Development of natural tolerance and induced desensitization in cow's milk allergy

Pediatric Allergy and Immunology

Volumn 24, Issue 2, 2013, Pages 114-121

  Savilahti, Emma M ^a   Savilahti, Erkki ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Cow's milk allergy; Desensitization; Oral immunotherapy; Oral tolerance

Indexed keywords

IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G4;

ANTIBODY RESPONSE; CD4+ CD25+ T LYMPHOCYTE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DESENSITIZATION; HUMAN; IMMUNOGLOBULIN A DEFICIENCY; IMMUNOLOGICAL TOLERANCE; INTESTINE FLORA; LACTOBACILLUS RHAMNOSUS; MILK ALLERGY; ORAL IMMUNOTHERAPY; PRICK TEST; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REVIEW; STOMACH ACID SECRETION; TH1 CELL; TH1 TH2 BALANCE; TH2 CELL;

ADMINISTRATION, ORAL; ANTIBODIES; CHILD, PRESCHOOL; DESENSITIZATION, IMMUNOLOGIC; HUMANS; IMMUNE TOLERANCE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INFANT; MILK HYPERSENSITIVITY; MILK PROTEINS; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; TH2 CELLS; TREATMENT OUTCOME;

EID: 84875500281     PISSN: 09056157     EISSN: 13993038     Source Type: Journal    
DOI: 10.1111/pai.12004     Document Type: Review

References (80)

1. Kemeny DM, Price JF, Richardson V, Richards D, Lessof MH. The IgE and IgG subclass antibody response to foods in babies during the first year of life and their relationship to feeding regimen and the development of food allergy. J Allergy Clin Immunol 1991: 87: 920-9.
2. Saarinen KM, Juntunen-Backman K, Jarvenpaa AL, et al. Supplementary feeding in maternity hospitals and the risk of cow's milk allergy: a prospective study of 6209 infants. J Allergy Clin Immunol 1999: 104: 457-61.
3. Host A, Halken S. A prospective study of cow milk allergy in Danish infants during the first 3years of life. Clinical course in relation to clinical and immunological type of hypersensitivity reaction. Allergy 1990: 45: 587-96.
4. Fiocchi A, Schunemann HJ, Brozek J, et al. Diagnosis and Rationale for Action Against Cow's Milk Allergy (DRACMA): a summary report. J Allergy Clin Immunol 2010: 126: 1119-28.e12.
5. Sicherer SH. Epidemiology of food allergy. J Allergy Clin Immunol 2011: 127: 594-602.
6. Wang J, Sampson HA. Food allergy. J Clin Invest 2011: 121: 827-35.
7. Nowak-Wegrzyn A, Sampson HA. Future therapies for food allergies. J Allergy Clin Immunol 2011: 127: 558-73; quiz 574-5.
8. Brozek JL, Terracciano L, Hsu J, et al. Oral immunotherapy for IgE-mediated cow's milk allergy: a systematic review and meta-analysis. Clin Exp Allergy 2012: 42: 363-74.
9. Perrier C, Corthesy B. Gut permeability and food allergies. Clin Exp Allergy 2011: 41: 20-8.
10. Cerutti A, Chen K, Chorny A. Immunoglobulin responses at the mucosal interface. Annu Rev Immunol 2011: 29: 273-93.
11. Saarinen KM, Pelkonen AS, Makela MJ, Savilahti E. Clinical course and prognosis of cow's milk allergy are dependent on milk-specific IgE status. J Allergy Clin Immunol 2005: 116: 869-75.
12. Bjorksten B, Sepp E, Julge K, Voor T, Mikelsaar M. Allergy development and the intestinal microflora during the first year of life. J Allergy Clin Immunol 2001: 108: 516-20.
13. Berni Canani R, Nocerino R, Terrin G, et al. Effect of Lactobacillus GG on tolerance acquisition in infants with cow's milk allergy: a randomized trial. J Allergy Clin Immunol 2012: 129: 580-2, 582.e1-5.
14. Pohjavuori E, Viljanen M, Korpela R, et al. Lactobacillus GG effect in increasing IFN-gamma production in infants with cow's milk allergy. J Allergy Clin Immunol 2004: 114: 131-6.
15. Martelli A, De Chiara A, Corvo M, Restani P, Fiocchi A. Beef allergy in children with cow's milk allergy; cow's milk allergy in children with beef allergy. Ann Allergy Asthma Immunol 2002: 89: 38-43.
16. Jarvinen KM, Geller L, Bencharitiwong R, Sampson HA. Presence of functional, autoreactive human milk-specific IgE in infants with cow's milk allergy. Clin Exp Allergy 2012: 42: 238-47.
17. Skripak JM, Matsui EC, Mudd K, Wood RA. The natural history of IgE-mediated cow's milk allergy. J Allergy Clin Immunol 2007: 120: 1172-7.
18. Prescott S, Allen KJ. Food allergy: riding the second wave of the allergy epidemic. Pediatr Allergy Immunol 2011: 22: 155-60.
19. Elizur A, Rajuan N, Goldberg MR, Leshno M, Cohen A, Katz Y. Natural course and risk factors for persistence of IgE-mediated cow's milk allergy. J Pediatr 2012: Apr 4 [Epub ahead of print].
20. Vanto T, Helppila S, Juntunen-Backman K, et al. Prediction of the development of tolerance to milk in children with cow's milk hypersensitivity. J Pediatr 2004: 144: 218-22.
21. Garcia-Ara MC, Boyano-Martinez MT, Diaz-Pena JM, Martin-Munoz MF, Martin-Esteban M. Cow's milk-specific immunoglobulin E levels as predictors of clinical reactivity in the follow-up of the cow's milk allergy infants. Clin Exp Allergy 2004: 34: 866-70.
22. Fiocchi A, Terracciano L, Bouygue GR, et al. Incremental prognostic factors associated with cow's milk allergy outcomes in infant and child referrals: the Milan Cow's Milk Allergy Cohort study. Ann Allergy Asthma Immunol 2008: 101: 166-73.
23. Kim JS, Nowak-Wegrzyn A, Sicherer SH, Noone S, Moshier EL, Sampson HA. Dietary baked milk accelerates the resolution of cow's milk allergy in children. J Allergy Clin Immunol 2011: 128: 125-31.e2.
24. Terracciano L, Bouygue GR, Sarratud T, Veglia F, Martelli A, Fiocchi A. Impact of dietary regimen on the duration of cow's milk allergy: a random allocation study. Clin Exp Allergy 2010: 40: 637-42.
25. Beyer K, Castro R, Birnbaum A, Benkov K, Pittman N, Sampson HA. Human milk-specific mucosal lymphocytes of the gastrointestinal tract display a TH2 cytokine profile. J Allergy Clin Immunol 2002: 109: 707-13.
26. Perez-Machado MA, Ashwood P, Thomson MA, et al. Reduced transforming growth factor-beta1-producing T cells in the duodenal mucosa of children with food allergy. Eur J Immunol 2003: 33: 2307-15.
27. Schade RP, Van Ieperen-Van Dijk AG, Van Reijsen FC, et al. Differences in antigen-specific T-cell responses between infants with atopic dermatitis with and without cow's milk allergy: relevance of TH2 cytokines. J Allergy Clin Immunol 2000: 106: 1155-62.
28. Tiemessen MM, Van Ieperen-Van Dijk AG, Bruijnzeel-Koomen CA, Garssen J, Knol EF, Van Hoffen E. Cow's milk-specific T-cell reactivity of children with and without persistent cow's milk allergy: key role for IL-10. J Allergy Clin Immunol 2004: 113: 932-9.
29. Vocca I, Canani RB, Camarca A, et al. Peripheral blood immune response elicited by beta-lactoglobulin in childhood cow's milk allergy. Pediatr Res 2011: 70: 549-54.
30. Wanich N, Nowak-Wegrzyn A, Sampson HA, Shreffler WG. Allergen-specific basophil suppression associated with clinical tolerance in patients with milk allergy. J Allergy Clin Immunol 2009: 123: 789-94.e20.
31. Akdis M, Verhagen J, Taylor A, et al. Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J Exp Med 2004: 199: 1567-75.
32. Ling EM, Smith T, Nguyen XD, et al. Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease. Lancet 2004: 363: 608-15.
33. Torgerson TR, Linane A, Moes N, et al. Severe food allergy as a variant of IPEX syndrome caused by a deletion in a noncoding region of the FOXP3 gene. Gastroenterology 2007: 132: 1705-17.
34. Smith M, Tourigny MR, Noakes P, Thornton CA, Tulic MK, Prescott SL. Children with egg allergy have evidence of reduced neonatal CD4(+)CD25(+)CD127(lo/-) regulatory T cell function. J Allergy Clin Immunol 2008: 121: 1460-6, 1466.e1-7.
35. Karlsson MR, Rugtveit J, Brandtzaeg P. Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow's milk allergy. J Exp Med 2004: 199: 1679-88.
36. Shreffler WG, Wanich N, Moloney M, Nowak-Wegrzyn A, Sampson HA. Association of allergen-specific regulatory T cells with the onset of clinical tolerance to milk protein. J Allergy Clin Immunol 2009: 123: 43-52.e7.
37. Savilahti EM, Karinen S, Salo HM, et al. Combined T regulatory cell and Th2 expression profile identifies children with cow's milk allergy. Clin Immunol 2010: 136: 16-20.
38. Westerholm-Ormio M, Vaarala O, Tiittanen M, Savilahti E. Infiltration of Foxp3- and Toll-like receptor-4-positive cells in the intestines of children with food allergy. J Pediatr Gastroenterol Nutr 2010: 50: 367-76.
39. Szepfalusi Z, Nentwich I, Gerstmayr M, et al. Prenatal allergen contact with milk proteins. Clin Exp Allergy 1997: 27: 28-35.
40. Vaarala O, Saukkonen T, Savilahti E, Klemola T, Akerblom HK. Development of immune response to cow's milk proteins in infants receiving cow's milk or hydrolyzed formula. J Allergy Clin Immunol 1995: 96: 917-23.
41. Kuitunen M, Savilahti E. Mucosal IgA, mucosal cow's milk antibodies, serum cow's milk antibodies and gastrointestinal permeability in infants. Pediatr Allergy Immunol 1995: 6: 30-5.
42. Hattevig G, Kjellman B, Bjorksten B. Appearance of IgE antibodies to ingested and inhaled allergens during the first 12years of life in atopic and non-atopic children. Pediatr Allergy Immunol 1993: 4: 182-6.
43. Savilahti EM, Saarinen KM, Savilahti E. Duration of clinical reactivity in cow's milk allergy is associated with levels of specific immunoglobulin G4 and immunoglobulin A antibodies to beta-lactoglobulin. Clin Exp Allergy 2010: 40: 251-6.
44. Shek LP, Soderstrom L, Ahlstedt S, Beyer K, Sampson HA. Determination of food specific IgE levels over time can predict the development of tolerance in cow's milk and hen's egg allergy. J Allergy Clin Immunol 2004: 114: 387-91.
45. Vila L, Beyer K, Jarvinen KM, Chatchatee P, Bardina L, Sampson HA. Role of conformational and linear epitopes in the achievement of tolerance in cow's milk allergy. Clin Exp Allergy 2001: 31: 1599-606.
46. Cerecedo I, Zamora J, Shreffler WG, et al. Mapping of the IgE and IgG4 sequential epitopes of milk allergens with a peptide microarray-based immunoassay. J Allergy Clin Immunol 2008: 122: 589-94.
47. Wang J, Lin J, Bardina L, et al. Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy. J Allergy Clin Immunol 2010: 125: 695-702, 702.e1-702.e6.
48. Savilahti EM, Rantanen V, Lin JS, et al. Early recovery from cow's milk allergy is associated with decreasing IgE and increasing IgG4 binding to cow's milk epitopes. J Allergy Clin Immunol 2010: 125: 1315-21.e9.
49. Jarvinen KM, Beyer K, Vila L, Chatchatee P, Busse PJ, Sampson HA. B-cell epitopes as a screening instrument for persistent cow's milk allergy. J Allergy Clin Immunol 2002: 110: 293-7.
50. Stapel SO, Asero R, Ballmer-Weber BK, et al. Testing for IgG4 against foods is not recommended as a diagnostic tool: EAACI Task Force Report. Allergy 2008: 63: 793-6.
51. Jenmalm MC, Bjorksten B. Exposure to cow's milk during the first 3months of life is associated with increased levels of IgG subclass antibodies to beta-lactoglobulin to 8years. J Allergy Clin Immunol 1998: 102: 671-8.
52. Juvonen P, Mansson M, Kjellman NI, Bjorksten B, Jakobsson I. Development of immunoglobulin G and immunoglobulin E antibodies to cow's milk proteins and ovalbumin after a temporary neonatal exposure to hydrolyzed and whole cow's milk proteins. Pediatr Allergy Immunol 1999: 10: 191-8.
53. Akdis CA, Akdis M. Mechanisms of allergen-specific immunotherapy. J Allergy Clin Immunol 2011: 127: 18-27; quiz 28-9.
54. Ruiter B, Knol EF, van Neerven RJ, et al. Maintenance of tolerance to cow's milk in atopic individuals is characterized by high levels of specific immunoglobulin G4. Clin Exp Allergy 2007: 37: 1103-10.
55. Lemon-Mule H, Sampson HA, Sicherer SH, Shreffler WG, Noone S, Nowak-Wegrzyn A. Immunologic changes in children with egg allergy ingesting extensively heated egg. J Allergy Clin Immunol 2008: 122: 977-83.e1.
56. Tomicic S, Norrman G, Falth-Magnusson K, Jenmalm MC, Devenney I, Bottcher MF. High levels of IgG(4) antibodies to foods during infancy are associated with tolerance to corresponding foods later in life. Pediatr Allergy Immunol 2009: 20: 35-41.
57. Satoguina JS, Weyand E, Larbi J, Hoerauf A. T regulatory-1 cells induce IgG4 production by B cells: role of IL-10. J Immunol 2005: 174: 4718-26.
58. Meiler F, Klunker S, Zimmermann M, Akdis CA, Akdis M. Distinct regulation of IgE, IgG4 and IgA by T regulatory cells and toll-like receptors. Allergy 2008: 63: 1455-63.
59. Kukkonen K, Kuitunen M, Haahtela T, Korpela R, Poussa T, Savilahti E. High intestinal IgA associates with reduced risk of IgE-associated allergic diseases. Pediatr Allergy Immunol 2010: 1: 67-73.
60. Perkkio M. Immunohistochemical study of intestinal biopsies from children with atopic eczema due to food allergy. Allergy 1980: 35: 573-80.
61. Savilahti E, Tainio VM, Salmenpera L, et al. Low colostral IgA associated with cow's milk allergy. Acta Paediatr Scand 1991: 80: 1207-13.
62. Jarvinen KM, Laine ST, Jarvenpaa AL, Suomalainen HK. Does low IgA in human milk predispose the infant to development of cow's milk allergy?. Pediatr Res 2000: 48: 457-62.
63. Bottcher MF, Haggstrom P, Bjorksten B, Jenmalm MC. Total and allergen-specific immunoglobulin A levels in saliva in relation to the development of allergy in infants up to 2years of age. Clin Exp Allergy 2002: 32: 1293-8.
64. Kukkonen K, Kuitunen M, Haahtela T, Korpela R, Poussa T, Savilahti E. High intestinal IgA associates with reduced risk of IgE-associated allergic diseases. Pediatr Allergy Immunol 2010: 21: 67-73.
65. Scadding GW, Shamji MH, Jacobson MR, et al. Sublingual grass pollen immunotherapy is associated with increases in sublingual Foxp3-expressing cells and elevated allergen-specific immunoglobulin G4, immunoglobulin A and serum inhibitory activity for immunoglobulin E-facilitated allergen binding to B cells. Clin Exp Allergy 2010: 40: 598-606.
66. Pilette C, Nouri-Aria KT, Jacobson MR, et al. Grass pollen immunotherapy induces an allergen-specific IgA2 antibody response associated with mucosal TGF-beta expression. J Immunol 2007: 178: 4658-66.
67. Miranda DO, Silva DA, Fernandes JF, et al. Serum and salivary IgE, IgA, and IgG4 antibodies to Dermatophagoides pteronyssinus and its major allergens, Der p1 and Der p2, in allergic and nonallergic children. Clin Dev Immunol 2011: 2011: 302739.
68. Martorell A, De la Hoz B, Ibanez MD, et al. Oral desensitization as a useful treatment in 2-year-old children with cow's milk allergy. Clin Exp Allergy 2011: 41: 1297-304.
69. Meglio P, Bartone E, Plantamura M, Arabito E, Giampietro PG. A protocol for oral desensitization in children with IgE-mediated cow's milk allergy. Allergy 2004: 59: 980-7.
70. Staden U, Rolinck-Werninghaus C, Brewe F, Wahn U, Niggemann B, Beyer K. Specific oral tolerance induction in food allergy in children: efficacy and clinical patterns of reaction. Allergy 2007: 62: 1261-9.
71. Skripak JM, Nash SD, Rowley H, et al. A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy. J Allergy Clin Immunol 2008: 122: 1154-60.
72. Pajno GB, Caminiti L, Ruggeri P, et al. Oral immunotherapy for cow's milk allergy with a weekly up-dosing regimen: a randomized single-blind controlled study. Ann Allergy Asthma Immunol 2010: 105: 376-81.
73. Longo G, Barbi E, Berti I, et al. Specific oral tolerance induction in children with very severe cow's milk-induced reactions. J Allergy Clin Immunol 2008: 121: 343-7.
74. Alvaro M, Giner MT, Vazquez M, et al. Specific oral desensitization in children with IgE-mediated cow's milk allergy. Evolution in one year. Eur J Pediatr 2012: 171: 1389-95.
75. Meglio P, Giampietro PG, Gianni S, Galli E. Oral desensitization in children with immunoglobulin E-mediated cow's milk allergy--follow-up at 4yr and 8months. Pediatr Allergy Immunol 2008: 19: 412-9.
76. Bedoret D, Singh AK, Shaw V, et al. Changes in antigen-specific T-cell number and function during oral desensitization in cow's milk allergy enabled with omalizumab. Mucosal Immunol 2012: 5: 267-76.
77. Narisety SD, Skripak JM, Steele P, et al. Open-label maintenance after milk oral immunotherapy for IgE-mediated cow's milk allergy. J Allergy Clin Immunol 2009: 124: 610-2.
78. Varshney P, Jones SM, Scurlock AM, et al. A randomized controlled study of peanut oral immunotherapy: clinical desensitization and modulation of the allergic response. J Allergy Clin Immunol 2011: 127: 654-60.
79. Jones SM, Pons L, Roberts JL, et al. Clinical efficacy and immune regulation with peanut oral immunotherapy. J Allergy Clin Immunol 2009: 124: 292-300, 300.e1-97.
80. Morisset M, Moneret-Vautrin DA, Guenard L, et al. Oral desensitization in children with milk and egg allergies obtains recovery in a significant proportion of cases. A randomized study in 60 children with cow's milk allergy and 90 children with egg allergy. Eur Ann Allergy Clin Immunol 2007: 39: 12-9.