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Volumn 63, Issue 1, 2006, Pages 60-72

Glucocorticoids in T cell apoptosis and function

Author keywords

Apoptosis; Bcl 2 family; Caspase; Gene targeting; Glucocorticoid; T cell development; Transgenesis

Indexed keywords

CASPASE; CELL NUCLEUS RECEPTOR; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; PROTEIN BCL 2; STEROID HORMONE;

EID: 30744460611     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-005-5390-y     Document Type: Review
Times cited : (310)

References (131)
  • 2
    • 0030806085 scopus 로고    scopus 로고
    • In thymic selection, peptide diversity gives and takes away
    • Bevan M. J. (1997) In thymic selection, peptide diversity gives and takes away. Immunity 7: 175-178
    • (1997) Immunity , vol.7 , pp. 175-178
    • Bevan, M.J.1
  • 3
    • 0035366202 scopus 로고    scopus 로고
    • Activation-induced cell death
    • Budd R. C. (2001) Activation-induced cell death. Curr. Opin. Immunol. 13: 356-362
    • (2001) Curr. Opin. Immunol. , vol.13 , pp. 356-362
    • Budd, R.C.1
  • 4
    • 0038393112 scopus 로고    scopus 로고
    • Apoptosis in the development and maintenance of the immune system
    • Opferman J. T. and Korsmeyer S. J. (2003) Apoptosis in the development and maintenance of the immune system. Nat. Immunol. 4: 410-415
    • (2003) Nat. Immunol. , vol.4 , pp. 410-415
    • Opferman, J.T.1    Korsmeyer, S.J.2
  • 5
    • 18244397482 scopus 로고    scopus 로고
    • Molecular mechanisms of glucocorticoids in the control of inflammation and lymphocyte apoptosis
    • Tuckermann J. P., Kleiman A., McPherson K. G. and Reichardt H. M. (2005) Molecular mechanisms of glucocorticoids in the control of inflammation and lymphocyte apoptosis. Crit. Rev. Clin. Lab. Sci. 42: 71-104
    • (2005) Crit. Rev. Clin. Lab. Sci. , vol.42 , pp. 71-104
    • Tuckermann, J.P.1    Kleiman, A.2    McPherson, K.G.3    Reichardt, H.M.4
  • 6
    • 0018830636 scopus 로고
    • Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
    • Wyllie A. H. (1980) Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284: 555-556
    • (1980) Nature , vol.284 , pp. 555-556
    • Wyllie, A.H.1
  • 7
    • 0029618368 scopus 로고
    • Steroid hormone receptors: Many actors in search of a plot
    • Beato M., Herrlich P. and Schütz G. (1995) Steroid hormone receptors: many actors in search of a plot. Cell 83: 851-857
    • (1995) Cell , vol.83 , pp. 851-857
    • Beato, M.1    Herrlich, P.2    Schütz, G.3
  • 8
    • 18144444807 scopus 로고    scopus 로고
    • DNA binding of the glucocorticoid receptor is not essential for survival
    • Reichardt H. M., Kaestner K. H., Tuckermann J., Kretz O., Wessely O., Bock R. et al. (1998) DNA binding of the glucocorticoid receptor is not essential for survival. Cell 93: 531-541
    • (1998) Cell , vol.93 , pp. 531-541
    • Reichardt, H.M.1    Kaestner, K.H.2    Tuckermann, J.3    Kretz, O.4    Wessely, O.5    Bock, R.6
  • 9
    • 0036143203 scopus 로고    scopus 로고
    • Recent insights into the mechanism of glucocorticosteroid-induced apoptosis
    • Distelhorst C. W. (2002) Recent insights into the mechanism of glucocorticosteroid-induced apoptosis. Cell Death Differ. 9: 6-19
    • (2002) Cell Death Differ. , vol.9 , pp. 6-19
    • Distelhorst, C.W.1
  • 10
    • 8344271002 scopus 로고    scopus 로고
    • Mechanisms of glucocorticoid-induced apoptosis in hematologic malignancies: Updates
    • Frankfurt O. and Rosen S. T. (2004) Mechanisms of glucocorticoid-induced apoptosis in hematologic malignancies: updates. Curr. Opin. Oncol. 16: 553-563
    • (2004) Curr. Opin. Oncol. , vol.16 , pp. 553-563
    • Frankfurt, O.1    Rosen, S.T.2
  • 11
    • 0033735544 scopus 로고    scopus 로고
    • Glucocorticoids and thymocyte development
    • Vacchio M. S. and Ashwell J. D. (2000) Glucocorticoids and thymocyte development. Semin. Immunol. 12: 475-485
    • (2000) Semin. Immunol. , vol.12 , pp. 475-485
    • Vacchio, M.S.1    Ashwell, J.D.2
  • 12
    • 22144465538 scopus 로고    scopus 로고
    • Glucocorticoids inhibit activation-induced cell death (AICD) via direct DNA-dependent repression of the CD95 ligand gene by a glucocorticoid receptor dimer
    • Baumann S., Dostert A., Novac N., Bauer A., Schmid W., Fas S. C. et al. (2005) Glucocorticoids inhibit activation-induced cell death (AICD) via direct DNA-dependent repression of the CD95 ligand gene by a glucocorticoid receptor dimer. Blood 106: 617-625
    • (2005) Blood , vol.106 , pp. 617-625
    • Baumann, S.1    Dostert, A.2    Novac, N.3    Bauer, A.4    Schmid, W.5    Fas, S.C.6
  • 13
    • 0037103223 scopus 로고    scopus 로고
    • Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo
    • Brewer J. A., Kanagawa O., Sleckman B. P. and Muglia L. J. (2002) Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo. J. Immunol. 169: 1837-1843
    • (2002) J. Immunol. , vol.169 , pp. 1837-1843
    • Brewer, J.A.1    Kanagawa, O.2    Sleckman, B.P.3    Muglia, L.J.4
  • 15
    • 4444319484 scopus 로고    scopus 로고
    • Immunomodulatory activities of glucocorticoids: Insights from transgenesis and gene targeting
    • Reichardt H. M. (2004) Immunomodulatory activities of glucocorticoids: insights from transgenesis and gene targeting. Curr. Pharm. Des. 10: 2797-2805
    • (2004) Curr. Pharm. Des. , vol.10 , pp. 2797-2805
    • Reichardt, H.M.1
  • 17
    • 0029681032 scopus 로고    scopus 로고
    • Molecular chaperoning of steroid hormone receptors
    • Pratt W. B., Gehring U. and Toft D. O. (1996) Molecular chaperoning of steroid hormone receptors. EXS 11: 79-95
    • (1996) EXS , vol.11 , pp. 79-95
    • Pratt, W.B.1    Gehring, U.2    Toft, D.O.3
  • 18
    • 0025780755 scopus 로고
    • Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA
    • Luisi B. F., Xu W. X., Otwinowski Z., Freedman L. P., Yamamoto K. R. and Sigler P. B. (1991) Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA. Nature 352: 497-505
    • (1991) Nature , vol.352 , pp. 497-505
    • Luisi, B.F.1    Xu, W.X.2    Otwinowski, Z.3    Freedman, L.P.4    Yamamoto, K.R.5    Sigler, P.B.6
  • 19
    • 0035320538 scopus 로고    scopus 로고
    • Novel glucocorticoid receptor coactivator effector mechanisms
    • Jenkins B. D., Pullen C. B. and Darimont B. D. (2001) Novel glucocorticoid receptor coactivator effector mechanisms. Trends Endocrinol. Metab. 12: 122-126
    • (2001) Trends Endocrinol. Metab. , vol.12 , pp. 122-126
    • Jenkins, B.D.1    Pullen, C.B.2    Darimont, B.D.3
  • 20
    • 0037705388 scopus 로고    scopus 로고
    • Glucocorticoids inhibit apoptosis during fibrosarcoma development by transcriptionally activating Bcl-xL
    • Gascoyne D. M., Kypta R. M. and Vivanco M. M. (2003) Glucocorticoids inhibit apoptosis during fibrosarcoma development by transcriptionally activating Bcl-xL. J. Biol. Chem. 278: 18022-18029
    • (2003) J. Biol. Chem. , vol.278 , pp. 18022-18029
    • Gascoyne, D.M.1    Kypta, R.M.2    Vivanco, M.M.3
  • 21
    • 0035200120 scopus 로고    scopus 로고
    • Glucocorticoid receptor activation of the I kappa B alpha promoter within chromatin
    • Deroo B. J. and Archer T. K. (2001) Glucocorticoid receptor activation of the I kappa B alpha promoter within chromatin. Mol. Biol. Cell. 12: 3365-3374
    • (2001) Mol. Biol. Cell. , vol.12 , pp. 3365-3374
    • Deroo, B.J.1    Archer, T.K.2
  • 22
    • 0031415218 scopus 로고    scopus 로고
    • A new dexamethasone-induced gene of the leucine zipper family protects T lymphocytes from TCR/CD3-activated cell death
    • D'Adamio F., Zollo O., Moraca R., Ayroldi E., Bruscoli S., Bartoli A. et al. (1997) A new dexamethasone-induced gene of the leucine zipper family protects T lymphocytes from TCR/CD3-activated cell death. Immunity 7: 803-812
    • (1997) Immunity , vol.7 , pp. 803-812
    • D'Adamio, F.1    Zollo, O.2    Moraca, R.3    Ayroldi, E.4    Bruscoli, S.5    Bartoli, A.6
  • 23
    • 0030962132 scopus 로고    scopus 로고
    • A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis
    • USA
    • Nocentini G., Giunchi L., Ronchetti S., Krausz L. T. Bartoli A., Moraca R. et al. (1997) A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc. Natl. Acad. Sci. USA 94: 6216-6221
    • (1997) Proc. Natl. Acad. Sci. , vol.94 , pp. 6216-6221
    • Nocentini, G.1    Giunchi, L.2    Ronchetti, S.3    Krausz, L.T.4    Bartoli, A.5    Moraca, R.6
  • 24
    • 0023213560 scopus 로고
    • Transcription activation of the tyrosine aminotransferase gene by glucocorticoids and cAMP in primary hepatocytes
    • Schmid E., Schmid W., Jantzen M., Mayer D., Jastorff B. and Schutz G. (1987) Transcription activation of the tyrosine aminotransferase gene by glucocorticoids and cAMP in primary hepatocytes. Eur. J. Biochem. 165: 499-506
    • (1987) Eur. J. Biochem. , vol.165 , pp. 499-506
    • Schmid, E.1    Schmid, W.2    Jantzen, M.3    Mayer, D.4    Jastorff, B.5    Schutz, G.6
  • 25
    • 0030998776 scopus 로고    scopus 로고
    • Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression
    • Hanson R. W. and Reshef L. (1997) Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression. Annu. Rev. Biochem. 66: 581-611
    • (1997) Annu. Rev. Biochem. , vol.66 , pp. 581-611
    • Hanson, R.W.1    Reshef, L.2
  • 26
    • 0030789420 scopus 로고    scopus 로고
    • I kappaB alpha-independent downregulation of NF-kappaB activity by glucocorticoid receptor
    • Heck S., Bender K., Kullmann M., Gottlicher M., Herrlich P. and Cato A. C. (1997) I kappaB alpha-independent downregulation of NF-kappaB activity by glucocorticoid receptor. EMBO J. 16: 4698-4707
    • (1997) EMBO J. , vol.16 , pp. 4698-4707
    • Heck, S.1    Bender, K.2    Kullmann, M.3    Gottlicher, M.4    Herrlich, P.5    Cato, A.C.6
  • 27
    • 0027934108 scopus 로고
    • A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1
    • Heck S., Kullmann M., Gast A., Ponta H., Rahmsdorf H. J., Herrlich P. et al. (1994) A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1. EMBO J. 13: 4087-4095
    • (1994) EMBO J. , vol.13 , pp. 4087-4095
    • Heck, S.1    Kullmann, M.2    Gast, A.3    Ponta, H.4    Rahmsdorf, H.J.5    Herrlich, P.6
  • 28
    • 0026507209 scopus 로고
    • Glucocorticoid receptor-mediated suppression of the interleukin 2 gene expression through impairment of the cooperativity between nuclear factor of activated T cells and AP-1 enhancer elements
    • Vacca A., Felli M. P., Farina A. R., Martinotti S., Maroder M., Screpanti I. et al. (1992) Glucocorticoid receptor-mediated suppression of the interleukin 2 gene expression through impairment of the cooperativity between nuclear factor of activated T cells and AP-1 enhancer elements. J. Exp. Med. 175: 637-646
    • (1992) J. Exp. Med. , vol.175 , pp. 637-646
    • Vacca, A.1    Felli, M.P.2    Farina, A.R.3    Martinotti, S.4    Maroder, M.5    Screpanti, I.6
  • 29
    • 0027415164 scopus 로고
    • Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids
    • Imai E., Miner J. N., Mitchell J. A., Yamamoto K. R. and Granner D. K. (1993) Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids. J. Biol. Chem. 268: 5353-5356
    • (1993) J. Biol. Chem. , vol.268 , pp. 5353-5356
    • Imai, E.1    Miner, J.N.2    Mitchell, J.A.3    Yamamoto, K.R.4    Granner, D.K.5
  • 30
    • 0030868701 scopus 로고    scopus 로고
    • Specific DNA binding of Stat5, but not of glucocorticoid receptor, is required for their functional cooperation in the regulation of gene transcription
    • Stoecklin E., Wissler M., Moriggl R. and Groner B. (1997) Specific DNA binding of Stat5, but not of glucocorticoid receptor, is required for their functional cooperation in the regulation of gene transcription. Mol. Cell. Biol. 17: 6708-6716
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 6708-6716
    • Stoecklin, E.1    Wissler, M.2    Moriggl, R.3    Groner, B.4
  • 31
    • 0033611050 scopus 로고    scopus 로고
    • The DNA binding-independent function of the glucocorticoid receptor mediates repression of AP-1-dependent genes in skin
    • Tuckermann J. P., Reichardt H. M., Arribas R., Richter K. H., Schutz G. and Angel P. (1999) The DNA binding-independent function of the glucocorticoid receptor mediates repression of AP-1-dependent genes in skin. J. Cell. Biol. 147: 1365-1370
    • (1999) J. Cell. Biol. , vol.147 , pp. 1365-1370
    • Tuckermann, J.P.1    Reichardt, H.M.2    Arribas, R.3    Richter, K.H.4    Schutz, G.5    Angel, P.6
  • 32
    • 0034815629 scopus 로고    scopus 로고
    • Mammary gland development and lactation are controlled by different glucocorticoid receptor activities
    • Reichardt H. M., Horsch K., Gröne H. J., Kolbus A., Beug H., Hynes N. et al. (2001) Mammary gland development and lactation are controlled by different glucocorticoid receptor activities. Eur. J. Endocrinol. 145: 519-527
    • (2001) Eur. J. Endocrinol. , vol.145 , pp. 519-527
    • Reichardt, H.M.1    Horsch, K.2    Gröne, H.J.3    Kolbus, A.4    Beug, H.5    Hynes, N.6
  • 33
    • 0037126620 scopus 로고    scopus 로고
    • Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor
    • Reichardt H. M., Tuckermann J. P., Göttlicher M., Vujic M., Weih F., Angel P. et al. (2001) Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor. EMBO J. 20: 7168-7173.
    • (2001) EMBO J. , vol.20 , pp. 7168-7173
    • Reichardt, H.M.1    Tuckermann, J.P.2    Göttlicher, M.3    Vujic, M.4    Weih, F.5    Angel, P.6
  • 34
    • 12144287247 scopus 로고    scopus 로고
    • Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth
    • Tronche F., Opherk C., Moriggl R., Kellendonk C., Reimann A., Schwake L. et al. (2004) Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth. Genes Dev. 18: 492-497
    • (2004) Genes Dev. , vol.18 , pp. 492-497
    • Tronche, F.1    Opherk, C.2    Moriggl, R.3    Kellendonk, C.4    Reimann, A.5    Schwake, L.6
  • 35
    • 0036897343 scopus 로고    scopus 로고
    • Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids
    • Limbourg F. P., Huang Z., Plumier J. C., Simoncini T., Fujioka M., Tuckermann J. et al. (2002) Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids. J. Clin. Invest. 110: 1729-1738
    • (2002) J. Clin. Invest. , vol.110 , pp. 1729-1738
    • Limbourg, F.P.1    Huang, Z.2    Plumier, J.C.3    Simoncini, T.4    Fujioka, M.5    Tuckermann, J.6
  • 36
    • 20844437424 scopus 로고    scopus 로고
    • Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes
    • Lu N. Z. and Cidlowski J. A. (2005) Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes. Mol. Cell 18: 331-342
    • (2005) Mol. Cell , vol.18 , pp. 331-342
    • Lu, N.Z.1    Cidlowski, J.A.2
  • 37
    • 0034745378 scopus 로고    scopus 로고
    • 5′UTR sequences of the glucocorticoid receptor 1A transcript encode a peptide associated with translational regulation of the glucocorticoid receptor
    • Diba F., Watson C. S. and Gametchu B. (2001) 5′UTR sequences of the glucocorticoid receptor 1A transcript encode a peptide associated with translational regulation of the glucocorticoid receptor. J. Cell. Biochem. 81: 149-161
    • (2001) J. Cell. Biochem. , vol.81 , pp. 149-161
    • Diba, F.1    Watson, C.S.2    Gametchu, B.3
  • 38
    • 4644304217 scopus 로고    scopus 로고
    • Expression of the glucocorticoid receptor from the IA promoter correlates with T lymphocyte sensitivity to glucocorticoid-induced cell death
    • Purton J. F., Monk J. A., Liddicoat D. R., Kyparissoudis K., Sakkal S., Richardson S. J. et al. (2004) Expression of the glucocorticoid receptor from the IA promoter correlates with T lymphocyte sensitivity to glucocorticoid- induced cell death. J. Immunol. 173: 3816-3824
    • (2004) J. Immunol. , vol.173 , pp. 3816-3824
    • Purton, J.F.1    Monk, J.A.2    Liddicoat, D.R.3    Kyparissoudis, K.4    Sakkal, S.5    Richardson, S.J.6
  • 39
    • 18144399332 scopus 로고    scopus 로고
    • The human glucocorticoid receptor: One gene, multiple proteins and diverse responses
    • Zhou J. and Cidlowski J. A. (2005) The human glucocorticoid receptor: one gene, multiple proteins and diverse responses. Steroids 70: 407-417
    • (2005) Steroids , vol.70 , pp. 407-417
    • Zhou, J.1    Cidlowski, J.A.2
  • 40
    • 3342979528 scopus 로고    scopus 로고
    • Glucocorticoid regulation of the inflammatory response to injury
    • Yeager M. P., Guyre P. M. and Munck A. U. (2004) Glucocorticoid regulation of the inflammatory response to injury. Acta Anaesthesiol. Scand. 48: 799-813
    • (2004) Acta Anaesthesiol. Scand. , vol.48 , pp. 799-813
    • Yeager, M.P.1    Guyre, P.M.2    Munck, A.U.3
  • 41
    • 76549251874 scopus 로고
    • Effects of cortisone acetate and pituitray ACTH on rheumatoid arthritis, rheumatic fever and certain other conditions
    • Hench P. S., Kendall E. C., Slocumb C. H. and Policy H. F. (1950) Effects of cortisone acetate and pituitray ACTH on rheumatoid arthritis, rheumatic fever and certain other conditions. Arch. Intern. Med. 85: 545-566
    • (1950) Arch. Intern. Med. , vol.85 , pp. 545-566
    • Hench, P.S.1    Kendall, E.C.2    Slocumb, C.H.3    Policy, H.F.4
  • 44
    • 0028806218 scopus 로고
    • A targeted glucocorticoid receptor antisense transgene increases thymocyte apoptosis and alters thymocyte development
    • King L. B., Vacchio M. S., Dixon K., Hunziker R., Margulies D. H. and Ashwell J. D. (1995) A targeted glucocorticoid receptor antisense transgene increases thymocyte apoptosis and alters thymocyte development. Immunity 3: 647-656
    • (1995) Immunity , vol.3 , pp. 647-656
    • King, L.B.1    Vacchio, M.S.2    Dixon, K.3    Hunziker, R.4    Margulies, D.H.5    Ashwell, J.D.6
  • 45
    • 0036581326 scopus 로고    scopus 로고
    • Effects of altered glucocorticoid sensitivity in the T cell lineage on thymocyte and T cell homeostasis
    • Pazirandeh A., Xue Y., Prestegaard T., Jondal M. and Okret S. (2002) Effects of altered glucocorticoid sensitivity in the T cell lineage on thymocyte and T cell homeostasis. FASEB J. 16: 727-729
    • (2002) FASEB J. , vol.16 , pp. 727-729
    • Pazirandeh, A.1    Xue, Y.2    Prestegaard, T.3    Jondal, M.4    Okret, S.5
  • 46
    • 0029088326 scopus 로고
    • Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation
    • Cole T. J., Blendy J. A., Monaghan A. P., Krieglstein K., Schmid W., Aguzzi A. et al. (1995) Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes Dev. 9: 1608-1621
    • (1995) Genes Dev. , vol.9 , pp. 1608-1621
    • Cole, T.J.1    Blendy, J.A.2    Monaghan, A.P.3    Krieglstein, K.4    Schmid, W.5    Aguzzi, A.6
  • 47
    • 0033715726 scopus 로고    scopus 로고
    • Intrathymic T cell development and selection proceeds normally in the absence of glucocorticoid receptor signaling
    • Purton J. F., Boyd R. L., Cole T. J. and Godfrey D. I. (2000) Intrathymic T cell development and selection proceeds normally in the absence of glucocorticoid receptor signaling. Immunity 13: 179-186
    • (2000) Immunity , vol.13 , pp. 179-186
    • Purton, J.F.1    Boyd, R.L.2    Cole, T.J.3    Godfrey, D.I.4
  • 48
    • 0036909641 scopus 로고    scopus 로고
    • Glucocorticoid receptor deficient thymic and peripheral T cells develop normally in adult mice
    • Purton J. F., Zhan Y., Liddicoat D. R., Hardy C. L., Lew A. M., Cole T. J. et al. (2002) Glucocorticoid receptor deficient thymic and peripheral T cells develop normally in adult mice. Eur. J. Immunol. 32: 3546-3555
    • (2002) Eur. J. Immunol. , vol.32 , pp. 3546-3555
    • Purton, J.F.1    Zhan, Y.2    Liddicoat, D.R.3    Hardy, C.L.4    Lew, A.M.5    Cole, T.J.6
  • 49
    • 0142137222 scopus 로고    scopus 로고
    • T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation
    • Brewer J. A., Khor B., Vogt S. K., Muglia L. M., Fujiwara H., Haegele K. E. et al. (2003) T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation. Nat. Med. 9: 1318-1322
    • (2003) Nat. Med. , vol.9 , pp. 1318-1322
    • Brewer, J.A.1    Khor, B.2    Vogt, S.K.3    Muglia, L.M.4    Fujiwara, H.5    Haegele, K.E.6
  • 50
    • 0034460335 scopus 로고    scopus 로고
    • Mice with an increased glucocorticoid receptor gene dosage show enhanced resistance to stress and endotoxic shock
    • Reichardt H. M., Umland T., Bauer A., Kretz O. and Schütz G. (2000) Mice with an increased glucocorticoid receptor gene dosage show enhanced resistance to stress and endotoxic shock. Mol. Cell. Biol. 20: 9009-9017
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 9009-9017
    • Reichardt, H.M.1    Umland, T.2    Bauer, A.3    Kretz, O.4    Schütz, G.5
  • 51
    • 18844421375 scopus 로고    scopus 로고
    • Conditional expression of a glucocorticoid receptor transgene in thymocytes reveals a role for thymic-derived glucocorticoids in thymopoiesis in vivo
    • Pazirandeh A., Jondal M. and Okret S. (2005) Conditional expression of a glucocorticoid receptor transgene in thymocytes reveals a role for thymic-derived glucocorticoids in thymopoiesis in vivo. Endocrinology 146: 2501-2507
    • (2005) Endocrinology , vol.146 , pp. 2501-2507
    • Pazirandeh, A.1    Jondal, M.2    Okret, S.3
  • 52
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner M. O. (2000) The biochemistry of apoptosis. Nature 407: 770-776
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 53
    • 14944348965 scopus 로고    scopus 로고
    • The role of BH3-only proteins in the immune system
    • Strasser A. (2005) The role of BH3-only proteins in the immune system. Nat. Rev. Immunol. 5: 189-200
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 189-200
    • Strasser, A.1
  • 54
    • 0035890085 scopus 로고    scopus 로고
    • The expanding role of mitochondria in apoptosis
    • Wang X. (2001) The expanding role of mitochondria in apoptosis. Genes Dev. 15: 2922-2933
    • (2001) Genes Dev. , vol.15 , pp. 2922-2933
    • Wang, X.1
  • 55
    • 0034786019 scopus 로고    scopus 로고
    • BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis
    • Cheng E. H., Wei M. C., Weiler S., Flavell R. A., Mak T. W., Lindsten T. et al. (2001) BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol. Cell 8: 705-711
    • (2001) Mol. Cell , vol.8 , pp. 705-711
    • Cheng, E.H.1    Wei, M.C.2    Weiler, S.3    Flavell, R.A.4    Mak, T.W.5    Lindsten, T.6
  • 56
    • 3442886811 scopus 로고    scopus 로고
    • The pathophysiology of mitochondrial cell death
    • Green D. R. and Kroemer G. (2004) The pathophysiology of mitochondrial cell death. Science 305: 626-629
    • (2004) Science , vol.305 , pp. 626-629
    • Green, D.R.1    Kroemer, G.2
  • 57
    • 0033558215 scopus 로고    scopus 로고
    • The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis
    • Zong W. X., Edelstein L. C., Chen C., Bash J. and Gelinas C. (1999) The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis. Genes Dev. 13: 382-387
    • (1999) Genes Dev. , vol.13 , pp. 382-387
    • Zong, W.X.1    Edelstein, L.C.2    Chen, C.3    Bash, J.4    Gelinas, C.5
  • 58
    • 0037421190 scopus 로고    scopus 로고
    • Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane
    • Kaufmann T., Schlipf S., Sanz J., Neubert K., Stein R. and Borner C. (2003) Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane. J. Cell. Biol. 160: 53-64
    • (2003) J. Cell. Biol. , vol.160 , pp. 53-64
    • Kaufmann, T.1    Schlipf, S.2    Sanz, J.3    Neubert, K.4    Stein, R.5    Borner, C.6
  • 59
    • 1842472069 scopus 로고    scopus 로고
    • Phosphorylation of BCL-2 regulates ER Ca(2+) homeostasis and apoptosis
    • Bassik M. C., Scorrano L., Oakes S. A., Pozzan T. and Korsmeyer S. J. (2004) Phosphorylation of BCL-2 regulates ER Ca(2+) homeostasis and apoptosis. EMBO J. 23: 1207-1216
    • (2004) EMBO J. , vol.23 , pp. 1207-1216
    • Bassik, M.C.1    Scorrano, L.2    Oakes, S.A.3    Pozzan, T.4    Korsmeyer, S.J.5
  • 60
    • 7644231187 scopus 로고    scopus 로고
    • Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis
    • Herrant M., Jacquel A., Marchetti S., Belhacene N., Colosetti P., Luciano F. et al. (2004) Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis. Oncogene 23: 7863-7873
    • (2004) Oncogene , vol.23 , pp. 7863-7873
    • Herrant, M.1    Jacquel, A.2    Marchetti, S.3    Belhacene, N.4    Colosetti, P.5    Luciano, F.6
  • 62
    • 14644412456 scopus 로고    scopus 로고
    • Do inducers of apoptosis trigger caspase-independent cell death?
    • Chipuk J. E. and Green D. R. (2005) Do inducers of apoptosis trigger caspase-independent cell death? Nat. Rev. Mol. Cell Biol. 6: 268-275
    • (2005) Nat. Rev. Mol. Cell Biol. , vol.6 , pp. 268-275
    • Chipuk, J.E.1    Green, D.R.2
  • 63
    • 22544444514 scopus 로고    scopus 로고
    • Caspase-independent cell death
    • Kroemer G. and Martin S. J. (2005) Caspase-independent cell death. Nat. Med. 11: 725-730
    • (2005) Nat. Med. , vol.11 , pp. 725-730
    • Kroemer, G.1    Martin, S.J.2
  • 64
    • 0242579153 scopus 로고    scopus 로고
    • Cathepsin-B-dependent apoptosis triggered by antithymocyte globulins: A novel mechanism of T-cell depletion
    • Michallet M. C., Saltel F., Preville X., Flacher M., Revillard J. P. and Genestier L. (2003) Cathepsin-B-dependent apoptosis triggered by antithymocyte globulins: a novel mechanism of T-cell depletion. Blood 102: 3719-3726
    • (2003) Blood , vol.102 , pp. 3719-3726
    • Michallet, M.C.1    Saltel, F.2    Preville, X.3    Flacher, M.4    Revillard, J.P.5    Genestier, L.6
  • 65
    • 0043234207 scopus 로고    scopus 로고
    • Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis
    • Bidere N., Lorenzo H. K., Carmona S., Laforge M., Harper F., Dumont C. et al. (2003) Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis. J. Biol. Chem. 278: 31401-31411
    • (2003) J. Biol. Chem. , vol.278 , pp. 31401-31411
    • Bidere, N.1    Lorenzo, H.K.2    Carmona, S.3    Laforge, M.4    Harper, F.5    Dumont, C.6
  • 67
    • 4544385218 scopus 로고    scopus 로고
    • Autophagy: Many paths to the same end
    • Cuervo A. M. (2004) Autophagy: many paths to the same end. Mol. Cell. Biochem. 263: 55-72
    • (2004) Mol. Cell. Biochem. , vol.263 , pp. 55-72
    • Cuervo, A.M.1
  • 68
    • 4644295842 scopus 로고    scopus 로고
    • Serine protease inhibitor 2A is a protective factor for memory T cell development
    • Liu N., Phillips T., Zhang M., Wang Y. Opferman J. T., Shah R. et al. (2004) Serine protease inhibitor 2A is a protective factor for memory T cell development. Nat. Immunol. 5: 919-926
    • (2004) Nat. Immunol. , vol.5 , pp. 919-926
    • Liu, N.1    Phillips, T.2    Zhang, M.3    Wang, Y.4    Opferman, J.T.5    Shah, R.6
  • 69
    • 0023609541 scopus 로고
    • Glucocorticoid regulation of transcription of the c-myc cellular protooncogene in P1798 cells
    • Forsthoefel A. M. and Thompson E. A. (1987) Glucocorticoid regulation of transcription of the c-myc cellular protooncogene in P1798 cells. Mol. Endocrinol. 1: 899-907
    • (1987) Mol. Endocrinol. , vol.1 , pp. 899-907
    • Forsthoefel, A.M.1    Thompson, E.A.2
  • 70
    • 0037944248 scopus 로고    scopus 로고
    • Critical function of T cell death-associated gene 8 in glucocorticoid-induced thymocyte apoptosis
    • Tosa N., Murakami M., Jia W. Y., Yokoyama M., Masunaga T., Iwabuchi C. et al. (2003) Critical function of T cell death-associated gene 8 in glucocorticoid-induced thymocyte apoptosis. Int. Immunol. 15: 741-749
    • (2003) Int. Immunol. , vol.15 , pp. 741-749
    • Tosa, N.1    Murakami, M.2    Jia, W.Y.3    Yokoyama, M.4    Masunaga, T.5    Iwabuchi, C.6
  • 71
    • 11244287290 scopus 로고    scopus 로고
    • The glucocorticoid-induced gene tdag8 encodes a pro-apoptotic G protein-coupled receptor whose activation promotes glucocorticoid-induced apoptosis
    • Malone M. H., Wang Z. and Distelhorst C. W. (2004) The glucocorticoid-induced gene tdag8 encodes a pro-apoptotic G protein-coupled receptor whose activation promotes glucocorticoid-induced apoptosis. J. Biol. Chem. 279: 52850-52859
    • (2004) J. Biol. Chem. , vol.279 , pp. 52850-52859
    • Malone, M.H.1    Wang, Z.2    Distelhorst, C.W.3
  • 72
    • 0038373385 scopus 로고    scopus 로고
    • Dexamethasone-induced gene 2 (dig2) is a novel pro-survival stress gene induced rapidly by diverse apoptotic signals
    • Wang Z., Malone M. H., Thomenius M. J., Zhong F., Xu F. and Distelhorst C. W. (2003) Dexamethasone-induced gene 2 (dig2) is a novel pro-survival stress gene induced rapidly by diverse apoptotic signals. J. Biol. Chem. 278: 27053-27058
    • (2003) J. Biol. Chem. , vol.278 , pp. 27053-27058
    • Wang, Z.1    Malone, M.H.2    Thomenius, M.J.3    Zhong, F.4    Xu, F.5    Distelhorst, C.W.6
  • 73
    • 0037592259 scopus 로고    scopus 로고
    • Microarray analysis uncovers the induction of the proapoptotic BH3-only protein Bim in multiple models of glucocorticoid-induced apoptosis
    • Wang Z., Malone M. H., He H., McColl K. S. and Distelhorst C. W. (2003) Microarray analysis uncovers the induction of the proapoptotic BH3-only protein Bim in multiple models of glucocorticoid-induced apoptosis. J. Biol. Chem. 278: 23861-23867
    • (2003) J. Biol. Chem. , vol.278 , pp. 23861-23867
    • Wang, Z.1    Malone, M.H.2    He, H.3    McColl, K.S.4    Distelhorst, C.W.5
  • 74
    • 11244305855 scopus 로고    scopus 로고
    • Inhibition of glucocorticoid-induced apoptosis by targeting the major splice variants of BIM mRNA with small interfering RNA and short hairpin RNA
    • Abrams M. T., Robertson N. M., Yoon K. and Wickstrom E. (2004) Inhibition of glucocorticoid-induced apoptosis by targeting the major splice variants of BIM mRNA with small interfering RNA and short hairpin RNA. J. Biol. Chem. 279: 55809-55817
    • (2004) J. Biol. Chem. , vol.279 , pp. 55809-55817
    • Abrams, M.T.1    Robertson, N.M.2    Yoon, K.3    Wickstrom, E.4
  • 75
    • 0035949470 scopus 로고    scopus 로고
    • Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals
    • USA
    • Han J., Flemington C., Houghton A. B., Gu Z., Zambetti G. P., Lutz R. J. et al. (2001) Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. Proc. Natl. Acad. Sci. USA 98: 11318-11323
    • (2001) Proc. Natl. Acad. Sci. , vol.98 , pp. 11318-11323
    • Han, J.1    Flemington, C.2    Houghton, A.B.3    Gu, Z.4    Zambetti, G.P.5    Lutz, R.J.6
  • 76
    • 0035088322 scopus 로고    scopus 로고
    • Gene expression profiles of proliferating vs. G1/G0 arrested human leukemia cells suggest a mechanism for glucocorticoid-induced apoptosis
    • Tonko M., Ausserlechner M. J., Bernhard D., Helmberg A. and Kofler R. (2001) Gene expression profiles of proliferating vs. G1/G0 arrested human leukemia cells suggest a mechanism for glucocorticoid-induced apoptosis. FASEB J. 15: 693-699
    • (2001) FASEB J. , vol.15 , pp. 693-699
    • Tonko, M.1    Ausserlechner, M.J.2    Bernhard, D.3    Helmberg, A.4    Kofler, R.5
  • 77
    • 0038362418 scopus 로고    scopus 로고
    • Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis
    • Medh R. D., Webb M. S., Miller A. L., Johnson B. H., Fofanov Y., Li T. et al. (2003) Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics 81: 543-555
    • (2003) Genomics , vol.81 , pp. 543-555
    • Medh, R.D.1    Webb, M.S.2    Miller, A.L.3    Johnson, B.H.4    Fofanov, Y.5    Li, T.6
  • 78
    • 0033607506 scopus 로고    scopus 로고
    • Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
    • Bouillet P., Metcalf D., Huang D. C., Tarlinton D. M., Kay T. W., Kontgen F. et al. (1999) Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286: 1735-1738
    • (1999) Science , vol.286 , pp. 1735-1738
    • Bouillet, P.1    Metcalf, D.2    Huang, D.C.3    Tarlinton, D.M.4    Kay, T.W.5    Kontgen, F.6
  • 79
    • 0037057629 scopus 로고    scopus 로고
    • Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome
    • Marsden V. S., O'Connor L., O'Reilly L. A., Silke J., Metcalf D., Ekert P. G. et al. (2002) Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome. Nature 419: 634-637
    • (2002) Nature , vol.419 , pp. 634-637
    • Marsden, V.S.1    O'Connor, L.2    O'Reilly, L.A.3    Silke, J.4    Metcalf, D.5    Ekert, P.G.6
  • 80
    • 0028790829 scopus 로고
    • Bcl-2 blocks glucocorticoid- but not Fas- or activation-induced apoptosis in a T cell hybridoma
    • Memon S. A., Moreno M. B., Petrak D. and Zacharchuk C. M. (1995) Bcl-2 blocks glucocorticoid- but not Fas- or activation-induced apoptosis in a T cell hybridoma. J. Immunol. 155: 4644-4652
    • (1995) J. Immunol. , vol.155 , pp. 4644-4652
    • Memon, S.A.1    Moreno, M.B.2    Petrak, D.3    Zacharchuk, C.M.4
  • 81
    • 0036275462 scopus 로고    scopus 로고
    • Phosphorylation status modulates Bcl-2 function during glucocorticoid-induced apoptosis in T lymphocytes
    • Huang S. T. and Cidlowski J. A. (2002) Phosphorylation status modulates Bcl-2 function during glucocorticoid-induced apoptosis in T lymphocytes. FASEB J. 16: 825-832
    • (2002) FASEB J. , vol.16 , pp. 825-832
    • Huang, S.T.1    Cidlowski, J.A.2
  • 82
    • 0034464839 scopus 로고    scopus 로고
    • Delineation of the signaling pathways involved in glucocorticoid-induced and spontaneous apoptosis of rat thymocytes
    • Mann C. L., Hughes F. M. Jr and Cidlowski J. A. (2000) Delineation of the signaling pathways involved in glucocorticoid-induced and spontaneous apoptosis of rat thymocytes. Endocrinology 141: 528-538
    • (2000) Endocrinology , vol.141 , pp. 528-538
    • Mann, C.L.1    Hughes Jr., F.M.2    Cidlowski, J.A.3
  • 83
    • 0033521741 scopus 로고    scopus 로고
    • Molecular characterization of mitochondrial apoptosis-inducing factor
    • Susin S. A., Lorenzo H. K., Zamzami N., Marzo I., Snow B. E., Brothers G. M. et al. (1999) Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397: 441-446
    • (1999) Nature , vol.397 , pp. 441-446
    • Susin, S.A.1    Lorenzo, H.K.2    Zamzami, N.3    Marzo, I.4    Snow, B.E.5    Brothers, G.M.6
  • 84
    • 0027427492 scopus 로고
    • Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair
    • Veis D. J., Sorenson C. M., Shutter J. R. and Korsmeyer S. J. (1993) Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 75: 229-240
    • (1993) Cell , vol.75 , pp. 229-240
    • Veis, D.J.1    Sorenson, C.M.2    Shutter, J.R.3    Korsmeyer, S.J.4
  • 85
    • 0030963602 scopus 로고    scopus 로고
    • Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis
    • USA
    • Hsu Y. T., Wolter K. G. and Youle R. J. (1997) Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis. Proc. Natl. Acad. Sci. USA 94: 3668-3672
    • (1997) Proc. Natl. Acad. Sci. , vol.94 , pp. 3668-3672
    • Hsu, Y.T.1    Wolter, K.G.2    Youle, R.J.3
  • 86
    • 0033120383 scopus 로고    scopus 로고
    • Subcellular distribution and redistribution of Bcl-2 family proteins in human leukemia cells undergoing apoptosis
    • Jia L., Macey M. G., Yin Y. Newland A. C. and Kelsey S. M. (1999) Subcellular distribution and redistribution of Bcl-2 family proteins in human leukemia cells undergoing apoptosis. Blood 93: 2353-2359
    • (1999) Blood , vol.93 , pp. 2353-2359
    • Jia, L.1    Macey, M.G.2    Yin, Y.3    Newland, A.C.4    Kelsey, S.M.5
  • 87
    • 1542267685 scopus 로고    scopus 로고
    • Resistance of single-positive thymocytes to glucocorticoid-induced apoptosis is mediated by CD28 signaling
    • Brandt J. van den, Wang D. and Reichardt H. M. (2004) Resistance of single-positive thymocytes to glucocorticoid-induced apoptosis is mediated by CD28 signaling. Mol. Endocrinol. 18: 687-695
    • (2004) Mol. Endocrinol. , vol.18 , pp. 687-695
    • Van Den Brandt, J.1    Wang, D.2    Reichardt, H.M.3
  • 88
    • 0028922885 scopus 로고
    • Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice
    • Motoyama N., Wang F., Roth K. A., Sawa H., Nakayama K., Negishi I. et al. (1995) Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science 267: 1506-1510
    • (1995) Science , vol.267 , pp. 1506-1510
    • Motoyama, N.1    Wang, F.2    Roth, K.A.3    Sawa, H.4    Nakayama, K.5    Negishi, I.6
  • 89
    • 0034508217 scopus 로고    scopus 로고
    • The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues
    • Lindsten T., Ross A. J., King A., Zong W. X., Rathmell J. C., Shiels H. A. et al. (2000) The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol. Cell 6: 1389-1399
    • (2000) Mol. Cell , vol.6 , pp. 1389-1399
    • Lindsten, T.1    Ross, A.J.2    King, A.3    Zong, W.X.4    Rathmell, J.C.5    Shiels, H.A.6
  • 90
    • 0035957653 scopus 로고    scopus 로고
    • Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death
    • Wei M. C., Zong W. X., Cheng E. H., Lindsten T., Panoutsakopoulou V., Ross A. J. et al. (2001) Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292: 727-730
    • (2001) Science , vol.292 , pp. 727-730
    • Wei, M.C.1    Zong, W.X.2    Cheng, E.H.3    Lindsten, T.4    Panoutsakopoulou, V.5    Ross, A.J.6
  • 91
    • 0035876483 scopus 로고    scopus 로고
    • BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak
    • Zong W. X., Lindsten T., Ross A. J., MacGregor G. R. and Thompson C. B. (2001) BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak. Genes Dev. 15: 1481-1486
    • (2001) Genes Dev. , vol.15 , pp. 1481-1486
    • Zong, W.X.1    Lindsten, T.2    Ross, A.J.3    MacGregor, G.R.4    Thompson, C.B.5
  • 92
    • 0036794390 scopus 로고    scopus 로고
    • Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis
    • Rathmell J. C., Lindsten T., Zong W. X., Cinalli R. M. and Thompson C. B. (2002) Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. Nat. Immunol. 3: 932-939
    • (2002) Nat. Immunol. , vol.3 , pp. 932-939
    • Rathmell, J.C.1    Lindsten, T.2    Zong, W.X.3    Cinalli, R.M.4    Thompson, C.B.5
  • 93
    • 0038021272 scopus 로고    scopus 로고
    • Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more
    • Marsden V. S. and Strasser A. (2003) Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more. Annu. Rev. Immunol. 21: 71-105
    • (2003) Annu. Rev. Immunol. , vol.21 , pp. 71-105
    • Marsden, V.S.1    Strasser, A.2
  • 94
    • 0033944665 scopus 로고    scopus 로고
    • Bid, a critical mediator for apoptosis induced by the activation of Fas/TNF-R1 death receptors in hepatocytes
    • Yin X. M. (2000) Bid, a critical mediator for apoptosis induced by the activation of Fas/TNF-R1 death receptors in hepatocytes. J. Mol. Med. 78: 203-211
    • (2000) J. Mol. Med. , vol.78 , pp. 203-211
    • Yin, X.M.1
  • 95
    • 0033607006 scopus 로고    scopus 로고
    • Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis
    • Yin X. M., Wang K., Gross A., Zhao Y., Zinkel S., Klocke B. et al. (1999) Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature 400: 886-891
    • (1999) Nature , vol.400 , pp. 886-891
    • Yin, X.M.1    Wang, K.2    Gross, A.3    Zhao, Y.4    Zinkel, S.5    Klocke, B.6
  • 96
    • 0345129987 scopus 로고    scopus 로고
    • Bad can act as a key regulator of T cell apoptosis and T cell development
    • Mok C. L., Gil-Gomez G., Williams O., Coles M., Taga S., Tolaini M. et al. (1999) Bad can act as a key regulator of T cell apoptosis and T cell development. J. Exp. Med. 189: 575-586
    • (1999) J. Exp. Med. , vol.189 , pp. 575-586
    • Mok, C.L.1    Gil-Gomez, G.2    Williams, O.3    Coles, M.4    Taga, S.5    Tolaini, M.6
  • 97
    • 0036849192 scopus 로고    scopus 로고
    • Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis
    • Datta S. R., Ranger A. M., Lin M. Z., Sturgill J. F., Ma Y. C., Cowan C. W. et al. (2002) Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev. Cell 3: 631-643
    • (2002) Dev. Cell , vol.3 , pp. 631-643
    • Datta, S.R.1    Ranger, A.M.2    Lin, M.Z.3    Sturgill, J.F.4    Ma, Y.C.5    Cowan, C.W.6
  • 99
    • 10744228800 scopus 로고    scopus 로고
    • Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
    • Jeffers J. R., Parganas E., Lee Y. Yang C., Wang J., Brennan J. et al. (2003) Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 4: 321-328
    • (2003) Cancer Cell , vol.4 , pp. 321-328
    • Jeffers, J.R.1    Parganas, E.2    Lee, Y.3    Yang, C.4    Wang, J.5    Brennan, J.6
  • 100
    • 0242410719 scopus 로고    scopus 로고
    • p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa
    • Villunger A., Michalak E. M., Coultas L., Mullauer F., Bock G., Ausserlechner M. J. et al. (2003) p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 302: 1036-1038
    • (2003) Science , vol.302 , pp. 1036-1038
    • Villunger, A.1    Michalak, E.M.2    Coultas, L.3    Mullauer, F.4    Bock, G.5    Ausserlechner, M.J.6
  • 102
    • 0032052315 scopus 로고    scopus 로고
    • Glucocorticoid-induced thymocyte apoptosis: Protease-dependent activation of cell shrinkage and DNA degradation
    • Hughes F. M. Jr and Cidlowski J. A. (1998) Glucocorticoid-induced thymocyte apoptosis: protease-dependent activation of cell shrinkage and DNA degradation. J. Steroid Biochem. Mol. Biol. 65: 207-217
    • (1998) J. Steroid Biochem. Mol. Biol. , vol.65 , pp. 207-217
    • Hughes Jr., F.M.1    Cidlowski, J.A.2
  • 103
    • 0037438473 scopus 로고    scopus 로고
    • Dexamethasone-induced apoptosis of thymocytes: Role of glucocorticoid receptor-associated Src kinase and caspase-8 activation
    • Marchetti M. C., Di Marco B., Cifone G., Migliorati G. and Riccardi C. (2003) Dexamethasone-induced apoptosis of thymocytes: role of glucocorticoid receptor-associated Src kinase and caspase-8 activation. Blood 101: 585-593
    • (2003) Blood , vol.101 , pp. 585-593
    • Marchetti, M.C.1    Di Marco, B.2    Cifone, G.3    Migliorati, G.4    Riccardi, C.5
  • 104
    • 0031044777 scopus 로고    scopus 로고
    • Characterization of mice deficient in interleukin-1 beta converting enzyme
    • Li P., Allen H., Banerjee S. and Seshadri T. (1997) Characterization of mice deficient in interleukin-1 beta converting enzyme. J. Cell. Biochem. 64: 27-32
    • (1997) J. Cell. Biochem. , vol.64 , pp. 27-32
    • Li, P.1    Allen, H.2    Banerjee, S.3    Seshadri, T.4
  • 105
    • 0036024020 scopus 로고    scopus 로고
    • Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9
    • O'Reilly L. A., Ekert P., Harvey N., Marsden V., Cullen L., Vaux D. L. et al. (2002) Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9. Cell Death Differ. 9: 832-841
    • (2002) Cell Death Differ. , vol.9 , pp. 832-841
    • O'Reilly, L.A.1    Ekert, P.2    Harvey, N.3    Marsden, V.4    Cullen, L.5    Vaux, D.L.6
  • 107
    • 0032493910 scopus 로고    scopus 로고
    • Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
    • Kuida K., Haydar T. F., Kuan C. Y., Gu Y., Taya C., Karasuyama H. et al. (1998) Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94: 325-337
    • (1998) Cell , vol.94 , pp. 325-337
    • Kuida, K.1    Haydar, T.F.2    Kuan, C.Y.3    Gu, Y.4    Taya, C.5    Karasuyama, H.6
  • 108
    • 0032544564 scopus 로고    scopus 로고
    • Apaf1 is required for mitochondrial pathways of apoptosis and brain development
    • Yoshida H., Kong Y. Y., Yoshida R., Elia A. J., Hakem A., Hakem R. et al. (1998) Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Cell 94: 739-750
    • (1998) Cell , vol.94 , pp. 739-750
    • Yoshida, H.1    Kong, Y.Y.2    Yoshida, R.3    Elia, A.J.4    Hakem, A.5    Hakem, R.6
  • 109
    • 0029956641 scopus 로고    scopus 로고
    • Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
    • Kuida K., Zheng T. S., Na S., Kuan C., Yang D., Karasuyama H. et al. (1996) Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384: 368-372
    • (1996) Nature , vol.384 , pp. 368-372
    • Kuida, K.1    Zheng, T.S.2    Na, S.3    Kuan, C.4    Yang, D.5    Karasuyama, H.6
  • 110
    • 0344211823 scopus 로고    scopus 로고
    • Glucocorticoid-induced apoptosis of thymocytes: Requirement of proteasome-dependent mitochondrial activity
    • Tonomura N., McLaughlin K., Grimm L., Goldsby R. A. and Osborne B. A. (2003) Glucocorticoid-induced apoptosis of thymocytes: requirement of proteasome-dependent mitochondrial activity. J. Immunol. 170: 2469-2478
    • (2003) J. Immunol. , vol.170 , pp. 2469-2478
    • Tonomura, N.1    McLaughlin, K.2    Grimm, L.3    Goldsby, R.A.4    Osborne, B.A.5
  • 111
    • 0034607655 scopus 로고    scopus 로고
    • Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli
    • Yang Y., Fang S., Jensen J. P., Weissman A. M. and Ashwell J. D. (2000) Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli. Science 288: 874-877
    • (2000) Science , vol.288 , pp. 874-877
    • Yang, Y.1    Fang, S.2    Jensen, J.P.3    Weissman, A.M.4    Ashwell, J.D.5
  • 112
    • 0036911138 scopus 로고    scopus 로고
    • Hydrogen peroxide as second messenger in lymphocyte activation
    • Reth M. (2002) Hydrogen peroxide as second messenger in lymphocyte activation. Nat. Immunol. 3: 1129-1134
    • (2002) Nat. Immunol. , vol.3 , pp. 1129-1134
    • Reth, M.1
  • 113
    • 0033120424 scopus 로고    scopus 로고
    • Dexamethasone-induced thymocyte apoptosis: Apoptotic signal involves the sequential activation of phosphoinositide-specific phospholipase C, acidic sphingomyelinase, and caspases
    • Cifone M. G., Migliorati G., Parroni R., Marchetti C., Millimaggi D., Santoni A. et al. (1999) Dexamethasone-induced thymocyte apoptosis: apoptotic signal involves the sequential activation of phosphoinositide-specific phospholipase C, acidic sphingomyelinase, and caspases. Blood 93: 2282-2296
    • (1999) Blood , vol.93 , pp. 2282-2296
    • Cifone, M.G.1    Migliorati, G.2    Parroni, R.3    Marchetti, C.4    Millimaggi, D.5    Santoni, A.6
  • 114
    • 0031451872 scopus 로고    scopus 로고
    • A primary role for K+ and Na+ efflux in the activation of apoptosis
    • Bortner C. D., Hughes F. M. Jr and Cidlowski J. A. (1997) A primary role for K+ and Na+ efflux in the activation of apoptosis. J. Biol. Chem. 272: 32436-32442
    • (1997) J. Biol. Chem. , vol.272 , pp. 32436-32442
    • Bortner, C.D.1    Hughes Jr., F.M.2    Cidlowski, J.A.3
  • 115
    • 0030973158 scopus 로고    scopus 로고
    • T cells deficient in inositol 1,4,5-trisphosphate receptor are resistant to apoptosis
    • Jayaraman T. and Marks A. R. (1997) T cells deficient in inositol 1,4,5-trisphosphate receptor are resistant to apoptosis. Mol. Cell. Biol. 17: 3005-3012
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 3005-3012
    • Jayaraman, T.1    Marks, A.R.2
  • 116
    • 0031865468 scopus 로고    scopus 로고
    • Transcriptional cross-talk, the second mode of steroid hormone receptor action
    • Göttlicher M., Heck S. and Herrlich P. (1998) Transcriptional cross-talk, the second mode of steroid hormone receptor action. J. Mol. Med. 76: 480-489
    • (1998) J. Mol. Med. , vol.76 , pp. 480-489
    • Göttlicher, M.1    Heck, S.2    Herrlich, P.3
  • 117
    • 0024379772 scopus 로고
    • Steroid sensitivity of thymocyte subpopulations during intrathymic differentiation: Effects of 17 beta-estradiol and dexamethasone on subsets expressing T cell antigen receptor or IL-2 receptor
    • Screpanti I., Morrone S., Meco D., Santoni A., Gulino A., Paolini R. et al. (1989) Steroid sensitivity of thymocyte subpopulations during intrathymic differentiation: effects of 17 beta-estradiol and dexamethasone on subsets expressing T cell antigen receptor or IL-2 receptor. J. Immunol. 142: 3378-3383
    • (1989) J. Immunol. , vol.142 , pp. 3378-3383
    • Screpanti, I.1    Morrone, S.2    Meco, D.3    Santoni, A.4    Gulino, A.5    Paolini, R.6
  • 118
    • 0029014953 scopus 로고
    • Cellular distribution and costimulatory function of rat CD28: Regulated expression during thymocyte maturation and induction of cyclosporin A sensitivity of costimulated T cell responses by phorbol ester
    • Tacke M., Clark G. J., Dallman M. J. and Hünig T. (1995) Cellular distribution and costimulatory function of rat CD28: regulated expression during thymocyte maturation and induction of cyclosporin A sensitivity of costimulated T cell responses by phorbol ester. J. Immunol. 154: 5121-5127
    • (1995) J. Immunol. , vol.154 , pp. 5121-5127
    • Tacke, M.1    Clark, G.J.2    Dallman, M.J.3    Hünig, T.4
  • 119
    • 0028136298 scopus 로고
    • The costimulatory molecule B7 is expressed in the medullary region of the murine thymus
    • Reiser H. and Schneeberger E. E. (1994) The costimulatory molecule B7 is expressed in the medullary region of the murine thymus. Immunology 81: 532-537
    • (1994) Immunology , vol.81 , pp. 532-537
    • Reiser, H.1    Schneeberger, E.E.2
  • 120
    • 0027248447 scopus 로고
    • bcl-2 proto-oncogene expression during human T cell development: Evidence for biphasic regulation
    • Gratiot-Deans J., Ding L., Turka L. A. and Nunez G. (1993) bcl-2 proto-oncogene expression during human T cell development: evidence for biphasic regulation. J. Immunol. 151: 83-91
    • (1993) J. Immunol. , vol.151 , pp. 83-91
    • Gratiot-Deans, J.1    Ding, L.2    Turka, L.A.3    Nunez, G.4
  • 121
    • 0027199233 scopus 로고
    • Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes
    • Veis D. J., Sentman C. L., Bach E. A. and Korsmeyer S. J. (1993) Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes. J. Immunol. 151: 2546-2554
    • (1993) J. Immunol. , vol.151 , pp. 2546-2554
    • Veis, D.J.1    Sentman, C.L.2    Bach, E.A.3    Korsmeyer, S.J.4
  • 122
    • 0028970662 scopus 로고
    • Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice
    • Grillot D. A., Merino R. and Nunez G. (1995) Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice. J. Exp. Med. 182: 1973-1983
    • (1995) J. Exp. Med. , vol.182 , pp. 1973-1983
    • Grillot, D.A.1    Merino, R.2    Nunez, G.3
  • 123
    • 0031907999 scopus 로고    scopus 로고
    • Thymocyte glucocorticoid resistance alters positive selection and inhibits autoimmunity and lymphoproliferative disease in MRL-lpr/lpr mice
    • Tolosa E., King L. B. and Ashwell J. D. (1998) Thymocyte glucocorticoid resistance alters positive selection and inhibits autoimmunity and lymphoproliferative disease in MRL-lpr/lpr mice. Immunity 8: 67-76
    • (1998) Immunity , vol.8 , pp. 67-76
    • Tolosa, E.1    King, L.B.2    Ashwell, J.D.3
  • 124
    • 0034143917 scopus 로고    scopus 로고
    • Thymocyte resistance to glucocorticoids leads to antigen-specific unresponsiveness due to holes in the T cell repertoire
    • Lu F. W., Yasutomo K., Goodman G. B., McHeyzer-Williams L. J., McHeyzer-Williams M. G., Germain R. N. et al. (2000) Thymocyte resistance to glucocorticoids leads to antigen-specific unresponsiveness due to holes in the T cell repertoire. Immunity 12: 183-192
    • (2000) Immunity , vol.12 , pp. 183-192
    • Lu, F.W.1    Yasutomo, K.2    Goodman, G.B.3    McHeyzer-Williams, L.J.4    McHeyzer-Williams, M.G.5    Germain, R.N.6
  • 125
    • 5644233890 scopus 로고    scopus 로고
    • Different roles for glucocorticoids in thymocyte homeostasis?
    • Jondal M., Pazirandeh A. and Okret S. (2004) Different roles for glucocorticoids in thymocyte homeostasis? Trends Immunol. 25: 595-600
    • (2004) Trends Immunol. , vol.25 , pp. 595-600
    • Jondal, M.1    Pazirandeh, A.2    Okret, S.3
  • 126
    • 0028233225 scopus 로고
    • Steroid production in the thymus: Implications for thymocyte selection
    • Vacchio M. S., Papadopoulos V. and Ashwell J. D. (1994) Steroid production in the thymus: implications for thymocyte selection. J. Exp. Med. 179: 1835-1846
    • (1994) J. Exp. Med. , vol.179 , pp. 1835-1846
    • Vacchio, M.S.1    Papadopoulos, V.2    Ashwell, J.D.3
  • 127
    • 0032896835 scopus 로고    scopus 로고
    • Paracrine glucocorticoid activity produced by mouse thymic epithelial cells
    • Pazirandeh A., Xue Y., Rafter I., Sjovall J., Jondal M. and Okret S. (1999) Paracrine glucocorticoid activity produced by mouse thymic epithelial cells. FASEB J. 13: 893-901
    • (1999) FASEB J. , vol.13 , pp. 893-901
    • Pazirandeh, A.1    Xue, Y.2    Rafter, I.3    Sjovall, J.4    Jondal, M.5    Okret, S.6
  • 129
    • 0022393794 scopus 로고
    • Primary structure and expression of a functional human glucocorticoid receptor cDNA
    • Hollenberg S. M., Weinberger C., Ong E. S., Cerelli G., Oro A., Lebo R. et al. (1985) Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature 318: 635-641
    • (1985) Nature , vol.318 , pp. 635-641
    • Hollenberg, S.M.1    Weinberger, C.2    Ong, E.S.3    Cerelli, G.4    Oro, A.5    Lebo, R.6
  • 130
    • 0242417043 scopus 로고    scopus 로고
    • Mutually antagonistic signals regulate selection of the T cell repertoire
    • Stephens G. L., Ashwell J. D. and Ignatowicz L. (2003) Mutually antagonistic signals regulate selection of the T cell repertoire. Int. Immunol. 15: 623-632
    • (2003) Int. Immunol. , vol.15 , pp. 623-632
    • Stephens, G.L.1    Ashwell, J.D.2    Ignatowicz, L.3
  • 131
    • 0032797306 scopus 로고    scopus 로고
    • Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cells
    • Finotto S., Krieglstein K., Schober A., Deimling F., Lindner K., Bruhl B. et al. (1999) Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cells. Development 126: 2935-2944
    • (1999) Development , vol.126 , pp. 2935-2944
    • Finotto, S.1    Krieglstein, K.2    Schober, A.3    Deimling, F.4    Lindner, K.5    Bruhl, B.6


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