-
1
-
-
67649217159
-
Inhibiting the transcription factor HSF1 as an anticancer strategy
-
Whitesell L, Lindquist S. Inhibiting the transcription factor HSF1 as an anticancer strategy. Expert Opin Ther Targets 2009; 13:469-78.
-
(2009)
Expert Opin Ther Targets
, vol.13
, pp. 469-478
-
-
Whitesell, L.1
Lindquist, S.2
-
2
-
-
74849095191
-
Drugging the heat shock factor 1 pathway: Exploitation of the critical cancer cell dependence on the guardian of the proteome
-
de Billy E, Powers MV, Smith JR, Workman P. Drugging the heat shock factor 1 pathway: Exploitation of the critical cancer cell dependence on the guardian of the proteome. Cell Cycle 2009; 8:3806-8.
-
(2009)
Cell Cycle
, vol.8
, pp. 3806-3808
-
-
De Billy, E.1
Powers, M.V.2
Smith, J.R.3
Workman, P.4
-
3
-
-
35348890981
-
Drugging the cancer chaperone HSP90: Combinatorial therapeutic exploitation of oncogene addiction and tumor stress
-
Workman P, Burrows F, Neckers L, Rosen N. Drugging the cancer chaperone HSP90: combinatorial therapeutic exploitation of oncogene addiction and tumor stress. Ann NY Acad Sci 2007; 1113:202-16.
-
(2007)
Ann NY Acad Sci
, vol.1113
, pp. 202-216
-
-
Workman, P.1
Burrows, F.2
Neckers, L.3
Rosen, N.4
-
4
-
-
34548658230
-
Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis
-
Dai C, Whitesell L, Rogers AB, Lindquist S. Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell 2007; 130:1005-18.
-
(2007)
Cell
, vol.130
, pp. 1005-1018
-
-
Dai, C.1
Whitesell, L.2
Rogers, A.B.3
Lindquist, S.4
-
5
-
-
33746191768
-
Inhibitors of the HSP90 molecular chaperone: Current status
-
Sharp S, Workman P. Inhibitors of the HSP90 molecular chaperone: current status. Adv Cancer Res 2006; 95:323-48.
-
(2006)
Adv Cancer Res
, vol.95
, pp. 323-348
-
-
Sharp, S.1
Workman, P.2
-
6
-
-
74249085361
-
Update on Hsp90 inhibitors in clinical trial
-
Kim YS, Alarcon SV, Lee S, Lee MJ, Giaccone G, Neckers L, et al. Update on Hsp90 inhibitors in clinical trial. Curr Top Med Chem 2009; 9:1479-92.
-
(2009)
Curr Top Med Chem
, vol.9
, pp. 1479-1492
-
-
Kim, Y.S.1
Alarcon, S.V.2
Lee, S.3
Lee, M.J.4
Giaccone, G.5
Neckers, L.6
-
7
-
-
34447528828
-
The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions
-
Daugaard M, Rohde M, Jaattela M. The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions. FEBS Lett 2007; 581:3702-10.
-
(2007)
FEBS Lett
, vol.581
, pp. 3702-3710
-
-
Daugaard, M.1
Rohde, M.2
Jaattela, M.3
-
8
-
-
34447507818
-
Inhibitors of the heat shock response: Biology and pharmacology
-
Powers MV, Workman P. Inhibitors of the heat shock response: biology and pharmacology. FEBS Lett 2007; 581:3758-69.
-
(2007)
FEBS Lett
, vol.581
, pp. 3758-3769
-
-
Powers, M.V.1
Workman, P.2
-
10
-
-
33746330168
-
Hsp70 molecular chaperones: Emerging roles in human disease and identification of small molecule modulators
-
Brodsky JL, Chiosis G. Hsp70 molecular chaperones: emerging roles in human disease and identification of small molecule modulators. Curr Top Med Chem 2006; 6:1215-25.
-
(2006)
Curr Top Med Chem
, vol.6
, pp. 1215-1225
-
-
Brodsky, J.L.1
Chiosis, G.2
-
11
-
-
0025100372
-
Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein
-
Flaherty KM, DeLuca-Flaherty C, McKay DB. Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein. Nature 1990; 346:623-8.
-
(1990)
Nature
, vol.346
, pp. 623-628
-
-
Flaherty, K.M.1
DeLuca-Flaherty, C.2
McKay, D.B.3
-
12
-
-
0031569356
-
Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain
-
Sriram M, Osipiuk J, Freeman B, Morimoto R, Joachimiak A. Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain. Structure 1997; 5:403-14.
-
(1997)
Structure
, vol.5
, pp. 403-414
-
-
Sriram, M.1
Osipiuk, J.2
Freeman, B.3
Morimoto, R.4
Joachimiak, A.5
-
13
-
-
77952530199
-
Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B' and HSPA5/BiP/GRP78
-
Wisniewska M, Karlberg T, Lehtio L, Johansson I, Kotenyova T, Moche M, et al. Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B' and HSPA5/BiP/GRP78. PLoS ONE 2010; 5:e8625.
-
(2010)
PLoS ONE
, vol.5
-
-
Wisniewska, M.1
Karlberg, T.2
Lehtio, L.3
Johansson, I.4
Kotenyova, T.5
Moche, M.6
-
14
-
-
0030936995
-
Crystal structure of the nucleotide exchange factor GrpE bound to the ATPase domain of the molecular chaperone DnaK
-
Harrison CJ, Hayer-Hartl M, Di Liberto M, Hartl F, Kuriyan J. Crystal structure of the nucleotide exchange factor GrpE bound to the ATPase domain of the molecular chaperone DnaK. Science 1997; 276:431-5.
-
(1997)
Science
, vol.276
, pp. 431-435
-
-
Harrison, C.J.1
Hayer-Hartl, M.2
Di Liberto, M.3
Hartl, F.4
Kuriyan, J.5
-
15
-
-
0035936826
-
Structure of a Bag/Hsc70 complex: Convergent functional evolution of Hsp70 nucleotide exchange factors
-
Sondermann H, Scheufler C, Schneider C, Hohfeld J, Hartl FU, Moarefi I. Structure of a Bag/Hsc70 complex: convergent functional evolution of Hsp70 nucleotide exchange factors. Science 2001; 291:1553-7.
-
(2001)
Science
, vol.291
, pp. 1553-1557
-
-
Sondermann, H.1
Scheufler, C.2
Schneider, C.3
Hohfeld, J.4
Hartl, F.U.5
Moarefi, I.6
-
16
-
-
57149092290
-
Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2
-
Xu Z, Page RC, Gomes MM, Kohli E, Nix JC, Herr AB, et al. Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2. Nat Struct Mol Biol 2008; 15:1309-17.
-
(2008)
Nat Struct Mol Biol
, vol.15
, pp. 1309-1317
-
-
Xu, Z.1
Page, R.C.2
Gomes, M.M.3
Kohli, E.4
Nix, J.C.5
Herr, A.B.6
-
17
-
-
3142677815
-
The 70-kDa heat shock protein chaperone nucleotide-binding domain in solution unveiled as a molecular machine that can reorient its functional subdomains
-
Zhang Y, Zuiderweg ER. The 70-kDa heat shock protein chaperone nucleotide-binding domain in solution unveiled as a molecular machine that can reorient its functional subdomains. Proc Natl Acad Sci USA 2004; 101:10272-7.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 10272-10277
-
-
Zhang, Y.1
Zuiderweg, E.R.2
-
18
-
-
0029937037
-
Structural analysis of substrate binding by the molecular chaperone DnaK
-
Zhu X, Zhao X, Burkholder WF, Gragerov A, Ogata CM, Gottesman ME, et al. Structural analysis of substrate binding by the molecular chaperone DnaK. Science 1996; 272:1606-14.
-
(1996)
Science
, vol.272
, pp. 1606-1614
-
-
Zhu, X.1
Zhao, X.2
Burkholder, W.F.3
Gragerov, A.4
Ogata, C.M.5
Gottesman, M.E.6
-
19
-
-
0033603631
-
High-resolution solution structure of the 18 kDa substrate-binding domain of the mammalian chaperone protein Hsc70
-
DOI 10.1006/jmbi.1999.2776
-
Morshauser RC, Hu W, Wang H, Pang Y, Flynn GC, Zuiderweg ER. High-resolution solution structure of the 18 kDa substrate-binding domain of the mammalian chaperone protein Hsc70. J Mol Biol 1999; 289:1387-403. (Pubitemid 29296712)
-
(1999)
Journal of Molecular Biology
, vol.289
, Issue.5
, pp. 1387-1403
-
-
Morshauser, R.C.1
Hu, W.2
Wang, H.3
Pang, Y.4
Flynn, G.C.5
Zuiderweg, E.R.P.6
-
20
-
-
34047268015
-
Hsp70 Chaperone Ligands Control Domain Association via an Allosteric Mechanism Mediated by the Interdomain Linker
-
DOI 10.1016/j.molcel.2007.02.020, PII S1097276507001207
-
Swain JF, Dinler G, Sivendran R, Montgomery DL, Stotz M, Gierasch LM. Hsp70 chaperone ligands control domain association via an allosteric mechanism mediated by the interdomain linker. Mol Cell 2007; 26:27-39. (Pubitemid 46550933)
-
(2007)
Molecular Cell
, vol.26
, Issue.1
, pp. 27-39
-
-
Swain, J.F.1
Dinler, G.2
Sivendran, R.3
Montgomery, D.L.4
Stotz, M.5
Gierasch, L.M.6
-
21
-
-
0028980922
-
Solution small-angle X-ray scattering study of the molecular chaperone Hsc70 and its subfragments
-
Wilbanks SM, Chen L, Tsuruta H, Hodgson KO, McKay DB. Solution small-angle X-ray scattering study of the molecular chaperone Hsc70 and its subfragments. Biochemistry 1995; 34:12095-106.
-
(1995)
Biochemistry
, vol.34
, pp. 12095-12106
-
-
Wilbanks, S.M.1
Chen, L.2
Tsuruta, H.3
Hodgson, K.O.4
McKay, D.B.5
-
22
-
-
34848869936
-
Insights into Hsp70 Chaperone Activity from a Crystal Structure of the Yeast Hsp110 Sse1
-
DOI 10.1016/j.cell.2007.08.039, PII S0092867407011026
-
Liu Q, Hendrickson WA. Insights into Hsp70 chaperone activity from a crystal structure of the yeast Hsp110 Sse1. Cell 2007; 131:106-20. (Pubitemid 47498533)
-
(2007)
Cell
, vol.131
, Issue.1
, pp. 106-120
-
-
Liu, Q.1
Hendrickson, W.A.2
-
23
-
-
44649169371
-
Crystal structures of the 70-kDa heat shock proteins in domain disjoining conformation
-
Chang YW, Sun YJ, Wang C, Hsiao CD. Crystal structures of the 70-kDa heat shock proteins in domain disjoining conformation. J Biol Chem 2008; 283:15502-11.
-
(2008)
J Biol Chem
, vol.283
, pp. 15502-15511
-
-
Chang, Y.W.1
Sun, Y.J.2
Wang, C.3
Hsiao, C.D.4
-
24
-
-
64649094781
-
Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate
-
Bertelsen EB, Chang L, Gestwicki JE, Zuiderweg ER. Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate. Proc Natl Acad Sci USA 2009; 106:8471-6.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 8471-8476
-
-
Bertelsen, E.B.1
Chang, L.2
Gestwicki, J.E.3
Zuiderweg, E.R.4
-
25
-
-
50349096803
-
Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis
-
Powers MV, Clarke PA, Workman P. Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis. Cancer Cell 2008; 14:250-62.
-
(2008)
Cancer Cell
, vol.14
, pp. 250-262
-
-
Powers, M.V.1
Clarke, P.A.2
Workman, P.3
-
26
-
-
0028230782
-
Quantitation of the interaction of the immunosuppressant deoxyspergualin and analogs with Hsc70 and Hsp90
-
Nadeau K, Nadler SG, Saulnier M, Tepper MA, Walsh CT. Quantitation of the interaction of the immunosuppressant deoxyspergualin and analogs with Hsc70 and Hsp90. Biochemistry 1994; 33:2561-7. (Pubitemid 24099664)
-
(1994)
Biochemistry
, vol.33
, Issue.9
, pp. 2561-2567
-
-
Nadeau, K.1
Nadler, S.G.2
Saulnier, M.3
Tepper, M.A.4
Walsh, C.T.5
-
27
-
-
0033561687
-
Selectivity of the molecular chaperone-specific immunosuppressive agent 15-deoxyspergualin: Modulation of Hsc70 ATPase activity without compromising DnaJ chaperone interactions
-
Brodsky JL. Selectivity of the molecular chaperone-specific immunosuppressive agent 15-deoxyspergualin: modulation of Hsc70 ATPase activity without compromising DnaJ chaperone interactions. Biochem Pharmacol 1999; 57:877-80.
-
(1999)
Biochem Pharmacol
, vol.57
, pp. 877-880
-
-
Brodsky, J.L.1
-
28
-
-
0035847010
-
Identification of an inhibitor of hsc70-mediated protein translocation and ATP hydrolysis
-
Fewell SW, Day BW, Brodsky JL. Identification of an inhibitor of hsc70-mediated protein translocation and ATP hydrolysis. J Biol Chem 2001; 276:910-4.
-
(2001)
J Biol Chem
, vol.276
, pp. 910-914
-
-
Fewell, S.W.1
Day, B.W.2
Brodsky, J.L.3
-
29
-
-
10944263745
-
Small molecule modulators of endogenous and co-chaperone-stimulated Hsp70 ATPase activity
-
DOI 10.1074/jbc.M404857200
-
Fewell SW, Smith CM, Lyon MA, Dumitrescu TP, Wipf P, Day BW, et al. Small molecule modulators of endogenous and co-chaperone-stimulated Hsp70 ATPase activity. J Biol Chem 2004; 279: 51131-40. (Pubitemid 40017855)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.49
, pp. 51131-51140
-
-
Fewell, S.W.1
Smith, C.M.2
Lyon, M.A.3
Dumitrescu, T.P.4
Wipf, P.5
Day, B.W.6
Brodsky, J.L.7
-
30
-
-
54749143530
-
An apoptosis-inducing small molecule that binds to heat shock protein 70
-
Williams DR, Ko SK, Park S, Lee MR, Shin I. An apoptosis-inducing small molecule that binds to heat shock protein 70. Angew Chem Int Ed Engl 2008; 47:7466-9.
-
(2008)
Angew Chem Int Ed Engl
, vol.47
, pp. 7466-7469
-
-
Williams, D.R.1
Ko, S.K.2
Park, S.3
Lee, M.R.4
Shin, I.5
-
31
-
-
3242757468
-
Contribution of ionization and lipophilicity to drug binding to albumin: A preliminary step toward biodistribution prediction
-
DOI 10.1021/jm040760a
-
Ermondi G, Lorenti M, Caron G. Contribution of ionization and lipophilicity to drug binding to albumin: a preliminary step toward biodistribution prediction. J Med Chem 2004; 47:3949-61. (Pubitemid 38970957)
-
(2004)
Journal of Medicinal Chemistry
, vol.47
, Issue.16
, pp. 3949-3961
-
-
Ermondi, G.1
Lorenti, M.2
Caron, G.3
-
32
-
-
70349768075
-
A small molecule inhibitor of inducible heat shock protein 70
-
Leu JI, Pimkina J, Frank A, Murphy ME, George DL. A small molecule inhibitor of inducible heat shock protein 70. Mol Cell 2009; 36:15-27.
-
(2009)
Mol Cell
, vol.36
, pp. 15-27
-
-
Leu, J.I.1
Pimkina, J.2
Frank, A.3
Murphy, M.E.4
George, D.L.5
-
33
-
-
33747620737
-
Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation
-
DOI 10.1038/nchembio809, PII NCHEMBIO809
-
Strom E, Sathe S, Komarov PG, Chernova OB, Pavlovska I, Shyshynova I, et al. Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nat Chem Biol 2006; 2:474-9. (Pubitemid 44266309)
-
(2006)
Nature Chemical Biology
, vol.2
, Issue.9
, pp. 474-479
-
-
Strom, E.1
Sathe, S.2
Komarov, P.G.3
Chernova, O.B.4
Pavlovska, I.5
Shyshynova, I.6
Bosykh, D.A.7
Burdelya, L.G.8
Macklis, R.M.9
Skaliter, R.10
Komarova, E.A.11
Gudkov, A.V.12
-
34
-
-
42949149763
-
6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases
-
Wood ER, Shewchuk LM, Ellis B, Brignola P, Brashear RL, Caferro TR, et al. 6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases. Proc Natl Acad Sci USA 2008; 105:2773-8.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 2773-2778
-
-
Wood, E.R.1
Shewchuk, L.M.2
Ellis, B.3
Brignola, P.4
Brashear, R.L.5
Caferro, T.R.6
-
35
-
-
33748595526
-
Mechanism-based profiling of enzyme families
-
Evans MJ, Cravatt BF. Mechanism-based profiling of enzyme families. Chem Rev 2006; 106:3279-301.
-
(2006)
Chem Rev
, vol.106
, pp. 3279-3301
-
-
Evans, M.J.1
Cravatt, B.F.2
-
36
-
-
69849089290
-
2-Phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells
-
Steele AJ, Prentice AG, Hoffbrand AV, Yogashangary BC, Hart SM, Lowdell MW, et al. 2-Phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells. Blood 2009; 114:1217-25.
-
(2009)
Blood
, vol.114
, pp. 1217-1225
-
-
Steele, A.J.1
Prentice, A.G.2
Hoffbrand, A.V.3
Yogashangary, B.C.4
Hart, S.M.5
Lowdell, M.W.6
-
37
-
-
33746286154
-
Spectroscopic and thermodynamic measurements of nucleotide-induced changes in the human 70-kDa heat shock cognate protein
-
Borges JC, Ramos CH. Spectroscopic and thermodynamic measurements of nucleotide-induced changes in the human 70-kDa heat shock cognate protein. Arch Biochem Biophys 2006; 452:46-54.
-
(2006)
Arch Biochem Biophys
, vol.452
, pp. 46-54
-
-
Borges, J.C.1
Ramos, C.H.2
-
38
-
-
0034602451
-
C-terminal regions of Hsp90 are important for trapping the nucleotide during the ATPase cycle
-
Weikl T, Muschler P, Richter K, Veit T, Reinstein J, Buchner J. C-terminal regions of Hsp90 are important for trapping the nucleotide during the ATPase cycle. J Mol Biol 2000; 303:583-92.
-
(2000)
J Mol Biol
, vol.303
, pp. 583-592
-
-
Weikl, T.1
Muschler, P.2
Richter, K.3
Veit, T.4
Reinstein, J.5
Buchner, J.6
-
39
-
-
65249117514
-
Identifying and characterizing binding sites and assessing druggability
-
Halgren TA. Identifying and characterizing binding sites and assessing druggability. J Chem Inf Model 2009; 49:377-89.
-
(2009)
J Chem Inf Model
, vol.49
, pp. 377-389
-
-
Halgren, T.A.1
-
40
-
-
64349121987
-
Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design
-
Williamson DS, Borgognoni J, Clay A, Daniels Z, Dokurno P, Drysdale MJ, et al. Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design. J Med Chem 2009; 52:1510-3.
-
(2009)
J Med Chem
, vol.52
, pp. 1510-1513
-
-
Williamson, D.S.1
Borgognoni, J.2
Clay, A.3
Daniels, Z.4
Dokurno, P.5
Drysdale, M.J.6
-
41
-
-
77954662908
-
A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells
-
doi:10/1007/s00280-009-1194-3
-
Massey AJ, Williamson DS, Browne H, Murray JB, Dokurno P, Shaw T, et al. A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells. Cancer Chemother Pharmacol 2009. doi:10/1007/s00280-009-1194-3.
-
(2009)
Cancer Chemother Pharmacol
-
-
Massey, A.J.1
Williamson, D.S.2
Browne, H.3
Murray, J.B.4
Dokurno, P.5
Shaw, T.6
-
42
-
-
18844378888
-
Increased expression of the major heat shock protein Hsp72 in human prostate carcinoma cells is dispensable for their viability but confers resistance to a variety of anticancer agents
-
Gabai VL, Budagova KR, Sherman MY. Increased expression of the major heat shock protein Hsp72 in human prostate carcinoma cells is dispensable for their viability but confers resistance to a variety of anticancer agents. Oncogene 2005; 24:3328-38.
-
(2005)
Oncogene
, vol.24
, pp. 3328-3338
-
-
Gabai, V.L.1
Budagova, K.R.2
Sherman, M.Y.3
-
43
-
-
28544433004
-
Abrogation of heat shock protein 70 induction as a strategy to increase antileukemia activity of heat shock protein 90 inhibitor 17-allylamino-demethoxy geldanamycin
-
DOI 10.1158/0008-5472.CAN-05-1799
-
Guo F, Rocha K, Bali P, Pranpat M, Fiskus W, Boyapalle S, et al. Abrogation of heat shock protein 70 induction as a strategy to increase antileukemia activity of heat shock protein 90 inhibitor 17-allylamino-demethoxy geldanamycin. Cancer Res 2005; 65:10536-44. (Pubitemid 41743748)
-
(2005)
Cancer Research
, vol.65
, Issue.22
, pp. 10536-10544
-
-
Guo, F.1
Rocha, K.2
Bali, P.3
Pranpat, M.4
Fiskus, W.5
Boyapalle, S.6
Kumaraswamy, S.7
Balasis, M.8
Greedy, B.9
Armitage, E.S.M.10
Lawrence, N.11
Bhalla, K.12
-
44
-
-
23044441106
-
Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies
-
DOI 10.1200/JCO.2005.00.612
-
Banerji U, O'Donnell A, Scurr M, Pacey S, Stapleton S, Asad Y, et al. Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies. J Clin Oncol 2005; 23:4152-61. (Pubitemid 46211321)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.18
, pp. 4152-4161
-
-
Banerji, U.1
O'Donnell, A.2
Scurr, M.3
Pacey, S.4
Stapleton, S.5
Asad, Y.6
Simmons, L.7
Maloney, A.8
Raynaud, F.9
Campbell, M.10
Walton, M.11
Lakhani, S.12
Kaye, S.13
Workman, P.14
Judson, I.15
-
45
-
-
36849055007
-
Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: A phase I dose-escalation study
-
Modi S, Stopeck AT, Gordon MS, Mendelson D, Solit DB, Bagatell R, et al. Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: a phase I dose-escalation study. J Clin Oncol 2007; 25:5410-7.
-
(2007)
J Clin Oncol
, vol.25
, pp. 5410-5417
-
-
Modi, S.1
Stopeck, A.T.2
Gordon, M.S.3
Mendelson, D.4
Solit, D.B.5
Bagatell, R.6
-
46
-
-
0027729168
-
Studies on the interaction of the immunosuppressant 15-deoxyspergualin with heat shock proteins
-
Nadler SG, Cleaveland J, Tepper MA, Walsh C, Nadeau K. Studies on the interaction of the immunosuppressant 15-deoxyspergualin with heat shock proteins. Ann NY Acad Sci 1993; 696:412-4.
-
(1993)
Ann NY Acad Sci
, vol.696
, pp. 412-414
-
-
Nadler, S.G.1
Cleaveland, J.2
Tepper, M.A.3
Walsh, C.4
Nadeau, K.5
-
47
-
-
0036850256
-
The CCP4 molecular-graphics project
-
Potterton E, McNicholas S, Krissinel E, Cowtan K, Noble M. The CCP4 molecular-graphics project. Acta Crystallogr D Biol Crystallogr 2002; 58:1955-7.
-
(2002)
Acta Crystallogr D Biol Crystallogr
, vol.58
, pp. 1955-1957
-
-
Potterton, E.1
McNicholas, S.2
Krissinel, E.3
Cowtan, K.4
Noble, M.5
-
48
-
-
33749460895
-
(-)-Epigallocatechin gallate overcomes resistance to etoposide-induced cell death by targeting the molecular chaperone glucose-regulated protein 78
-
Ermakova SP, Kang BS, Choi BY, Choi HS, Schuster TF, Ma WY, et al. (-)-Epigallocatechin gallate overcomes resistance to etoposide-induced cell death by targeting the molecular chaperone glucose-regulated protein 78. Cancer Res 2006; 66:9260-9.
-
(2006)
Cancer Res
, vol.66
, pp. 9260-9269
-
-
Ermakova, S.P.1
Kang, B.S.2
Choi, B.Y.3
Choi, H.S.4
Schuster, T.F.5
Ma, W.Y.6
-
49
-
-
70349617699
-
Chemical manipulation of hsp70 ATPase activity regulates tau stability
-
Jinwal UK, Miyata Y, Koren J, III, Jones JR, Trotter JH, Chang L, et al. Chemical manipulation of hsp70 ATPase activity regulates tau stability. J Neurosci 2009; 29:12079-88.
-
(2009)
J Neurosci
, vol.29
, pp. 12079-12088
-
-
Jinwal, U.K.1
Miyata, Y.2
Koren III, J.3
Jones, J.R.4
Trotter, J.H.5
Chang, L.6
-
50
-
-
0034671731
-
Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function
-
Wadhwa R, Sugihara T, Yoshida A, Nomura H, Reddel RR, Simpson R, et al. Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function. Cancer Res 2000; 60:6818-21.
-
(2000)
Cancer Res
, vol.60
, pp. 6818-6821
-
-
Wadhwa, R.1
Sugihara, T.2
Yoshida, A.3
Nomura, H.4
Reddel, R.R.5
Simpson, R.6
-
51
-
-
34249291074
-
Mortalin sensitizes human cancer cells to MKT-077-induced senescence
-
Deocaris CC, Widodo N, Shrestha BG, Kaur K, Ohtaka M, Yamasaki K, et al. Mortalin sensitizes human cancer cells to MKT-077-induced senescence. Cancer Lett 2007; 252:259-69.
-
(2007)
Cancer Lett
, vol.252
, pp. 259-269
-
-
Deocaris, C.C.1
Widodo, N.2
Shrestha, B.G.3
Kaur, K.4
Ohtaka, M.5
Yamasaki, K.6
-
52
-
-
0035808322
-
The ATPase domain of hsp70 possesses a unique binding specificity for 3′-sulfogalactolipids
-
Mamelak D, Lingwood C. The ATPase domain of hsp70 possesses a unique binding specificity for 3′-sulfogalactolipids. J Biol Chem 2001; 276:449-56.
-
(2001)
J Biol Chem
, vol.276
, pp. 449-456
-
-
Mamelak, D.1
Lingwood, C.2
-
53
-
-
0028834648
-
Members of the 70 kDa heat shock protein family specifically recognize sulfoglycolipids: Role in gamete recognition and mycoplasma-related infertility
-
Boulanger J, Faulds D, Eddy EM, Lingwood CA. Members of the 70 kDa heat shock protein family specifically recognize sulfoglycolipids: role in gamete recognition and mycoplasma-related infertility. J Cell Physiol 1995; 165:7-17.
-
(1995)
J Cell Physiol
, vol.165
, pp. 7-17
-
-
Boulanger, J.1
Faulds, D.2
Eddy, E.M.3
Lingwood, C.A.4
-
54
-
-
0037452541
-
3′sulfogalactolipid binding specifically inhibits Hsp70 ATPase activity in vitro
-
DOI 10.1021/bi026735t
-
Whetstone H, Lingwood C. 3′Sulfogalactolipid binding specifically inhibits Hsp70 ATPase activity in vitro. Biochemistry 2003; 42:1611-7. (Pubitemid 36205968)
-
(2003)
Biochemistry
, vol.42
, Issue.6
, pp. 1611-1617
-
-
Whetstone, H.1
Lingwood, C.2
-
55
-
-
2342503733
-
The insect antimicrobial peptide, L-pyrrhocoricin, binds to and stimulates the ATPase activity of both wild-type and lidless DnaK
-
Chesnokova LS, Slepenkov SV, Witt SN. The insect antimicrobial peptide, L-pyrrhocoricin, binds to and stimulates the ATPase activity of both wild-type and lidless DnaK. FEBS Lett 2004; 565:65-9.
-
(2004)
FEBS Lett
, vol.565
, pp. 65-69
-
-
Chesnokova, L.S.1
Slepenkov, S.V.2
Witt, S.N.3
-
56
-
-
0034700271
-
Interaction between heat shock proteins and antimicrobial peptides
-
Otvos L Jr, O I, Rogers ME, Consolvo PJ, Condie BA, Lovas S, et al. Interaction between heat shock proteins and antimicrobial peptides. Biochemistry 2000; 39:14150-9.
-
(2000)
Biochemistry
, vol.39
, pp. 14150-14159
-
-
Otvos Jr., L.1
O, I.2
Rogers, M.E.3
Consolvo, P.J.4
Condie, B.A.5
Lovas, S.6
-
57
-
-
0035853022
-
The antibacterial peptide pyrrhocoricin inhibits the ATPase actions of DnaK and prevents chaperone-assisted protein folding
-
DOI 10.1021/bi002656a
-
Kragol G, Lovas S, Varadi G, Condie BA, Hoffmann R, Otvos L Jr. The antibacterial peptide pyrrhocoricin inhibits the ATPase actions of DnaK and prevents chaperone-assisted protein folding. Biochemistry 2001; 40:3016-26. (Pubitemid 32206189)
-
(2001)
Biochemistry
, vol.40
, Issue.10
, pp. 3016-3026
-
-
Kragol, G.1
Lovas, S.2
Varadi, G.3
Condie, B.A.4
Hoffmann, R.5
Otvos Jr., L.6
-
58
-
-
62649101873
-
Allosteric coupling between the lid and interdomain linker in DnaK revealed by inhibitor binding studies
-
Liebscher M, Roujeinikova A. Allosteric coupling between the lid and interdomain linker in DnaK revealed by inhibitor binding studies. J Bacteriol 2009; 191:1456-62.
-
(2009)
J Bacteriol
, vol.191
, pp. 1456-1462
-
-
Liebscher, M.1
Roujeinikova, A.2
-
59
-
-
33845755480
-
The induction mechanism of the molecular chaperone HSP70 in the gastric mucosa by Geranylgeranylacetone (HSP-inducer)
-
Otaka M, Yamamoto S, Ogasawara K, Takaoka Y, Noguchi S, Miyazaki T, et al. The induction mechanism of the molecular chaperone HSP70 in the gastric mucosa by Geranylgeranylacetone (HSP-inducer). Biochem Biophys Res Commun 2007; 353:399-404.
-
(2007)
Biochem Biophys Res Commun
, vol.353
, pp. 399-404
-
-
Otaka, M.1
Yamamoto, S.2
Ogasawara, K.3
Takaoka, Y.4
Noguchi, S.5
Miyazaki, T.6
-
60
-
-
33947533484
-
Fatty acyl benzamido antibacterials based on inhibition of DnaK-catalyzed protein folding
-
Liebscher M, Jahreis G, Lucke C, Grabley S, Raina S, Schiene-Fischer C. Fatty acyl benzamido antibacterials based on inhibition of DnaK-catalyzed protein folding. J Biol Chem 2007; 282:4437-46.
-
(2007)
J Biol Chem
, vol.282
, pp. 4437-4446
-
-
Liebscher, M.1
Jahreis, G.2
Lucke, C.3
Grabley, S.4
Raina, S.5
Schiene-Fischer, C.6
-
61
-
-
0032501429
-
Identification of a binding site on Hsc70 for the immunosuppressant 15-deoxyspergualin
-
DOI 10.1006/bbrc.1998.9775
-
Nadler SG, Dischino DD, Malacko AR, Cleaveland JS, Fujihara SM, Marquardt H. Identification of a binding site on Hsc70 for the immunosuppressant 15-deoxyspergualin. Biochem Biophys Res Commun 1998; 253:176-80. (Pubitemid 29015620)
-
(1998)
Biochemical and Biophysical Research Communications
, vol.253
, Issue.1
, pp. 176-180
-
-
Nadler, S.G.1
Dischino, D.D.2
Malacko, A.R.3
Cleaveland, J.S.4
Fujihara, S.M.5
Marquardt, H.6
-
62
-
-
61449200234
-
Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen
-
Wright CM, Seguin SP, Fewell SW, Zhang H, Ishwad C, Vats A, et al. Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen. Virus Res 2009; 141:71-80.
-
(2009)
Virus Res
, vol.141
, pp. 71-80
-
-
Wright, C.M.1
Seguin, S.P.2
Fewell, S.W.3
Zhang, H.4
Ishwad, C.5
Vats, A.6
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