Mesenteric lymph nodes are critical for the induction of high-dose oral tolerance in the absence of Peyer's patches

European Journal of Immunology

Volumn 32, Issue 4, 2002, Pages 1109-1113

  Spahn, Thomas W ^a   Weiner, Howard L ^b   Rennert, Paul D ^c   Lgering, Norbert ^a   Fontana, Adriano ^b   Domschke, Wolfram ^a   Kucharzik, Torsten ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BIOGEN   (United States)

Author keywords

Intestinal antigen presentation; Lymph node; Suppression; Tolerance

Indexed keywords

CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN G; LYMPHOTOXIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

AGONIST; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DELAYED HYPERSENSITIVITY; FETUS DEVELOPMENT; GENE DELETION; IMMUNE DEFICIENCY; IMMUNOLOGICAL TOLERANCE; INTESTINE LYMPHATIC TISSUE; MESENTERY LYMPH NODE; MOUSE; NONHUMAN; PEYER PATCH; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS; ANTIGENS, CD; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; FEMALE; GENOTYPE; HYPERSENSITIVITY, DELAYED; IMMUNE TOLERANCE; IMMUNOGLOBULIN G; IMMUNOSUPPRESSION; INTERFERON TYPE II; LYMPHOTOXIN BETA RECEPTOR; LYMPHOTOXIN-ALPHA; MESENTERY; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; OVALBUMIN; PEYER'S PATCHES; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RECEPTORS, TUMOR NECROSIS FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RECOMBINANT FUSION PROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036237353     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200204)32:4<1109::AID-IMMU1109>3.0.CO;2-K     Document Type: Article

References (14)

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3. Induction of anergy or active suppression following oral tolerance is determined by antigen dosage
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5. Induction of oral tolerance to cellular immune responses in the absence of Peyer's patches
6. Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-alpha double-deficient mice
7. Lymph node genesis is induced by signaling through the lymphotoxin beta receptor
8. Organogenic role of B lymphocytes in mucosal immunity
9. The role of dendritic cells, B cells, and M cells in gut-oriented immune responses
10. Induction of oral tolerance in rats without Peyers's patches
11. Peyer's patches are required for oral tolerance to proteins
12. Splenectomy abrogates the induction of oral tolerance in experimental autoimmune uveoretinitis
13. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria
14. Surface lymphotoxin alpha/beta complex is required for the development of peripheral lymphoid organs