-
1
-
-
0842324785
-
The nucleosome: From genomic organization to genomic regulation
-
Khorasanidazeh S. The nucleosome: from genomic organization to genomic regulation. Cell 2004;116:259-72
-
(2004)
Cell
, vol.116
, pp. 259-272
-
-
Khorasanidazeh, S.1
-
2
-
-
0030798245
-
Histone acetylation in chromatin structure and transcription
-
DOI 10.1038/38664
-
Grunstein M. Histone acetylation in chromatin structure and transcription. Nature 1997;389:349-52 (Pubitemid 27415209)
-
(1997)
Nature
, vol.389
, Issue.6649
, pp. 349-352
-
-
Grunstein, M.1
-
3
-
-
0041347519
-
Histone deacetylase inhibitors in cancer therapy: Is transcription the primary target?
-
DOI 10.1016/S1535-6108(03)00165-X
-
Johnstone RE, Licht JD. Histone deacetylase inhibitors in cancer therapy: is transcription the primary target? Cancer Cell 2003;4:13-18 (Pubitemid 36904157)
-
(2003)
Cancer Cell
, vol.4
, Issue.1
, pp. 13-18
-
-
Johnstone, R.W.1
Licht, J.D.2
-
4
-
-
16244366803
-
Class II histone deacetylases: From sequence to function, regulation, and clinical implication
-
DOI 10.1128/MCB.25.8.2873-2884.2005
-
Yang XJ, Gregoire S. Class II histone deacetylases:from sequence to function, regulation, and clinical implication. Mol Cell Biol 2005;25:2873-84 (Pubitemid 40464294)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.8
, pp. 2873-2884
-
-
Yang, X.-J.1
Gregoire, S.2
-
5
-
-
79957968813
-
Medicinal chemistry of sirtuin inhibitors
-
Chen L. Medicinal chemistry of sirtuin inhibitors. Curr Med Chem 2001;18:1936-46
-
(2001)
Curr Med Chem
, vol.18
, pp. 1936-1946
-
-
Chen, L.1
-
6
-
-
28644440158
-
Histone deacetylase inhibitors: Discovery and development as anticancer agents
-
DOI 10.1517/13543784.14.12.1497
-
Marks PA, Dokmanovic M. Histone deacetylase inhibitors: discovery and development as anticancer agents. Expert Opin Investig Drugs 2005;14:1497-511 (Pubitemid 41749195)
-
(2005)
Expert Opinion on Investigational Drugs
, vol.14
, Issue.12
, pp. 1497-1511
-
-
Marks, P.A.1
Dokmanovic, M.2
-
7
-
-
33748451151
-
Anticancer activities of histone deacetylase inhibitors
-
DOI 10.1038/nrd2133, PII NRD2133
-
Bolden JE, Peart MJ, Jhnstone RW. Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov 2006;5:769-84 (Pubitemid 44348499)
-
(2006)
Nature Reviews Drug Discovery
, vol.5
, Issue.9
, pp. 769-784
-
-
Bolden, J.E.1
Peart, M.J.2
Johnstone, R.W.3
-
8
-
-
4143101371
-
Class I histone deacetylase-selective novel synthetic inhibitors potently inhibit human tumor proliferation
-
DOI 10.1158/1078-0432.CCR-03-0709
-
Park JH, Jung Y, Kim TY, et al. Class I histone deacetylase-selective novel synthetic inhibitors potently inhibit human tumor proliferation. Clin Cancer Res 2004;10:5271-81 (Pubitemid 39099802)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.15
, pp. 5271-5281
-
-
Park, J.-H.1
Jung, Y.2
Kim, T.Y.3
Kim, S.G.4
Jong, H.-S.5
Lee, J.W.6
Kim, D.-K.7
Lee, J.-S.8
Kim, N.K.9
Kim, T.-Y.10
Bang, Y.-J.11
-
9
-
-
17144378591
-
Cip1/WAF1 expression, independent of histone deacetylase 1
-
DOI 10.1038/sj.cdd.4401567
-
Huang BH, Laban M, Leung CH, et al. Inhibition of histone deacetylase 2 increases apoptosis and p21CIp1/WAF1 expression, independent of histone deacetylase 1. Cell Death Differ 2005;12:395-404 (Pubitemid 40520691)
-
(2005)
Cell Death and Differentiation
, vol.12
, Issue.4
, pp. 395-404
-
-
Huang, B.H.1
Laban, M.2
Leung, C.H.-W.3
Lee, L.4
Lee, C.K.5
Salto-Tellez, M.6
Raju, G.C.7
Hooi, S.C.8
-
10
-
-
0037728615
-
HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis
-
DOI 10.1016/S1074-7613(03)00109-2
-
Dequiedt F, Kasler H, Fischle W, et al. HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcritpion and TCR-mediated apoptosis. Immunity 2003;18:687-98 (Pubitemid 36588585)
-
(2003)
Immunity
, vol.18
, Issue.5
, pp. 687-698
-
-
Dequiedt, F.1
Kasler, H.2
Fischle, W.3
Kiermer, V.4
Weinstein, M.5
Herndier, B.G.6
Verdin, E.7
-
11
-
-
34548075217
-
Hydroxamic acid analogue histone deacetylase inhibitors attenuate estrogen receptor-α levels and transcriptional activity: A result of hyperacetylation and inhibition of chaperone function of heat shock protein 90
-
DOI 10.1158/1078-0432.CCR-06-3093
-
Fiskus W, Ren Y, Mohaptra A, et al. Hydroxyamic acid analogue histone deacetylase inhibitors attenuate estrogen receptor-alpha levels and transcriptional activity: a result of hyperacetylation and inhibition of chaperone function of heat shock protein 90. Clin Cancer Res 2007;13:4882-90 (Pubitemid 47294796)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.16
, pp. 4882-4890
-
-
Fiskus, W.1
Ren, Y.2
Mohapatra, A.3
Bali, P.4
Mandawat, A.5
Rao, R.6
Herger, B.7
Yang, Y.8
Atadja, P.9
Wu, J.10
Bhalla, K.11
-
12
-
-
28044471827
-
Acetylation and deacetylation of non-histone proteins
-
DOI 10.1016/j.gene.2005.09.010, PII S037811190500572X
-
Glozak MA, Sengupta N, Zhang X, Seto E. Acetylation and deacetylation of non-histone proteins. Gene 2005;363:15-23 (Pubitemid 41691888)
-
(2005)
Gene
, vol.363
, Issue.1-2
, pp. 15-23
-
-
Glozak, M.A.1
Sengupta, N.2
Zhang, X.3
Seto, E.4
-
13
-
-
21144444486
-
HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor
-
DOI 10.1016/j.molcel.2005.04.021, PII S1097276505012840
-
Kovacs JJ, Murphy PJ, Gaillard S, et al. HDAC6 regulates Hsp() acetylation and chaperone dependent activation of glucocorticoid receptor. Mol Cell 2005;18:601-7 (Pubitemid 40726236)
-
(2005)
Molecular Cell
, vol.18
, Issue.5
, pp. 601-607
-
-
Kovacs, J.J.1
Murphy, P.J.M.2
Gaillard, S.3
Zhao, X.4
Wu, J.-T.5
Nicchitta, C.V.6
Yoshida, M.7
Toft, D.O.8
Pratt, W.B.9
Yao, T.-P.10
-
14
-
-
0037161744
-
HDAC6 is a microtubule-associated deacetylase
-
DOI 10.1038/417455a
-
Hubbert C, Guardiola A, Shao R, et al. HDAC6 is a microtubule-associated deacetylase. Nature 2002;417:455-8 (Pubitemid 34563539)
-
(2002)
Nature
, vol.417
, Issue.6887
, pp. 455-458
-
-
Hubbert, C.1
Guardiola, A.2
Shao, R.3
Kawaguchi, Y.4
Ito, A.5
Nixon, A.6
Yoshida, M.7
Wang, X.-F.8
Yao, T.-P.9
-
15
-
-
0034908978
-
Inhibitors of histone deacetylase are potentially effective anticancer agents
-
Marks PA, Rifkind RA, Richon VM, Breslow R. Inhibitors of histone deacetylase are potentially effective anticancer agents. Clin Cancer Res 2001;7:759-60 (Pubitemid 32708707)
-
(2001)
Clinical Cancer Research
, vol.7
, Issue.4
, pp. 759-760
-
-
Marks, P.A.1
Rifkind, R.A.2
Richon, V.M.3
Breslow, R.4
-
16
-
-
26444439216
-
Prospects: Histone deacetylase inhibitors
-
DOI 10.1002/jcb.20532
-
Dokmanovic M, Marks PA. Prospects: histone deacetylase inhibitors. J Cell Biochem 2005;96:293-304 (Pubitemid 41437862)
-
(2005)
Journal of Cellular Biochemistry
, vol.96
, Issue.2
, pp. 293-304
-
-
Dokmanovic, M.1
Marks, P.A.2
-
17
-
-
0042905956
-
Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: Defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines
-
Glaser KB, Staver MJ, Waring JF, et al. Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines. Mol Cancer Ther 2003;2:151-63
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 151-163
-
-
Glaser, K.B.1
Staver, M.J.2
Waring, J.F.3
-
18
-
-
51649126841
-
Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma
-
Ellis L, Pan Y, Smyth GK, et al. Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma. Clin Cancer Res 2008;14:4500-10
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4500-4510
-
-
Ellis, L.1
Pan, Y.2
Smyth, G.K.3
-
19
-
-
36148950997
-
FDA approval summary: Vorinostat for treatment of advanced primary cutaneous T-cell lymphoma
-
DOI 10.1634/theoncologist.12-10-1247
-
Mann BS, Johnson JR, Cohen MH, et al. FDA approved summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma. Oncologist 2007;12:1247-52 (Pubitemid 350106355)
-
(2007)
Oncologist
, vol.12
, Issue.10
, pp. 1247-1252
-
-
Mann, B.S.1
Johnson, J.R.2
Cohen, M.H.3
Justice, R.4
Pazdur, R.5
-
20
-
-
34247860871
-
Vorinostat for treatment of cutaneous manifestations of advanced primary cutaneous T-cell lymphoma
-
DOI 10.1158/1078-0432.CCR-06-2672
-
Mann BS, Johnson JR, He K, et al. Vorinostat for treatment of cutaneous manisfestations of advanced primary cutaneous T-cell lymphoma. Clin Cancer Res 2007;13:2318-22 (Pubitemid 46698579)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.8
, pp. 2318-2322
-
-
Mann, B.S.1
Johnson, J.R.2
He, K.3
Sridhara, R.4
Abraham, S.5
Booth, B.P.6
Verbois, L.7
Morse, D.E.8
Jee, J.M.9
Pope, S.10
Harapanhalli, R.S.11
Dagher, R.12
Farrell, A.13
Justice, R.14
Pazdur, R.15
-
21
-
-
73949149251
-
Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma
-
Piekarz RL, Frye R, Turner M, et al. Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma. J Clin Oncol 2009;27:5410-17
-
(2009)
J Clin Oncol
, vol.27
, pp. 5410-5417
-
-
Piekarz, R.L.1
Frye, R.2
Turner, M.3
-
22
-
-
79952977561
-
Phase II trial of romidepsin in patients with peripheral T-cell lymphoma
-
Piekarz RL, Frye R, Prince HM, et al. Phase II trial of romidepsin in patients with peripheral T-cell lymphoma. Blood 2011;117:5827-34
-
(2011)
Blood
, vol.117
, pp. 5827-5834
-
-
Piekarz, R.L.1
Frye, R.2
Prince, H.M.3
-
23
-
-
77649171884
-
Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents
-
Tan J, Cang S, Ma Y, et al. Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents. J Hematol Oncol 2010;3:5
-
(2010)
J Hematol Oncol
, vol.3
, pp. 5
-
-
Tan, J.1
Cang, S.2
Ma, Y.3
-
24
-
-
1642453460
-
Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histone deacetylase inhibitors PXD101
-
Plumb JA, Finn PW, Williams RJ, et al. Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histone deacetylase inhibitors PXD101. Mol Cancer Ther 2003;2:721-8
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 721-728
-
-
Plumb, J.A.1
Finn, P.W.2
Williams, R.J.3
-
25
-
-
37849019672
-
Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors
-
DOI 10.1042/BJ20070779
-
Khan N, Jeffers M, Kumar S, et al. Determination of the class and isoform selectivity of small molecule histone deacetylase inhibitors. Biochem J 2008;409:581-9 (Pubitemid 351184977)
-
(2008)
Biochemical Journal
, vol.409
, Issue.2
, pp. 581-589
-
-
Khan, N.1
Jeffers, M.2
Kumar, S.3
Hackett, C.4
Boldog, F.5
Khramtsov, N.6
Qian, X.7
Mills, E.8
Berghs, S.C.9
Carey, N.10
Finn, P.W.11
Collins, L.S.12
Tumber, A.13
Ritchie, J.W.14
Jensen, P.B.15
Lichenstein, H.S.16
Sehested, M.17
-
26
-
-
38949146399
-
A phase 1 pharmacokinetic and pharmacodynamic study of the histone deacetylase inhibitor belinostat in patients with advanced solid tumors
-
DOI 10.1158/1078-0432.CCR-07-1786
-
Steele N. Olumb JA, Vidal, L, et al. A phase I pharmacokinetic and pharmacodynamic study of the histone deacetylase inhibitor belinostat in patients with advanced solid tumors. Clin Cancer Res 2008;14:804-10 (Pubitemid 351231163)
-
(2008)
Clinical Cancer Research
, vol.14
, Issue.3
, pp. 804-810
-
-
Steele, N.L.1
Plumb, J.A.2
Vidal, L.3
Tjrornelund, J.4
Knoblauch, P.5
Rasmussen, A.6
Chean, E.O.7
Buhl-Jensen, P.8
Brown, R.9
Evans, T.R.J.10
DeBono, J.S.11
-
27
-
-
49349104503
-
A phase i clinical trial of the histone deacetylase inhibitor belinostat in patients with advanced haematological neoplasia
-
Gimsing P, Hansen M, Knudsen LM, et al. A phase I clinical trial of the histone deacetylase inhibitor belinostat in patients with advanced haematological neoplasia. Eur J Haematol 2008;81:170-6
-
(2008)
Eur J Haematol
, vol.81
, pp. 170-176
-
-
Gimsing, P.1
Hansen, M.2
Knudsen, L.M.3
-
28
-
-
79959611523
-
Pharmacokinetic and pharmacodynamis properties of an oral formulation of the histone deacetylase inhibitor belinostat (PXD101)
-
Steele NL, Plumb JA, Vidal L, et al. Pharmacokinetic and pharmacodynamis properties of an oral formulation of the histone deacetylase inhibitor belinostat (PXD101). Cancer Chemother Pharmacol 2001;67:1273-9
-
(2001)
Cancer Chemother Pharmacol
, vol.67
, pp. 1273-1279
-
-
Steele, N.L.1
Plumb, J.A.2
Vidal, L.3
-
29
-
-
81555216959
-
A phase i study of oral belinostat (PXD101) in paitents with advanced solid tumors
-
Molife R, Lee J, Petrylak D, et al. A phase I study of oral belinostat (PXD101) in paitents with advanced solid tumors. Mol Cancer Ther 2007;6:3476S
-
(2007)
Mol Cancer Ther
, vol.6
-
-
Molife, R.1
Lee, J.2
Petrylak, D.3
-
30
-
-
77954872326
-
Final results of a phase i study of oral belinostat (PXD101) in patients with solid tumors
-
Kelly WmK, Blumenschein G, Lassen U, et al. Final results of a phase I study of oral belinostat (PXD101) in patients with solid tumors. J Clin Oncol 2009;27:3531
-
(2009)
J Clin Oncol
, vol.27
, pp. 3531
-
-
Wmk, K.1
Blumenschein, G.2
Lassen, U.3
-
31
-
-
79958806773
-
Interim results of a phase i trial of an oral histone deacetylase inhibitor belinostat in patients with lymphoid malignancies
-
Zain J, Moss F, de Bono J, et al. Interim results of a phase I trial of an oral histone deacetylase inhibitor belinostat in patients with lymphoid malignancies. Blood 2010;116:1787
-
(2010)
Blood
, vol.116
, pp. 1787
-
-
Zain, J.1
Moss, F.2
De Bono, J.3
-
32
-
-
33748353002
-
Activity of PXD101, a histone deacetylase inhibitor, in preclinical ovarian cancer studies
-
DOI 10.1158/1535-7163.MCT-06-0111
-
Qian X, LaRochelle WJ, Ara G, et al. Activity of PXD101,a histone deacetylase inhibitor, in preclinical ovarian cancer studies. Mol Cancer Ther 2006;5:2086-95 (Pubitemid 44336581)
-
(2006)
Molecular Cancer Therapeutics
, vol.5
, Issue.8
, pp. 2086-2095
-
-
Qian, X.1
LaRochelle, W.J.2
Ara, G.3
Wu, F.4
Petersen, K.D.5
Thougaard, A.6
Sehested, M.7
Lichenstein, H.S.8
Jeffers, M.9
-
33
-
-
34248399662
-
The histone deacetylase inhibitor PXD101 synergises with 5-fluorouracil to inhibit colon cancer cell growth in vitro and in vivo
-
DOI 10.1007/s00280-006-0374-7
-
Tumber A, Collins LS, Petersen KD, et al. The histone deacetylase inhibitor PXD101 synergises with 5-fluorouracil to inhibit colon cancer cell growth in vitro and in vivo. Cancer Chemother Pharmacol. 2007;60:275-83 (Pubitemid 46742543)
-
(2007)
Cancer Chemotherapy and Pharmacology
, vol.60
, Issue.2
, pp. 275-283
-
-
Tumber, A.1
Collins, L.S.2
Petersen, K.D.3
Thougaard, A.4
Christiansen, S.J.5
Dejligbjerg, M.6
Jensen, P.B.7
Sehested, M.8
Ritchie, J.W.A.9
-
34
-
-
79960912286
-
The histone deacetylase inhibitor PXD101 increases the efficacy of irinotecan in in vitro and in vivo colon cancer models
-
Na YS, Jung KA, Kim SM, et al. The histone deacetylase inhibitor PXD101 increases the efficacy of irinotecan in in vitro and in vivo colon cancer models. Cancer Chemother Pharmacol 2001;68:389-98
-
(2001)
Cancer Chemother Pharmacol
, vol.68
, pp. 389-398
-
-
Na, Y.S.1
Jung, K.A.2
Kim, S.M.3
-
35
-
-
77954167626
-
A phase i study of the safety and pharmacokinetics of the histone deacetylase inhibitor belinostat administered in combination with carboplatin and/or paclitaxel in patients with solid tumors
-
Lassen U, Molife LR, Sorensen M, et al. A phase I study of the safety and pharmacokinetics of the histone deacetylase inhibitor belinostat administered in combination with carboplatin and/or paclitaxel in patients with solid tumors. Br J Cancer 2010;103:12-17
-
(2010)
Br J Cancer
, vol.103
, pp. 12-17
-
-
Lassen, U.1
Molife, L.R.2
Sorensen, M.3
-
36
-
-
67649625064
-
A phase i clinical trial of belinostat (PXD101) in combination with doxorubicin (BelDox) in advanced solid tumours including soft tissue sarcomas (STS)
-
Brunetto AT, Krarup-Hansen A, Nielsen OS, et al. A phase I clinical trial of belinostat (PXD101) in combination with doxorubicin (BelDox) in advanced solid tumours including soft tissue sarcomas (STS). Eur J Cnacer 2008;6:132
-
(2008)
Eur J Cnacer
, vol.6
, pp. 132
-
-
Brunetto, A.T.1
Krarup-Hansen, A.2
Nielsen, O.S.3
-
37
-
-
77956538685
-
Belinostat (Bel) down-regulates thymidylate synthase (TS) in tumor tissue: A dose escalation study of belinostat alone and in combinatiom with 5-fluorouracil (5FU)
-
Northfelt DW, Bonnem E, Fagerberg J, et al. Belinostat (Bel) down-regulates thymidylate synthase (TS) in tumor tissue: a dose escalation study of belinostat alone and in combinatiom with 5-fluorouracil (5FU). Proceedings, 2009 Gastrointestinal Cancers Symposium; 2009. p. 333
-
(2009)
Proceedings 2009 Gastrointestinal Cancers Symposium
, pp. 333
-
-
Northfelt, D.W.1
Bonnem, E.2
Fagerberg, J.3
-
38
-
-
67449111955
-
Phase i study of belinostat (PXD101) plus azacitidine (AZC) in patients with advanced myeloid malignancies
-
Odenike O, Green M, Larson A, et al. Phase I study of belinostat (PXD101) plus azacitidine (AZC) in patients with advanced myeloid malignancies. J Clin Oncol 2008;26:7057
-
(2008)
J Clin Oncol
, vol.26
, pp. 7057
-
-
Odenike, O.1
Green, M.2
Larson, A.3
-
39
-
-
81555223805
-
A phase i study and pharmacokinetic (PK) study of 3 and 6 hours (h) intravenously administered belinostat (PXD101) plus carboplatin (C) and paclitaxel (P) in patients (pts) with advanced
-
Sorenson M, Tjornelund J, Jensen PB. A phase I study and pharmacokinetic (PK) study of 3 and 6 hours (h) intravenously administered belinostat (PXD101) plus carboplatin (C) and paclitaxel (P) in patients (pts) with advanced. Eur J Cancer 2008;6:132
-
(2008)
Eur J Cancer
, vol.6
, pp. 132
-
-
Sorenson, M.1
Tjornelund, J.2
Jensen, P.B.3
-
40
-
-
36849084965
-
The histone deacetylase inhibitor belinostat (PXD101) suppresses bladder cancer cell growth in vitro and in vivo
-
Buckley MT, Yoon J, Yee H, et al. The histone deacetylase inhibitor belinostat (PXD101) suppresses bladder cancer cell growth in vitro and in vivo. J Transl Med 2007;5:49
-
(2007)
J Transl Med
, vol.5
, pp. 49
-
-
Buckley, M.T.1
Yoon, J.2
Yee, H.3
-
41
-
-
1942438028
-
Microtubules as a target for anticancer drugs
-
Jordan MA, Wilson L. Microtubules as a target for anticancer drugs. Nat Rev Cancer 2004;4:253-65 (Pubitemid 38525281)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.4
, pp. 253-265
-
-
Jordan, M.A.1
Wilson, L.2
-
42
-
-
0345169048
-
Post-translational modifications regulate microtubule function
-
DOI 10.1038/nrm1260
-
Westermann S, Webe K. Post translational modifications regulate microtubule function. Nat Rev Mol Cell Biol 2003;4:938-47 (Pubitemid 37493642)
-
(2003)
Nature Reviews Molecular Cell Biology
, vol.4
, Issue.12
, pp. 938-947
-
-
Westermann, S.1
Weber, K.2
-
43
-
-
20444391346
-
Chromatin in need of a fix: Phosphorylation of H2AX connects chromatin to DNA repair
-
DOI 10.1016/j.molcel.2005.05.008, PII S1097276505013146
-
Thiriet C, Hayes JJ. Chromatin in need of a fix: phosphorylation of H2AX connects chromatin to DNA repair. Mol Cell 2005;18:617-22 (Pubitemid 40804798)
-
(2005)
Molecular Cell
, vol.18
, Issue.6
, pp. 617-622
-
-
Thiriet, C.1
Hayes, J.J.2
-
44
-
-
1942534150
-
Assessment of Histone H2AX Phosphorylation Induced by DNA Topoisomerase I and II Inhibitors Topotecan and Mitoxantrone and by the DNA Cross-Linking Agent Cisplatin
-
Huang X, Okafuji M, Traganos F, et al. Assessment of histone H2AX phosphorylation induced by DNA topoisomerase I and II inhibitors topotecan and mitoxantrone and by the DNA cross-linking agent cisplatin. Cytometry A 2004;58:99-110 (Pubitemid 38509171)
-
(2004)
Cytometry Part A
, vol.58
, Issue.2
, pp. 99-110
-
-
Huang, X.1
Okafuji, M.2
Traganos, F.3
Luther, E.4
Holden, E.5
Darzynkiewicz, Z.6
-
45
-
-
0029052988
-
Thymidylate synthase gene amplification in human colon cancer cell lines resistant to 5-fluorouracil
-
Copur S, Aiba K, Drake JC, et al. Thymidylate synthase gene amplification in human colon cancer cell lines resistant to 5-fluorouracil. Biochem Pharmacol 1995;49:1419-26
-
(1995)
Biochem Pharmacol
, vol.49
, pp. 1419-1426
-
-
Copur, S.1
Aiba, K.2
Drake, J.C.3
-
46
-
-
74549173443
-
Romidepsin and belinostat synergize the antineoplastic effect of bortezomib in mantle cell lymphoma
-
Paoluzzi L, Scotto L, Marchi E, et al. Romidepsin and belinostat synergize the antineoplastic effect of bortezomib in mantle cell lymphoma. Clin Cancer Res 2010;16:554-65
-
(2010)
Clin Cancer Res
, vol.16
, pp. 554-565
-
-
Paoluzzi, L.1
Scotto, L.2
Marchi, E.3
-
47
-
-
81555223804
-
A phase i study of belinostat (PXD101) in combination with bortezomib in patients with advanced solid tumors or lymphoma
-
Nallapreddy S, Leong SM, CamidgeR, et al. A phase I study of belinostat (PXD101) in combination with bortezomib in patients with advanced solid tumors or lymphoma. Mol Cancer Ther 2009;8:B238
-
(2009)
Mol Cancer Ther
, vol.8
-
-
Nallapreddy, S.1
Camidger, L.S.2
-
48
-
-
77649133111
-
Histone deacetylase inhibitors in malignant pleural mesothelioma: Preclinical rationale and clinical trials
-
Paik PK, Krug LM. Histone deacetylase inhibitors in malignant pleural mesothelioma: preclinical rationale and clinical trials. J Thorac Oncol 2010;5:275-9
-
(2010)
J Thorac Oncol
, vol.5
, pp. 275-279
-
-
Paik, P.K.1
Krug, L.M.2
-
49
-
-
33244458274
-
Potential role of histone deacetylase inhibitors in mesothelioma: Clinical experience with suberoylanilide hydroxamic acid
-
Krug LM, Curley T, Schwartz L, et al. Potential role of histone deacetylase inhibitors in mesothelioma: clinical experience with suberoylanilide hydroxamic acid. Clin Lung Cancer 2006;7:257-61 (Pubitemid 43280028)
-
(2006)
Clinical Lung Cancer
, vol.7
, Issue.4
, pp. 257-261
-
-
Krug, L.M.1
Curley, T.2
Schwartz, L.3
Richardson, S.4
Marks, P.5
Chiao, J.6
Kelly, W.K.7
-
50
-
-
61549123363
-
Phase II study of belinostat (PXD101), a histone deacetylase inhibitor, for second line therapy of advanced malignant pleural mesothelioma
-
Ramalingam SS, Belani CP, Ruel C, et al. Phase II study of belinostat (PXD101), a histone deacetylase inhibitor, for second line therapy of advanced malignant pleural mesothelioma. J Thorac Oncol 2009;4:97-101
-
(2009)
J Thorac Oncol
, vol.4
, pp. 97-101
-
-
Ramalingam, S.S.1
Belani, C.P.2
Ruel, C.3
-
51
-
-
77952240320
-
The preclinical activity of the histone deacetylase inhibitor PXD101 (belinostat) in hepatocellular carcinoma cell lines
-
Ma BB, Sung F, Tao Q, et al. The preclinical activity of the histone deacetylase inhibitor PXD101 (belinostat) in hepatocellular carcinoma cell lines. Invest New Drugs 2010;28:107-14
-
(2010)
Invest New Drugs
, vol.28
, pp. 107-114
-
-
Ma, B.B.1
Sung, F.2
Tao, Q.3
-
52
-
-
67649573777
-
A phase I/II study of belinostat (PXD101) in patients with unresectable hepatocellular carcinoma
-
Yeo W, Lim R, Ma BB, et al. A phase I/II study of belinostat (PXD101) in patients with unresectable hepatocellular carcinoma. J Clin Oncol 2007;25:15081
-
(2007)
J Clin Oncol
, vol.25
, pp. 15081
-
-
Yeo, W.1
Lim, R.2
Ma, B.B.3
-
53
-
-
77952585540
-
Phase II trial of the histone deacetylase inhibitor belinostat in women with platinum resistant epithelial ovarian cancer and micropapillary (LMP) ovarian tumours
-
Mackay HJ, Hirte H, Colgan T, et al. Phase II trial of the histone deacetylase inhibitor belinostat in women with platinum resistant epithelial ovarian cancer and micropapillary (LMP) ovarian tumours. Eur J Cancer 2010;46:1573-9
-
(2010)
Eur J Cancer
, vol.46
, pp. 1573-1579
-
-
MacKay, H.J.1
Hirte, H.2
Colgan, T.3
-
54
-
-
79956325272
-
Phase II study of belinostat in patients with recurrent or refractory advanced thymic epithelial tumors
-
Giaccone G, Rajan A, Berman A, et al. Phase II study of belinostat in patients with recurrent or refractory advanced thymic epithelial tumors. J Clin Oncol. 2011;29:2052-9
-
(2011)
J Clin Oncol
, vol.29
, pp. 2052-2059
-
-
Giaccone, G.1
Rajan, A.2
Berman, A.3
-
55
-
-
65349137584
-
Histone deacetylase 1, 2, and acetylated histone H4 in B-and T-cell lymphomas
-
Marquard L, Poulsen CB, Gjerdrum LM, et al. Histone deacetylase 1, 2, and acetylated histone H4 in B-and T-cell lymphomas. Histopathology 2009;54:688-98
-
(2009)
Histopathology
, vol.54
, pp. 688-698
-
-
Marquard, L.1
Poulsen, C.B.2
Gjerdrum, L.M.3
-
56
-
-
77954504404
-
Final results of a phase II trial of belinostat (PXD101) in patients with recurrent or refractory peripheral or cutaneous T-cell lymphoma
-
Pohlman B, Advani R, Duvic M, et al. Final results of a phase II trial of belinostat (PXD101) in patients with recurrent or refractory peripheral or cutaneous T-cell lymphoma. Blood 2009;114:920
-
(2009)
Blood
, vol.114
, pp. 920
-
-
Pohlman, B.1
Advani, R.2
Duvic, M.3
-
57
-
-
67649576501
-
Phase II multi-centre trial of belinostat (PXD101) in combination with carboplatin and paclitaxel (BELCAP) for patients (pts) with transitional cell carcinoma (TCC) of the bladder
-
BarriusoJ, daugaard G, FrentzasS, et al. Phase II multi-centre trial of belinostat (PXD101) in combination with carboplatin and paclitaxel (BELCAP) for patients (pts) with transitional cell carcinoma (TCC) of the bladder. Eur J Cancer 2008;6:213
-
(2008)
Eur J Cancer
, vol.6
, pp. 213
-
-
Barriuso, J.1
Daugaard, G.2
Frentzas, S.3
-
58
-
-
67349278924
-
Phase II multicenter trial of the histone deacetylase inhibitor (HDACi) belinostat, carboplatin and paclitaxel (BelCaP) in patients (pts) with relapsed ovarian cancer
-
Finkler NJ, Dizon DS, Braly P, et al. Phase II multicenter trial of the histone deacetylase inhibitor (HDACi) belinostat, carboplatin and paclitaxel (BelCaP) in patients (pts) with relapsed ovarian cancer. J Clin Oncol 2008;26:5519
-
(2008)
J Clin Oncol
, vol.26
, pp. 5519
-
-
Finkler, N.J.1
Dizon, D.S.2
Braly, P.3
-
59
-
-
78349308653
-
An open label randomized phase II trial of belinostat (PXD101) in combination with carboplatin and paclitaxel (BelCaP) compared to carboplatin and paclitaxel in patients with previously untreated carcinoma unknown primary
-
Daugaard G, Fizazi K, Huebner G, et al. An open label randomized phase II trial of belinostat (PXD101) in combination with carboplatin and paclitaxel (BelCaP) compared to carboplatin and paclitaxel in patients with previously untreated carcinoma unknown primary. J Clin Oncol 2010;28:TPS185
-
(2010)
J Clin Oncol
, vol.28
-
-
Daugaard, G.1
Fizazi, K.2
Huebner, G.3
-
60
-
-
37249071337
-
Histone deacetylase inhibitors in cancer treatment: A review of the clinical toxicity and the modulation of gene expression in cancer cells
-
DOI 10.2174/138920107783018417
-
Bruserud O, Stapnes E, Ersvaer BT, et al. Histone deacetylase inhibitors in cancer treatment: a review of the clinical toxicity and the modulation of gene expression in cancer cells. Curr Pharm Biotechnol 2007;8:388-400 (Pubitemid 350268198)
-
(2007)
Current Pharmaceutical Biotechnology
, vol.8
, Issue.6
, pp. 388-400
-
-
Bruserud, O.1
Stapnes, C.2
Ersvaer, E.3
Gjertsen, B.T.4
Ryningen, A.5
-
62
-
-
67349157687
-
Biomarkers for predicting clinical responses to HDAC inhibitors
-
Stimson L, La Thangue NB. Biomarkers for predicting clinical responses to HDAC inhibitors. Cancer Lett 2009;280:177-83
-
(2009)
Cancer Lett
, vol.280
, pp. 177-183
-
-
Stimson, L.1
La Thangue, N.B.2
-
63
-
-
0033822112
-
P21-dependent g(1) arrest with downregulation of cyclin D1 and upregulation of cyclin e by the histone deacetylase inhibitor FR901228
-
Sandor V, Senderowicz A, Mertins S, et al. P21-dependent g(1) arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228. Br J Cancer 2000;83:817-25
-
(2000)
Br J Cancer
, vol.83
, pp. 817-825
-
-
Sandor, V.1
Senderowicz, A.2
Mertins, S.3
-
64
-
-
0033604457
-
Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-x(L), c-Jun, and p21(CIP1), but independent of p53
-
Vrana J, Decker R, Johnson C, et al. Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun, and p21CIP1, but independent of p53. Oncogene 1999;18:7016-25 (Pubitemid 30028872)
-
(1999)
Oncogene
, vol.18
, Issue.50
, pp. 7016-7025
-
-
Vrana, J.A.1
Decker, R.H.2
Johnson, C.R.3
Wang, Z.4
Jarvis, W.D.5
Richon, V.M.6
Ehinger, M.7
Fisher, P.B.8
Grant, S.9
-
65
-
-
41549159879
-
Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: Specific role of class I histone deacetylases in vitro and in vivo
-
DOI 10.1158/1078-0432.CCR-07-0990
-
Weichert W, Roske A, Niesporek S, et al. Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: specific role of class I histone deacetylases in vitro and in vivo. Clin Cancer Res 2008;14:1669-77 (Pubitemid 351469450)
-
(2008)
Clinical Cancer Research
, vol.14
, Issue.6
, pp. 1669-1677
-
-
Weichert, W.1
Roske, A.2
Niesporek, S.3
Noske, A.4
Buckendahl, A.-C.5
Dietel, M.6
Gekeler, V.7
Boehm, M.8
Beckers, T.9
Denkert, C.10
-
66
-
-
38949086502
-
Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy
-
DOI 10.1038/sj.bjc.6604199, PII 6604199
-
Weichert W, Roske A, Gekeler V, et al. Histone deacetylases 1, 2 and 3 are highly expressed in prostate cabcer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy. Br J Cancer 2008;98:604-10 (Pubitemid 351214528)
-
(2008)
British Journal of Cancer
, vol.98
, Issue.3
, pp. 604-610
-
-
Weichert, W.1
Roske, A.2
Gekeler, V.3
Beckers, T.4
Stephan, C.5
Jung, K.6
Fritzsche, F.R.7
Niesporek, S.8
Denkert, C.9
Dietel, M.10
Kristiansen, G.11
-
67
-
-
50049108874
-
Prognostic significance of the therapeutic targets histone deacetylase 1,2, 6 and acetylated histone H4 in cutaneous T-cell lymphoma
-
Marquard L, Gjerdrum LM, Christensen IJ, et al. Prognostic significance of the therapeutic targets histone deacetylase 1, 2, 6 and acetylated histone H4 in cutaneous T-cell lymphoma. Histopathology 2008;53:267-77
-
(2008)
Histopathology
, vol.53
, pp. 267-277
-
-
Marquard, L.1
Gjerdrum, L.M.2
Christensen, I.J.3
-
68
-
-
70349334004
-
Gene expression-signature of belinostat in cell lines is specific for histone deacetylase inhibitor treatment, with a corresponding signature in xenografts
-
Monks A, Hose CD, Pezzolo P, et al. Gene expression-signature of belinostat in cell lines is specific for histone deacetylase inhibitor treatment, with a corresponding signature in xenografts. Anticancer Drugs 2009;20:682-92
-
(2009)
Anticancer Drugs
, vol.20
, pp. 682-692
-
-
Monks, A.1
Hose, C.D.2
Pezzolo, P.3
-
69
-
-
44049101802
-
Identification of predictive biomarkers for the histone deacetylase inhibitor belinostat in a panel of human cancer cell lines
-
Dejligbjerg M, Grausland M, Christensen IJ, et al. Identification of predictive biomarkers for the histone deacetylase inhibitor belinostat in a panel of human cancer cell lines. Cancer Biomark 2008;4:101-9 (Pubitemid 351712270)
-
(2008)
Cancer Biomarkers
, vol.4
, Issue.2
, pp. 101-109
-
-
Dejligbjerg, M.1
Grauslund, M.2
Christensen, I.J.3
Tjornelund, J.4
Buhl Jensen, P.5
Sehested, M.6
-
70
-
-
58049208190
-
Genome-wide loss-of-function screen reveals an important role for the proteasome in HDAC inhibitor-induced apoptosis
-
Fotheringham S, Epping MT, Stimson L, et al. Genome-wide loss-of-function screen reveals an important role for the proteasome in HDAC inhibitor-induced apoptosis. Cancer Cell 2009;15:57-66
-
(2009)
Cancer Cell
, vol.15
, pp. 57-66
-
-
Fotheringham, S.1
Epping, M.T.2
Stimson, L.3
|