The future of biologics: Applications for food allergy

Journal of Allergy and Clinical Immunology

Volumn 135, Issue 2, 2015, Pages 312-323

  Bauer, Rebecca N ^a   Manohar, Monali ^a   Singh, Anne Marie ^b   Jay, David C ^a   Nadeau, Kari C ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

allergen sensitization; anaphylaxis; anti IgE; biologics; Food allergy; immunotherapy; oral tolerance

Indexed keywords

ANTIGEN; FC EPSILON RECEPTOR I; FC RECEPTOR; FOOD ALLERGEN; IMMUNOGLOBULIN E; IMMUNOLOGICAL ADJUVANT; MEPOLIZUMAB; POLYMER; RESLIZUMAB; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG; ANTIALLERGIC AGENT; BIOLOGICAL PRODUCT;

ARTICLE; CLONAL ANERGY; FOOD ALLERGY; HUMAN; IMMUNOGLOBULIN PRODUCTION; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; IMMUNOTHERAPY; MAST CELL ANERGY; NONHUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; SENSITIZATION; TH1 TH2 BALANCE; ANIMAL; DRUG EFFECTS; FOOD HYPERSENSITIVITY; IMMUNOLOGY; MAST CELL; METABOLISM; SIGNAL TRANSDUCTION; TH1 CELL; TH2 CELL;

ANIMALS; ANTI-ALLERGIC AGENTS; BIOLOGICAL PRODUCTS; FOOD HYPERSENSITIVITY; HUMANS; IMMUNOGLOBULIN E; MAST CELLS; SIGNAL TRANSDUCTION; TH1 CELLS; TH2 CELLS;

EID: 84922388567     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2014.12.1908     Document Type: Review

References (168)

1. R. Pawankar, S.T. Holgate, G.W. Canonica, R.F. Lockey, and M.S. Blaiss The WAO white book on allergy 2013 World Allergy Organization Milwaukee (WI)
2. T. Zheng, J. Yu, M.H. Oh, and Z. Zhu The atopic march: progression from atopic dermatitis to allergic rhinitis and asthma Allergy Asthma Immunol Res 3 2011 67 73
3. J.A. Boyce, A. Assa'ad, A.W. Burks, S.M. Jones, H.A. Sampson, and R.A. Wood Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel J Allergy Clin Immunol 126 suppl 2010 S1 S58
4. P. Small, and H. Kim Allergic rhinitis Allergy Asthma Clin Immunol 7 suppl 1 2011 S3
5. L.F. Eichenfield, W.L. Tom, S.L. Chamlin, S.R. Feldman, J.M. Hanifin, and E.L. Simpson Guidelines of care for the management of atopic dermatitis J Am Acad Dermatol 70 2014 338 351
6. Expert Panel Report 3 (EPR-3): guidelines for the diagnosis and management of asthma-summary report 2007 J Allergy Clin Immunol 120 2007 S94 S138
7. R.A. Rader (Re)defining biopharmaceutical Nat Biotech 26 2008 743 751
8. G. Pelaia, A. Vatrella, and R. Maselli The potential of biologics for the treatment of asthma Nat Rev Drug Discov 11 2012 958 972
9. W.W. Busse, W.J. Morgan, P.J. Gergen, H.E. Mitchell, J.E. Gern, and A.H. Liu Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children N Engl J Med 364 2011 1005 1015
10. M. Maurer, K. Rosén, H.-J. Hsieh, S. Saini, C. Grattan, and A. Gimenéz-Arnau Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria N Engl J Med 368 2013 924 935
11. S. Wenzel, L. Ford, D. Pearlman, S. Spector, L. Sher, and F. Skobieranda Dupilumab in persistent asthma with elevated eosinophil levels N Engl J Med 368 2013 2455 2466
12. S.H. Sicherer, and H.A. Sampson Food allergy: epidemiology, pathogenesis, diagnosis, and treatment J Allergy Clin Immunol 133 2014 291 307.e5
13. A.M. Branum, and S.L. Lukacs Food allergy among children in the United States Pediatrics 124 2009 1549 1555
14. E. Kern, and I. Hirano Emerging drugs for eosinophilic esophagitis Expert Opin Emerg Drugs 18 2013 353 364
15. K.M. Jarvinen, and A. Nowak-Wegrzyn Food protein-induced enterocolitis syndrome (FPIES): current management strategies and review of the literature J Allergy Clin Immunol Pract 1 2013 317 322
16. D.L. Neuman-Sunshine, J.A. Eckman, C.A. Keet, E.C. Matsui, R.D. Peng, and P.J. Lenehan The natural history of persistent peanut allergy Ann Allergy Asthma Immunol 108 2012 326 331.e3
17. D.M. Fleischer, T.T. Perry, D. Atkins, R.A. Wood, A.W. Burks, and S.M. Jones Allergic reactions to foods in preschool-aged children in a prospective observational food allergy study Pediatrics 130 2012 e25 e32
18. I. Otani, P. Begin, C. Kearney, T. Dominguez, A. Mehrotra, and L. Bacal Multiple-allergen oral immunotherapy improves quality of life in caregivers of food-allergic pediatric subjects Allergy Asthma Clin Immunol 10 2014 25
19. O. Cavkaytar, C.A. Akdis, and M. Akdis Modulation of immune responses by immunotherapy in allergic diseases Curr Opin Pharmacol 2014 30 37
20. K. Anagnostou, S. Islam, Y. King, L. Foley, L. Pasea, and S. Bond Assessing the efficacy of oral immunotherapy for the desensitisation of peanut allergy in children (STOP II): a phase 2 randomised controlled trial Lancet 383 2014 1297 1304
21. A. Suárez-Fueyo, T. Ramos, A. Galán, L. Jimeno, P.A. Wurtzen, and A. Marin Grass tablet sublingual immunotherapy downregulates the TH2 cytokine response followed by regulatory T-cell generation J Allergy Clin Immunol 133 2014 130 138.e2
22. B.P. Vickery, A.M. Scurlock, M. Kulis, P.H. Steele, J. Kamilaris, and J.P. Berglund Sustained unresponsiveness to peanut in subjects who have completed peanut oral immunotherapy J Allergy Clin Immunol 133 2014 468 475.e6
23. H.A. Sampson Peanut oral immunotherapy: is it ready for clinical practice? J Allergy Clin Immunol Pract 1 2013 15 21
24. S.Y. Lin, N. Erekosima, J.M. Kim, M. Ramanathan, C. Suarez-Cuervo, and Y. Chelladurai Sublingual immunotherapy for the treatment of allergic rhinoconjunctivitis and asthma: a systematic review JAMA 309 2013 1278 1288
25. J. Wang, and H.A. Sampson Food allergy J Clin Invest 121 2011 827 835
26. J.R. McDole, L.W. Wheeler, K.G. McDonald, B. Wang, V. Konjufca, and K.A. Knoop Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine Nature 483 2012 345 349
27. M. Rescigno, M. Urbano, B. Valzasina, M. Francolini, G. Rotta, and R. Bonasio Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria Nat Immunol 2 2001 361 367
28. H. Lelouard, M. Fallet, B. de Bovis, S. Meresse, and J.P. Gorvel Peyer's patch dendritic cells sample antigens by extending dendrites through M cell-specific transcellular pores Gastroenterology 142 2012 592 601.e3
29. J.L. Coombes, K.R. Siddiqui, C.V. Arancibia-Carcamo, J. Hall, C.M. Sun, and Y. Belkaid A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism J Exp Med 204 2007 1757 1764
30. G. Bakdash, L.T. Vogelpoel, T.M. van Capel, M.L. Kapsenberg, and E.C. de Jong Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells Mucosal Immunol 2014 [Epub ahead of print]
31. C.-M. Sun, J.A. Hall, R.B. Blank, N. Bouladoux, M. Oukka, and J.R. Mora Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid J Exp Med 204 2007 1775 1785
32. T.W. Spahn, H.L. Weiner, P.D. Rennert, N. Lugering, A. Fontana, and W. Domschke Mesenteric lymph nodes are critical for the induction of high-dose oral tolerance in the absence of Peyer's patches Eur J Immunol 32 2002 1109 1113
33. N. Anandasabapathy, R. Feder, S. Mollah, S.W. Tse, M.P. Longhi, and S. Mehandru Classical Flt3L-dependent dendritic cells control immunity to protein vaccine J Exp Med 211 2014 1875 1891
34. J.C. Marie, J.J. Letterio, M. Gavin, and A.Y. Rudensky TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells J Exp Med 201 2005 1061 1067
35. Y.P. Rubtsov, J.P. Rasmussen, E.Y. Chi, J. Fontenot, L. Castelli, and X. Ye Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces Immunity 28 2008 546 558
36. K.S. Barone, S.L. Jain, and J.G. Michael Effect of in vivo depletion of CD4+ and CD8+ cells on the induction and maintenance of oral tolerance Cell Immunol 163 1995 19 29
37. H.J. Kim, S.J. Hwang, B.K. Kim, K.C. Jung, and D.H. Chung NKT cells play critical roles in the induction of oral tolerance by inducing regulatory T cells producing IL-10 and transforming growth factor beta, and by clonally deleting antigen-specific T cells Immunology 118 2006 101 111
38. Z.Q. Liu, Y. Wu, J.P. Song, X. Liu, Z. Liu, and P.Y. Zheng Tolerogenic CX3CR1+ B cells suppress food allergy-induced intestinal inflammation in mice Allergy 68 2013 1241 1248
39. A. Friedman, and H.L. Weiner Induction of anergy or active suppression following oral tolerance is determined by antigen dosage Proc Natl Acad Sci U S A 91 1994 6688 6692
40. D. Bedoret, A.K. Singh, V. Shaw, E.G. Hoyte, R. Hamilton, and R.H. DeKruyff Changes in antigen-specific T-cell number and function during oral desensitization in cow's milk allergy enabled with omalizumab Mucosal Immunol 5 2012 267 276
41. A. Syed, M.A. Garcia, S.C. Lyu, R. Bucayu, A. Kohli, and S. Ishida Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3) J Allergy Clin Immunol 133 2014 500 510.e11
42. M.C. Berin, and W.G. Shreffler T(H)2 adjuvants: implications for food allergy J Allergy Clin Immunol 121 2008 1311 1322
43. S.C. Bischoff, G. Sellge, A. Lorentz, W. Sebald, R. Raab, and M.P. Manns IL-4 enhances proliferation and mediator release in mature human mast cells Proc Natl Acad Sci U S A 96 1999 8080 8085
44. T.R. Mosmann, H. Cherwinski, M.W. Bond, M.A. Giedlin, and R.L. Coffman Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins J Immunol 136 1986 2348 2357
45. F.D. Finkelman, I.M. Katona, J.F. Urban, J. Holmes, J. Ohara, and A.S. Tung IL-4 is required to generate and sustain in vivo IgE responses J Immunol 141 1988 2335 2341
46. S. Sur, H. Kita, G.J. Gleich, T.C. Chenier, and L.W. Hunt Eosinophil recruitment is associated with IL-5, but not with RANTES, twenty-four hours after allergen challenge J Allergy Clin Immunol 97 1996 1272 1278
47. Y. Yamaguchi, T. Suda, J. Suda, M. Eguchi, Y. Miura, and N. Harada Purified interleukin 5 supports the terminal differentiation and proliferation of murine eosinophilic precursors J Exp Med 167 1988 43 56
48. J. Punnonen, and J.E. de Vries IL-13 induces proliferation, Ig isotype switching, and Ig synthesis by immature human fetal B cells J Immunol 152 1994 1094 1102
49. S.M. Pope, E.B. Brandt, A. Mishra, S.P. Hogan, N. Zimmermann, and K.I. Matthaei IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism J Allergy Clin Immunol 108 2001 594 601
50. D. Voehringer, T.A. Reese, X. Huang, K. Shinkai, and R.M. Locksley Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system J Exp Med 203 2006 1435 1446
51. D.A. Kuperman, X. Huang, L.L. Koth, G.H. Chang, G.M. Dolganov, and Z. Zhu Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma Nat Med 8 2002 885 889
52. C.L. Bennett, J. Christie, F. Ramsdell, M.E. Brunkow, P.J. Ferguson, and L. Whitesell The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3 Nat Genet 27 2001 20 21
53. T.R. Torgerson, A. Linane, N. Moes, S. Anover, V. Mateo, and F. Rieux-Laucat Severe food allergy as a variant of IPEX syndrome caused by a deletion in a noncoding region of the FOXP3 gene Gastroenterology 132 2007 1705 1717
54. M. Miyara, K. Wing, and S. Sakaguchi Therapeutic approaches to allergy and autoimmunity based on FoxP3+ regulatory T-cell activation and expansion J Allergy Clin Immunol 123 2009 749 755
55. M.K. Oyoshi, H.C. Oettgen, T.A. Chatila, R.S. Geha, and P.J. Bryce Food allergy: insights into etiology, prevention, and treatment provided by murine models J Allergy Clin Immunol 133 2014 309 317
56. E.M. Savilahti, and E. Savilahti Development of natural tolerance and induced desensitization in cow's milk allergy Pediatr Allergy Immunol 24 2013 114 121
57. W.G. Shreffler, N. Wanich, M. Moloney, A. Nowak-Wegrzyn, and H.A. Sampson Association of allergen-specific regulatory T cells with the onset of clinical tolerance to milk protein J Allergy Clin Immunol 123 2009 43 52.e7
58. R.S. Swamy, N. Reshamwala, T. Hunter, S. Vissamsetti, C.B. Santos, and F.M. Baroody Epigenetic modifications and improved regulatory T-cell function in subjects undergoing dual sublingual immunotherapy J Allergy Clin Immunol 130 2012 215 224.e7
59. G.W. Scadding, M.H. Shamji, M.R. Jacobson, D.I. Lee, D. Wilson, and M.T. Lima Sublingual grass pollen immunotherapy is associated with increases in sublingual Foxp3-expressing cells and elevated allergen-specific immunoglobulin G4, immunoglobulin A and serum inhibitory activity for immunoglobulin E-facilitated allergen binding to B cells Clin Exp Allergy 40 2010 598 606
60. J.R. Turner Intestinal mucosal barrier function in health and disease Nat Rev Immunol 9 2009 799 809
61. M.T. Ventura, L. Polimeno, A.C. Amoruso, F. Gatti, E. Annoscia, and M. Marinaro Intestinal permeability in patients with adverse reactions to food Dig Liver Dis 38 2006 732 736
62. D.K. Chu, A. Llop-Guevara, T.D. Walker, K. Flader, S. Goncharova, and J.E. Boudreau IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization J Allergy Clin Immunol 131 2013 187 200 e1-8
63. S.A. Saenz, M.C. Siracusa, L.A. Monticelli, C.G. Ziegler, B.S. Kim, and J.R. Brestoff IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multipotent progenitor type 2 (MPPtype2) cells J Exp Med 210 2013 1823 1837
64. J.M. Leyva-Castillo, P. Hener, P. Michea, H. Karasuyama, S. Chan, and V. Soumelis Skin thymic stromal lymphopoietin initiates Th2 responses through an orchestrated immune cascade Nat Commun 4 2013 2847
65. H.Y. Kim, Y.-J. Chang, S. Subramanian, H.-H. Lee, L.A. Albacker, and P. Matangkasombut Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity J Allergy Clin Immunol 129 2012 216 227.e6
66. R. Reekers, M. Busche, M. Wittmann, A. Kapp, and T. Werfel Birch pollen-related foods trigger atopic dermatitis in patients with specific cutaneous T-cell responses to birch pollen antigens J Allergy Clin Immunol 104 1999 466 472
67. P.A. Eigenmann, S.H. Sicherer, T.A. Borkowski, B.A. Cohen, and H.A. Sampson Prevalence of IgE-mediated food allergy among children with atopic dermatitis Pediatrics 101 1998 e8
68. D. Venkataraman, N. Soto-Ramirez, R.J. Kurukulaaratchy, J.W. Holloway, W. Karmaus, and S.L. Ewart Filaggrin loss-of-function mutations are associated with food allergy in childhood and adolescence J Allergy Clin Immunol 134 2014 876 882.e4
69. H.A. Brough, A. Simpson, K. Makinson, J. Hankinson, S. Brown, and A. Douiri Peanut allergy: Effect of environmental peanut exposure in children with filaggrin loss-of-function mutations J Allergy Clin Immunol 134 2014 867 875.e1
70. Y. Asai, C. Greenwood, P.R. Hull, R. Alizadehfar, M. Ben-Shoshan, and S.J. Brown Filaggrin gene mutation associations with peanut allergy persist despite variations in peanut allergy diagnostic criteria or asthma status J Allergy Clin Immunol 132 2013 239 242.e7
71. D. Ruane, L. Brane, B.S. Reis, C. Cheong, J. Poles, and Y. Do Lung dendritic cells induce migration of protective T cells to the gastrointestinal tract J Exp Med 210 2013 1871 1888
72. R.D. Peavy, and D.D. Metcalfe Understanding the mechanisms of anaphylaxis Curr Opin Allergy Clin Immunol 8 2008 310 315
73. P. Lieberman Biphasic anaphylactic reactions Ann Allergy Asthma Immunol 95 2005 217 226 58
74. S. Kraft, and J.P. Kinet New developments in FcepsilonRI regulation, function and inhibition Nat Rev Immunol 7 2007 365 378
75. M. Wang, K. Takeda, Y. Shiraishi, M. Okamoto, A. Dakhama, and A. Joetham Peanut-induced intestinal allergy is mediated through a mast cell-IgE-FcεRI-IL-13 pathway J Allergy Clin Immunol 126 2010 306 316.e12
76. B.S. Sihra, O.M. Kon, J.A. Grant, and A.B. Kay Expression of high-affinity IgE receptors (FcεRI) on peripheral blood basophils, monocytes, and eosinophils in atopic and nonatopic subjects: relationship to total serum IgE concentrations J Allergy Clin Immunol 99 1997 699 706
77. S.G. Brown, S.F. Stone, D.M. Fatovich, S.A. Burrows, A. Holdgate, and A. Celenza Anaphylaxis: clinical patterns, mediator release, and severity J Allergy Clin Immunol 132 2013 1141 1149.e5
78. P. Vadas, M. Gold, B. Perelman, G.M. Liss, G. Lack, and T. Blyth Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis N Engl J Med 358 2008 28 35
79. P. Vadas, B. Perelman, and G. Liss Platelet-activating factor, histamine, and tryptase levels in human anaphylaxis J Allergy Clin Immunol 131 2013 144 149
80. Y. Kurashima, and H. Kiyono New era for mucosal mast cells: their roles in inflammation, allergic immune responses and adjuvant development Exp Mol Med 46 2014 e83
81. K. Arias, D.K. Chu, K. Flader, F. Botelho, T. Walker, and N. Arias Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice J Allergy Clin Immunol 127 2011 1552 1561.e1
82. I. Miyajima, D. Dombrowicz, T.R. Martin, J.V. Ravetch, J.P. Kinet, and S.J. Galli Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis J Clin Invest 99 1997 901 914
83. S.J. Galli, M. Tsai, and A.M. Piliponsky The development of allergic inflammation Nature 454 2008 445 454
84. A. Syed, A. Kohli, and K.C. Nadeau Food allergy diagnosis and therapy: where are we now? Immunotherapy 5 2013 931 944
85. V.E. Prescott, E. Forbes, P.S. Foster, K. Matthaei, and S.P. Hogan Mechanistic analysis of experimental food allergen-induced cutaneous reactions J Leukoc Biol 80 2006 258 266
86. C.R. Cardoso, P.R. Provinciatto, D.F. Godoi, B.R. Ferreira, G. Teixeira, and M.A. Rossi IL-4 regulates susceptibility to intestinal inflammation in murine food allergy Am J Physiol Gastrointest Liver Physiol 296 2009 G593 G600
87. B. Michaud, J. Aroulandom, N. Baiz, F. Amat, R. Gouvis-Echraghi, and S. Candon Casein-specific IL-4- and IL-13-secreting T cells: a tool to implement diagnosis of cow's milk allergy Allergy 69 2014 1473 1480
88. S.H. Sicherer, R.A. Wood, D. Stablein, A.W. Burks, A.H. Liu, and S.M. Jones Immunologic features of infants with milk or egg allergy enrolled in an observational study (Consortium of Food Allergy Research) of food allergy J Allergy Clin Immunol 125 2010 1077 1083.e8
89. E.H. Kim, J.A. Bird, M. Kulis, S. Laubach, L. Pons, and W. Shreffler Sublingual immunotherapy for peanut allergy: clinical and immunologic evidence of desensitization J Allergy Clin Immunol 127 2011 640 646.e1
90. S.E. Zitnik, F. Ruschendorf, S. Muller, C. Sengler, Y.A. Lee, and R.W. Griffioen IL13 variants are associated with total serum IgE and early sensitization to food allergens in children with atopic dermatitis Pediatr Allergy Immunol 20 2009 551 555
91. X. Liu, T.H. Beaty, P. Deindl, S.K. Huang, S. Lau, and C. Sommerfeld Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study J Allergy Clin Immunol 113 2004 489 495
92. S. Wenzel, D. Wilbraham, R. Fuller, E.B. Getz, and M. Longphre Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies Lancet 370 2007 1422 1431
93. J. Corren, W. Busse, E.O. Meltzer, L. Mansfield, G. Bensch, and J. Fahrenholz A randomized, controlled, phase 2 study of AMG 317, an IL-4Rα antagonist, in patients with asthma Am J Respir Crit Care Med 181 2010 788 796
94. L.A. Beck, D. Thaçi, J.D. Hamilton, N.M. Graham, T. Bieber, and R. Rocklin Dupilumab treatment in adults with moderate-to-severe atopic dermatitis N Engl J Med 371 2014 130 139
95. A. Straumann, S. Conus, P. Grzonka, H. Kita, G. Kephart, and C. Bussmann Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: a randomised, placebo-controlled, double-blind trial Gut 59 2010 21 30
96. M.L. Stein, M.H. Collins, J.M. Villanueva, J.P. Kushner, P.E. Putnam, and B.K. Buckmeier Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis J Allergy Clin Immunol 118 2006 1312 1319
97. J.M. Spergel, M.E. Rothenberg, M.H. Collins, G.T. Furuta, J.E. Markowitz, and G. Fuchs 3rd Reslizumab in children and adolescents with eosinophilic esophagitis: results of a double-blind, randomized, placebo-controlled trial J Allergy Clin Immunol 129 2012 456 463 e1-3
98. C.A. Keet, and R.A. Wood Emerging therapies for food allergy J Clin Invest 124 2014 1880 1886
99. F. Grela, A. Aumeunier, E. Bardel, L.P. Van, E. Bourgeois, and J. Vanoirbeek The TLR7 agonist R848 alleviates allergic inflammation by targeting invariant NKT cells to produce IFN-γ J Immunol 186 2011 284 290
100. P.S. Creticos, J.T. Schroeder, R.G. Hamilton, S.L. Balcer-Whaley, A.P. Khattignavong, and R. Lindblad Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis N Engl J Med 355 2006 1445 1455
101. M.K. Tulic, P.O. Fiset, P. Christodoulopoulos, P. Vaillancourt, M. Desrosiers, and F. Lavigne Amb a 1-immunostimulatory oligodeoxynucleotide conjugate immunotherapy decreases the nasal inflammatory response J Allergy Clin Immunol 113 2004 235 241
102. M. Rosewich, J. Schulze, O. Eickmeier, T. Telles, M.A. Rose, and R. Schubert Tolerance induction after specific immunotherapy with pollen allergoids adjuvanted by monophosphoryl lipid A in children Clin Exp Immunol 160 2010 403 410
103. P. Patel, T. Holdich, K.J. Fischer von Weikersthal-Drachenberg, and B. Huber Efficacy of a short course of specific immunotherapy in patients with allergic rhinoconjunctivitis to ragweed pollen J Allergy Clin Immunol 133 2014 121 129.e2
104. L.M. DuBuske, A.J. Frew, F. Horak, P.K. Keith, C.J. Corrigan, and W. Aberer Ultrashort-specific immunotherapy successfully treats seasonal allergic rhinoconjunctivitis to grass pollen Allergy Asthma Proc 32 2011 239 247
105. D. Mittag, N. Varese, A. Scholzen, A. Mansell, G. Barker, and G. Rice TLR ligands of ryegrass pollen microbial contaminants enhance Th1 and Th2 responses and decrease induction of Foxp3hi regulatory T cells Eur J Immunol 43 2013 723 733
106. Y.-G. Tsai, K.D. Yang, D.-M. Niu, J.-W. Chien, and C.-Y. Lin TLR2 agonists enhance CD8+Foxp3+ regulatory T cells and suppress Th2 immune responses during allergen immunotherapy J Immunol 184 2010 7229 7237
107. A.E. Ibanez, P. Smaldini, L.M. Coria, M.V. Delpino, L.G. Pacifico, and S.C. Oliveira Unlipidated outer membrane protein Omp16 (U-Omp16) from Brucella spp. as nasal adjuvant induces a Th1 immune response and modulates the Th2 allergic response to cow's milk proteins PLoS One 8 2013 e69438
108. M.J. Bae, H.S. Shin, E.K. Kim, J. Kim, and D.H. Shon Oral administration of chitin and chitosan prevents peanut-induced anaphylaxis in a murine food allergy model Int J Biol Macromol 61 2013 164 168
109. C.B. Smarr, C.L. Hsu, A.J. Byrne, S.D. Miller, and P.J. Bryce Antigen-fixed leukocytes tolerize Th2 responses in mouse models of allergy J Immunol 187 2011 5090 5098
110. D.M. Turley, and S.D. Miller Peripheral tolerance induction using ethylenecarbodiimide-fixed APCs uses both direct and indirect mechanisms of antigen presentation for prevention of experimental autoimmune encephalomyelitis J Immunol 178 2007 2212 2220
111. B.N. Lambrecht, and H. Hammad Allergens and the airway epithelium response: gateway to allergic sensitization J Allergy Clin Immunol 134 2014 499 507
112. F. Salazar, and A.M. Ghaemmaghami Allergen recognition by innate immune cells: critical role of dendritic and epithelial cells Front Immunol 4 2013 356
113. V. Soumelis, P.A. Reche, H. Kanzler, W. Yuan, G. Edward, and B. Homey Human epithelial cells trigger dendritic cell-mediated allergic inflammation by producing TSLP Nat Immunol 3 2002 673 680
114. L.J. Rosenwasser, and J. Meng Anti-CD23 Clin Rev Allergy Immunol 29 2005 61 72
115. D. Kaiserlian, A. Lachaux, I. Grosjean, P. Graber, and J.Y. Bonnefoy Intestinal epithelial cells express the CD23/Fc epsilon RII molecule: enhanced expression in enteropathies Immunology 80 1993 90 95
116. Y. Tu, S. Salim, J. Bourgeois, V. Di Leo, E.J. Irvine, and J.K. Marshall CD23-mediated IgE transport across human intestinal epithelium: inhibition by blocking sites of translation or binding Gastroenterology 129 2005 928 940
117. H. Li, A. Nowak-Wegrzyn, Z. Charlop-Powers, W. Shreffler, M. Chehade, and S. Thomas Transcytosis of IgE-antigen complexes by CD23a in human intestinal epithelial cells and its role in food allergy Gastroenterology 131 2006 47 58
118. H.J. Gould, and B.J. Sutton IgE in allergy and asthma today Nat Rev Immunol 8 2008 205 217
119. T. Eiwegger, and C.A. Akdis IL-33 links tissue cells, dendritic cells and Th2 cell development in a mouse model of asthma Eur J Immunol 41 2011 1535 1538
120. M. Noti, E.D. Wojno, B.S. Kim, M.C. Siracusa, P.R. Giacomin, and M.G. Nair Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis Nat Med 19 2013 1005 1013
121. J.D. Sherrill, P.S. Gao, E.M. Stucke, C. Blanchard, M.H. Collins, and P.E. Putnam Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitis J Allergy Clin Immunol 126 2010 160 165.e3
122. M. Noti, B.S. Kim, M.C. Siracusa, G.D. Rak, M. Kubo, and A.E. Moghaddam Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin-basophil axis J Allergy Clin Immunol 133 2014 1390 1399 e1-6
123. F. Roan, B.D. Bell, T.A. Stoklasek, M. Kitajima, H. Han, and S.F. Ziegler The multiple facets of thymic stromal lymphopoietin (TSLP) during allergic inflammation and beyond J Leukoc Biol 91 2012 877 886
124. G.M. Gauvreau, P.M. O'Byrne, L.P. Boulet, Y. Wang, D. Cockcroft, and J. Bigler Effects of an anti-TSLP antibody on allergen-induced asthmatic responses N Engl J Med 370 2014 2102 2110
125. T. Muto, A. Fukuoka, K. Kabashima, S.F. Ziegler, K. Nakanishi, and K. Matsushita The role of basophils and proallergic cytokines, TSLP and IL-33, in cutaneously sensitized food allergy Int Immunol 26 2014 539 549
126. Z. Yang, R. Sun, V. Grinchuk, J.A. Fernandez-Blanco, L. Notari, and J.A. Bohl IL-33-induced alterations in murine intestinal function and cytokine responses are MyD88, STAT6, and IL-13 dependent Am J Physiol Gastrointest Liver Physiol 304 2013 G381 G389
127. L.K. Johnston, K.B. Chien, and P.J. Bryce The immunology of food allergy J Immunol 192 2014 2529 2534
128. D. Li, R. Guabiraba, A.-G. Besnard, M. Komai-Koma, M.S. Jabir, and L. Zhang IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice J Allergy Clin Immunol 134 2014 1422 1432.e11
129. Y.H. Kim, T.Y. Yang, C.S. Park, S.H. Ahn, B.K. Son, and J.H. Kim Anti-IL-33 antibody has a therapeutic effect in a murine model of allergic rhinitis Allergy 67 2012 183 190
130. X. Liu, M. Li, Y. Wu, Y. Zhou, L. Zeng, and T. Huang Anti-IL-33 antibody treatment inhibits airway inflammation in a murine model of allergic asthma Biochem Biophys Res Commun 386 2009 181 185
131. L.C. Wu, and H. Scheerens Targeting IgE production in mice and humans Curr Opin Immunol 31 2014 8 15
132. K.C. Nadeau, L.C. Schneider, L. Hoyte, I. Borras, and D.T. Umetsu Rapid oral desensitization in combination with omalizumab therapy in patients with cow's milk allergy J Allergy Clin Immunol 127 2011 1622 1624
133. H.A. Sampson, D.Y. Leung, A.W. Burks, G. Lack, S.L. Bahna, and S.M. Jones A phase II, randomized, doubleblind, parallelgroup, placebocontrolled oral food challenge trial of Xolair (omalizumab) in peanut allergy J Allergy Clin Immunol 127 2011 1309 1310.e1
134. A. Rafi, L.T. Do, R. Katz, L.E. Sheinkopf, C.W. Simons, and W. Klaustermeyer Effects of omalizumab in patients with food allergy Allergy Asthma Proc 31 2010 76 83
135. L.C. Schneider, R. Rachid, J. LeBovidge, E. Blood, M. Mittal, and D.T. Umetsu A pilot study of omalizumab to facilitate rapid oral desensitization in high-risk peanut-allergic patients J Allergy Clin Immunol 132 2013 1368 1374
136. J. Liu, P. Lester, S. Builder, and S.J. Shire Characterization of complex formation by humanized anti-IgE monoclonal antibody and monoclonal human IgE Biochemistry 34 1995 10474 10482
137. S. Holgate, N. Smith, M. Massanari, and P. Jimenez Effects of omalizumab on markers of inflammation in patients with allergic asthma Allergy 64 2009 1728 1736
138. L.A. Beck, G.V. Marcotte, D. MacGlashan Jr., A. Togias, and S. Saini Omalizumab-induced reductions in mast cell FcεRI expression and function J Allergy Clin Immunol 114 2004 527 530
139. H. Lin, K.M. Boesel, D.T. Griffith, C. Prussin, B. Foster, and F.A. Romero Omalizumab rapidly decreases nasal allergic response and FcεRI on basophils J Allergy Clin Immunol 113 2004 297 302
140. C. Prussin, D.T. Griffith, K.M. Boesel, H. Lin, B. Foster, and T.B. Casale Omalizumab treatment downregulates dendritic cell FcεRI expression J Allergy Clin Immunol 112 2003 1147 1154
141. J.T. Schroeder, A.P. Bieneman, K.L. Chichester, R.G. Hamilton, H. Xiao, and S.S. Saini Decreases in human dendritic cell-dependent TH2-like responses after acute in vivo IgE neutralization J Allergy Clin Immunol 125 2010 896 901.e6
142. T.W. Chang The pharmacological basis of anti-IgE therapy Nat Biotechnol 18 2000 157 162
143. T.W. Chang, J.B. Chen, and C.Y. Chu The pharmacological mechanisms of omalizumab in patients with very high IgE levels - clues from studies on atopic dermatitis Dermatologica Sinica 30 2012 147 153
144. D.J. Maselli, H. Singh, J. Diaz, and J.I. Peters Efficacy of omalizumab in asthmatic patients with IgE levels above 700 IU/mL: a retrospective study Ann Allergy Asthma Immunol 110 2013 457 461
145. J.P. Arm, I. Bottoli, A. Skerjanec, D. Floch, A. Groenewegen, and S. Maahs Pharmacokinetics, pharmacodynamics and safety of QGE031 (ligelizumab), a novel high-affinity anti-IgE antibody, in atopic subjects Clin Exp Allergy 44 2014 1371 1385
146. D.W. MacGlashan Jr. Relationship between spleen tyrosine kinase and phosphatidylinositol 5′ phosphatase expression and secretion from human basophils in the general population J Allergy Clin Immunol 119 2007 626 633
147. A.M. Cooper, P.S. Hobson, M.R. Jutton, M.W. Kao, B. Drung, and B. Schmidt Soluble CD23 controls IgE synthesis and homeostasis in human B cells J Immunol 188 2012 3199 3207
148. J.A. Poole, J. Meng, M. Reff, M.C. Spellman, and L.J. Rosenwasser Anti-CD23 monoclonal antibody, lumiliximab, inhibited allergen-induced responses in antigen-presenting cells and T cells from atopic subjects J Allergy Clin Immunol 116 2005 780 788
149. T. Nakamura, W.S. Kloetzer, P. Brams, K. Hariharan, S. Chamat, and X. Cao In vitro IgE inhibition in B cells by anti-CD23 monoclonal antibodies is functionally dependent on the immunoglobulin Fc domain Int J Immunopharmacol 22 2000 131 141
150. M. Zhou, D. Du, K. Zhao, and C. Zheng In vivo intranasal anti-CD23 treatment inhibits allergic responses in a murine model of allergic rhinitis J Mol Histol 44 2013 327 338
151. L.J. Rosenwasser, W.W. Busse, R.G. Lizambri, T.A. Olejnik, and M.C. Totoritis Allergic asthma and an anti-CD23 mAb (IDEC-152): results of a phase I, single-dose, dose-escalating clinical trial J Allergy Clin Immunol 112 2003 563 570
152. C. Peng, F.M. Davis, L.K. Sun, R.S. Liou, Y.W. Kim, and T.W. Chang A new isoform of human membrane-bound IgE J Immunol 148 1992 129 136
153. H.D. Brightbill, S. Jeet, Z. Lin, D. Yan, M. Zhou, and M. Tan Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice J Clin Invest 120 2010 2218 2229
154. J.B. Chen, P.C. Wu, A.F. Hung, C.Y. Chu, T.F. Tsai, and H.M. Yu Unique epitopes on CεmX in IgE-B cell receptors are potentially applicable for targeting IgE-committed B cells J Immunol 184 2010 1748 1756
155. G.M. Gauvreau, J.M. Harris, L.-P. Boulet, H. Scheerens, J.M. Fitzgerald, and W.S. Putnam Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production Sci Transl Med 6 2014 243ra85
156. J. Jackman, Y. Chen, A. Huang, B. Moffat, J.M. Scheer, and S.R. Leong Development of a two-part strategy to identify a therapeutic human bispecific antibody that inhibits IgE receptor signaling J Biol Chem 285 2010 20850 20859
157. A. Eggel, P. Buschor, M.J. Baumann, P. Amstutz, B.M. Stadler, and M. Vogel Inhibition of ongoing allergic reactions using a novel anti-IgE DARPin-Fc fusion protein Allergy 66 2011 961 968
158. T. Terada, K. Zhang, J. Belperio, V. Londhe, and A. Saxon A chimeric human-cat Fcγ-Fel d1 fusion protein inhibits systemic, pulmonary, and cutaneous allergic reactivity to intratracheal challenge in mice sensitized to Fel d1, the major cat allergen Clin Immunol 120 2006 45 56
159. D. Zhu, C.L. Kepley, K. Zhang, T. Terada, T. Yamada, and A. Saxon A chimeric human-cat fusion protein blocks cat-induced allergy Nat Med 11 2005 446 449
160. Y. Liu, Y. Sun, L.-J. Chang, N. Li, H. Li, and Y. Yu Blockade of peanut allergy with a novel Ara h 2-Fcγ fusion protein in mice J Allergy Clin Immunol 131 2013 213 221.e5
161. E. Wambre, J.H. DeLong, E.A. James, N. Torres-Chinn, W. Pfützner, and C. Möbs Specific immunotherapy modifies allergen-specific CD4+ T-cell responses in an epitope-dependent manner J Allergy Clin Immunol 133 2014 872 879.e7
162. O.T. Burton, S.L. Logsdon, J.S. Zhou, J. Medina-Tamayo, A. Abdel-Gadir, and M. Noval Rivas Oral immunotherapy induces IgG antibodies that act through FcγRIIb to suppress IgE-mediated hypersensitivity J Allergy Clin Immunol 134 2014 1310 1317.e6
163. L.D. Smith, R.J. Leatherbarrow, and A.C. Spivey Development of small molecules to target the IgE: FcεRI protein-protein interaction in allergies Future Med Chem 5 2013 1423 1435
164. B. Kim, A. Eggel, S.S. Tarchevskaya, M. Vogel, H. Prinz, and T.S. Jardetzky Accelerated disassembly of IgE-receptor complexes by a disruptive macromolecular inhibitor Nature 491 2012 613 617
165. A. Eggel, G. Baravalle, G. Hobi, B. Kim, P. Buschor, and P. Forrer Accelerated dissociation of IgE-FcεRI complexes by disruptive inhibitors actively desensitizes allergic effector cells J Allergy Clin Immunol 133 2014 1709 1719.e8
166. O.T. Burton, M. Noval Rivas, J.S. Zhou, S.L. Logsdon, A.R. Darling, and K.J. Koleoglou Immunoglobulin E signal inhibition during allergen ingestion leads to reversal of established food allergy and induction of regulatory T cells Immunity 41 2014 141 151
167. R.T. Strait, S.C. Morris, M. Yang, X.-W. Qu, and F.D. Finkelman Pathways of anaphylaxis in the mouse J Allergy Clin Immunol 109 2002 658 668
168. M.V. Khodoun, Z.Y. Kucuk, R.T. Strait, D. Krishnamurthy, K. Janek, and I. Lewkowich Rapid polyclonal desensitization with antibodies to IgE and FcεRIα J Allergy Clin Immunol 131 2013 1555 1564.e7