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Volumn 18, Issue 2, 2000, Pages 157-162

The pharmacological basis of anti-IgE therapy

Author keywords

Allergy; Anti IgE; Asthma; Fc RI; Humanized antibodies; Immune complexes; Immunoglobulin E

Indexed keywords

IMMUNOGLOBULIN E ANTIBODY; MONOCLONAL ANTIBODY;

EID: 0000898623     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/72601     Document Type: Review
Times cited : (285)

References (61)
  • 2
    • 0031753198 scopus 로고    scopus 로고
    • Searching for the cause of the increase in asthma
    • Carter, S.E. & Patts-Mills, T.A. Searching for the cause of the increase in asthma. Curr. Opin. Pediatr. 10, 594-599 (1998).
    • (1998) Curr. Opin. Pediatr. , vol.10 , pp. 594-599
    • Carter, S.E.1    Patts-Mills, T.A.2
  • 3
    • 0031837176 scopus 로고    scopus 로고
    • Epidemiology of rhinitis and asthma
    • Lundback, B. Epidemiology of rhinitis and asthma. Clin. Exp. Allergy 28 (suppl. 2), 3-10 (1998).
    • (1998) Clin. Exp. Allergy , vol.28 , Issue.2 SUPPL. , pp. 3-10
    • Lundback, B.1
  • 4
    • 0030714630 scopus 로고    scopus 로고
    • Quality of life in adults and children with asthma and rhinitis
    • Juniper, E.F. Quality of life in adults and children with asthma and rhinitis. Allergy 52, 971-977 (1997).
    • (1997) Allergy , vol.52 , pp. 971-977
    • Juniper, E.F.1
  • 5
    • 0030876380 scopus 로고    scopus 로고
    • A national estimate of the economic costs of asthma
    • Smith, D.H. et al. A national estimate of the economic costs of asthma. Am. J. Respir. Crit. Care Med. 156, 787-793 (1997).
    • (1997) Am. J. Respir. Crit. Care Med. , vol.156 , pp. 787-793
    • Smith, D.H.1
  • 7
    • 0033549827 scopus 로고    scopus 로고
    • Long-term clinical efficacy of grass pollen immunotherapy
    • Durham, S.R. et al. Long-term clinical efficacy of grass pollen immunotherapy. N. Engl. J. Med. 341, 468-475 (1999).
    • (1999) N. Engl. J. Med. , vol.341 , pp. 468-475
    • Durham, S.R.1
  • 8
    • 0027155071 scopus 로고
    • Can anti-IgE be used to treat allergy?
    • Davis, F.M. et al. Can anti-IgE be used to treat allergy? Springer Semin. Immunopathol. 15, 51-73 (1993).
    • (1993) Springer Semin. Immunopathol. , vol.15 , pp. 51-73
    • Davis, F.M.1
  • 9
    • 0031474128 scopus 로고    scopus 로고
    • Therapeutic potential of anti-IgE antibodies
    • Heusser, C. & Jardieu, P. Therapeutic potential of anti-IgE antibodies. Curr. Opin. Immunol. 9, 805-813 (1997).
    • (1997) Curr. Opin. Immunol. , vol.9 , pp. 805-813
    • Heusser, C.1    Jardieu, P.2
  • 10
    • 17644441947 scopus 로고    scopus 로고
    • The effect of intravenous administration of a chimeric anti-IgE antibody on serum IgE levels in atopic subjects: Efficacy, safety, and pharmacokinetics
    • Corne, J. et al. The effect of intravenous administration of a chimeric anti-IgE antibody on serum IgE levels in atopic subjects: efficacy, safety, and pharmacokinetics. J. Clin. Invest. 99, 879-887 (1997).
    • (1997) J. Clin. Invest. , vol.99 , pp. 879-887
    • Corne, J.1
  • 11
    • 13144282659 scopus 로고    scopus 로고
    • Clinical efficacy of CGP 51901, an anti-IgE chimeric monoclonal antibody, in patients with allergic rhinitis: Is it related to the extent of IgE suppression and pharmacokinetics?
    • Racine-Poon, A. et al. Clinical efficacy of CGP 51901, an anti-IgE chimeric monoclonal antibody, in patients with allergic rhinitis: is it related to the extent of IgE suppression and pharmacokinetics? Clin. Pharmcol. Ther. 62, 675-690 (1997).
    • (1997) Clin. Pharmcol. Ther. , vol.62 , pp. 675-690
    • Racine-Poon, A.1
  • 12
    • 0027364063 scopus 로고
    • Humanization of a mouse anti-human IgE antibody: A potential therapeutic for IgE-mediated allergies
    • Kolbinger, F., Saldanha, J., Hardman, N. & Bendig, M.M. Humanization of a mouse anti-human IgE antibody: a potential therapeutic for IgE-mediated allergies. Protein Eng. 6, 971-980 (1993).
    • (1993) Protein Eng. , vol.6 , pp. 971-980
    • Kolbinger, F.1    Saldanha, J.2    Hardman, N.3    Bendig, M.M.4
  • 13
    • 0027244256 scopus 로고
    • Humanization of an antibody directed against IgE
    • Presta, L.G. et al. Humanization of an antibody directed against IgE. J. Immunol. 151, 2623-2632 (1993).
    • (1993) J. Immunol. , vol.151 , pp. 2623-2632
    • Presta, L.G.1
  • 14
    • 0030956903 scopus 로고    scopus 로고
    • The effect of an anti-IgE monoclonal antibody on the early- And late-phase responses to allergen inhalation in asthmatic patients
    • Fahy, J.V. et al. The effect of an anti-IgE monoclonal antibody on the early- and late-phase responses to allergen inhalation in asthmatic patients. Am. J. Respir. Crit. Care Med. 155, 1824-1834 (1997).
    • (1997) Am. J. Respir. Crit. Care Med. , vol.155 , pp. 1824-1834
    • Fahy, J.V.1
  • 15
    • 8244226656 scopus 로고    scopus 로고
    • Inhibitory effects of an anti-IgE antibody E25 on allergen-induced early asthmatic response
    • Boulet, L.P. et al. Inhibitory effects of an anti-IgE antibody E25 on allergen-induced early asthmatic response. Am. J. Respir. Crit. Care Med. 155, 1835-1840 (1997).
    • (1997) Am. J. Respir. Crit. Care Med. , vol.155 , pp. 1835-1840
    • Boulet, L.P.1
  • 16
    • 0033599043 scopus 로고    scopus 로고
    • Treatment of allergic asthma with monoclonal anti-IgE antibody
    • Milgrom, E. et al. Treatment of allergic asthma with monoclonal anti-IgE antibody. N. Engl. J. Med. 341, 1966-1973 (1999).
    • (1999) N. Engl. J. Med. , vol.341 , pp. 1966-1973
    • Milgrom, E.1
  • 17
    • 0343467238 scopus 로고    scopus 로고
    • RhuMAb-E25 treatment controls the symptoms of birch pollen induced seasonal allergic rhinitis adn reduces the treatment for rescue medication
    • Oslo, Norway, May 14
    • th Nordic Congress of Allergology, Oslo, Norway, May 14, 1999.
    • (1999) th Nordic Congress of Allergology
    • Adelroth, E.1
  • 19
    • 0033599058 scopus 로고    scopus 로고
    • Anti-IgE antibody therapy for asthma
    • Barnes, P.J. Anti-IgE antibody therapy for asthma. N. Engl. J. Med. 341, 2006-2008 (1999).
    • (1999) N. Engl. J. Med. , vol.341 , pp. 2006-2008
    • Barnes, P.J.1
  • 21
    • 11944270019 scopus 로고
    • Monoclonal antibodies specific for human IgE-producing B cells: A potential therapeutic for IgE-mediated allergic diseases
    • Chang, T.W. et al. Monoclonal antibodies specific for human IgE-producing B cells: a potential therapeutic for IgE-mediated allergic diseases. Bio/Technology 8, 122-126 (1990).
    • (1990) Bio/Technology , vol.8 , pp. 122-126
    • Chang, T.W.1
  • 22
    • 0025089806 scopus 로고
    • Can antibodies to IgE act as anti-allergies?
    • Bialy, H. Can antibodies to IgE act as anti-allergies? Bio/Technology 8, 96 (1990).
    • (1990) Bio/Technology , vol.8 , pp. 96
    • Bialy, H.1
  • 24
    • 0027417128 scopus 로고
    • Releasability of human basophils: Cellular sensitivity and maximal histamine release are independent variables
    • MacGlashan, D.W. Releasability of human basophils: cellular sensitivity and maximal histamine release are independent variables. J. Allergy Clin. Immunol. 91, 605-615 (1993).
    • (1993) J. Allergy Clin. Immunol. , vol.91 , pp. 605-615
    • MacGlashan, D.W.1
  • 25
    • 0024399082 scopus 로고
    • Blocking of passive sensitization of human mast cells and basophil granulocytes with IgE antibodies by a recombinant human ε-chain fragment of 76 amino acids. Proc
    • Helm, B. et al. Blocking of passive sensitization of human mast cells and basophil granulocytes with IgE antibodies by a recombinant human ε-chain fragment of 76 amino acids. Proc. Natl. Acad. Sci. USA 86, 9465-9469 (1989).
    • (1989) Natl. Acad. Sci. USA , vol.86 , pp. 9465-9469
    • Helm, B.1
  • 26
    • 0026078016 scopus 로고
    • Mapping of the high affinity Fc epsilon receptor binding site to the third constant domain of IgE
    • Nissim, A., Jouvin, M.H. & Eshhar, Z. Mapping of the high affinity Fc epsilon receptor binding site to the third constant domain of IgE. EMBO J. 10, 101-107 (1991).
    • (1991) EMBO J. , vol.10 , pp. 101-107
    • Nissim, A.1    Jouvin, M.H.2    Eshhar, Z.3
  • 27
    • 0028143496 scopus 로고
    • The binding site on human immunoglobulin E for its high affinity receptor
    • Presta, L. et al. The binding site on human immunoglobulin E for its high affinity receptor. J. Biol. Chem. 269, 26368-26373 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 26368-26373
    • Presta, L.1
  • 28
    • 0031443213 scopus 로고    scopus 로고
    • Participation of the N-terminal region of Cε3 in the binding of human IgE to its high-affinity receptor FcεRI
    • Henry, A.J. et al. Participation of the N-terminal region of Cε3 in the binding of human IgE to its high-affinity receptor FcεRI. Biochemistry 36, 15568-15578 (1997).
    • (1997) Biochemistry , vol.36 , pp. 15568-15578
    • Henry, A.J.1
  • 29
    • 0031872148 scopus 로고    scopus 로고
    • Prediction of an anti-IgE binding site on IgE
    • Wright, J.D. & Lim, C. Prediction of an anti-IgE binding site on IgE. Protein Eng. 11, 421-427 (1998).
    • (1998) Protein Eng. , vol.11 , pp. 421-427
    • Wright, J.D.1    Lim, C.2
  • 30
    • 0025939199 scopus 로고
    • Conformations of IgE bound to its receptor FcεRI and in solution
    • Zheng, Y., Shopes, B., Holowka, D. & Baird, B. Conformations of IgE bound to its receptor FcεRI and in solution. Biochemistry 30, 9125-9132 (1991).
    • (1991) Biochemistry , vol.30 , pp. 9125-9132
    • Zheng, Y.1    Shopes, B.2    Holowka, D.3    Baird, B.4
  • 31
    • 0030849786 scopus 로고    scopus 로고
    • Basis of the 1:1 stoichiometry of the high affinity receptor FcεRI-IgE complex
    • Keown, M.B., Ghirlando, R., Mackay, G.A., Sutton, B.J. & Gould, H.J. Basis of the 1:1 stoichiometry of the high affinity receptor FcεRI-IgE complex. Eur. Biophys. J. 25, 471-476 (1997).
    • (1997) Eur. Biophys. J. , vol.25 , pp. 471-476
    • Keown, M.B.1    Ghirlando, R.2    Mackay, G.A.3    Sutton, B.J.4    Gould, H.J.5
  • 32
    • 0029740925 scopus 로고    scopus 로고
    • A conformational rearrangement upon binding of IgE to its high affinity receptor
    • Sechi, S., Roller, P.P., Willette-Brown, J. & Kinet, J.P. A conformational rearrangement upon binding of IgE to its high affinity receptor. J. Biol. Chem. 271, 19256-19263 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 19256-19263
    • Sechi, S.1    Roller, P.P.2    Willette-Brown, J.3    Kinet, J.P.4
  • 33
    • 0032560608 scopus 로고    scopus 로고
    • Thermodynamics of the interaction of human immunoglobulin E with its high-affinity receptor FcεRI
    • Keown, M.B., Henry, A.J., Ghirlando, R., Sutton, B.J. & Gould, H.J. Thermodynamics of the interaction of human immunoglobulin E with its high-affinity receptor FcεRI. Biochemistry 23, 8863-8869 (1998).
    • (1998) Biochemistry , vol.23 , pp. 8863-8869
    • Keown, M.B.1    Henry, A.J.2    Ghirlando, R.3    Sutton, B.J.4    Gould, H.J.5
  • 34
    • 0027316113 scopus 로고
    • The oligomeric nature of the murine FcεRII/CD23. Implications for function
    • Dierks, S.E. et al. The oligomeric nature of the murine FcεRII/CD23. Implications for function. J. Immunol. 150, 2372-2382 (1993).
    • (1993) J. Immunol. , vol.150 , pp. 2372-2382
    • Dierks, S.E.1
  • 35
    • 0027715015 scopus 로고
    • The human IgE network
    • Sutton, B.J. & Gould, H.J. The human IgE network. Nature 366, 421-428 (1993).
    • (1993) Nature , vol.366 , pp. 421-428
    • Sutton, B.J.1    Gould, H.J.2
  • 36
    • 0027965679 scopus 로고
    • Inhibition of human IgE synthesis by anti-IgE antibodies requires divalent recognition
    • Stämpfli, M.R., Miescher, S., Aebischer, I., Zurcher, A.W. & Stadler, B.M. Inhibition of human IgE synthesis by anti-IgE antibodies requires divalent recognition. Eur. J. Immunol. 24, 2161-2167 (1994).
    • (1994) Eur. J. Immunol. , vol.24 , pp. 2161-2167
    • Stämpfli, M.R.1    Miescher, S.2    Aebischer, I.3    Zurcher, A.W.4    Stadler, B.M.5
  • 37
    • 0026515406 scopus 로고
    • A new isoform of human membrane-bound IgE
    • Peng, C. et al. A new isoform of human membrane-bound IgE. J. Immunol. 148, 129-136 (1992).
    • (1992) J. Immunol. , vol.148 , pp. 129-136
    • Peng, C.1
  • 38
    • 0028044554 scopus 로고
    • B-cell antigen receptors
    • Reth, M. B-cell antigen receptors. Curr. Opin. Immunol. 6, 3-8 (1994).
    • (1994) Curr. Opin. Immunol. , vol.6 , pp. 3-8
    • Reth, M.1
  • 39
    • 0024565449 scopus 로고
    • Expression of high-affinity binding of human immunoglobulin E by transfected cells
    • Miller, L., Blank, U., Metzger, H. & Kinet, J.P. Expression of high-affinity binding of human immunoglobulin E by transfected cells. Science 244, 334-337 (1989).
    • (1989) Science , vol.244 , pp. 334-337
    • Miller, L.1    Blank, U.2    Metzger, H.3    Kinet, J.P.4
  • 40
    • 0019813493 scopus 로고
    • IgE concentrations measured by PRIST in serum of healthy adults and in patients with respiratory allergy. A diagnostic approach
    • Zetterstrom, O. & Johansson, S.G. IgE concentrations measured by PRIST in serum of healthy adults and in patients with respiratory allergy. A diagnostic approach. Allergy 36, 537-547 (1981).
    • (1981) Allergy , vol.36 , pp. 537-547
    • Zetterstrom, O.1    Johansson, S.G.2
  • 41
    • 0025728766 scopus 로고
    • A polyclonal model for B cell tolerance. Fc-dependent and Fc-independent induction of nonresponsiveness by pretreatment of normal splenic B cells with anti-Ig
    • Warner, G.L. & Scott, D.W. A polyclonal model for B cell tolerance. Fc-dependent and Fc-independent induction of nonresponsiveness by pretreatment of normal splenic B cells with anti-Ig. J. Immunol. 146, 2185-2191 (1991).
    • (1991) J. Immunol. , vol.146 , pp. 2185-2191
    • Warner, G.L.1    Scott, D.W.2
  • 42
    • 0028569209 scopus 로고
    • Cross-linking of surface IgG induces apoptosis in a bcl-2 expressing human follicular lymphoma line of mature B cell phenotype
    • Eray, M. et al. Cross-linking of surface IgG induces apoptosis in a bcl-2 expressing human follicular lymphoma line of mature B cell phenotype. Int. Immunol. 6, 1817-1827 (1994).
    • (1994) Int. Immunol. , vol.6 , pp. 1817-1827
    • Eray, M.1
  • 43
    • 8244256660 scopus 로고    scopus 로고
    • Demonstration of the therapeutic potential of non-anaphylactogenic anti-IgE antibodies in murine models of skin reaction, lung function and inflammation
    • Heusser, C.H. et al. Demonstration of the therapeutic potential of non-anaphylactogenic anti-IgE antibodies in murine models of skin reaction, lung function and inflammation. Int. Arch. Allergy Immunol. 113, 231-235 (1997).
    • (1997) Int. Arch. Allergy Immunol. , vol.113 , pp. 231-235
    • Heusser, C.H.1
  • 44
    • 0028057011 scopus 로고
    • Effects of syngeneic anti-IgE antibodies on the development of IgE memory and on the secondary IgE response
    • Haba, S. & Nisonoff, A. Effects of syngeneic anti-IgE antibodies on the development of IgE memory and on the secondary IgE response. J. Immunol. 152, 51-57 (1994).
    • (1994) J. Immunol. , vol.152 , pp. 51-57
    • Haba, S.1    Nisonoff, A.2
  • 45
    • 17144455839 scopus 로고    scopus 로고
    • IDEC-C2B8: Results of a phase I multiple-dose trial in patients with relapsed non-Hodgkin's lymphoma
    • Manoney, D.G. et al. IDEC-C2B8: results of a phase I multiple-dose trial in patients with relapsed non-Hodgkin's lymphoma. J. Clin. Oncol. 15, 3266-3274 (1997).
    • (1997) J. Clin. Oncol. , vol.15 , pp. 3266-3274
    • Manoney, D.G.1
  • 46
    • 0019411168 scopus 로고
    • Regulation of the IgE antibody response in mice. II. Radioresistance of established IgE antibody production
    • Peeters, S.H. & Carter, B.G. Regulation of the IgE antibody response in mice. II. radioresistance of established IgE antibody production. Immunology 43, 25-32 (1981).
    • (1981) Immunology , vol.43 , pp. 25-32
    • Peeters, S.H.1    Carter, B.G.2
  • 47
    • 0025797373 scopus 로고
    • Memory B and T cells
    • Vitetta, E.S. et al. Memory B and T cells. Ann. Rev. Immunol. 9, 193-217 (1991).
    • (1991) Ann. Rev. Immunol. , vol.9 , pp. 193-217
    • Vitetta, E.S.1
  • 48
    • 0028057011 scopus 로고
    • Effects of syngeneic anti-IgE antibodies on the development of IgE memory and on the secondary IgE response
    • Haba, S. & Nisonoff, A. Effects of syngeneic anti-IgE antibodies on the development of IgE memory and on the secondary IgE response. J. Immunol. 152, 51-57 (1994).
    • (1994) J. Immunol. , vol.152 , pp. 51-57
    • Haba, S.1    Nisonoff, A.2
  • 49
    • 0015110449 scopus 로고
    • Biologic properties of E myeloma proteins
    • Ogawa, M. et al. Biologic properties of E myeloma proteins. Am. J. Med. 51, 193-199 (1971).
    • (1971) Am. J. Med. , vol.51 , pp. 193-199
    • Ogawa, M.1
  • 50
    • 0029117815 scopus 로고
    • Characterization of complex formation by humanized anti-IgE monoclonal antibody and monoclonal human IgE
    • Liu, J., Lester, P., Builder, S. & Shire, S.J. Characterization of complex formation by humanized anti-IgE monoclonal antibody and monoclonal human IgE. Biochemistry 34, 10474-10482 (1995).
    • (1995) Biochemistry , vol.34 , pp. 10474-10482
    • Liu, J.1    Lester, P.2    Builder, S.3    Shire, S.J.4
  • 51
    • 0026544668 scopus 로고
    • Quantitative IgE- And IgG-subclass responses during and after long-term ragweed immunotherapy
    • Peng, Z.K., Naclerio, R.M., Norman, P.S. & Adkinson, N.F. Quantitative IgE- and IgG-subclass responses during and after long-term ragweed immunotherapy. J. Allergy Clin. Immunol. 89, 519-529 (1992).
    • (1992) J. Allergy Clin. Immunol. , vol.89 , pp. 519-529
    • Peng, Z.K.1    Naclerio, R.M.2    Norman, P.S.3    Adkinson, N.F.4
  • 52
    • 0029991846 scopus 로고    scopus 로고
    • Characterization of latex allergens and correlation of serum IgE/IgG antibody ratio with clinical symptoms
    • Chen, H.D. Chen, C.L. & Huang, S.W. Characterization of latex allergens and correlation of serum IgE/IgG antibody ratio with clinical symptoms. Allergy Asthma Proc. 17, 143-148 (1996).
    • (1996) Allergy Asthma Proc. , vol.17 , pp. 143-148
    • Chen, H.D.1    Chen, C.L.2    Huang, S.W.3
  • 53
    • 0021343233 scopus 로고
    • Antibodies to hepatitis B surface antigen potentiate the response of human T lymphocyte clones to the same antigen
    • Celis, E. & Chang, T.W. Antibodies to hepatitis B surface antigen potentiate the response of human T lymphocyte clones to the same antigen. Science 224, 297-299 (1984).
    • (1984) Science , vol.224 , pp. 297-299
    • Celis, E.1    Chang, T.W.2
  • 54
    • 0030049224 scopus 로고    scopus 로고
    • FcεRII on human B cells can mediate enhanced antigen presentation
    • Liu, C., Gosselin, E.J. & Guyre, P.M. FcεRII on human B cells can mediate enhanced antigen presentation. Cell Immunol. 167, 188-194 (1996).
    • (1996) Cell Immunol. , vol.167 , pp. 188-194
    • Liu, C.1    Gosselin, E.J.2    Guyre, P.M.3
  • 55
    • 0029120165 scopus 로고
    • Consequences of IgE/CD23-mediated antigen presentation in allergy
    • Muddle, G.C., Bheekha, R. & Bruijnzeel-Koomen, C.A. Consequences of IgE/CD23-mediated antigen presentation in allergy. Immunol. Today 16, 380-383 (1995).
    • (1995) Immunol. Today , vol.16 , pp. 380-383
    • Muddle, G.C.1    Bheekha, R.2    Bruijnzeel-Koomen, C.A.3
  • 56
    • 0029066660 scopus 로고
    • The high affinity IgE receptor (FcεRI) mediates IgE-dependent allergen presentation
    • Maurer, D. et al. The high affinity IgE receptor (FcεRI) mediates IgE-dependent allergen presentation. J. Immunol. 154, 6285-6290 (1995).
    • (1995) J. Immunol. , vol.154 , pp. 6285-6290
    • Maurer, D.1
  • 57
  • 58
    • 0031065108 scopus 로고    scopus 로고
    • Down-regulation of FcεRI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibody
    • MacGlashan, D.W. et al. Down-regulation of FcεRI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibody. J. Immunol. 158, 1438-1445 (1997).
    • (1997) J. Immunol. , vol.158 , pp. 1438-1445
    • MacGlashan, D.W.1
  • 59
    • 0032012867 scopus 로고    scopus 로고
    • In vitro regulation of FcεRIα expression on human basophils by IgE antibody
    • MacGlashan, D.W et al. In vitro regulation of FcεRIα expression on human basophils by IgE antibody. Blood 91, 1633-1643 (1998).
    • (1998) Blood , vol.91 , pp. 1633-1643
    • MacGlashan, D.W.1
  • 60
    • 0031569178 scopus 로고    scopus 로고
    • IgE regulates mouse basophil FcεRI expression in vivo
    • Lantz, C.S. et al. IgE regulates mouse basophil FcεRI expression in vivo. J. Immunol. 158, 2517-2521 (1997).
    • (1997) J. Immunol. , vol.158 , pp. 2517-2521
    • Lantz, C.S.1
  • 61
    • 0342530626 scopus 로고
    • Mouse/human chimeric monoclonal antibody in man: Kinetics and immune response
    • LoBuglio, A.F. et al. Mouse/human chimeric monoclonal antibody in man: kinetics and immune response. Proc. Natl. Acad. Sci. USA 86, 4220-4224 (1989).
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 4220-4224
    • Lobuglio, A.F.1


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