Ligand binding to domain-3 of human serum albumin: A chemometric analysis

Journal of Computer-Aided Molecular Design

Volumn 17, Issue 2-4, 2003, Pages 93-102

  Hajduk, Philip J ^a   Mendoza, Renaldo ^a   Petros, Andrew M ^a   Huth, Jeffrey R ^a   Bures, Mark ^a   Fesik, Stephen W ^a   Martin, Yvonne C ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Albumin binding; Chemometric analysis; Human serum albumin; Ligand binding; NMR

Indexed keywords

BODY FLUIDS; CHEMICAL ANALYSIS; TABLE LOOKUP;

ALBUMIN BINDINGS; CHEMICAL FRAGMENTS; CHEMOMETRIC ANALYSIS; DRUG DEVELOPMENT; GROUP CONTRIBUTION MODEL; HUMAN SERUM ALBUMINS; LIGAND BINDING; LOOKUP TABLES (LUTS); MODEL-BASED OPC; STRUCTURAL DESCRIPTORS;

LIGANDS;

ACETYLSALICYLIC ACID; ATENOLOL; CAPTOPRIL; CHLORPROPAMIDE; CLOFIBRATE; CLOTRIMAZOLE; HUMAN SERUM ALBUMIN; INDOMETACIN; KETOPROFEN; LIDOCAINE; LIGAND; NAPROXEN; NORFLOXACIN; PHENYTOIN; PINDOLOL; SALICYLIC ACID; TOLBUTAMIDE; TRIMETHOPRIM;

ARTICLE; BINDING AFFINITY; CHEMOMETRIC ANALYSIS; COMPUTER MODEL; CONTROLLED STUDY; DRUG PROTEIN BINDING; FLUORESCENCE SPECTROSCOPY; LIGAND BINDING; MATHEMATICAL COMPUTING; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS; SOLUBILITY;

EID: 0042856657     PISSN: 0920654X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1025305520585     Document Type: Article

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