A pilot study of omalizumab to facilitate rapid oral desensitization in high-risk peanut-allergic patients

Journal of Allergy and Clinical Immunology

Volumn 132, Issue 6, 2013, Pages 1368-1374

  Schneider, Lynda C ^a   Rachid, Rima ^a   Lebovidge, Jennifer ^a   Blood, Emily ^a   Mittal, Mudita ^a   Umetsu, Dale T ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

desensitization; food allergy; omalizumab; Oral immunotherapy; peanut allergy

Indexed keywords

ADRENALIN; ANTIHISTAMINIC AGENT; DIPHENHYDRAMINE; FOOD ALLERGEN; IMMUNOGLOBULIN E; OMALIZUMAB; PLACEBO;

ADOLESCENT; ANAPHYLAXIS; ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; DESENSITIZATION; DOUBLE BLIND PLACEBO CONTROLLED FOOD CHALLENGE; DRUG WITHDRAWAL; FEMALE; FLOUR; FOOD ALLERGY; FOOD INTAKE; HIGH RISK PATIENT; HUMAN; IMMUNOTHERAPY; INJECTION SITE PAIN; INJECTION SITE SWELLING; MALE; ORAL DESENSITIZATION; PEANUT; PEANUT ALLERGY; PILOT STUDY; PRIORITY JOURNAL; PROVOCATION TEST; RAPID DESENSITIZATION; TREATMENT FAILURE; TREATMENT OUTCOME;

EID: 85027930521     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.09.046     Document Type: Article

References (38)

1. S.H. Sicherer, and H.A. Sampson Food allergy J Allergy Clin Immunol 125 2010 S116 S125
2. G. Lack Clinical practice. Food allergy N Engl J Med 359 2008 1252 1260
3. A.W. Burks Peanut allergy Lancet 371 2008 1538 1546
4. G. Lack, D. Fox, K. Northstone, and J. Golding Factors associated with the development of peanut allergy in childhood N Engl J Med 348 2003 977 985
5. S.H. Sicherer, A. Munoz-Furlong, J.H. Godbold, and H.A. Sampson US prevalence of self-reported peanut, tree nut, and sesame allergy: 11-year follow-up J Allergy Clin Immunol 125 2010 1322 1326
6. S.A. Bock, A. Munoz-Furlong, and H.A. Sampson Fatalities due to anaphylactic reactions to foods J Allergy Clin Immunol 107 2001 191 193
7. A.J. Cummings, R.C. Knibb, R.M. King, and J.S. Lucas The psychosocial impact of food allergy and food hypersensitivity in children, adolescents and their families: a review Allergy 65 2010 933 945
8. D.M. Fleischer, M.K. Conover-Walker, L. Christie, A.W. Burks, and R.A. Wood The natural progression of peanut allergy: resolution and the possibility of recurrence J Allergy Clin Immunol 112 2003 183 189
9. P. Meglio, E. Bartone, M. Plantamura, E. Arabito, and P.G. Giampietro A protocol for oral desensitization in children with IgE-mediated cow's milk allergy Allergy 59 2004 980 987
10. G. Longo, E. Barbi, I. Berti, R. Meneghetti, A. Pittalis, and L. Ronfani Specific oral tolerance induction in children with very severe cow's milk-induced reactions J Allergy Clin Immunol 121 2008 343 347
11. U. Staden, K. Blumchen, N. Blankenstein, N. Dannenberg, H. Ulbricht, and K. Dobberstein Rush oral immunotherapy in children with persistent cow's milk allergy J Allergy Clin Immunol 122 2008 418 419
12. A.D. Buchanan, T.D. Green, S.M. Jones, A.M. Scurlock, L. Christie, and K.A. Althage Egg oral immunotherapy in nonanaphylactic children with egg allergy J Allergy Clin Immunol 119 2007 199 205
13. A.W. Burks, S.M. Jones, R.A. Wood, D.M. Fleischer, S.H. Sicherer, and R.W. Lindblad Oral immunotherapy for treatment of egg allergy in children N Engl J Med 367 2012 233 243
14. S. Nash, P. Steele, J. Kamilaris, L. Pons, M. Kulis, and L. Lee Oral peanut immunotherapy for children with peanut allergy J Allergy Clin Immunol 121 2008 S147
15. A.T. Clark, S. Islam, Y. King, J. Deighton, K. Anagnostou, and P.W. Ewan Successful oral tolerance induction in severe peanut allergy Allergy 64 2009 1218 1220
16. A.M. Hofmann, A.M. Scurlock, S.M. Jones, K.P. Palmer, Y. Lokhnygina, and P.H. Steele Safety of a peanut oral immunotherapy protocol in children with peanut allergy J Allergy Clin Immunol 124 2009 286 291 291.e1-6
17. E. Enrique, F. Pineda, T. Malek, J. Bartra, M. Basagana, and R. Tella Sublingual immunotherapy for hazelnut food allergy: a randomized, double-blind, placebo-controlled study with a standardized hazelnut extract J Allergy Clin Immunol 116 2005 1073 1079
18. C.A. Keet, P.A. Frischmeyer-Guerrerio, A. Thyagarajan, J.T. Schroeder, R.G. Hamilton, and S. Boden The safety and efficacy of sublingual and oral immunotherapy for milk allergy J Allergy Clin Immunol 129 2012 448 455 455.e1-5
19. M. Calvani, V. Giorgio, and S. Miceli Sopo Specific oral tolerance induction for food: a systematic review Eur Ann Allergy Clin Immunol 42 2010 11 19
20. H. Sampson Peanut oral immunotherapy: is it ready for clinical practice? J Allergy Clin Immunol Pract 1 2013 15 21
21. K. Blumchen, H. Ulbricht, U. Staden, K. Dobberstein, J. Beschorner, and L.C. de Oliveira Oral peanut immunotherapy in children with peanut anaphylaxis J Allergy Clin Immunol 126 2010 83 91.e1
22. P. Meglio, P.G. Giampietro, R. Carello, I. Gabriele, S. Avitabile, and E. Galli Oral food desensitization in children with IgE-mediated hen's egg allergy: a new protocol with raw hen's egg Pediatr Allergy Immunol 24 2013 75 83
23. K. Anagnostou, A. Clark, Y. King, S. Islam, J. Deighton, and P. Ewan Efficacy and safety of high-dose peanut oral immunotherapy with factors predicting outcome Clin Exp Allergy 41 2011 1273 1281
24. C.H. Fanta Asthma. N Engl J Med 360 2009 1002 1014
25. D.Y. Leung, H.A. Sampson, J.W. Yunginger, A.W. Burks Jr., L.C. Schneider, and C.H. Wortel Effect of anti-IgE therapy in patients with peanut allergy N Engl J Med 348 2003 986 993
26. H.A. Sampson, D.Y. Leung, A.W. Burks, G. Lack, S.L. Bahna, and S.M. Jones A phase II, randomized, double-blind, parallel group, placebo-controlled oral food challenge trial of Xolair (omalizumab) in peanut allergy J Allergy Clin Immunol 127 2011 1309 1310.e1
27. K. Nadeau, L. Schneider, E. Hoyte, I. Borras, and D. Umetsu Rapid oral desensitization in combination with omalizumab therapy in patients with cow's milk allergy J Allergy Clin Immunol 127 2011 1722 1724
28. K.C. Nadeau, A. Kohli, S. Iyengar, R.H. DeKruyff, and D.T. Umetsu Oral immunotherapy and anti-IgE antibody-adjunctive treatment for food allergy Immunol Allergy Clin North Am 32 2012 111 133
29. D. Bedoret, A.K. Singh, V. Shaw, E.G. Hoyte, R. Hamilton, and R.H. Dekruyff Changes in antigen-specific T-cell number and function during oral desensitization in cow's milk allergy enabled with omalizumab Mucosal Immunol 5 2012 267 276
30. Dosing, Xolair. Available at: http://www.ema.europa.eu/docs/en-GB/ document-library/EPAR-Product-Information/human/000606/WC500057298.pdf. Accessed October 12, 2013.
31. D.W. MacGlashan Jr., B.S. Bochner, D.C. Adelman, P.M. Jardieu, A. Togias, and J. McKenzie-White Down-regulation of Fc(epsilon)RI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibody J Immunol 158 1997 1438 1445
32. S.A. Bock, H.A. Sampson, F.M. Atkins, R.S. Zeiger, S. Lehrer, and M. Sachs Double-blind, placebo-controlled food challenge (DBPCFC) as an office procedure: a manual J Allergy Clin Immunol 82 1988 986 997
33. A. Nowak-Wegrzyn, and A. Fiocchi Is oral immunotherapy the cure for food allergies? Curr Opin Allergy Clin Immunol 10 2010 214 219
34. S.M. Jones, L. Pons, J.L. Roberts, A.M. Scurlock, T.T. Perry, and M. Kulis Clinical efficacy and immune regulation with peanut oral immunotherapy J Allergy Clin Immunol 124 2009 292 300 300.e1-97
35. J.M. Skripak, S.D. Nash, H. Rowley, N.H. Brereton, S. Oh, and R.G. Hamilton A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy J Allergy Clin Immunol 122 2008 1154 1160
36. P. Varshney, S.M. Jones, A.M. Scurlock, T.T. Perry, A. Kemper, and P. Steele A randomized controlled study of peanut oral immunotherapy: clinical desensitization and modulation of the allergic response J Allergy Clin Immunol 127 2011 654 660
37. G.P. Yu, B. Weldon, S. Neale-May, and K.C. Nadeau The safety of peanut oral immunotherapy in peanut-allergic subjects in a single-center trial Int Arch Allergy Immunol 159 2012 179 182
38. S. Sanchez-Garcia, P. Rodriguez Del Rio, C. Escudero, M.J. Martinez-Gomez, and M.D. Ibanez Possible eosinophilic esophagitis induced by milk oral immunotherapy J Allergy Clin Immunol 129 2012 1155 1157