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Volumn 113, Issue 2, 2004, Pages 235-241

Amb a 1-immunostimulatory oligodeoxynucleotide conjugate immunotherapy decreases the nasal inflammatory response

Author keywords

Amb a 1 immunostimulatory phosphorothioate oligonucleotide conjugate; Immunotherapy; Ragweed; Rhinitis

Indexed keywords

ALLERGEN; AMB A 1 IMMUNOSTIMULATORY PHOSPHOROTHIOATE OLIGONUCLEOTIDE CONJUGATE; AMB A I PROTEIN, AMBROSIA ARTEMISIIFOLIA; BASIC PROTEIN; CYTOKINE; GAMMA INTERFERON; IMMUNOMODULATING AGENT; INTERLEUKIN 4; INTERLEUKIN 5; MESSENGER RNA; NUCLEOTIDE; OLIGONUCLEOTIDE; PLACEBO; RAGWEED ANTIGEN; UNCLASSIFIED DRUG; VEGETABLE PROTEIN;

EID: 1142273128     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2003.11.001     Document Type: Article
Times cited : (224)

References (15)
  • 1
    • 0026730709 scopus 로고
    • Immunohistology of the nasal mucosa following allergen-induced rhinitis. Identification of activated T lymphocytes, eosinophils, and neutrophils
    • Varney VA, Jacobson MR, Sudderick RM, Robinson DS, Irani AM, Schwartz LB, et al. Immunohistology of the nasal mucosa following allergen-induced rhinitis. Identification of activated T lymphocytes, eosinophils, and neutrophils. Am Rev Respir Dis 1992;146:170-6.
    • (1992) Am Rev Respir Dis , vol.146 , pp. 170-176
    • Varney, V.A.1    Jacobson, M.R.2    Sudderick, R.M.3    Robinson, D.S.4    Irani, A.M.5    Schwartz, L.B.6
  • 2
    • 0029077881 scopus 로고
    • Changes in allergic inflammation associated with successful immunotherapy
    • Durham SR, Kay AB, Hamid Q. Changes in allergic inflammation associated with successful immunotherapy. Intern Arch Allergy Immunol 1995;107:282-4.
    • (1995) Intern Arch Allergy Immunol , vol.107 , pp. 282-284
    • Durham, S.R.1    Kay, A.B.2    Hamid, Q.3
  • 3
    • 0030003889 scopus 로고    scopus 로고
    • Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocytes and eosinophils in the nasal mucosa and increases the number of cells expressing messenger RNA for interferon-gamma
    • Durham SR, Ying S, Varney VA, Jacobson MR, Sudderick RM, Mackay IS, et al. Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocytes and eosinophils in the nasal mucosa and increases the number of cells expressing messenger RNA for interferon-gamma. J Allergy Clin Immunol 1996;97:1356-65.
    • (1996) J Allergy Clin Immunol , vol.97 , pp. 1356-1365
    • Durham, S.R.1    Ying, S.2    Varney, V.A.3    Jacobson, M.R.4    Sudderick, R.M.5    Mackay, I.S.6
  • 6
    • 0031041686 scopus 로고    scopus 로고
    • Increases in 1L-12 messenger RNA+ cells accompany inhibition of allergen-induced late skin responses after successful grass pollen immunotherapy
    • Hamid QA, Schotman E, Jacobson MR, Walker SM, Durham SR. Increases in 1L-12 messenger RNA+ cells accompany inhibition of allergen-induced late skin responses after successful grass pollen immunotherapy. J Allergy Clin Immunol 1997;99:254-60.
    • (1997) J Allergy Clin Immunol , vol.99 , pp. 254-260
    • Hamid, Q.A.1    Schotman, E.2    Jacobson, M.R.3    Walker, S.M.4    Durham, S.R.5
  • 7
    • 0343953087 scopus 로고    scopus 로고
    • Conjugation of immunostimulatory DNA to the short ragweed allergen Amb a 1 enhances its immunogenicity and reduces its allergenicity
    • Tighe H, Takabayashi K, Schwartz D, Van Nest G, Tuck S, Eiden JD, et al. Conjugation of immunostimulatory DNA to the short ragweed allergen Amb a 1 enhances its immunogenicity and reduces its allergenicity. J Allergy Clin Immunol 2000;106:124-34.
    • (2000) J Allergy Clin Immunol , vol.106 , pp. 124-134
    • Tighe, H.1    Takabayashi, K.2    Schwartz, D.3    Van Nest, G.4    Tuck, S.5    Eiden, J.D.6
  • 8
    • 17844371968 scopus 로고    scopus 로고
    • Immunostimulatory sequence DNA linked to the Amb a 1 allergen promotes Th1 cytokine expression while downregulating Th2 cytokine expression in PBMCs from human patients with ragweed allergy
    • Marshall JD, Abtahi S, Eiden JJ, Tuck S, Milley R, Haycock F, et al. Immunostimulatory sequence DNA linked to the Amb a 1 allergen promotes Th1 cytokine expression while downregulating Th2 cytokine expression in PBMCs from human patients with ragweed allergy. J Allergy Clin Immunol 2001;108:191-7.
    • (2001) J Allergy Clin Immunol , vol.108 , pp. 191-197
    • Marshall, J.D.1    Abtahi, S.2    Eiden, J.J.3    Tuck, S.4    Milley, R.5    Haycock, F.6
  • 9
    • 0036126748 scopus 로고    scopus 로고
    • Amb a 1-linked CpG oligodeoxynucleotides reverse established airway hyperresponsiveness in a murine model of asthma
    • Santeliz JV, Van Nest G, Traquina P, Larsen E, Wills-Karp M. Amb a 1-linked CpG oligodeoxynucleotides reverse established airway hyperresponsiveness in a murine model of asthma. J Allergy Clin Immunol 2002;109:455-62.
    • (2002) J Allergy Clin Immunol , vol.109 , pp. 455-462
    • Santeliz, J.V.1    Van Nest, G.2    Traquina, P.3    Larsen, E.4    Wills-Karp, M.5
  • 10
    • 0000836828 scopus 로고    scopus 로고
    • Immunostimulatory oligonucleotides conjugated to Amb a 1: Safety, skin test reactivity, and basophil histamine release
    • Creticos PS, Eiden JJ, Balcer SL, Van Nest G, Kagey-Sobotka A, Tuck S, et al. Immunostimulatory oligonucleotides conjugated to Amb a 1: safety, skin test reactivity, and basophil histamine release. J Allergy Clin Immunol 2000;105(suppl):S70.
    • (2000) J Allergy Clin Immunol , vol.105 , Issue.SUPPL.
    • Creticos, P.S.1    Eiden, J.J.2    Balcer, S.L.3    Van Nest, G.4    Kagey-Sobotka, A.5    Tuck, S.6
  • 12
    • 0024210524 scopus 로고
    • The relationship between infiltrating CD4+ lymphocytes, activated eosinophils, and the magnitude of the allergen-induced late phase cutaneous reaction in man
    • Frew AJ, Kay AB. The relationship between infiltrating CD4+ lymphocytes, activated eosinophils, and the magnitude of the allergen-induced late phase cutaneous reaction in man. J Immunol 1988;141:4158-64.
    • (1988) J Immunol , vol.141 , pp. 4158-4164
    • Frew, A.J.1    Kay, A.B.2
  • 13
    • 0023574283 scopus 로고
    • Localization of atrial natriuretic peptide mRNA and immunoreactivity in the rat heart and human atrial appendage
    • Hamid Q, Wharton J, Terenghi G, Hassall CJ, Aimi J, Taylor KM, et al. Localization of atrial natriuretic peptide mRNA and immunoreactivity in the rat heart and human atrial appendage. Proc Natl Acad Sci USA 1987;84:6760-4.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 6760-6764
    • Hamid, Q.1    Wharton, J.2    Terenghi, G.3    Hassall, C.J.4    Aimi, J.5    Taylor, K.M.6
  • 14


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.