-
2
-
-
0030806085
-
In thymic selection, peptide diversity gives and takes away
-
Bevan M. J. (1997) In thymic selection, peptide diversity gives and takes away. Immunity 7: 175-178
-
(1997)
Immunity
, vol.7
, pp. 175-178
-
-
Bevan, M.J.1
-
3
-
-
0035366202
-
Activation-induced cell death
-
Budd R. C. (2001) Activation-induced cell death. Curr. Opin. Immunol. 13: 356-362
-
(2001)
Curr. Opin. Immunol.
, vol.13
, pp. 356-362
-
-
Budd, R.C.1
-
4
-
-
0038393112
-
Apoptosis in the development and maintenance of the immune system
-
Opferman J. T. and Korsmeyer S. J. (2003) Apoptosis in the development and maintenance of the immune system. Nat. Immunol. 4: 410-415
-
(2003)
Nat. Immunol.
, vol.4
, pp. 410-415
-
-
Opferman, J.T.1
Korsmeyer, S.J.2
-
5
-
-
18244397482
-
Molecular mechanisms of glucocorticoids in the control of inflammation and lymphocyte apoptosis
-
Tuckermann J. P., Kleiman A., McPherson K. G. and Reichardt H. M. (2005) Molecular mechanisms of glucocorticoids in the control of inflammation and lymphocyte apoptosis. Crit. Rev. Clin. Lab. Sci. 42: 71-104
-
(2005)
Crit. Rev. Clin. Lab. Sci.
, vol.42
, pp. 71-104
-
-
Tuckermann, J.P.1
Kleiman, A.2
McPherson, K.G.3
Reichardt, H.M.4
-
6
-
-
0018830636
-
Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
-
Wyllie A. H. (1980) Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284: 555-556
-
(1980)
Nature
, vol.284
, pp. 555-556
-
-
Wyllie, A.H.1
-
7
-
-
0029618368
-
Steroid hormone receptors: Many actors in search of a plot
-
Beato M., Herrlich P. and Schütz G. (1995) Steroid hormone receptors: many actors in search of a plot. Cell 83: 851-857
-
(1995)
Cell
, vol.83
, pp. 851-857
-
-
Beato, M.1
Herrlich, P.2
Schütz, G.3
-
8
-
-
18144444807
-
DNA binding of the glucocorticoid receptor is not essential for survival
-
Reichardt H. M., Kaestner K. H., Tuckermann J., Kretz O., Wessely O., Bock R. et al. (1998) DNA binding of the glucocorticoid receptor is not essential for survival. Cell 93: 531-541
-
(1998)
Cell
, vol.93
, pp. 531-541
-
-
Reichardt, H.M.1
Kaestner, K.H.2
Tuckermann, J.3
Kretz, O.4
Wessely, O.5
Bock, R.6
-
9
-
-
0036143203
-
Recent insights into the mechanism of glucocorticosteroid-induced apoptosis
-
Distelhorst C. W. (2002) Recent insights into the mechanism of glucocorticosteroid-induced apoptosis. Cell Death Differ. 9: 6-19
-
(2002)
Cell Death Differ.
, vol.9
, pp. 6-19
-
-
Distelhorst, C.W.1
-
10
-
-
8344271002
-
Mechanisms of glucocorticoid-induced apoptosis in hematologic malignancies: Updates
-
Frankfurt O. and Rosen S. T. (2004) Mechanisms of glucocorticoid-induced apoptosis in hematologic malignancies: updates. Curr. Opin. Oncol. 16: 553-563
-
(2004)
Curr. Opin. Oncol.
, vol.16
, pp. 553-563
-
-
Frankfurt, O.1
Rosen, S.T.2
-
11
-
-
0033735544
-
Glucocorticoids and thymocyte development
-
Vacchio M. S. and Ashwell J. D. (2000) Glucocorticoids and thymocyte development. Semin. Immunol. 12: 475-485
-
(2000)
Semin. Immunol.
, vol.12
, pp. 475-485
-
-
Vacchio, M.S.1
Ashwell, J.D.2
-
12
-
-
22144465538
-
Glucocorticoids inhibit activation-induced cell death (AICD) via direct DNA-dependent repression of the CD95 ligand gene by a glucocorticoid receptor dimer
-
Baumann S., Dostert A., Novac N., Bauer A., Schmid W., Fas S. C. et al. (2005) Glucocorticoids inhibit activation-induced cell death (AICD) via direct DNA-dependent repression of the CD95 ligand gene by a glucocorticoid receptor dimer. Blood 106: 617-625
-
(2005)
Blood
, vol.106
, pp. 617-625
-
-
Baumann, S.1
Dostert, A.2
Novac, N.3
Bauer, A.4
Schmid, W.5
Fas, S.C.6
-
13
-
-
0037103223
-
Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo
-
Brewer J. A., Kanagawa O., Sleckman B. P. and Muglia L. J. (2002) Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo. J. Immunol. 169: 1837-1843
-
(2002)
J. Immunol.
, vol.169
, pp. 1837-1843
-
-
Brewer, J.A.1
Kanagawa, O.2
Sleckman, B.P.3
Muglia, L.J.4
-
14
-
-
18044384629
-
Glucocorticoid-induced apoptosis and glucocorticoid resistance in acute lymphoblastic leukemia
-
Ploner C., Schmidt S., Presul E., Renner K., Schrocksnadel K., Rainer J. et al. (2005) Glucocorticoid-induced apoptosis and glucocorticoid resistance in acute lymphoblastic leukemia. J. Steroid Biochem. Mol. Biol. 93: 153-160
-
(2005)
J. Steroid Biochem. Mol. Biol.
, vol.93
, pp. 153-160
-
-
Ploner, C.1
Schmidt, S.2
Presul, E.3
Renner, K.4
Schrocksnadel, K.5
Rainer, J.6
-
15
-
-
4444319484
-
Immunomodulatory activities of glucocorticoids: Insights from transgenesis and gene targeting
-
Reichardt H. M. (2004) Immunomodulatory activities of glucocorticoids: insights from transgenesis and gene targeting. Curr. Pharm. Des. 10: 2797-2805
-
(2004)
Curr. Pharm. Des.
, vol.10
, pp. 2797-2805
-
-
Reichardt, H.M.1
-
16
-
-
0012473279
-
The nuclear receptor superfamily: The second decade
-
Mangelsdorf D. J., Thummel C., Beato M., Herrlich P., Schütz G., Umesono K. et al. (1995) The nuclear receptor superfamily: the second decade. Cell 83: 835-839
-
(1995)
Cell
, vol.83
, pp. 835-839
-
-
Mangelsdorf, D.J.1
Thummel, C.2
Beato, M.3
Herrlich, P.4
Schütz, G.5
Umesono, K.6
-
17
-
-
0029681032
-
Molecular chaperoning of steroid hormone receptors
-
Pratt W. B., Gehring U. and Toft D. O. (1996) Molecular chaperoning of steroid hormone receptors. EXS 11: 79-95
-
(1996)
EXS
, vol.11
, pp. 79-95
-
-
Pratt, W.B.1
Gehring, U.2
Toft, D.O.3
-
18
-
-
0025780755
-
Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA
-
Luisi B. F., Xu W. X., Otwinowski Z., Freedman L. P., Yamamoto K. R. and Sigler P. B. (1991) Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA. Nature 352: 497-505
-
(1991)
Nature
, vol.352
, pp. 497-505
-
-
Luisi, B.F.1
Xu, W.X.2
Otwinowski, Z.3
Freedman, L.P.4
Yamamoto, K.R.5
Sigler, P.B.6
-
20
-
-
0037705388
-
Glucocorticoids inhibit apoptosis during fibrosarcoma development by transcriptionally activating Bcl-xL
-
Gascoyne D. M., Kypta R. M. and Vivanco M. M. (2003) Glucocorticoids inhibit apoptosis during fibrosarcoma development by transcriptionally activating Bcl-xL. J. Biol. Chem. 278: 18022-18029
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 18022-18029
-
-
Gascoyne, D.M.1
Kypta, R.M.2
Vivanco, M.M.3
-
21
-
-
0035200120
-
Glucocorticoid receptor activation of the I kappa B alpha promoter within chromatin
-
Deroo B. J. and Archer T. K. (2001) Glucocorticoid receptor activation of the I kappa B alpha promoter within chromatin. Mol. Biol. Cell. 12: 3365-3374
-
(2001)
Mol. Biol. Cell.
, vol.12
, pp. 3365-3374
-
-
Deroo, B.J.1
Archer, T.K.2
-
22
-
-
0031415218
-
A new dexamethasone-induced gene of the leucine zipper family protects T lymphocytes from TCR/CD3-activated cell death
-
D'Adamio F., Zollo O., Moraca R., Ayroldi E., Bruscoli S., Bartoli A. et al. (1997) A new dexamethasone-induced gene of the leucine zipper family protects T lymphocytes from TCR/CD3-activated cell death. Immunity 7: 803-812
-
(1997)
Immunity
, vol.7
, pp. 803-812
-
-
D'Adamio, F.1
Zollo, O.2
Moraca, R.3
Ayroldi, E.4
Bruscoli, S.5
Bartoli, A.6
-
23
-
-
0030962132
-
A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis
-
USA
-
Nocentini G., Giunchi L., Ronchetti S., Krausz L. T. Bartoli A., Moraca R. et al. (1997) A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc. Natl. Acad. Sci. USA 94: 6216-6221
-
(1997)
Proc. Natl. Acad. Sci.
, vol.94
, pp. 6216-6221
-
-
Nocentini, G.1
Giunchi, L.2
Ronchetti, S.3
Krausz, L.T.4
Bartoli, A.5
Moraca, R.6
-
24
-
-
0023213560
-
Transcription activation of the tyrosine aminotransferase gene by glucocorticoids and cAMP in primary hepatocytes
-
Schmid E., Schmid W., Jantzen M., Mayer D., Jastorff B. and Schutz G. (1987) Transcription activation of the tyrosine aminotransferase gene by glucocorticoids and cAMP in primary hepatocytes. Eur. J. Biochem. 165: 499-506
-
(1987)
Eur. J. Biochem.
, vol.165
, pp. 499-506
-
-
Schmid, E.1
Schmid, W.2
Jantzen, M.3
Mayer, D.4
Jastorff, B.5
Schutz, G.6
-
25
-
-
0030998776
-
Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression
-
Hanson R. W. and Reshef L. (1997) Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression. Annu. Rev. Biochem. 66: 581-611
-
(1997)
Annu. Rev. Biochem.
, vol.66
, pp. 581-611
-
-
Hanson, R.W.1
Reshef, L.2
-
26
-
-
0030789420
-
I kappaB alpha-independent downregulation of NF-kappaB activity by glucocorticoid receptor
-
Heck S., Bender K., Kullmann M., Gottlicher M., Herrlich P. and Cato A. C. (1997) I kappaB alpha-independent downregulation of NF-kappaB activity by glucocorticoid receptor. EMBO J. 16: 4698-4707
-
(1997)
EMBO J.
, vol.16
, pp. 4698-4707
-
-
Heck, S.1
Bender, K.2
Kullmann, M.3
Gottlicher, M.4
Herrlich, P.5
Cato, A.C.6
-
27
-
-
0027934108
-
A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1
-
Heck S., Kullmann M., Gast A., Ponta H., Rahmsdorf H. J., Herrlich P. et al. (1994) A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1. EMBO J. 13: 4087-4095
-
(1994)
EMBO J.
, vol.13
, pp. 4087-4095
-
-
Heck, S.1
Kullmann, M.2
Gast, A.3
Ponta, H.4
Rahmsdorf, H.J.5
Herrlich, P.6
-
28
-
-
0026507209
-
Glucocorticoid receptor-mediated suppression of the interleukin 2 gene expression through impairment of the cooperativity between nuclear factor of activated T cells and AP-1 enhancer elements
-
Vacca A., Felli M. P., Farina A. R., Martinotti S., Maroder M., Screpanti I. et al. (1992) Glucocorticoid receptor-mediated suppression of the interleukin 2 gene expression through impairment of the cooperativity between nuclear factor of activated T cells and AP-1 enhancer elements. J. Exp. Med. 175: 637-646
-
(1992)
J. Exp. Med.
, vol.175
, pp. 637-646
-
-
Vacca, A.1
Felli, M.P.2
Farina, A.R.3
Martinotti, S.4
Maroder, M.5
Screpanti, I.6
-
29
-
-
0027415164
-
Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids
-
Imai E., Miner J. N., Mitchell J. A., Yamamoto K. R. and Granner D. K. (1993) Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids. J. Biol. Chem. 268: 5353-5356
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 5353-5356
-
-
Imai, E.1
Miner, J.N.2
Mitchell, J.A.3
Yamamoto, K.R.4
Granner, D.K.5
-
30
-
-
0030868701
-
Specific DNA binding of Stat5, but not of glucocorticoid receptor, is required for their functional cooperation in the regulation of gene transcription
-
Stoecklin E., Wissler M., Moriggl R. and Groner B. (1997) Specific DNA binding of Stat5, but not of glucocorticoid receptor, is required for their functional cooperation in the regulation of gene transcription. Mol. Cell. Biol. 17: 6708-6716
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 6708-6716
-
-
Stoecklin, E.1
Wissler, M.2
Moriggl, R.3
Groner, B.4
-
31
-
-
0033611050
-
The DNA binding-independent function of the glucocorticoid receptor mediates repression of AP-1-dependent genes in skin
-
Tuckermann J. P., Reichardt H. M., Arribas R., Richter K. H., Schutz G. and Angel P. (1999) The DNA binding-independent function of the glucocorticoid receptor mediates repression of AP-1-dependent genes in skin. J. Cell. Biol. 147: 1365-1370
-
(1999)
J. Cell. Biol.
, vol.147
, pp. 1365-1370
-
-
Tuckermann, J.P.1
Reichardt, H.M.2
Arribas, R.3
Richter, K.H.4
Schutz, G.5
Angel, P.6
-
32
-
-
0034815629
-
Mammary gland development and lactation are controlled by different glucocorticoid receptor activities
-
Reichardt H. M., Horsch K., Gröne H. J., Kolbus A., Beug H., Hynes N. et al. (2001) Mammary gland development and lactation are controlled by different glucocorticoid receptor activities. Eur. J. Endocrinol. 145: 519-527
-
(2001)
Eur. J. Endocrinol.
, vol.145
, pp. 519-527
-
-
Reichardt, H.M.1
Horsch, K.2
Gröne, H.J.3
Kolbus, A.4
Beug, H.5
Hynes, N.6
-
33
-
-
0037126620
-
Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor
-
Reichardt H. M., Tuckermann J. P., Göttlicher M., Vujic M., Weih F., Angel P. et al. (2001) Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor. EMBO J. 20: 7168-7173.
-
(2001)
EMBO J.
, vol.20
, pp. 7168-7173
-
-
Reichardt, H.M.1
Tuckermann, J.P.2
Göttlicher, M.3
Vujic, M.4
Weih, F.5
Angel, P.6
-
34
-
-
12144287247
-
Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth
-
Tronche F., Opherk C., Moriggl R., Kellendonk C., Reimann A., Schwake L. et al. (2004) Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth. Genes Dev. 18: 492-497
-
(2004)
Genes Dev.
, vol.18
, pp. 492-497
-
-
Tronche, F.1
Opherk, C.2
Moriggl, R.3
Kellendonk, C.4
Reimann, A.5
Schwake, L.6
-
35
-
-
0036897343
-
Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids
-
Limbourg F. P., Huang Z., Plumier J. C., Simoncini T., Fujioka M., Tuckermann J. et al. (2002) Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids. J. Clin. Invest. 110: 1729-1738
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 1729-1738
-
-
Limbourg, F.P.1
Huang, Z.2
Plumier, J.C.3
Simoncini, T.4
Fujioka, M.5
Tuckermann, J.6
-
36
-
-
20844437424
-
Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes
-
Lu N. Z. and Cidlowski J. A. (2005) Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes. Mol. Cell 18: 331-342
-
(2005)
Mol. Cell
, vol.18
, pp. 331-342
-
-
Lu, N.Z.1
Cidlowski, J.A.2
-
37
-
-
0034745378
-
5′UTR sequences of the glucocorticoid receptor 1A transcript encode a peptide associated with translational regulation of the glucocorticoid receptor
-
Diba F., Watson C. S. and Gametchu B. (2001) 5′UTR sequences of the glucocorticoid receptor 1A transcript encode a peptide associated with translational regulation of the glucocorticoid receptor. J. Cell. Biochem. 81: 149-161
-
(2001)
J. Cell. Biochem.
, vol.81
, pp. 149-161
-
-
Diba, F.1
Watson, C.S.2
Gametchu, B.3
-
38
-
-
4644304217
-
Expression of the glucocorticoid receptor from the IA promoter correlates with T lymphocyte sensitivity to glucocorticoid-induced cell death
-
Purton J. F., Monk J. A., Liddicoat D. R., Kyparissoudis K., Sakkal S., Richardson S. J. et al. (2004) Expression of the glucocorticoid receptor from the IA promoter correlates with T lymphocyte sensitivity to glucocorticoid- induced cell death. J. Immunol. 173: 3816-3824
-
(2004)
J. Immunol.
, vol.173
, pp. 3816-3824
-
-
Purton, J.F.1
Monk, J.A.2
Liddicoat, D.R.3
Kyparissoudis, K.4
Sakkal, S.5
Richardson, S.J.6
-
39
-
-
18144399332
-
The human glucocorticoid receptor: One gene, multiple proteins and diverse responses
-
Zhou J. and Cidlowski J. A. (2005) The human glucocorticoid receptor: one gene, multiple proteins and diverse responses. Steroids 70: 407-417
-
(2005)
Steroids
, vol.70
, pp. 407-417
-
-
Zhou, J.1
Cidlowski, J.A.2
-
40
-
-
3342979528
-
Glucocorticoid regulation of the inflammatory response to injury
-
Yeager M. P., Guyre P. M. and Munck A. U. (2004) Glucocorticoid regulation of the inflammatory response to injury. Acta Anaesthesiol. Scand. 48: 799-813
-
(2004)
Acta Anaesthesiol. Scand.
, vol.48
, pp. 799-813
-
-
Yeager, M.P.1
Guyre, P.M.2
Munck, A.U.3
-
41
-
-
76549251874
-
Effects of cortisone acetate and pituitray ACTH on rheumatoid arthritis, rheumatic fever and certain other conditions
-
Hench P. S., Kendall E. C., Slocumb C. H. and Policy H. F. (1950) Effects of cortisone acetate and pituitray ACTH on rheumatoid arthritis, rheumatic fever and certain other conditions. Arch. Intern. Med. 85: 545-566
-
(1950)
Arch. Intern. Med.
, vol.85
, pp. 545-566
-
-
Hench, P.S.1
Kendall, E.C.2
Slocumb, C.H.3
Policy, H.F.4
-
43
-
-
0034730493
-
Resetting of circadian time in peripheral tissues by glucocorticoid signaling
-
Balsalobre A., Brown S. A., Marcacci L., Tronche F., Kellendonk C., Reichardt H. M. et al. (2000) Resetting of circadian time in peripheral tissues by glucocorticoid signaling. Science 289: 2344-2347
-
(2000)
Science
, vol.289
, pp. 2344-2347
-
-
Balsalobre, A.1
Brown, S.A.2
Marcacci, L.3
Tronche, F.4
Kellendonk, C.5
Reichardt, H.M.6
-
44
-
-
0028806218
-
A targeted glucocorticoid receptor antisense transgene increases thymocyte apoptosis and alters thymocyte development
-
King L. B., Vacchio M. S., Dixon K., Hunziker R., Margulies D. H. and Ashwell J. D. (1995) A targeted glucocorticoid receptor antisense transgene increases thymocyte apoptosis and alters thymocyte development. Immunity 3: 647-656
-
(1995)
Immunity
, vol.3
, pp. 647-656
-
-
King, L.B.1
Vacchio, M.S.2
Dixon, K.3
Hunziker, R.4
Margulies, D.H.5
Ashwell, J.D.6
-
45
-
-
0036581326
-
Effects of altered glucocorticoid sensitivity in the T cell lineage on thymocyte and T cell homeostasis
-
Pazirandeh A., Xue Y., Prestegaard T., Jondal M. and Okret S. (2002) Effects of altered glucocorticoid sensitivity in the T cell lineage on thymocyte and T cell homeostasis. FASEB J. 16: 727-729
-
(2002)
FASEB J.
, vol.16
, pp. 727-729
-
-
Pazirandeh, A.1
Xue, Y.2
Prestegaard, T.3
Jondal, M.4
Okret, S.5
-
46
-
-
0029088326
-
Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation
-
Cole T. J., Blendy J. A., Monaghan A. P., Krieglstein K., Schmid W., Aguzzi A. et al. (1995) Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes Dev. 9: 1608-1621
-
(1995)
Genes Dev.
, vol.9
, pp. 1608-1621
-
-
Cole, T.J.1
Blendy, J.A.2
Monaghan, A.P.3
Krieglstein, K.4
Schmid, W.5
Aguzzi, A.6
-
47
-
-
0033715726
-
Intrathymic T cell development and selection proceeds normally in the absence of glucocorticoid receptor signaling
-
Purton J. F., Boyd R. L., Cole T. J. and Godfrey D. I. (2000) Intrathymic T cell development and selection proceeds normally in the absence of glucocorticoid receptor signaling. Immunity 13: 179-186
-
(2000)
Immunity
, vol.13
, pp. 179-186
-
-
Purton, J.F.1
Boyd, R.L.2
Cole, T.J.3
Godfrey, D.I.4
-
48
-
-
0036909641
-
Glucocorticoid receptor deficient thymic and peripheral T cells develop normally in adult mice
-
Purton J. F., Zhan Y., Liddicoat D. R., Hardy C. L., Lew A. M., Cole T. J. et al. (2002) Glucocorticoid receptor deficient thymic and peripheral T cells develop normally in adult mice. Eur. J. Immunol. 32: 3546-3555
-
(2002)
Eur. J. Immunol.
, vol.32
, pp. 3546-3555
-
-
Purton, J.F.1
Zhan, Y.2
Liddicoat, D.R.3
Hardy, C.L.4
Lew, A.M.5
Cole, T.J.6
-
49
-
-
0142137222
-
T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation
-
Brewer J. A., Khor B., Vogt S. K., Muglia L. M., Fujiwara H., Haegele K. E. et al. (2003) T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation. Nat. Med. 9: 1318-1322
-
(2003)
Nat. Med.
, vol.9
, pp. 1318-1322
-
-
Brewer, J.A.1
Khor, B.2
Vogt, S.K.3
Muglia, L.M.4
Fujiwara, H.5
Haegele, K.E.6
-
50
-
-
0034460335
-
Mice with an increased glucocorticoid receptor gene dosage show enhanced resistance to stress and endotoxic shock
-
Reichardt H. M., Umland T., Bauer A., Kretz O. and Schütz G. (2000) Mice with an increased glucocorticoid receptor gene dosage show enhanced resistance to stress and endotoxic shock. Mol. Cell. Biol. 20: 9009-9017
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 9009-9017
-
-
Reichardt, H.M.1
Umland, T.2
Bauer, A.3
Kretz, O.4
Schütz, G.5
-
51
-
-
18844421375
-
Conditional expression of a glucocorticoid receptor transgene in thymocytes reveals a role for thymic-derived glucocorticoids in thymopoiesis in vivo
-
Pazirandeh A., Jondal M. and Okret S. (2005) Conditional expression of a glucocorticoid receptor transgene in thymocytes reveals a role for thymic-derived glucocorticoids in thymopoiesis in vivo. Endocrinology 146: 2501-2507
-
(2005)
Endocrinology
, vol.146
, pp. 2501-2507
-
-
Pazirandeh, A.1
Jondal, M.2
Okret, S.3
-
52
-
-
0034641918
-
The biochemistry of apoptosis
-
Hengartner M. O. (2000) The biochemistry of apoptosis. Nature 407: 770-776
-
(2000)
Nature
, vol.407
, pp. 770-776
-
-
Hengartner, M.O.1
-
53
-
-
14944348965
-
The role of BH3-only proteins in the immune system
-
Strasser A. (2005) The role of BH3-only proteins in the immune system. Nat. Rev. Immunol. 5: 189-200
-
(2005)
Nat. Rev. Immunol.
, vol.5
, pp. 189-200
-
-
Strasser, A.1
-
54
-
-
0035890085
-
The expanding role of mitochondria in apoptosis
-
Wang X. (2001) The expanding role of mitochondria in apoptosis. Genes Dev. 15: 2922-2933
-
(2001)
Genes Dev.
, vol.15
, pp. 2922-2933
-
-
Wang, X.1
-
55
-
-
0034786019
-
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis
-
Cheng E. H., Wei M. C., Weiler S., Flavell R. A., Mak T. W., Lindsten T. et al. (2001) BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol. Cell 8: 705-711
-
(2001)
Mol. Cell
, vol.8
, pp. 705-711
-
-
Cheng, E.H.1
Wei, M.C.2
Weiler, S.3
Flavell, R.A.4
Mak, T.W.5
Lindsten, T.6
-
56
-
-
3442886811
-
The pathophysiology of mitochondrial cell death
-
Green D. R. and Kroemer G. (2004) The pathophysiology of mitochondrial cell death. Science 305: 626-629
-
(2004)
Science
, vol.305
, pp. 626-629
-
-
Green, D.R.1
Kroemer, G.2
-
57
-
-
0033558215
-
The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis
-
Zong W. X., Edelstein L. C., Chen C., Bash J. and Gelinas C. (1999) The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis. Genes Dev. 13: 382-387
-
(1999)
Genes Dev.
, vol.13
, pp. 382-387
-
-
Zong, W.X.1
Edelstein, L.C.2
Chen, C.3
Bash, J.4
Gelinas, C.5
-
58
-
-
0037421190
-
Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane
-
Kaufmann T., Schlipf S., Sanz J., Neubert K., Stein R. and Borner C. (2003) Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane. J. Cell. Biol. 160: 53-64
-
(2003)
J. Cell. Biol.
, vol.160
, pp. 53-64
-
-
Kaufmann, T.1
Schlipf, S.2
Sanz, J.3
Neubert, K.4
Stein, R.5
Borner, C.6
-
59
-
-
1842472069
-
Phosphorylation of BCL-2 regulates ER Ca(2+) homeostasis and apoptosis
-
Bassik M. C., Scorrano L., Oakes S. A., Pozzan T. and Korsmeyer S. J. (2004) Phosphorylation of BCL-2 regulates ER Ca(2+) homeostasis and apoptosis. EMBO J. 23: 1207-1216
-
(2004)
EMBO J.
, vol.23
, pp. 1207-1216
-
-
Bassik, M.C.1
Scorrano, L.2
Oakes, S.A.3
Pozzan, T.4
Korsmeyer, S.J.5
-
60
-
-
7644231187
-
Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis
-
Herrant M., Jacquel A., Marchetti S., Belhacene N., Colosetti P., Luciano F. et al. (2004) Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis. Oncogene 23: 7863-7873
-
(2004)
Oncogene
, vol.23
, pp. 7863-7873
-
-
Herrant, M.1
Jacquel, A.2
Marchetti, S.3
Belhacene, N.4
Colosetti, P.5
Luciano, F.6
-
62
-
-
14644412456
-
Do inducers of apoptosis trigger caspase-independent cell death?
-
Chipuk J. E. and Green D. R. (2005) Do inducers of apoptosis trigger caspase-independent cell death? Nat. Rev. Mol. Cell Biol. 6: 268-275
-
(2005)
Nat. Rev. Mol. Cell Biol.
, vol.6
, pp. 268-275
-
-
Chipuk, J.E.1
Green, D.R.2
-
63
-
-
22544444514
-
Caspase-independent cell death
-
Kroemer G. and Martin S. J. (2005) Caspase-independent cell death. Nat. Med. 11: 725-730
-
(2005)
Nat. Med.
, vol.11
, pp. 725-730
-
-
Kroemer, G.1
Martin, S.J.2
-
64
-
-
0242579153
-
Cathepsin-B-dependent apoptosis triggered by antithymocyte globulins: A novel mechanism of T-cell depletion
-
Michallet M. C., Saltel F., Preville X., Flacher M., Revillard J. P. and Genestier L. (2003) Cathepsin-B-dependent apoptosis triggered by antithymocyte globulins: a novel mechanism of T-cell depletion. Blood 102: 3719-3726
-
(2003)
Blood
, vol.102
, pp. 3719-3726
-
-
Michallet, M.C.1
Saltel, F.2
Preville, X.3
Flacher, M.4
Revillard, J.P.5
Genestier, L.6
-
65
-
-
0043234207
-
Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis
-
Bidere N., Lorenzo H. K., Carmona S., Laforge M., Harper F., Dumont C. et al. (2003) Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis. J. Biol. Chem. 278: 31401-31411
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 31401-31411
-
-
Bidere, N.1
Lorenzo, H.K.2
Carmona, S.3
Laforge, M.4
Harper, F.5
Dumont, C.6
-
66
-
-
0042744006
-
Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis
-
Canbay A., Guicciardi M. E., Higuchi H., Feldstein A., Bronk S. F., Rydzewski R. et al. (2003) Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis. J. Clin. Invest. 112: 152-159
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 152-159
-
-
Canbay, A.1
Guicciardi, M.E.2
Higuchi, H.3
Feldstein, A.4
Bronk, S.F.5
Rydzewski, R.6
-
67
-
-
4544385218
-
Autophagy: Many paths to the same end
-
Cuervo A. M. (2004) Autophagy: many paths to the same end. Mol. Cell. Biochem. 263: 55-72
-
(2004)
Mol. Cell. Biochem.
, vol.263
, pp. 55-72
-
-
Cuervo, A.M.1
-
68
-
-
4644295842
-
Serine protease inhibitor 2A is a protective factor for memory T cell development
-
Liu N., Phillips T., Zhang M., Wang Y. Opferman J. T., Shah R. et al. (2004) Serine protease inhibitor 2A is a protective factor for memory T cell development. Nat. Immunol. 5: 919-926
-
(2004)
Nat. Immunol.
, vol.5
, pp. 919-926
-
-
Liu, N.1
Phillips, T.2
Zhang, M.3
Wang, Y.4
Opferman, J.T.5
Shah, R.6
-
69
-
-
0023609541
-
Glucocorticoid regulation of transcription of the c-myc cellular protooncogene in P1798 cells
-
Forsthoefel A. M. and Thompson E. A. (1987) Glucocorticoid regulation of transcription of the c-myc cellular protooncogene in P1798 cells. Mol. Endocrinol. 1: 899-907
-
(1987)
Mol. Endocrinol.
, vol.1
, pp. 899-907
-
-
Forsthoefel, A.M.1
Thompson, E.A.2
-
70
-
-
0037944248
-
Critical function of T cell death-associated gene 8 in glucocorticoid-induced thymocyte apoptosis
-
Tosa N., Murakami M., Jia W. Y., Yokoyama M., Masunaga T., Iwabuchi C. et al. (2003) Critical function of T cell death-associated gene 8 in glucocorticoid-induced thymocyte apoptosis. Int. Immunol. 15: 741-749
-
(2003)
Int. Immunol.
, vol.15
, pp. 741-749
-
-
Tosa, N.1
Murakami, M.2
Jia, W.Y.3
Yokoyama, M.4
Masunaga, T.5
Iwabuchi, C.6
-
71
-
-
11244287290
-
The glucocorticoid-induced gene tdag8 encodes a pro-apoptotic G protein-coupled receptor whose activation promotes glucocorticoid-induced apoptosis
-
Malone M. H., Wang Z. and Distelhorst C. W. (2004) The glucocorticoid-induced gene tdag8 encodes a pro-apoptotic G protein-coupled receptor whose activation promotes glucocorticoid-induced apoptosis. J. Biol. Chem. 279: 52850-52859
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 52850-52859
-
-
Malone, M.H.1
Wang, Z.2
Distelhorst, C.W.3
-
72
-
-
0038373385
-
Dexamethasone-induced gene 2 (dig2) is a novel pro-survival stress gene induced rapidly by diverse apoptotic signals
-
Wang Z., Malone M. H., Thomenius M. J., Zhong F., Xu F. and Distelhorst C. W. (2003) Dexamethasone-induced gene 2 (dig2) is a novel pro-survival stress gene induced rapidly by diverse apoptotic signals. J. Biol. Chem. 278: 27053-27058
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 27053-27058
-
-
Wang, Z.1
Malone, M.H.2
Thomenius, M.J.3
Zhong, F.4
Xu, F.5
Distelhorst, C.W.6
-
73
-
-
0037592259
-
Microarray analysis uncovers the induction of the proapoptotic BH3-only protein Bim in multiple models of glucocorticoid-induced apoptosis
-
Wang Z., Malone M. H., He H., McColl K. S. and Distelhorst C. W. (2003) Microarray analysis uncovers the induction of the proapoptotic BH3-only protein Bim in multiple models of glucocorticoid-induced apoptosis. J. Biol. Chem. 278: 23861-23867
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 23861-23867
-
-
Wang, Z.1
Malone, M.H.2
He, H.3
McColl, K.S.4
Distelhorst, C.W.5
-
74
-
-
11244305855
-
Inhibition of glucocorticoid-induced apoptosis by targeting the major splice variants of BIM mRNA with small interfering RNA and short hairpin RNA
-
Abrams M. T., Robertson N. M., Yoon K. and Wickstrom E. (2004) Inhibition of glucocorticoid-induced apoptosis by targeting the major splice variants of BIM mRNA with small interfering RNA and short hairpin RNA. J. Biol. Chem. 279: 55809-55817
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 55809-55817
-
-
Abrams, M.T.1
Robertson, N.M.2
Yoon, K.3
Wickstrom, E.4
-
75
-
-
0035949470
-
Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals
-
USA
-
Han J., Flemington C., Houghton A. B., Gu Z., Zambetti G. P., Lutz R. J. et al. (2001) Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. Proc. Natl. Acad. Sci. USA 98: 11318-11323
-
(2001)
Proc. Natl. Acad. Sci.
, vol.98
, pp. 11318-11323
-
-
Han, J.1
Flemington, C.2
Houghton, A.B.3
Gu, Z.4
Zambetti, G.P.5
Lutz, R.J.6
-
76
-
-
0035088322
-
Gene expression profiles of proliferating vs. G1/G0 arrested human leukemia cells suggest a mechanism for glucocorticoid-induced apoptosis
-
Tonko M., Ausserlechner M. J., Bernhard D., Helmberg A. and Kofler R. (2001) Gene expression profiles of proliferating vs. G1/G0 arrested human leukemia cells suggest a mechanism for glucocorticoid-induced apoptosis. FASEB J. 15: 693-699
-
(2001)
FASEB J.
, vol.15
, pp. 693-699
-
-
Tonko, M.1
Ausserlechner, M.J.2
Bernhard, D.3
Helmberg, A.4
Kofler, R.5
-
77
-
-
0038362418
-
Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis
-
Medh R. D., Webb M. S., Miller A. L., Johnson B. H., Fofanov Y., Li T. et al. (2003) Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics 81: 543-555
-
(2003)
Genomics
, vol.81
, pp. 543-555
-
-
Medh, R.D.1
Webb, M.S.2
Miller, A.L.3
Johnson, B.H.4
Fofanov, Y.5
Li, T.6
-
78
-
-
0033607506
-
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
-
Bouillet P., Metcalf D., Huang D. C., Tarlinton D. M., Kay T. W., Kontgen F. et al. (1999) Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286: 1735-1738
-
(1999)
Science
, vol.286
, pp. 1735-1738
-
-
Bouillet, P.1
Metcalf, D.2
Huang, D.C.3
Tarlinton, D.M.4
Kay, T.W.5
Kontgen, F.6
-
79
-
-
0037057629
-
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome
-
Marsden V. S., O'Connor L., O'Reilly L. A., Silke J., Metcalf D., Ekert P. G. et al. (2002) Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome. Nature 419: 634-637
-
(2002)
Nature
, vol.419
, pp. 634-637
-
-
Marsden, V.S.1
O'Connor, L.2
O'Reilly, L.A.3
Silke, J.4
Metcalf, D.5
Ekert, P.G.6
-
80
-
-
0028790829
-
Bcl-2 blocks glucocorticoid- but not Fas- or activation-induced apoptosis in a T cell hybridoma
-
Memon S. A., Moreno M. B., Petrak D. and Zacharchuk C. M. (1995) Bcl-2 blocks glucocorticoid- but not Fas- or activation-induced apoptosis in a T cell hybridoma. J. Immunol. 155: 4644-4652
-
(1995)
J. Immunol.
, vol.155
, pp. 4644-4652
-
-
Memon, S.A.1
Moreno, M.B.2
Petrak, D.3
Zacharchuk, C.M.4
-
81
-
-
0036275462
-
Phosphorylation status modulates Bcl-2 function during glucocorticoid-induced apoptosis in T lymphocytes
-
Huang S. T. and Cidlowski J. A. (2002) Phosphorylation status modulates Bcl-2 function during glucocorticoid-induced apoptosis in T lymphocytes. FASEB J. 16: 825-832
-
(2002)
FASEB J.
, vol.16
, pp. 825-832
-
-
Huang, S.T.1
Cidlowski, J.A.2
-
82
-
-
0034464839
-
Delineation of the signaling pathways involved in glucocorticoid-induced and spontaneous apoptosis of rat thymocytes
-
Mann C. L., Hughes F. M. Jr and Cidlowski J. A. (2000) Delineation of the signaling pathways involved in glucocorticoid-induced and spontaneous apoptosis of rat thymocytes. Endocrinology 141: 528-538
-
(2000)
Endocrinology
, vol.141
, pp. 528-538
-
-
Mann, C.L.1
Hughes Jr., F.M.2
Cidlowski, J.A.3
-
83
-
-
0033521741
-
Molecular characterization of mitochondrial apoptosis-inducing factor
-
Susin S. A., Lorenzo H. K., Zamzami N., Marzo I., Snow B. E., Brothers G. M. et al. (1999) Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397: 441-446
-
(1999)
Nature
, vol.397
, pp. 441-446
-
-
Susin, S.A.1
Lorenzo, H.K.2
Zamzami, N.3
Marzo, I.4
Snow, B.E.5
Brothers, G.M.6
-
84
-
-
0027427492
-
Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair
-
Veis D. J., Sorenson C. M., Shutter J. R. and Korsmeyer S. J. (1993) Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 75: 229-240
-
(1993)
Cell
, vol.75
, pp. 229-240
-
-
Veis, D.J.1
Sorenson, C.M.2
Shutter, J.R.3
Korsmeyer, S.J.4
-
85
-
-
0030963602
-
Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis
-
USA
-
Hsu Y. T., Wolter K. G. and Youle R. J. (1997) Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis. Proc. Natl. Acad. Sci. USA 94: 3668-3672
-
(1997)
Proc. Natl. Acad. Sci.
, vol.94
, pp. 3668-3672
-
-
Hsu, Y.T.1
Wolter, K.G.2
Youle, R.J.3
-
86
-
-
0033120383
-
Subcellular distribution and redistribution of Bcl-2 family proteins in human leukemia cells undergoing apoptosis
-
Jia L., Macey M. G., Yin Y. Newland A. C. and Kelsey S. M. (1999) Subcellular distribution and redistribution of Bcl-2 family proteins in human leukemia cells undergoing apoptosis. Blood 93: 2353-2359
-
(1999)
Blood
, vol.93
, pp. 2353-2359
-
-
Jia, L.1
Macey, M.G.2
Yin, Y.3
Newland, A.C.4
Kelsey, S.M.5
-
87
-
-
1542267685
-
Resistance of single-positive thymocytes to glucocorticoid-induced apoptosis is mediated by CD28 signaling
-
Brandt J. van den, Wang D. and Reichardt H. M. (2004) Resistance of single-positive thymocytes to glucocorticoid-induced apoptosis is mediated by CD28 signaling. Mol. Endocrinol. 18: 687-695
-
(2004)
Mol. Endocrinol.
, vol.18
, pp. 687-695
-
-
Van Den Brandt, J.1
Wang, D.2
Reichardt, H.M.3
-
88
-
-
0028922885
-
Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice
-
Motoyama N., Wang F., Roth K. A., Sawa H., Nakayama K., Negishi I. et al. (1995) Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science 267: 1506-1510
-
(1995)
Science
, vol.267
, pp. 1506-1510
-
-
Motoyama, N.1
Wang, F.2
Roth, K.A.3
Sawa, H.4
Nakayama, K.5
Negishi, I.6
-
89
-
-
0034508217
-
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues
-
Lindsten T., Ross A. J., King A., Zong W. X., Rathmell J. C., Shiels H. A. et al. (2000) The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol. Cell 6: 1389-1399
-
(2000)
Mol. Cell
, vol.6
, pp. 1389-1399
-
-
Lindsten, T.1
Ross, A.J.2
King, A.3
Zong, W.X.4
Rathmell, J.C.5
Shiels, H.A.6
-
90
-
-
0035957653
-
Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death
-
Wei M. C., Zong W. X., Cheng E. H., Lindsten T., Panoutsakopoulou V., Ross A. J. et al. (2001) Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292: 727-730
-
(2001)
Science
, vol.292
, pp. 727-730
-
-
Wei, M.C.1
Zong, W.X.2
Cheng, E.H.3
Lindsten, T.4
Panoutsakopoulou, V.5
Ross, A.J.6
-
91
-
-
0035876483
-
BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak
-
Zong W. X., Lindsten T., Ross A. J., MacGregor G. R. and Thompson C. B. (2001) BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak. Genes Dev. 15: 1481-1486
-
(2001)
Genes Dev.
, vol.15
, pp. 1481-1486
-
-
Zong, W.X.1
Lindsten, T.2
Ross, A.J.3
MacGregor, G.R.4
Thompson, C.B.5
-
92
-
-
0036794390
-
Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis
-
Rathmell J. C., Lindsten T., Zong W. X., Cinalli R. M. and Thompson C. B. (2002) Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. Nat. Immunol. 3: 932-939
-
(2002)
Nat. Immunol.
, vol.3
, pp. 932-939
-
-
Rathmell, J.C.1
Lindsten, T.2
Zong, W.X.3
Cinalli, R.M.4
Thompson, C.B.5
-
93
-
-
0038021272
-
Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more
-
Marsden V. S. and Strasser A. (2003) Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more. Annu. Rev. Immunol. 21: 71-105
-
(2003)
Annu. Rev. Immunol.
, vol.21
, pp. 71-105
-
-
Marsden, V.S.1
Strasser, A.2
-
94
-
-
0033944665
-
Bid, a critical mediator for apoptosis induced by the activation of Fas/TNF-R1 death receptors in hepatocytes
-
Yin X. M. (2000) Bid, a critical mediator for apoptosis induced by the activation of Fas/TNF-R1 death receptors in hepatocytes. J. Mol. Med. 78: 203-211
-
(2000)
J. Mol. Med.
, vol.78
, pp. 203-211
-
-
Yin, X.M.1
-
95
-
-
0033607006
-
Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis
-
Yin X. M., Wang K., Gross A., Zhao Y., Zinkel S., Klocke B. et al. (1999) Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature 400: 886-891
-
(1999)
Nature
, vol.400
, pp. 886-891
-
-
Yin, X.M.1
Wang, K.2
Gross, A.3
Zhao, Y.4
Zinkel, S.5
Klocke, B.6
-
96
-
-
0345129987
-
Bad can act as a key regulator of T cell apoptosis and T cell development
-
Mok C. L., Gil-Gomez G., Williams O., Coles M., Taga S., Tolaini M. et al. (1999) Bad can act as a key regulator of T cell apoptosis and T cell development. J. Exp. Med. 189: 575-586
-
(1999)
J. Exp. Med.
, vol.189
, pp. 575-586
-
-
Mok, C.L.1
Gil-Gomez, G.2
Williams, O.3
Coles, M.4
Taga, S.5
Tolaini, M.6
-
97
-
-
0036849192
-
Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis
-
Datta S. R., Ranger A. M., Lin M. Z., Sturgill J. F., Ma Y. C., Cowan C. W. et al. (2002) Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev. Cell 3: 631-643
-
(2002)
Dev. Cell
, vol.3
, pp. 631-643
-
-
Datta, S.R.1
Ranger, A.M.2
Lin, M.Z.3
Sturgill, J.F.4
Ma, Y.C.5
Cowan, C.W.6
-
98
-
-
0042424706
-
Bad-deficient mice develop diffuse large B cell lymphoma
-
USA
-
Ranger A. M., Zha J., Harada H., Datta S. R., Danial N. N., Gilmore A. P. et al. (2003) Bad-deficient mice develop diffuse large B cell lymphoma. Proc. Natl. Acad. Sci. USA 100: 9324-9329
-
(2003)
Proc. Natl. Acad. Sci.
, vol.100
, pp. 9324-9329
-
-
Ranger, A.M.1
Zha, J.2
Harada, H.3
Datta, S.R.4
Danial, N.N.5
Gilmore, A.P.6
-
99
-
-
10744228800
-
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
-
Jeffers J. R., Parganas E., Lee Y. Yang C., Wang J., Brennan J. et al. (2003) Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 4: 321-328
-
(2003)
Cancer Cell
, vol.4
, pp. 321-328
-
-
Jeffers, J.R.1
Parganas, E.2
Lee, Y.3
Yang, C.4
Wang, J.5
Brennan, J.6
-
100
-
-
0242410719
-
p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa
-
Villunger A., Michalak E. M., Coultas L., Mullauer F., Bock G., Ausserlechner M. J. et al. (2003) p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 302: 1036-1038
-
(2003)
Science
, vol.302
, pp. 1036-1038
-
-
Villunger, A.1
Michalak, E.M.2
Coultas, L.3
Mullauer, F.4
Bock, G.5
Ausserlechner, M.J.6
-
101
-
-
0030948457
-
Substrate specificities of caspase family proteases
-
Talanian R. V., Quinlan C., Trautz S., Hackett M. C., Mankovich J. A., Banach D. et al. (1997) Substrate specificities of caspase family proteases. J. Biol. Chem. 272: 9677-9682
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 9677-9682
-
-
Talanian, R.V.1
Quinlan, C.2
Trautz, S.3
Hackett, M.C.4
Mankovich, J.A.5
Banach, D.6
-
102
-
-
0032052315
-
Glucocorticoid-induced thymocyte apoptosis: Protease-dependent activation of cell shrinkage and DNA degradation
-
Hughes F. M. Jr and Cidlowski J. A. (1998) Glucocorticoid-induced thymocyte apoptosis: protease-dependent activation of cell shrinkage and DNA degradation. J. Steroid Biochem. Mol. Biol. 65: 207-217
-
(1998)
J. Steroid Biochem. Mol. Biol.
, vol.65
, pp. 207-217
-
-
Hughes Jr., F.M.1
Cidlowski, J.A.2
-
103
-
-
0037438473
-
Dexamethasone-induced apoptosis of thymocytes: Role of glucocorticoid receptor-associated Src kinase and caspase-8 activation
-
Marchetti M. C., Di Marco B., Cifone G., Migliorati G. and Riccardi C. (2003) Dexamethasone-induced apoptosis of thymocytes: role of glucocorticoid receptor-associated Src kinase and caspase-8 activation. Blood 101: 585-593
-
(2003)
Blood
, vol.101
, pp. 585-593
-
-
Marchetti, M.C.1
Di Marco, B.2
Cifone, G.3
Migliorati, G.4
Riccardi, C.5
-
104
-
-
0031044777
-
Characterization of mice deficient in interleukin-1 beta converting enzyme
-
Li P., Allen H., Banerjee S. and Seshadri T. (1997) Characterization of mice deficient in interleukin-1 beta converting enzyme. J. Cell. Biochem. 64: 27-32
-
(1997)
J. Cell. Biochem.
, vol.64
, pp. 27-32
-
-
Li, P.1
Allen, H.2
Banerjee, S.3
Seshadri, T.4
-
105
-
-
0036024020
-
Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9
-
O'Reilly L. A., Ekert P., Harvey N., Marsden V., Cullen L., Vaux D. L. et al. (2002) Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9. Cell Death Differ. 9: 832-841
-
(2002)
Cell Death Differ.
, vol.9
, pp. 832-841
-
-
O'Reilly, L.A.1
Ekert, P.2
Harvey, N.3
Marsden, V.4
Cullen, L.5
Vaux, D.L.6
-
106
-
-
0037380628
-
Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity
-
Salmena L., Lemmers B., Hakem A., Matysiak-Zablocki E., Murakami K., Au P. Y. et al. (2003) Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity. Genes Dev. 17: 883-895
-
(2003)
Genes Dev.
, vol.17
, pp. 883-895
-
-
Salmena, L.1
Lemmers, B.2
Hakem, A.3
Matysiak-Zablocki, E.4
Murakami, K.5
Au, P.Y.6
-
107
-
-
0032493910
-
Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
-
Kuida K., Haydar T. F., Kuan C. Y., Gu Y., Taya C., Karasuyama H. et al. (1998) Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94: 325-337
-
(1998)
Cell
, vol.94
, pp. 325-337
-
-
Kuida, K.1
Haydar, T.F.2
Kuan, C.Y.3
Gu, Y.4
Taya, C.5
Karasuyama, H.6
-
108
-
-
0032544564
-
Apaf1 is required for mitochondrial pathways of apoptosis and brain development
-
Yoshida H., Kong Y. Y., Yoshida R., Elia A. J., Hakem A., Hakem R. et al. (1998) Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Cell 94: 739-750
-
(1998)
Cell
, vol.94
, pp. 739-750
-
-
Yoshida, H.1
Kong, Y.Y.2
Yoshida, R.3
Elia, A.J.4
Hakem, A.5
Hakem, R.6
-
109
-
-
0029956641
-
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
-
Kuida K., Zheng T. S., Na S., Kuan C., Yang D., Karasuyama H. et al. (1996) Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384: 368-372
-
(1996)
Nature
, vol.384
, pp. 368-372
-
-
Kuida, K.1
Zheng, T.S.2
Na, S.3
Kuan, C.4
Yang, D.5
Karasuyama, H.6
-
110
-
-
0344211823
-
Glucocorticoid-induced apoptosis of thymocytes: Requirement of proteasome-dependent mitochondrial activity
-
Tonomura N., McLaughlin K., Grimm L., Goldsby R. A. and Osborne B. A. (2003) Glucocorticoid-induced apoptosis of thymocytes: requirement of proteasome-dependent mitochondrial activity. J. Immunol. 170: 2469-2478
-
(2003)
J. Immunol.
, vol.170
, pp. 2469-2478
-
-
Tonomura, N.1
McLaughlin, K.2
Grimm, L.3
Goldsby, R.A.4
Osborne, B.A.5
-
111
-
-
0034607655
-
Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli
-
Yang Y., Fang S., Jensen J. P., Weissman A. M. and Ashwell J. D. (2000) Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli. Science 288: 874-877
-
(2000)
Science
, vol.288
, pp. 874-877
-
-
Yang, Y.1
Fang, S.2
Jensen, J.P.3
Weissman, A.M.4
Ashwell, J.D.5
-
112
-
-
0036911138
-
Hydrogen peroxide as second messenger in lymphocyte activation
-
Reth M. (2002) Hydrogen peroxide as second messenger in lymphocyte activation. Nat. Immunol. 3: 1129-1134
-
(2002)
Nat. Immunol.
, vol.3
, pp. 1129-1134
-
-
Reth, M.1
-
113
-
-
0033120424
-
Dexamethasone-induced thymocyte apoptosis: Apoptotic signal involves the sequential activation of phosphoinositide-specific phospholipase C, acidic sphingomyelinase, and caspases
-
Cifone M. G., Migliorati G., Parroni R., Marchetti C., Millimaggi D., Santoni A. et al. (1999) Dexamethasone-induced thymocyte apoptosis: apoptotic signal involves the sequential activation of phosphoinositide-specific phospholipase C, acidic sphingomyelinase, and caspases. Blood 93: 2282-2296
-
(1999)
Blood
, vol.93
, pp. 2282-2296
-
-
Cifone, M.G.1
Migliorati, G.2
Parroni, R.3
Marchetti, C.4
Millimaggi, D.5
Santoni, A.6
-
114
-
-
0031451872
-
A primary role for K+ and Na+ efflux in the activation of apoptosis
-
Bortner C. D., Hughes F. M. Jr and Cidlowski J. A. (1997) A primary role for K+ and Na+ efflux in the activation of apoptosis. J. Biol. Chem. 272: 32436-32442
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 32436-32442
-
-
Bortner, C.D.1
Hughes Jr., F.M.2
Cidlowski, J.A.3
-
115
-
-
0030973158
-
T cells deficient in inositol 1,4,5-trisphosphate receptor are resistant to apoptosis
-
Jayaraman T. and Marks A. R. (1997) T cells deficient in inositol 1,4,5-trisphosphate receptor are resistant to apoptosis. Mol. Cell. Biol. 17: 3005-3012
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 3005-3012
-
-
Jayaraman, T.1
Marks, A.R.2
-
116
-
-
0031865468
-
Transcriptional cross-talk, the second mode of steroid hormone receptor action
-
Göttlicher M., Heck S. and Herrlich P. (1998) Transcriptional cross-talk, the second mode of steroid hormone receptor action. J. Mol. Med. 76: 480-489
-
(1998)
J. Mol. Med.
, vol.76
, pp. 480-489
-
-
Göttlicher, M.1
Heck, S.2
Herrlich, P.3
-
117
-
-
0024379772
-
Steroid sensitivity of thymocyte subpopulations during intrathymic differentiation: Effects of 17 beta-estradiol and dexamethasone on subsets expressing T cell antigen receptor or IL-2 receptor
-
Screpanti I., Morrone S., Meco D., Santoni A., Gulino A., Paolini R. et al. (1989) Steroid sensitivity of thymocyte subpopulations during intrathymic differentiation: effects of 17 beta-estradiol and dexamethasone on subsets expressing T cell antigen receptor or IL-2 receptor. J. Immunol. 142: 3378-3383
-
(1989)
J. Immunol.
, vol.142
, pp. 3378-3383
-
-
Screpanti, I.1
Morrone, S.2
Meco, D.3
Santoni, A.4
Gulino, A.5
Paolini, R.6
-
118
-
-
0029014953
-
Cellular distribution and costimulatory function of rat CD28: Regulated expression during thymocyte maturation and induction of cyclosporin A sensitivity of costimulated T cell responses by phorbol ester
-
Tacke M., Clark G. J., Dallman M. J. and Hünig T. (1995) Cellular distribution and costimulatory function of rat CD28: regulated expression during thymocyte maturation and induction of cyclosporin A sensitivity of costimulated T cell responses by phorbol ester. J. Immunol. 154: 5121-5127
-
(1995)
J. Immunol.
, vol.154
, pp. 5121-5127
-
-
Tacke, M.1
Clark, G.J.2
Dallman, M.J.3
Hünig, T.4
-
119
-
-
0028136298
-
The costimulatory molecule B7 is expressed in the medullary region of the murine thymus
-
Reiser H. and Schneeberger E. E. (1994) The costimulatory molecule B7 is expressed in the medullary region of the murine thymus. Immunology 81: 532-537
-
(1994)
Immunology
, vol.81
, pp. 532-537
-
-
Reiser, H.1
Schneeberger, E.E.2
-
120
-
-
0027248447
-
bcl-2 proto-oncogene expression during human T cell development: Evidence for biphasic regulation
-
Gratiot-Deans J., Ding L., Turka L. A. and Nunez G. (1993) bcl-2 proto-oncogene expression during human T cell development: evidence for biphasic regulation. J. Immunol. 151: 83-91
-
(1993)
J. Immunol.
, vol.151
, pp. 83-91
-
-
Gratiot-Deans, J.1
Ding, L.2
Turka, L.A.3
Nunez, G.4
-
121
-
-
0027199233
-
Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes
-
Veis D. J., Sentman C. L., Bach E. A. and Korsmeyer S. J. (1993) Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes. J. Immunol. 151: 2546-2554
-
(1993)
J. Immunol.
, vol.151
, pp. 2546-2554
-
-
Veis, D.J.1
Sentman, C.L.2
Bach, E.A.3
Korsmeyer, S.J.4
-
122
-
-
0028970662
-
Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice
-
Grillot D. A., Merino R. and Nunez G. (1995) Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice. J. Exp. Med. 182: 1973-1983
-
(1995)
J. Exp. Med.
, vol.182
, pp. 1973-1983
-
-
Grillot, D.A.1
Merino, R.2
Nunez, G.3
-
123
-
-
0031907999
-
Thymocyte glucocorticoid resistance alters positive selection and inhibits autoimmunity and lymphoproliferative disease in MRL-lpr/lpr mice
-
Tolosa E., King L. B. and Ashwell J. D. (1998) Thymocyte glucocorticoid resistance alters positive selection and inhibits autoimmunity and lymphoproliferative disease in MRL-lpr/lpr mice. Immunity 8: 67-76
-
(1998)
Immunity
, vol.8
, pp. 67-76
-
-
Tolosa, E.1
King, L.B.2
Ashwell, J.D.3
-
124
-
-
0034143917
-
Thymocyte resistance to glucocorticoids leads to antigen-specific unresponsiveness due to holes in the T cell repertoire
-
Lu F. W., Yasutomo K., Goodman G. B., McHeyzer-Williams L. J., McHeyzer-Williams M. G., Germain R. N. et al. (2000) Thymocyte resistance to glucocorticoids leads to antigen-specific unresponsiveness due to holes in the T cell repertoire. Immunity 12: 183-192
-
(2000)
Immunity
, vol.12
, pp. 183-192
-
-
Lu, F.W.1
Yasutomo, K.2
Goodman, G.B.3
McHeyzer-Williams, L.J.4
McHeyzer-Williams, M.G.5
Germain, R.N.6
-
125
-
-
5644233890
-
Different roles for glucocorticoids in thymocyte homeostasis?
-
Jondal M., Pazirandeh A. and Okret S. (2004) Different roles for glucocorticoids in thymocyte homeostasis? Trends Immunol. 25: 595-600
-
(2004)
Trends Immunol.
, vol.25
, pp. 595-600
-
-
Jondal, M.1
Pazirandeh, A.2
Okret, S.3
-
126
-
-
0028233225
-
Steroid production in the thymus: Implications for thymocyte selection
-
Vacchio M. S., Papadopoulos V. and Ashwell J. D. (1994) Steroid production in the thymus: implications for thymocyte selection. J. Exp. Med. 179: 1835-1846
-
(1994)
J. Exp. Med.
, vol.179
, pp. 1835-1846
-
-
Vacchio, M.S.1
Papadopoulos, V.2
Ashwell, J.D.3
-
127
-
-
0032896835
-
Paracrine glucocorticoid activity produced by mouse thymic epithelial cells
-
Pazirandeh A., Xue Y., Rafter I., Sjovall J., Jondal M. and Okret S. (1999) Paracrine glucocorticoid activity produced by mouse thymic epithelial cells. FASEB J. 13: 893-901
-
(1999)
FASEB J.
, vol.13
, pp. 893-901
-
-
Pazirandeh, A.1
Xue, Y.2
Rafter, I.3
Sjovall, J.4
Jondal, M.5
Okret, S.6
-
128
-
-
0343550300
-
Glucocorticoid production in the murine thymus
-
Lechner O., Wiegers G. J., Oliveira-Dos-Santos A. J., Dietrich H., Recheis H., Waterman M. et al. (2000) Glucocorticoid production in the murine thymus. Eur. J. Immunol. 30: 337-346
-
(2000)
Eur. J. Immunol.
, vol.30
, pp. 337-346
-
-
Lechner, O.1
Wiegers, G.J.2
Oliveira-Dos-Santos, A.J.3
Dietrich, H.4
Recheis, H.5
Waterman, M.6
-
129
-
-
0022393794
-
Primary structure and expression of a functional human glucocorticoid receptor cDNA
-
Hollenberg S. M., Weinberger C., Ong E. S., Cerelli G., Oro A., Lebo R. et al. (1985) Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature 318: 635-641
-
(1985)
Nature
, vol.318
, pp. 635-641
-
-
Hollenberg, S.M.1
Weinberger, C.2
Ong, E.S.3
Cerelli, G.4
Oro, A.5
Lebo, R.6
-
130
-
-
0242417043
-
Mutually antagonistic signals regulate selection of the T cell repertoire
-
Stephens G. L., Ashwell J. D. and Ignatowicz L. (2003) Mutually antagonistic signals regulate selection of the T cell repertoire. Int. Immunol. 15: 623-632
-
(2003)
Int. Immunol.
, vol.15
, pp. 623-632
-
-
Stephens, G.L.1
Ashwell, J.D.2
Ignatowicz, L.3
-
131
-
-
0032797306
-
Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cells
-
Finotto S., Krieglstein K., Schober A., Deimling F., Lindner K., Bruhl B. et al. (1999) Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cells. Development 126: 2935-2944
-
(1999)
Development
, vol.126
, pp. 2935-2944
-
-
Finotto, S.1
Krieglstein, K.2
Schober, A.3
Deimling, F.4
Lindner, K.5
Bruhl, B.6
|