol.123
, Issue.43
, pp. 10429-10435
-
-
Mao, H.1
Hajduk, P.J.2
Craig, R.3
Bell, R.4
Borre, T.5
Fesik, S.W.6
-
145
-
-
0042856657
-
Ligand binding to domain-3 of human serum albumin: A chemometric analysis
-
P.J. Hajduk, R. Mendoza, A.M. Petros, J.R. Huth, M. Bures, and S.W. Fesik Ligand binding to domain-3 of human serum albumin: a chemometric analysis J Comput-Aided Mol Des 17 2003 93 102
-
(2003)
J Comput-Aided Mol des
, vol.17
, pp. 93-102
-
-
Hajduk, P.J.1
Mendoza, R.2
Petros, A.M.3
Huth, J.R.4
Bures, M.5
Fesik, S.W.6
-
146
-
-
79952291173
-
Phase I study of navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors
-
L. Gandhi, D.R. Camidge, M. Ribeiro de Oliveira, P. Bonomi, D. Gandara, and D. Khaira Phase I study of navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors J Clin Oncol 29 2011 909 916
-
(2011)
J Clin Oncol
, vol.29
, pp. 909-916
-
-
Gandhi, L.1
Camidge, D.R.2
Ribeiro De Oliveira, M.3
Bonomi, P.4
Gandara, D.5
Khaira, D.6
-
147
-
-
84861482216
-
Phase II study of single-agent Navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancer
-
C.M. Rudin, C.L. Hann, E.B. Garon, M. Ribeiro de Oliveira, P.D. Bonomi, and D.R. Camidge Phase II study of single-agent Navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancer Clin Cancer Res 18 2012 3163 3169
-
(2012)
Clin Cancer Res
, vol.18
, pp. 3163-3169
-
-
Rudin, C.M.1
Hann, C.L.2
Garon, E.B.3
Ribeiro De Oliveira, M.4
Bonomi, P.D.5
Camidge, D.R.6
-
148
-
-
83355166908
-
The Bcl-2/Bcl-XL/Bcl-w inhibitor, Navitoclax, enhances the activity of chemotherapeutic agents in vitro and in vivo
-
J. Chen, S. Jin, V. Abraham, X. Huang, B. Liu, and M.J. Mitten The Bcl-2/Bcl-XL/Bcl-w inhibitor, Navitoclax, enhances the activity of chemotherapeutic agents in vitro and in vivo Mol Cancer Ther 10 2011 2340 2349
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 2340-2349
-
-
Chen, J.1
Jin, S.2
Abraham, V.3
Huang, X.4
Liu, B.5
Mitten, M.J.6
-
149
-
-
84872387485
-
Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models
-
R.B. Corcoran, K.A. Cheng, A.N. Hata, A.C. Faber, H. Ebi, and E.M. Coffee Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models Cancer Cell 23 2013 121 128
-
(2013)
Cancer Cell
, vol.23
, pp. 121-128
-
-
Corcoran, R.B.1
Cheng, K.A.2
Hata, A.N.3
Faber, A.C.4
Ebi, H.5
Coffee, E.M.6
-
150
-
-
84899992324
-
The Bcl-2/xL inhibitor ABT-263 increases the stability of Mcl-1 mRNA and protein in hepatocellular carcinoma cells
-
B. Wang, Z. Ni, X. Dai, L. Qin, X. Li, and L. Xu The Bcl-2/xL inhibitor ABT-263 increases the stability of Mcl-1 mRNA and protein in hepatocellular carcinoma cells Mol Cancer 13 2014 98
-
(2014)
Mol Cancer
, vol.13
, pp. 98
-
-
Wang, B.1
Ni, Z.2
Dai, X.3
Qin, L.4
Li, X.5
Xu, L.6
-
151
-
-
84873038888
-
Apoptosis refined and lethal
-
D.J. Burgess Apoptosis refined and lethal Nat Rev Cancer 13 2013 79
-
(2013)
Nat Rev Cancer
, vol.13
, pp. 79
-
-
Burgess, D.J.1
-
152
-
-
84873540049
-
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
-
A.J. Souers, J.D. Leverson, E.R. Boghaert, S.L. Ackler, N.D. Catron, and J. Chen ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets Nat Med 19 2013 202 210
-
(2013)
Nat Med
, vol.19
, pp. 202-210
-
-
Souers, A.J.1
Leverson, J.D.2
Boghaert, E.R.3
Ackler, S.L.4
Catron, N.D.5
Chen, J.6
-
153
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
L.T. Vassilev, B.T. Vu, B. Graves, D. Carvajal, F. Podlaski, and Z. Filipovic In vivo activation of the p53 pathway by small-molecule antagonists of MDM2 Science 303 2004 844 848
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
Vu, B.T.2
Graves, B.3
Carvajal, D.4
Podlaski, F.5
Filipovic, Z.6
-
154
-
-
84895779578
-
Drugging the p53 pathway: Understanding the route to clinical efficacy
-
K.K. Hoe, C.S. Verma, and D.P. Lane Drugging the p53 pathway: understanding the route to clinical efficacy Nat Rev Drug Discov 13 2014 217 235
-
(2014)
Nat Rev Drug Discov
, vol.13
, pp. 217-235
-
-
Hoe, K.K.1
Verma, C.S.2
Lane, D.P.3
-
155
-
-
70450270900
-
Awakening guardian angels: Drugging the p53 pathway
-
C.J. Brown, S. Lain, C.S. Verma, A.R. Fersht, and D.P. Lane Awakening guardian angels: drugging the p53 pathway Nat Rev Cancer 9 2009 862 872
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 862-872
-
-
Brown, C.J.1
Lain, S.2
Verma, C.S.3
Fersht, A.R.4
Lane, D.P.5
-
156
-
-
0037317840
-
Inhibiting the p53-MDM2 interaction: An important target for cancer therapy
-
P. Chene Inhibiting the p53-MDM2 interaction: an important target for cancer therapy Nat Rev Cancer 3 2003 102 109
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 102-109
-
-
Chene, P.1
-
157
-
-
84877690432
-
Discovery of RG7112: A small-molecule MDM2 inhibitor in clinical development
-
B. Vu, P. Wovkulich, G. Pizzolato, A. Lovey, Q. Ding, and N. Jiang Discovery of RG7112: a small-molecule MDM2 inhibitor in clinical development ACS Med Chem Lett 4 2013 466 469
-
(2013)
ACS Med Chem Lett
, vol.4
, pp. 466-469
-
-
Vu, B.1
Wovkulich, P.2
Pizzolato, G.3
Lovey, A.4
Ding, Q.5
Jiang, N.6
-
158
-
-
84896405456
-
Targeting the nucleolus for cancer-specific activation of p53
-
D. Drygin, S.E. O'Brien, R.D. Hannan, G.A. McArthur, and D.D. Von Hoff Targeting the nucleolus for cancer-specific activation of p53 Drug Discov Today 19 2014 259 265
-
(2014)
Drug Discov Today
, vol.19
, pp. 259-265
-
-
Drygin, D.1
O'Brien, S.E.2
Hannan, R.D.3
McArthur, G.A.4
Von Hoff, D.D.5
-
159
-
-
84880896065
-
Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development
-
Q. Ding, Z. Zhang, J.J. Liu, N. Jiang, J. Zhang, and T.M. Ross Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development J Med Chem 56 2013 5979 5983
-
(2013)
J Med Chem
, vol.56
, pp. 5979-5983
-
-
Ding, Q.1
Zhang, Z.2
Liu, J.J.3
Jiang, N.4
Zhang, J.5
Ross, T.M.6
-
160
-
-
84857675728
-
The mTOR signalling pathway in human cancer
-
H. Pópulo, J. Lopes, and P. Soares The mTOR signalling pathway in human cancer Int J Mol Sci 13 2012 1886 1918
-
(2012)
Int J Mol Sci
, vol.13
, pp. 1886-1918
-
-
Pópulo, H.1
Lopes, J.2
Soares, P.3
-
162
-
-
84859778293
-
MTOR signaling in growth control and disease
-
M. Laplante, and D. Sabatini mTOR signaling in growth control and disease Cell 149 2012 274 293
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.2
-
163
-
-
84893249799
-
PI3K and cancer: Lessons, challenges and opportunities
-
D.A. Fruman, and C. Rommel PI3K and cancer: lessons, challenges and opportunities Nat Rev Drug Discov 13 2014 140 156
-
(2014)
Nat Rev Drug Discov
, vol.13
, pp. 140-156
-
-
Fruman, D.A.1
Rommel, C.2
-
165
-
-
84901651824
-
Rapamycin and mTOR: A serendipitous discovery and implications for breast cancer
-
B. Seto Rapamycin and mTOR: a serendipitous discovery and implications for breast cancer Clin Transl Med 1 2012 29
-
(2012)
Clin Transl Med
, vol.1
, pp. 29
-
-
Seto, B.1
-
166
-
-
79953709986
-
Targeting the mTOR kinase domain: The second generation of mTOR inhibitors
-
Y.J. Zhang, Y. Duan, and X.F.S. Zheng Targeting the mTOR kinase domain: the second generation of mTOR inhibitors Drug Discov Today 16 2011 325 331
-
(2011)
Drug Discov Today
, vol.16
, pp. 325-331
-
-
Zhang, Y.J.1
Duan, Y.2
Zheng, X.F.S.3
-
167
-
-
33746637660
-
Current development of mTOR inhibitors as anticancer agents
-
S. Faivre, G. Kroemer, and E. Raymond Current development of mTOR inhibitors as anticancer agents Nat Rev Drug Discov 5 2006 671 688
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 671-688
-
-
Faivre, S.1
Kroemer, G.2
Raymond, E.3
-
168
-
-
84879784821
-
Targeting protein-protein interactions as an anticancer strategy
-
A.A. Ivanov, F.R. Khuri, and H. Fu Targeting protein-protein interactions as an anticancer strategy Trends Pharmacol Sci 34 2013 393 400
-
(2013)
Trends Pharmacol Sci
, vol.34
, pp. 393-400
-
-
Ivanov, A.A.1
Khuri, F.R.2
Fu, H.3
|