-
1
-
-
0034129679
-
Steroid hormone receptors: An update
-
Beato M, Klug J. Steroid hormone receptors: an update. Hum Reprod Update 2000;6:225-36.
-
(2000)
Hum Reprod Update
, vol.6
, pp. 225-236
-
-
Beato, M.1
Klug, J.2
-
2
-
-
33644784718
-
Corticosteroids: The drugs To Beat
-
Barnes PJ. Corticosteroids: the drugs To Beat. Eur J Pharmacol 2006;533:2-14.
-
(2006)
Eur J Pharmacol
, vol.533
, pp. 2-14
-
-
Barnes, P.J.1
-
3
-
-
77349101801
-
Pharmacological strategies for improving the efficacy and therapeutic ratio of glucocorticoids in inflammatory lung diseases
-
Newton R, Leigh R, Giembycz MA. Pharmacological strategies for improving the efficacy and therapeutic ratio of glucocorticoids in inflammatory lung diseases. Pharmacol Ther 2010;125:286-327.
-
(2010)
Pharmacol Ther
, vol.125
, pp. 286-327
-
-
Newton, R.1
Leigh, R.2
Giembycz, M.A.3
-
4
-
-
84875225940
-
Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease
-
Barnes PJ. Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease. J Allergy Clin Immunol 2013;131:636-45.
-
(2013)
J Allergy Clin Immunol
, vol.131
, pp. 636-645
-
-
Barnes, P.J.1
-
5
-
-
40349092811
-
The epidemiology of glucocorticoid- associated adverse events
-
McDonough AK, Curtis JR, Saag KG. The epidemiology of glucocorticoid- associated adverse events. Curr Opin Rheumatol 2008;20:131-7.
-
(2008)
Curr Opin Rheumatol
, vol.20
, pp. 131-137
-
-
McDonough, A.K.1
Curtis, J.R.2
Saag, K.G.3
-
6
-
-
53849129191
-
Genomic and nongenomic effects of glucocorticoids
-
Stahn C, Buttgereit F. Genomic and nongenomic effects of glucocorticoids. Nat Clin Pract Rheumatol 2008;4:525-33.
-
(2008)
Nat Clin Pract Rheumatol
, vol.4
, pp. 525-533
-
-
Stahn, C.1
Buttgereit, F.2
-
7
-
-
34547872354
-
Glucocorticoid receptor action in beneficial and side effects of steroid therapy: Lessons from conditional knockout mice
-
Kleiman A, Tuckermann JP. Glucocorticoid receptor action in beneficial and side effects of steroid therapy: lessons from conditional knockout mice. Mol Cell Endocrinol 2007;275:98-108.
-
(2007)
Mol Cell Endocrinol
, vol.275
, pp. 98-108
-
-
Kleiman, A.1
Tuckermann, J.P.2
-
8
-
-
0034199529
-
The microcirculation and inflammation: Site of action for glucocorticoids
-
Perretti M, Ahluwalia A. The microcirculation and inflammation: site of action for glucocorticoids. Microcirculation 2000;7:147-61.
-
(2000)
Microcirculation
, vol.7
, pp. 147-161
-
-
Perretti, M.1
Ahluwalia, A.2
-
9
-
-
0031040280
-
The role of adrenocorticoids as modulators of immune function in health and disease: Neural, endocrine and immune interactions
-
McEwen BS, Biron CA, Brunson KW, Bulloch K, Chambers WH, Dhabhar FS, et al. The role of adrenocorticoids as modulators of immune function in health and disease: neural, endocrine and immune interactions. Brain Res Rev 1997;23:79-133.
-
(1997)
Brain Res Rev
, vol.23
, pp. 79-133
-
-
McEwen, B.S.1
Biron, C.A.2
Brunson, K.W.3
Bulloch, K.4
Chambers, W.H.5
Dhabhar, F.S.6
-
11
-
-
34548249241
-
Effects of glucocorticoids on apoptosis and clearance of apoptotic cells
-
McColl A, Michlewska S, Dransfield I, Rossi AG. Effects of glucocorticoids on apoptosis and clearance of apoptotic cells. Sci World J 2007;7:1165-81.
-
(2007)
Sci World J
, vol.7
, pp. 1165-1181
-
-
McColl, A.1
Michlewska, S.2
Dransfield, I.3
Rossi, A.G.4
-
12
-
-
8344233333
-
Mechanisms of glucocorticoid receptor signaling during inflammation
-
Smoak KA, Cidlowski JA. Mechanisms of glucocorticoid receptor signaling during inflammation. Mech Ageing Dev 2004;125:697-706.
-
(2004)
Mech Ageing Dev
, vol.125
, pp. 697-706
-
-
Smoak, K.A.1
Cidlowski, J.A.2
-
13
-
-
0034665748
-
The glucocorticoid receptor inhibits NFκB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain
-
Nissen RM, Yamamoto KR. The glucocorticoid receptor inhibits NFκB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain. Genes Dev 2000;14:2321-9.
-
(2000)
Genes Dev
, vol.14
, pp. 2321-2329
-
-
Nissen, R.M.1
Yamamoto, K.R.2
-
14
-
-
53849105836
-
Glucocorticoids
-
John HK, John HS, Leslie JC, Patience HW. Springer, 13th ed.
-
Buttgereit F, Burmester GR. Glucocorticoids. In: John HK, John HS, Leslie JC, Patience HW. Primer on the rheumatic diseases. Springer, 13th ed. 2008:644-50.
-
(2008)
Primer on the Rheumatic Diseases
, pp. 644-650
-
-
Buttgereit, F.1
Burmester, G.R.2
-
15
-
-
0036108564
-
Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase
-
Hafezi-Moghadam A, Simoncini T, Yang Z, Limbourg FP, Plumier JC, Rebsamen MC, et al. Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase. Nat Med 2002;8:473-9.
-
(2002)
Nat Med
, vol.8
, pp. 473-479
-
-
Hafezi-Moghadam, A.1
Simoncini, T.2
Yang, Z.3
Limbourg, F.P.4
Plumier, J.C.5
Rebsamen, M.C.6
-
16
-
-
0037388860
-
Dexamethasone induces rapid serine-phosphorylation and membrane translocation of annexin 1 in a human folliculostellate cell line via a novel nongenomic mechanism involving the glucocorticoid receptor, protein kinase C, phosphatidylinositol 3-kinase, and mitogen-activated protein kinase
-
Solito E, Mulla A, Morris JF, Christian HC, Flower RJ, Buckingham JC, et al. Dexamethasone induces rapid serine-phosphorylation and membrane translocation of annexin 1 in a human folliculostellate cell line via a novel nongenomic mechanism involving the glucocorticoid receptor, protein kinase C, phosphatidylinositol 3-kinase, and mitogen-activated protein kinase. Endocrinology 2003;144:1164-74.
-
(2003)
Endocrinology
, vol.144
, pp. 1164-1174
-
-
Solito, E.1
Mulla, A.2
Morris, J.F.3
Christian, H.C.4
Flower, R.J.5
Buckingham, J.C.6
-
17
-
-
0032951143
-
Membrane-initiated steroid actions and the proteins that mediate them
-
Watson CS, Gametchu B. Membrane-initiated steroid actions and the proteins that mediate them. Proc Soc Exp Biol Med 1999;220:9-19.
-
(1999)
Proc Soc Exp Biol Med
, vol.220
, pp. 9-19
-
-
Watson, C.S.1
Gametchu, B.2
-
18
-
-
58149094363
-
Annexin A1 and glucocorticoids as effectors of the resolution of inflammation
-
Perretti M, D'Acquisto F. Annexin A1 and glucocorticoids as effectors of the resolution of inflammation. Nat Rev Immunol 2009;9:62-70.
-
(2009)
Nat Rev Immunol
, vol.9
, pp. 62-70
-
-
Perretti, M.1
D'Acquisto, F.2
-
19
-
-
65249167505
-
DNA binding site sequence directs glucocorticoid receptor structure and activity
-
Meijsing SH, Pufall MA, So AY, Bates DL, Chen L, Yamamoto KR. DNA binding site sequence directs glucocorticoid receptor structure and activity. Science 2009;324:407-10.
-
(2009)
Science
, vol.324
, pp. 407-410
-
-
Meijsing, S.H.1
Pufall, M.A.2
So, A.Y.3
Bates, D.L.4
Chen, L.5
Yamamoto, K.R.6
-
20
-
-
34548252291
-
Nuclear receptor coregulators: Judges, juries, and executioners of cellular regulation
-
Lonard DM, O'Malley BW. Nuclear receptor coregulators: judges, juries, and executioners of cellular regulation. Mol Cell 2007;27:691-700.
-
(2007)
Mol Cell
, vol.27
, pp. 691-700
-
-
Lonard, D.M.1
O'Malley, B.W.2
-
21
-
-
0031862891
-
Anti-inflammatory actions of glucocorticoids: Molecular mechanisms
-
Barnes PJ. Anti-inflammatory actions of glucocorticoids: molecular mechanisms. Clin Sci (Lond 1998;94:557-72.
-
(1998)
Clin Sci Lond
, vol.94
, pp. 557-572
-
-
Barnes, P.J.1
-
22
-
-
79958118789
-
Role of GILZ in immune regulation, glucocorticoid actions and rheumatoid arthritis
-
Beaulieu E, Morand EF. Role of GILZ in immune regulation, glucocorticoid actions and rheumatoid arthritis. Nat Rev Rheumatol 2011;7:340-8.
-
(2011)
Nat Rev Rheumatol
, vol.7
, pp. 340-348
-
-
Beaulieu, E.1
Morand, E.F.2
-
23
-
-
70350534804
-
Glucocorticoid-induced leucine zipper (GILZ): A new important mediator of glucocorticoid action
-
Ayroldi E, Riccardi C. Glucocorticoid-induced leucine zipper (GILZ): a new important mediator of glucocorticoid action. FASEB J 2009;23:3649-58.
-
(2009)
FASEB J
, vol.23
, pp. 3649-3658
-
-
Ayroldi, E.1
Riccardi, C.2
-
24
-
-
0042819735
-
Modulation of enzymatic activity of human mast cell tryptase and chymase by protease inhibitors
-
He SH, Chen P, Chen HQ. Modulation of enzymatic activity of human mast cell tryptase and chymase by protease inhibitors. Acta Pharm Sin 2003;24:923-9.
-
(2003)
Acta Pharm Sin
, vol.24
, pp. 923-929
-
-
He, S.H.1
Chen, P.2
Chen, H.Q.3
-
25
-
-
0032127873
-
IL-6 stimulates annexin 1 expression and translocation and suggests a new biological role as class II acute phase protein
-
Solito E, de Coupade C, Parente L, Flower RJ, Russo-Marie F. IL-6 stimulates annexin 1 expression and translocation and suggests a new biological role as class II acute phase protein. Cytokine 1998;10:514-21.
-
(1998)
Cytokine
, vol.10
, pp. 514-521
-
-
Solito, E.1
De Coupade, C.2
Parente, L.3
Flower, R.J.4
Russo-Marie, F.5
-
26
-
-
0029113114
-
Lipocortin-1 and the control of arachidonic acid release in cell signalling. Glucocorticoids (changed from glucorticoids) inhibit G protein dependent activation of cPLA2 activity
-
Croxtall JD, Choudhury Q, Tokumoto H, Flower RJ. Lipocortin-1 and the control of arachidonic acid release in cell signalling. Glucocorticoids (changed from glucorticoids) inhibit G protein dependent activation of cPLA2 activity. Biochem Pharmacol 1995;50:465-74.
-
(1995)
Biochem Pharmacol
, vol.50
, pp. 465-474
-
-
Croxtall, J.D.1
Choudhury, Q.2
Tokumoto, H.3
Flower, R.J.4
-
27
-
-
14644414825
-
New insights into the molecular mechanism of inter-leukin-10-mediated immunosuppression
-
Grutz G. New insights into the molecular mechanism of inter-leukin-10-mediated immunosuppression. J Leukoc Biol 2005;77:3-15.
-
(2005)
J Leukoc Biol
, vol.77
, pp. 3-15
-
-
Grutz, G.1
-
28
-
-
84856013800
-
IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of trypanosoma cruzi infection
-
Roffe E, Rothfuchs AG, Santiago HC, Marino AP, Ribeiro-Gomes FL, Eckhaus M, et al. IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of trypanosoma cruzi infection. J Immunol 2012;188:649-60.
-
(2012)
J Immunol
, vol.188
, pp. 649-660
-
-
Roffe, E.1
Rothfuchs, A.G.2
Santiago, H.C.3
Marino, A.P.4
Ribeiro-Gomes, F.L.5
Eckhaus, M.6
-
29
-
-
0028867899
-
Immunosuppression by glucocorticoids: Inhibition of NF-kappa-B activity through induction of I-kappa-B synthesis
-
Auphan N, DiDonato JA, Rosette C, Helmberg A, Karin M. Immunosuppression by glucocorticoids: inhibition of NF-kappa-B activity through induction of I-kappa-B synthesis. Science 1995;270:286-90.
-
(1995)
Science
, vol.270
, pp. 286-290
-
-
Auphan, N.1
DiDonato, J.A.2
Rosette, C.3
Helmberg, A.4
Karin, M.5
-
30
-
-
0033773479
-
Molecular mechanisms of glucocorticosteroids actions
-
Adcock IM. Molecular mechanisms of glucocorticosteroids actions. Pulm Pharmacol Ther 2000;13:115-26.
-
(2000)
Pulm Pharmacol Ther
, vol.13
, pp. 115-126
-
-
Adcock, I.M.1
-
31
-
-
0032524357
-
New twists in gene regulation by glucocorticoid receptor: Is DNA binding dispensable?
-
Karin M. New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable?. Cell 1998;93:487-90.
-
(1998)
Cell
, vol.93
, pp. 487-490
-
-
Karin, M.1
-
32
-
-
0035813090
-
Coregulator codes of transcriptional regulation by nuclear receptors
-
Rosenfeld MG, Glass CK. Coregulator codes of transcriptional regulation by nuclear receptors. J Biol Chem 2001;276:36865-8.
-
(2001)
J Biol Chem
, vol.276
, pp. 36865-36868
-
-
Rosenfeld, M.G.1
Glass, C.K.2
-
33
-
-
26444471700
-
A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma
-
Pascual G, Fong AL, Ogawa S, Gamliel A, Li AC, Perissi V, et al. A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Nature 2005;437:759-63.
-
(2005)
Nature
, vol.437
, pp. 759-763
-
-
Pascual, G.1
Fong, A.L.2
Ogawa, S.3
Gamliel, A.4
Li, A.C.5
Perissi, V.6
-
34
-
-
18244381020
-
The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression
-
Luecke HF, Yamamoto KR. The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression. Genes Dev 2005;19:1116-27.
-
(2005)
Genes Dev
, vol.19
, pp. 1116-1127
-
-
Luecke, H.F.1
Yamamoto, K.R.2
-
35
-
-
65849427529
-
Glucocorticoid resistance in inflammatory diseases
-
Barnes PJ, Adcock IM. Glucocorticoid resistance in inflammatory diseases. Lancet 2009;373:1905-1917.
-
(2009)
Lancet
, vol.373
, pp. 1905-1917
-
-
Barnes, P.J.1
Adcock, I.M.2
-
36
-
-
77952732147
-
Corticosteroid insensitivity in severe asthma: Significance, mechanisms and aetiology
-
Hew M, Chung KF. Corticosteroid insensitivity in severe asthma: significance, mechanisms and aetiology. Intern Med J 2010;40:323-34.
-
(2010)
Intern Med J
, vol.40
, pp. 323-334
-
-
Hew, M.1
Chung, K.F.2
-
37
-
-
0242537115
-
Cigarette smoking impairs the therapeutic response to oral corticosteroids in chronic asthma
-
Chaudhuri R, Livingston E, McMahon AD, Thomson L, Borland W, Thomson NC. Cigarette smoking impairs the therapeutic response to oral corticosteroids in chronic asthma. Am J Respir Crit Care Med 2003;168:1308-11.
-
(2003)
Am J Respir Crit Care Med
, vol.168
, pp. 1308-1311
-
-
Chaudhuri, R.1
Livingston, E.2
McMahon, A.D.3
Thomson, L.4
Borland, W.5
Thomson, N.C.6
-
38
-
-
0033538027
-
Redox-dependent regulation of nuclear import of the glucocorticoid receptor
-
Okamoto K, Tanaka H, Ogawa H, Makino Y, Eguchi H, Hayashi S, et al. Redox-dependent regulation of nuclear import of the glucocorticoid receptor. J Biol Chem 1999;274:10363-71.
-
(1999)
J Biol Chem
, vol.274
, pp. 10363-10371
-
-
Okamoto, K.1
Tanaka, H.2
Ogawa, H.3
Makino, Y.4
Eguchi, H.5
Hayashi, S.6
-
39
-
-
0842308109
-
Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: Role of tyrosine nitration
-
Ito K, Hanazawa T, Tomita K, Barnes PJ, Adcock IM. Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration. Biochem Biophys Res Commun 2004;315:240-5.
-
(2004)
Biochem Biophys Res Commun
, vol.315
, pp. 240-245
-
-
Ito, K.1
Hanazawa, T.2
Tomita, K.3
Barnes, P.J.4
Adcock, I.M.5
-
40
-
-
0036173939
-
A defect in corticosteroid-induced IL-10 production in T lymphocytes from corticosteroid- resistant asthmatic patients
-
Hawrylowicz C, Richards D, Loke TK, Corrigan C, Lee T. A defect in corticosteroid-induced IL-10 production in T lymphocytes from corticosteroid- resistant asthmatic patients. J Allergy Clin Immunol 2002;109:369-70.
-
(2002)
J Allergy Clin Immunol
, vol.109
, pp. 369-370
-
-
Hawrylowicz, C.1
Richards, D.2
Loke, T.K.3
Corrigan, C.4
Lee, T.5
-
41
-
-
31044447205
-
Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients
-
Xystrakis E, Kusumakar S, Boswell S, Peek E, Urry Z, Richards DF, et al. Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients. J Clin Invest 2006;116:146-55.
-
(2006)
J Clin Invest
, vol.116
, pp. 146-155
-
-
Xystrakis, E.1
Kusumakar, S.2
Boswell, S.3
Peek, E.4
Urry, Z.5
Richards, D.F.6
-
42
-
-
24144434916
-
Overview of virus-induced airway disease
-
Johnston SL. Overview of virus-induced airway disease. Proc Am Thorac Soc 2005;2:150-6.
-
(2005)
Proc Am Thorac Soc
, vol.2
, pp. 150-156
-
-
Johnston, S.L.1
-
43
-
-
26144467138
-
Rhinovirus infection reduces glucocorticoid receptor nuclear translocation in airway epithelial cells
-
Bellattato C, Adcock IM, Ito K, Caramori G, Casolari P, Ciaccia A, et al. Rhinovirus infection reduces glucocorticoid receptor nuclear translocation in airway epithelial cells. Eur Respir J 2003;22:565S.
-
(2003)
Eur Respir J
, vol.22
, pp. 565S
-
-
Bellattato, C.1
Adcock, I.M.2
Ito, K.3
Caramori, G.4
Casolari, P.5
Ciaccia, A.6
-
44
-
-
0030859389
-
Bronchoscopic evaluation of severe asthma. Persistent inflammation associated with high dose glucocorticoids
-
Wenzel SE, Szefler SJ, Leung DY, Sloan SI, Rex MD, Martin RJ. Bronchoscopic evaluation of severe asthma. Persistent inflammation associated with high dose glucocorticoids. Am J Respir Crit Care Med 1997;156:737-43.
-
(1997)
Am J Respir Crit Care Med
, vol.156
, pp. 737-743
-
-
Wenzel, S.E.1
Szefler, S.J.2
Leung, D.Y.3
Sloan, S.I.4
Rex, M.D.5
Martin, R.J.6
-
45
-
-
24744435115
-
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
-
Camps M, Ruckle T, Ji H, Ardissone V, Rintelen F, Shaw J, et al. Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat Med 2005;11:936-43.
-
(2005)
Nat Med
, vol.11
, pp. 936-943
-
-
Camps, M.1
Ruckle, T.2
Ji, H.3
Ardissone, V.4
Rintelen, F.5
Shaw, J.6
-
46
-
-
0037119038
-
Divergent effect of mometasone on human eosinophil and neutrophil apoptosis
-
Zhang X, Moilanen E, Adcock IM, Lindsay MA, Kankaanranta H. Divergent effect of mometasone on human eosinophil and neutrophil apoptosis. Life Sci 2002;71:1523-34.
-
(2002)
Life Sci
, vol.71
, pp. 1523-1534
-
-
Zhang, X.1
Moilanen, E.2
Adcock, I.M.3
Lindsay, M.A.4
Kankaanranta, H.5
-
47
-
-
0037248247
-
Update on glucocorticoid action and resistance
-
Leung DY, Bloom JW. Update on glucocorticoid action and resistance. J Allergy Clin Immunol 2003;111:3-22.
-
(2003)
J Allergy Clin Immunol
, vol.111
, pp. 3-22
-
-
Leung, D.Y.1
Bloom, J.W.2
-
48
-
-
0031018474
-
Allergen exposure decreases glucocorticoid receptor binding affinity and steroid responsiveness in atopic asthmatics
-
Nimmagadda SR, Szefler SJ, Spahn JD, Surs W, Leung DY. Allergen exposure decreases glucocorticoid receptor binding affinity and steroid responsiveness in atopic asthmatics. Am J Respir Crit Care Med 1997;155:87-93.
-
(1997)
Am J Respir Crit Care Med
, vol.155
, pp. 87-93
-
-
Nimmagadda, S.R.1
Szefler, S.J.2
Spahn, J.D.3
Surs, W.4
Leung, D.Y.5
-
49
-
-
79955928909
-
Molecular mechanism of glucocorticoid resistance in inflammatory bowel disease
-
De Iudicibus S, Franca R, Martelossi S, Ventura A, Decorti G. Molecular mechanism of glucocorticoid resistance in inflammatory bowel disease. World J Gastroenterol 2011;17:1095-108.
-
(2011)
World J Gastroenterol
, vol.17
, pp. 1095-1108
-
-
De Iudicibus, S.1
Franca, R.2
Martelossi, S.3
Ventura, A.4
Decorti, G.5
-
50
-
-
1542301591
-
Corticosteroid resistance in chronic obstructive pulmonary disease: Inactivation of histone deacetylase
-
Barnes PJ, Ito K, Adcock IM. Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase. Lancet 2004;363:731-3.
-
(2004)
Lancet
, vol.363
, pp. 731-733
-
-
Barnes, P.J.1
Ito, K.2
Adcock, I.M.3
-
51
-
-
33745746529
-
Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma
-
Hew M, Bhavsar P, Torrego A, Meah S, Khorasani N, Barnes PJ, et al. Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma. Am J Respir Crit Care Med 2006;174:134-41.
-
(2006)
Am J Respir Crit Care Med
, vol.174
, pp. 134-141
-
-
Hew, M.1
Bhavsar, P.2
Torrego, A.3
Meah, S.4
Khorasani, N.5
Barnes, P.J.6
-
52
-
-
77958173826
-
Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease
-
To Y, Ito K, Kizawa Y, Failla M, Ito M, Kusama T, et al. Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2010;182:897-904.
-
(2010)
Am J Respir Crit Care Med
, vol.182
, pp. 897-904
-
-
To, Y.1
Ito, K.2
Kizawa, Y.3
Failla, M.4
Ito, M.5
Kusama, T.6
-
53
-
-
20444467085
-
Inflammatory hypoxia: Role of hypoxiainducible factor
-
Karhausen J, Haase VH, Colgan SP. Inflammatory hypoxia: role of hypoxiainducible factor. Cell Cycle 2005;4:256-8.
-
(2005)
Cell Cycle
, vol.4
, pp. 256-258
-
-
Karhausen, J.1
Haase, V.H.2
Colgan, S.P.3
-
54
-
-
4444334342
-
Dexamethasone blocks hypoxia-induced endothelial dysfunction in organ-cultured pulmonary arteries
-
Murata T, Hori M, Sakamoto K, Karaki H, Ozaki H. Dexamethasone blocks hypoxia-induced endothelial dysfunction in organ-cultured pulmonary arteries. Am J Respir Crit Care Med 2004;170:647-55.
-
(2004)
Am J Respir Crit Care Med
, vol.170
, pp. 647-655
-
-
Murata, T.1
Hori, M.2
Sakamoto, K.3
Karaki, H.4
Ozaki, H.5
-
55
-
-
0041856168
-
Role of the glucocorticoid receptor for regulation of hypoxia-dependent gene expression
-
Kodama T, Shimizu N, Yoshikawa N, Makino Y, Ouchida R, Okamoto K, et al. Role of the glucocorticoid receptor for regulation of hypoxia-dependent gene expression. J Biol Chem 2003;278:33384-91.
-
(2003)
J Biol Chem
, vol.278
, pp. 33384-33391
-
-
Kodama, T.1
Shimizu, N.2
Yoshikawa, N.3
Makino, Y.4
Ouchida, R.5
Okamoto, K.6
-
56
-
-
44649183304
-
Dexamethasone impairs hypoxia-inducible factor-1 function
-
Wagner AE, Huck G, Stiehl DP, Jelkmann W, Hellwig-Burgel T. Dexamethasone impairs hypoxia-inducible factor-1 function. Biochem Biophys Res Commun 2008;372:336-40.
-
(2008)
Biochem Biophys Res Commun
, vol.372
, pp. 336-340
-
-
Wagner, A.E.1
Huck, G.2
Stiehl, D.P.3
Jelkmann, W.4
Hellwig-Burgel, T.5
-
57
-
-
0028944915
-
Dysregulation of interleukin 4, interleukin 5, and interferon gamma gene expression in steroid-resistant asthma
-
Leung DY, Martin RJ, Szefler SJ, Sher ER, Ying S, Kay AB, et al. Dysregulation of interleukin 4, interleukin 5, and interferon gamma gene expression in steroid-resistant asthma. J Exp Med 1995;18:33-40.
-
(1995)
J Exp Med
, vol.18
, pp. 33-40
-
-
Leung, D.Y.1
Martin, R.J.2
Szefler, S.J.3
Sher, E.R.4
Ying, S.5
Kay, A.B.6
-
58
-
-
2342567291
-
Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients
-
Matthews JG, Ito K, Barnes PJ, Adcock IM. Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients. J Allergy Clin Immunol 2004;113:1100-8.
-
(2004)
J Allergy Clin Immunol
, vol.113
, pp. 1100-1108
-
-
Matthews, J.G.1
Ito, K.2
Barnes, P.J.3
Adcock, I.M.4
-
59
-
-
0036231010
-
P38 mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: Role in steroid-insensitive asthma
-
Irusen E, Matthews JG, Takahashi A, Barnes PJ, Chung KF, Adcock IM. P38 mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma. J Allergy Clin Immunol 2002;109:649-57.
-
(2002)
J Allergy Clin Immunol
, vol.109
, pp. 649-657
-
-
Irusen, E.1
Matthews, J.G.2
Takahashi, A.3
Barnes, P.J.4
Chung, K.F.5
Adcock, I.M.6
-
60
-
-
0032993527
-
Mucosal proinflammatory cytokine production correlates with endoscopic activity of ulcerative colitis
-
Ishiguro Y. Mucosal proinflammatory cytokine production correlates with endoscopic activity of ulcerative colitis. J Gastroenterol 1999;34:66-74.
-
(1999)
J Gastroenterol
, vol.34
, pp. 66-74
-
-
Ishiguro, Y.1
-
61
-
-
29744463898
-
Macrophage migration inhibitory factor promotes innate immune responses by suppressing glucocorticoid-induced expression of mitogen-activated protein kinase phosphatase-1
-
Roger T, Chanson AL, Knaup-Reymond M, Calandra T. Macrophage migration inhibitory factor promotes innate immune responses by suppressing glucocorticoid-induced expression of mitogen-activated protein kinase phosphatase-1. Eur J Immunol 2005;35:3405-13.
-
(2005)
Eur J Immunol
, vol.35
, pp. 3405-3413
-
-
Roger, T.1
Chanson, A.L.2
Knaup-Reymond, M.3
Calandra, T.4
-
62
-
-
0019412311
-
Corticosteroid resistance in asthma
-
Carmichael J, Paterson IC, Diaz P, Crompton GK, Kay AB, Grant IB. Corticosteroid resistance in asthma. BMJ 1981;282:1419-22.
-
(1981)
BMJ
, vol.282
, pp. 1419-1422
-
-
Carmichael, J.1
Paterson, I.C.2
Diaz, P.3
Crompton, G.K.4
Kay, A.B.5
Grant, I.B.6
-
63
-
-
26844520628
-
Profiling of genes expressed in peripheral blood mononuclear cells predicts glucocorticoid sensitivity in asthma patients
-
Hakonarson H, Bjornsdottir US, Halapi E, Bradfield J, Zink F, Mouy M, et al. Profiling of genes expressed in peripheral blood mononuclear cells predicts glucocorticoid sensitivity in asthma patients. Proc Natl Acad Sci USA 2005;102:14789-94.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 14789-14794
-
-
Hakonarson, H.1
Bjornsdottir, U.S.2
Halapi, E.3
Bradfield, J.4
Zink, F.5
Mouy, M.6
-
64
-
-
84863696640
-
Transforming growth factor-b impairs glucocorticoid activity in the A549 lung adenocarcinoma cell line
-
Salem S, Harris T, Mok JSL, Li MYS, Keenan CR, Schuliga MJ, et al. Transforming growth factor-b impairs glucocorticoid activity in the A549 lung adenocarcinoma cell line. Br J Pharmacol 2012;166:2036-48.
-
(2012)
Br J Pharmacol
, vol.166
, pp. 2036-2048
-
-
Salem, S.1
Harris, T.2
Mok, J.S.L.3
Li, M.Y.S.4
Keenan, C.R.5
Schuliga, M.J.6
-
65
-
-
0033309752
-
Tumor necrosis factors alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: Potential regulation of the glucocorticoid receptor
-
Franchimont D, Martens H, Hagelstein MT, Louis E, Dewe W, Chrousos GP, et al. Tumor necrosis factors alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor. J Clin Endocrinol Metab 1999;84:2834-9.
-
(1999)
J Clin Endocrinol Metab
, vol.84
, pp. 2834-2839
-
-
Franchimont, D.1
Martens, H.2
Hagelstein, M.T.3
Louis, E.4
Dewe, W.5
Chrousos, G.P.6
-
66
-
-
0004815929
-
Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor beta-isoform
-
Sousa AR, Lane SJ, Cidlowski JA, Staynov DZ, Lee TH. Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor beta-isoform. J Allergy Clin Immunol 2000;105:943-50.
-
(2000)
J Allergy Clin Immunol
, vol.105
, pp. 943-950
-
-
Sousa, A.R.1
Lane, S.J.2
Cidlowski, J.A.3
Staynov, D.Z.4
Lee, T.H.5
-
67
-
-
34047123776
-
The differential expression of corticosteroid receptor isoforms in corticoster-oid-resistant and -sensitive patients with rheumatoid arthritis
-
Kozaci DL, Chernajovsky Y, Chikanza IC. The differential expression of corticosteroid receptor isoforms in corticoster-oid-resistant and -sensitive patients with rheumatoid arthritis. Rheumatol 2007;46:579-85.
-
(2007)
Rheumatol
, vol.46
, pp. 579-585
-
-
Kozaci, D.L.1
Chernajovsky, Y.2
Chikanza, I.C.3
-
68
-
-
0036392066
-
Quantitative analysis for human glucocorticoid receptor alpha/beta mRNA in IBD
-
Orii F, Ashida T, Nomura M, Maemoto A, Fujiki T, Ayabe T, et al. Quantitative analysis for human glucocorticoid receptor alpha/beta mRNA in IBD. Biochem Biophys Res Commun 2002;296:1286-94.
-
(2002)
Biochem Biophys Res Commun
, vol.296
, pp. 1286-1294
-
-
Orii, F.1
Ashida, T.2
Nomura, M.3
Maemoto, A.4
Fujiki, T.5
Ayabe, T.6
-
69
-
-
2442466059
-
Microbial superantigens induce glucocorticoid receptor beta and steroid resistance in a nasal explant model
-
Fakhri S, Tulic M, Christodoulopoulos P, Fukakusa M, Frenkiel S, Leung DY, et al. Microbial superantigens induce glucocorticoid receptor beta and steroid resistance in a nasal explant model. Laryngoscope 2004;114:887-92.
-
(2004)
Laryngoscope
, vol.114
, pp. 887-892
-
-
Fakhri, S.1
Tulic, M.2
Christodoulopoulos, P.3
Fukakusa, M.4
Frenkiel, S.5
Leung, D.Y.6
-
70
-
-
0033821409
-
Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits IL-1β-induced histone H4 acetylation on lysines 8 and 12
-
Ito K, Barnes PJ, Adcock IM. Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits IL-1β-induced histone H4 acetylation on lysines 8 and 12. Mol Cell Biol 2000;20:6891-903.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 6891-6903
-
-
Ito, K.1
Barnes, P.J.2
Adcock, I.M.3
-
71
-
-
0034043868
-
Fibrosis and airway remodelling
-
Redington AE. Fibrosis and airway remodelling. Clin Exp Allergy 2000;30:42-5.
-
(2000)
Clin Exp Allergy
, vol.30
, pp. 42-45
-
-
Redington, A.E.1
-
72
-
-
0027181166
-
Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma: A 3-D morphometric study
-
Ebina M, Takahashi T, Chiba T, Motomiya M. Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma: a 3-D morphometric study. Am Rev Respir Dis 1993;148:720-6.
-
(1993)
Am Rev Respir Dis
, vol.148
, pp. 720-726
-
-
Ebina, M.1
Takahashi, T.2
Chiba, T.3
Motomiya, M.4
-
73
-
-
33750043230
-
Collagen impairs glucocorticoid actions in airway smooth muscle through integrin signalling
-
Bonacci JV, Schuliga M, Harris T, Stewart AG. Collagen impairs glucocorticoid actions in airway smooth muscle through integrin signalling. Br J Pharmacol 2006;149:365-73.
-
(2006)
Br J Pharmacol
, vol.149
, pp. 365-373
-
-
Bonacci, J.V.1
Schuliga, M.2
Harris, T.3
Stewart, A.G.4
-
74
-
-
33750537272
-
Cyclin D1 induction of cellular migration requires p27(KIP1)
-
Li Z, Jiao X, Wang C, Ju X, Lu Y, Yuan L, et al. Cyclin D1 induction of cellular migration requires p27(KIP1). Cancer Res 2006;66:9986-94.
-
(2006)
Cancer Res
, vol.66
, pp. 9986-9994
-
-
Li, Z.1
Jiao, X.2
Wang, C.3
Ju, X.4
Lu, Y.5
Yuan, L.6
-
75
-
-
33746674992
-
Systemic glucocorticoid reduces bronchial mucosal activation of activator protein 1 components in glucocorticoid-sensitive but not glucocorticoid-resistant asthmatic patients
-
Loke TK, Mallett KH, Ratoff J, O'Connor BJ, Ying S, Meng Q, et al. Systemic glucocorticoid reduces bronchial mucosal activation of activator protein 1 components in glucocorticoid-sensitive but not glucocorticoid-resistant asthmatic patients. J Allergy Clin Immunol 2006;118:368-75.
-
(2006)
J Allergy Clin Immunol
, vol.118
, pp. 368-375
-
-
Loke, T.K.1
Mallett, K.H.2
Ratoff, J.3
O'Connor, B.J.4
Ying, S.5
Meng, Q.6
-
76
-
-
0032535369
-
Corticosteroid-resistant bronchial asthma is associated with increased c-fos expression in monocytes and T-lymphocytes
-
Lane SJ, Adcock IM, Richards D, Hawrylowicz C, Barnes PJ, Lee TH. Corticosteroid-resistant bronchial asthma is associated with increased c-fos expression in monocytes and T-lymphocytes. J Clin Invest 1998;102:2156-64.
-
(1998)
J Clin Invest
, vol.102
, pp. 2156-2164
-
-
Lane, S.J.1
Adcock, I.M.2
Richards, D.3
Hawrylowicz, C.4
Barnes, P.J.5
Lee, T.H.6
-
77
-
-
34250832623
-
The macrophage migration inhibitory factor-glucocorticoid dyad: Regulation of inflammation and immunity
-
Flaster H, Bernhagen J, Calandra T, Bucala R. The macrophage migration inhibitory factor-glucocorticoid dyad: regulation of inflammation and immunity. Mol Endocrinol 2007;21:1267-80.
-
(2007)
Mol Endocrinol
, vol.21
, pp. 1267-1280
-
-
Flaster, H.1
Bernhagen, J.2
Calandra, T.3
Bucala, R.4
-
78
-
-
33746785986
-
Macrophage migration inhibitory factor has a proinflammatory activity via the p38 pathway in glucocorticoid-resistant ulcerative colitis
-
Ishiguro Y, Ohkawara T, Sakuraba H, Yamagata K, Hiraga H, Yamaguchi S, et al. Macrophage migration inhibitory factor has a proinflammatory activity via the p38 pathway in glucocorticoid-resistant ulcerative colitis. Clin Immunol 2006;120:335-41.
-
(2006)
Clin Immunol
, vol.120
, pp. 335-341
-
-
Ishiguro, Y.1
Ohkawara, T.2
Sakuraba, H.3
Yamagata, K.4
Hiraga, H.5
Yamaguchi, S.6
-
79
-
-
0033959944
-
High multidrug resistance (P-glycoprotein 170) expression in inflammatory bowel disease patients who fail medical therapy
-
Farrell RJ, Murphy A, Long A, Donnelly S, Cherikuri A, O'Toole D, et al. High multidrug resistance (P-glycoprotein 170) expression in inflammatory bowel disease patients who fail medical therapy. Gastroenterol 2000;118:279-88.
-
(2000)
Gastroenterol
, vol.118
, pp. 279-288
-
-
Farrell, R.J.1
Murphy, A.2
Long, A.3
Donnelly, S.4
Cherikuri, A.5
O'Toole, D.6
-
80
-
-
0141619279
-
Glucocorticoid resistance in inflammatory bowel disease
-
Farrell RJ, Kelleher D. Glucocorticoid resistance in inflammatory bowel disease. J Endocrinol 2003;178:339-46.
-
(2003)
J Endocrinol
, vol.178
, pp. 339-346
-
-
Farrell, R.J.1
Kelleher, D.2
-
81
-
-
39549115677
-
Overcoming drug resistance induced by P-glycoprotein on lymphocytes in patients with refractory rheumatoid arthritis
-
Tsujimura S, Saito K, Nawata M, Nakayamada S, Tanaka Y. Overcoming drug resistance induced by P-glycoprotein on lymphocytes in patients with refractory rheumatoid arthritis. Ann Rheum Dis 2008;67:380-8.
-
(2008)
Ann Rheum Dis
, vol.67
, pp. 380-388
-
-
Tsujimura, S.1
Saito, K.2
Nawata, M.3
Nakayamada, S.4
Tanaka, Y.5
-
82
-
-
28544433747
-
Regulatory T cells and IL-10 in allergic inflammation
-
Hawrylowicz CM. Regulatory T cells and IL-10 in allergic inflammation. J Exp Med 2005;202:1459-63.
-
(2005)
J Exp Med
, vol.202
, pp. 1459-1463
-
-
Hawrylowicz, C.M.1
-
83
-
-
41649097975
-
Is there a future for small molecule drugs in the treatment of rheumatic diseases?
-
Stanczyk J, Ospelt C, Gay S. Is there a future for small molecule drugs in the treatment of rheumatic diseases?. Curr Opin Rheumatol 2008;20:257-62.
-
(2008)
Curr Opin Rheumatol
, vol.20
, pp. 257-262
-
-
Stanczyk, J.1
Ospelt, C.2
Gay, S.3
-
84
-
-
4544379912
-
Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages
-
Cosio BG, Tsaprouni L, Ito K, Jazrawi E, Adcock IM, Barnes PJ. Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages. J Exp Med 2004;200:689-95.
-
(2004)
J Exp Med
, vol.200
, pp. 689-695
-
-
Cosio, B.G.1
Tsaprouni, L.2
Ito, K.3
Jazrawi, E.4
Adcock, I.M.5
Barnes, P.J.6
-
85
-
-
44649174528
-
Oral or inhaled corticosteroid combination therapy with low dose theophylline reverses corticosteroid insensitivity in a smoking mouse model
-
Fox JC, Spicer D, Ito K, Barnes PJ, Fitzgerald MF. Oral or inhaled corticosteroid combination therapy with low dose theophylline reverses corticosteroid insensitivity in a smoking mouse model. Proc Am Thorac Soc 2007;2:A637.
-
(2007)
Proc Am Thorac Soc
, vol.2
, pp. A637
-
-
Fox, J.C.1
Spicer, D.2
Ito, K.3
Barnes, P.J.4
Fitzgerald, M.F.5
-
86
-
-
57349158300
-
Oxidative stress-induced PI3-kinase activation reduces HDAC activity and is inhibited by theophylline
-
Failla M, To Y, Ito M, Adcock IM, Barnes PJ, Ito K. Oxidative stress-induced PI3-kinase activation reduces HDAC activity and is inhibited by theophylline. Proc Am Thorac Soc 2007;2:A45.
-
(2007)
Proc Am Thorac Soc
, vol.2
, pp. A45
-
-
Failla, M.1
To, Y.2
Ito, M.3
Adcock, I.M.4
Barnes, P.J.5
Ito, K.6
-
87
-
-
33750620057
-
Oxidative stress and redox regulation of lung inflammation in COPD
-
Rahman I, Adcock IM. Oxidative stress and redox regulation of lung inflammation in COPD. Eur Respir J 2006;28:219-42.
-
(2006)
Eur Respir J
, vol.28
, pp. 219-242
-
-
Rahman, I.1
Adcock, I.M.2
-
89
-
-
0030024018
-
Characteristics of cancer cell death after exposure to cytotoxic drugs in vitro
-
Huschtscha L, Bartier W, Ross C, Tattersall M. Characteristics of cancer cell death after exposure to cytotoxic drugs in vitro. Br J Cancer 1996;73:54-60.
-
(1996)
Br J Cancer
, vol.73
, pp. 54-60
-
-
Huschtscha, L.1
Bartier, W.2
Ross, C.3
Tattersall, M.4
-
90
-
-
0028899859
-
Methotrexate for the treatment of Crohn's disease
-
Feagan BG, Rochon J, Fedorak RN, Irvine EJ, Wild G, Sutherland L, et al. The North American Crohn's study group. Methotrexate for the treatment of Crohn's disease. N Engl J Med 1995;332:292-7.
-
(1995)
N Engl J Med
, vol.332
, pp. 292-297
-
-
Feagan, B.G.1
Rochon, J.2
Fedorak, R.N.3
Irvine, E.J.4
Wild, G.5
Sutherland, L.6
-
91
-
-
0032919760
-
Immunosuppressive therapy for ulcerative colitis: Results of a nation-wide survey among consultant physician members of the British society of gastroenterology
-
Stack W, Williams D, Stevenson M, Logan R. Immunosuppressive therapy for ulcerative colitis: results of a nation-wide survey among consultant physician members of the British society of gastroenterology. Aliment Pharmacol Ther 1999;13:569-75.
-
(1999)
Aliment Pharmacol Ther
, vol.13
, pp. 569-575
-
-
Stack, W.1
Williams, D.2
Stevenson, M.3
Logan, R.4
-
92
-
-
0016293798
-
Azathioprine in ulcerative colitis: Final report on controlled therapeutic trial
-
Jewell D, Truelove S. Azathioprine in ulcerative colitis: final report on controlled therapeutic trial. BMJ 1974;114:627-30.
-
(1974)
BMJ
, vol.114
, pp. 627-630
-
-
Jewell, D.1
Truelove, S.2
-
93
-
-
0034903450
-
A randomized placebo-controlled trial of a humanized monoclonal antibody to α4 integrin in active Crohn's disease
-
Gordon F, Lai C, Hamilton M, Allison M, Srivastava E, Fouweather M, et al. A randomized placebo-controlled trial of a humanized monoclonal antibody to α4 integrin in active Crohn's disease. Gastroenterology 2001;121:268-174.
-
(2001)
Gastroenterology
, vol.121
, pp. 268-1174
-
-
Gordon, F.1
Lai, C.2
Hamilton, M.3
Allison, M.4
Srivastava, E.5
Fouweather, M.6
-
94
-
-
0037285975
-
A pilot study on the use of the humanized anti-interleukin-2 receptor antibody daclizumab in active ulcerative colitis
-
Van Assche G, Dalle I, Noman M, Aerden I, Swijsen C, Asnong K, et al. A pilot study on the use of the humanized anti-interleukin-2 receptor antibody daclizumab in active ulcerative colitis. Am J Gastroenterol 2003;98:369-76.
-
(2003)
Am J Gastroenterol
, vol.98
, pp. 369-376
-
-
Van Assche, G.1
Dalle, I.2
Noman, M.3
Aerden, I.4
Swijsen, C.5
Asnong, K.6
-
95
-
-
34247161833
-
Cyclosporine and tacrolimus for the treatment of rheumatoid arthritis
-
Kitahara K, Kawai S. Cyclosporine and tacrolimus for the treatment of rheumatoid arthritis. Curr Opin Rheumatol 2007;19:238-45.
-
(2007)
Curr Opin Rheumatol
, vol.19
, pp. 238-245
-
-
Kitahara, K.1
Kawai, S.2
-
96
-
-
34247889972
-
Therapeutic benefit of PDE4 inhibitors in inflammatory diseases
-
Dastidar SG, Rajagopal D, Ray A. Therapeutic benefit of PDE4 inhibitors in inflammatory diseases. Curr Opin Investig Drugs 2007;8:364-72.
-
(2007)
Curr Opin Investig Drugs
, vol.8
, pp. 364-372
-
-
Dastidar, S.G.1
Rajagopal, D.2
Ray, A.3
-
98
-
-
79958710208
-
P38 mitogen-activated protein kinase pathways in asthma and COPD
-
Chung KF. P38 mitogen-activated protein kinase pathways in asthma and COPD. Chest 2011;139:1470-9.
-
(2011)
Chest
, vol.139
, pp. 1470-1479
-
-
Chung, K.F.1
-
99
-
-
79151475516
-
Phosphoinositide 3-kinase delta (PI3Kdelta) in leukocyte signaling and function
-
Fung-Leung WP. Phosphoinositide 3-kinase delta (PI3Kdelta) in leukocyte signaling and function. Cell Signal 2011;23:603-8.
-
(2011)
Cell Signal
, vol.23
, pp. 603-608
-
-
Fung-Leung, W.P.1
-
100
-
-
77951667667
-
A role for phosphoinositol 3- kinase delta in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease
-
Marwick JA, Caramori G, Casolari P, Mazzoni F, Kirkham PA, Adcock IM, et al. A role for phosphoinositol 3- kinase delta in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol 2010;125:1146-53.
-
(2010)
J Allergy Clin Immunol
, vol.125
, pp. 1146-1153
-
-
Marwick, J.A.1
Caramori, G.2
Casolari, P.3
Mazzoni, F.4
Kirkham, P.A.5
Adcock, I.M.6
-
101
-
-
80052706801
-
New insights into the immunology of chronic obstructive pulmonary disease
-
Brusselle GG, Joos GF, Bracke KR. New insights into the immunology of chronic obstructive pulmonary disease. Lancet 2011;378:1015-26.
-
(2011)
Lancet
, vol.378
, pp. 1015-1026
-
-
Brusselle, G.G.1
Joos, G.F.2
Bracke, K.R.3
-
102
-
-
44849090900
-
Cigarette smoke increases toll-like receptor 4 and modifies lipopolysaccharide-mediated responses in airway epithelial cells
-
Pace E, Ferraro M, Siena L, Melis M, Montalbano AM, Johnson M, et al. Cigarette smoke increases toll-like receptor 4 and modifies lipopolysaccharide-mediated responses in airway epithelial cells. Immunol 2008;124:401-11.
-
(2008)
Immunol
, vol.124
, pp. 401-411
-
-
Pace, E.1
Ferraro, M.2
Siena, L.3
Melis, M.4
Montalbano, A.M.5
Johnson, M.6
-
103
-
-
79956188587
-
Toll-like receptor modulators: A patent review (2006-2010)
-
Basith S, Manavalan B, Lee G, Kim SG, Choi S. Toll-like receptor modulators: a patent review (2006-2010). Expert Opin Ther Pat 2011;21:927-44.
-
(2011)
Expert Opin Ther Pat
, vol.21
, pp. 927-944
-
-
Basith, S.1
Manavalan, B.2
Lee, G.3
Kim, S.G.4
Choi, S.5
-
104
-
-
81855199748
-
Nuclear factor-kappa B inhibitors; a patent review (2006-2010)
-
Kwak JH, Jung JK, Lee H. Nuclear factor-kappa B inhibitors; a patent review (2006-2010). Expert Opin Ther Pat 2011;21:1897-910.
-
(2011)
Expert Opin Ther Pat
, vol.21
, pp. 1897-1910
-
-
Kwak, J.H.1
Jung, J.K.2
Lee, H.3
-
105
-
-
79953651813
-
Candidate genes for COPD in two large data sets
-
Bakke PS, Zhu G, Gulsvik A, Kong X, Agusti AG, Calverley PM, et al. Candidate genes for COPD in two large data sets. Eur Respir J 2011;37:255-63.
-
(2011)
Eur Respir J
, vol.37
, pp. 255-263
-
-
Bakke, P.S.1
Zhu, G.2
Gulsvik, A.3
Kong, X.4
Agusti, A.G.5
Calverley, P.M.6
-
106
-
-
0036153433
-
Scientific rationale for combination inhalers with a long-acting b2-agonists and corticosteroids
-
Barnes PJ. Scientific rationale for combination inhalers with a long-acting b2-agonists and corticosteroids. Eur Respir J 2002;19:182-91.
-
(2002)
Eur Respir J
, vol.19
, pp. 182-191
-
-
Barnes, P.J.1
-
107
-
-
24944482440
-
Glucocorticoid receptor nuclear translocation in airway cells following inhaled combination therapy
-
Usmani OS, Ito K, Maneechotesuwan K, Ito M, Johnson M, Barnes PJ, et al. Glucocorticoid receptor nuclear translocation in airway cells following inhaled combination therapy. Am J Respir Crit Care Med 2005;172:704-12.
-
(2005)
Am J Respir Crit Care Med
, vol.172
, pp. 704-712
-
-
Usmani, O.S.1
Ito, K.2
Maneechotesuwan, K.3
Ito, M.4
Johnson, M.5
Barnes, P.J.6
-
108
-
-
40949165358
-
Holy grail of asthma management: Toward understanding how long-acting beta(2)-adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids
-
Giembycz MA, Kaur M, Leigh R, Newton RA. Holy grail of asthma management: toward understanding how long-acting beta(2)-adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids. Br J Pharmacol 2008;153:1090-104.
-
(2008)
Br J Pharmacol
, vol.153
, pp. 1090-1104
-
-
Giembycz, M.A.1
Kaur, M.2
Leigh, R.3
Newton, R.A.4
-
109
-
-
84860636707
-
Increased corticosteroid sensitivity by a long acting beta2 agonist formoterol via beta2 adrenoceptor independent protein phosphatase 2a activation
-
Kobayashi Y, Mercado N, Miller-Larsson A, Barnes PJ, Ito K. Increased corticosteroid sensitivity by a long acting beta2 agonist formoterol via beta2 adrenoceptor independent protein phosphatase 2a activation. Pulm Pharmacol Ther 2012;25:201-7.
-
(2012)
Pulm Pharmacol Ther
, vol.25
, pp. 201-207
-
-
Kobayashi, Y.1
Mercado, N.2
Miller-Larsson, A.3
Barnes, P.J.4
Ito, K.5
|