The pharmacological mechanisms of omalizumab in patients with very high IgE levels - Clues from studies on atopic dermatitis

Dermatologica Sinica

Volumn 30, Issue 4, 2012, Pages 147-153

  Chang, Tse Wen ^a   Chen, Jiun Bo ^a   Chu, Chia Yu ^b  

^a GENOMICS RESEARCH CENTER   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

allergen trapping; anti IgE immune complexes; atopic dermatitis; IgE; omalizumab; serum IgE levels

Indexed keywords

FC RECEPTOR; IMMUNOGLOBULIN E; OMALIZUMAB;

ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS; ANAPHYLAXIS; ANTIGEN ANTIBODY COMPLEX; ATOPIC DERMATITIS; BASOPHIL; CHRONIC URTICARIA; DOWN REGULATION; DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG HALF LIFE; DRUG MECHANISM; DRUG MEGADOSE; FOOD ALLERGY; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOPATHOLOGY; LOW DRUG DOSE; MAST CELL; REVIEW; TREATMENT OUTCOME;

EID: 84870927448     PISSN: 10278117     EISSN: 2223330X     Source Type: Journal    
DOI: 10.1016/j.dsi.2012.10.001     Document Type: Review

References (65)

1. T.W. Chang The pharmacological basis of anti-IgE therapy Nat Biotechnol 18 2000 157 162 (Pubitemid 30091174)
2. T.W. Chang, P.C. Wu, C.L. Hsu, and A.F. Hung Anti-IgE antibodies for the treatment of IgE-mediated allergic diseases Adv Immunol 93 2007 63 119 (Pubitemid 46441429)
3. B.Q. Lanier, J. Corren, W. Lumry, J. Liu, A. Fowler-Taylor, and N. Gupta Omalizumab is effective in the long-term control of severe allergic asthma Ann Allergy Asthma Immunol 91 2003 154 159 (Pubitemid 36999474)
4. S.T. Holgate, R. Djukanović, T. Casale, and J. Bousquet Anti-immunoglobulin E treatment with omalizumab in allergic diseases: an update on anti-inflammatory activity and clinical efficacy Clin Exp Allergy 35 2005 408 416 (Pubitemid 40577231)
5. T.B. Casale, W.W. Busse, and J.N. Kline Omalizumab pretreatment decreases acute reactions after rush immunotherapy for ragweed-induced seasonal allergic rhinitis J Allergy Clin Immunol 117 2006 134 140 (Pubitemid 43017150)
6. H.A. Sampson, D.Y. Leung, and A.W. Burks A phase II, randomized, doubleblind, parallelgroup, placebocontrolled oral food challenge trial of Xolair (omalizumab) in peanut allergy J Allergy Clin Immunol 127 2011 1309 1310 e1
7. S. Saini, K.E. Rosen, and H.J. Hsieh A randomized, placebo-controlled, dose-ranging study of single-dose omalizumab in patients with H1-antihistamine-refractory chronic idiopathic urticaria J Allergy Clin Immunol 128 2011 567 573 e1
8. R.G. Townley, S. Agrawal, and K. Sapkota Omalizumab for pediatric asthma Expert Opin Biol Ther 10 2010 1595 1608
9. L.A. Beck, G.V. Marcotte, D. MacGlashan, A. Togias, and S. Saini Omalizumab-induced reductions in mast cell Fcepsilon RI expression and function J Allergy Clin Immunol 114 2004 527 530 (Pubitemid 39194924)
10. H. Lin, K.M. Boesel, and D.T. Griffith Omalizumab rapidly decreases nasal allergic response and FcepsilonRI on basophils J Allergy Clin Immunol 113 2004 297 302 (Pubitemid 38210553)
11. T.W. Chang, and Y.Y. Shiung Anti-IgE as a mast cell-stabilizing therapeutic agent J Allergy Clin Immunol 117 2006 1203 1212 (Pubitemid 43795763)
12. C. Prussin, D.T. Griffith, K.M. Boesel, H. Lin, B. Foster, and T.B. Casale Omalizumab treatment downregulates dendritic cell FcepsilonRI expression J Allergy Clin Immunol 112 2003 1147 1154 (Pubitemid 37550008)
13. H. Milgrom, W. Berger, and A. Nayak Treatment of childhood asthma with anti-immunoglobulin E antibody (omalizumab) Pediatrics 108 2001 E36
14. Xolair® (omalizumab for subcutaneous use) package insert 2003 Genentech Inc. San Francisco
15. N. Hayashi, Y. Tsukamoto, W.M. Sallas, and P.J. Lowe A mechanism-based binding model for the population pharmacokinetics and pharmacodynamics of omalizumab Br J Clin Pharmacol 63 2007 548 561 (Pubitemid 46632569)
16. P.J. Lowe, S. Tannenbaum, A. Gautier, and P. Jimenez Relationship between omalizumab pharmacokinetics, IgE pharmacodynamics and symptoms in patients with severe persistent allergic (IgE-mediated) asthma Br J Clin Pharmacol 68 2009 61 76
17. N. Laske, R. Bunikowski, and B. Niggemann Extraordinarily high serum IgE levels and consequences for atopic phenotypes Ann Allergy Asthma Immunol 91 2003 202 204 (Pubitemid 36999482)
18. R.A. Krathen, and S. Hsu Failure of omalizumab for treatment of severe adult atopic dermatitis J Am Acad Dermatol 53 2005 338 340 (Pubitemid 40979597)
19. J.E. Lane, J.M. Cheyney, T.N. Lane, D.E. Kent, and D.J. Cohen Treatment of recalcitrant atopic dermatitis with omalizumab J Am Acad Dermatol 54 2006 68 72 (Pubitemid 41832460)
20. P.G. Vigo, K.R. Girgis, B.L. Pfuetze, M.E. Critchlow, J. Fisher, and I. Hussain Efficacy of anti-IgE therapy in patients with atopic dermatitis J Am Acad Dermatol 55 2006 168 170 (Pubitemid 43867028)
21. B. Belloni, M. Ziai, and A. Lim Low-dose anti-IgE therapy in patients with atopic eczema with high serum IgE levels J Allergy Clin Immunol 120 2007 1223 1225 (Pubitemid 350047479)
22. S.B. Forman, and A.B. Garrett Success of omalizumab as monotherapy in adult atopic dermatitis: case report and discussion of the high-affinity immunoglobulin E receptor, FcepsilonRI Cutis 80 2007 38 40
23. L.T. Do, A. Rafi, and R.M. Katz Atopic dermatitis: a review and evaluation of treatment with omalizumab CML Dermatol 12 2007 63 70
24. L.E. Sheinkopf, A.W. Rafi, L.T. Do, R.M. Katz, and W.B. Klaustermeyer Efficacy of omalizumab in the treatment of atopic dermatitis: a pilot study Allergy Asthma Proc 29 2008 530 537
25. C. Incorvaia, C. Pravettoni, M. Mauro, M.R. Yacoub, F. Tarantini, and G.G. Riario-Sforza Effectiveness of omalizumab in a patient with severe asthma and atopic dermatitis Monaldi Arch Chest Dis 69 2008 78 80
26. C. Caruso, F. Gaeta, R.L. Valluzzi, and A. Romano Omalizumab efficacy in a girl with atopic eczema Allergy 65 2010 278 279
27. D. Amrol Anti-immunoglobulin e in the treatment of refractory atopic dermatitis South Med J 103 2010 554 558
28. P.M. Heil, D. Maurer, B. Klein, T. Hultsch, and G. Stingl Omalizumab therapy in atopic dermatitis: depletion of IgE does not improve the clinical course - a randomized, placebo-controlled and double blind pilot study J Dtsch Dermatol Ges 8 2010 990 998
29. S.Y. Park, M.R. Choi, J.I. Na, S.W. Youn, K.C. Park, and C.H. Huh Recalcitrant atopic dermatitis treated with omalizumab Ann Dermatol 22 2010 349 352
30. J.L. Barrios, L. Paradis, and A. Desroches Efficacy of omalizumab therapy in a case of severe atopic dermatitis Allergy Asthma Clin Immunol 7 Suppl. 2 2011 A33
31. M.E. Ramírez del Pozo, E. Contreras Contreras, J. López Tiro, and J. Gómez Vera Omalizumab (an anti-IgE antibody) in the treatment of severe atopic eczema J Investig Allergol Clin Immunol 21 2011 410 421
32. S. Thaiwat, and A. Sangasapaviliya Omalizumab treatment in severe adult atopic dermatitis Asian Pac J Allergy Immunol 29 2011 357 360
33. F. Toledo, J.F. Silvestre, and C. Muñoz Combined therapy with low-dose omalizumab and intravenous immunoglobulin for severe atopic dermatitis. Report of four cases J Eur Acad Dermatol Venereol 26 2011 1325 1327
34. P. Velling, D. Skowasch, S. Pabst, E. Jansen, I. Tuleta, and C. Grohé Improvement of quality of life in patients with concomitant allergic asthma and atopic dermatitis: one year follow-up of omalizumab therapy Eur J Med Res 16 2011 407 410
35. F.T. Liu, H. Goodarzi, and H.Y. Chen IgE, mast cells, and eosinophils in atopic dermatitis Clin Rev Allergy Immunol 41 2011 298 310
36. J.M. Spergel, E. Mizoguchi, H. Oettgen, A.K. Bhan, and R.S. Geha Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis J Clin Invest 103 1999 1103 1111 (Pubitemid 29207243)
37. C.K. van der Ent, H. Hoekstra, and G.T. Rijkers Successful treatment of allergic bronchopulmonary aspergillosis with recombinant anti-IgE antibody Thorax 62 2007 276 277 (Pubitemid 46579813)
38. J.M. Zirbes, and C.E. Milla Steroid-sparing effect of omalizumab for allergic bronchopulmonary aspergillosis and cystic fibrosis Pediatr Pulmonol 43 2008 607 610 (Pubitemid 351813015)
39. A. Kanu, and K. Patel Treatment of allergic bronchopulmonary aspergillosis (ABPA) in CF with anti-IgE antibody (omalizumab) Pediatr Pulmonol 43 2008 1249 1251
40. I. Randhawa, T. Chin, and E. Nussbaum Resolution of corticosteroid- induced diabetes in allergic bronchopulmonary aspergillosis with omalizumab therapy: a novel approach J Asthma 46 2009 445 447
41. P. Lebecque, A. Leonard, and C. Pilette Omalizumab for treatment of ABPA exacerbations in CF patients Pediatr Pulmonol 44 2009 516
42. R.Y. Lin, S. Sethi, and G.A. Bhargave Measured immunoglobulin E in allergic bronchopulmonary aspergillosis treated with omalizumab J Asthma 47 2010 942 945
43. I. Sastre, J. Blanco, H. Mata, and F. Garcia A case of allergic bronchopulmonary aspergillosis treated with omalizumab J Investig Allergol Clin Immunol 22 2012 145 147
44. J.D. Jones, S.R. Marney Jr., and J.M. Fahrenholz Idiopathic anaphylaxis successfully treated with omalizumab Ann Allergy Asthma Immunol 101 2008 550 551
45. P. Warrier, and T.B. Casale Omalizumab in idiopathic anaphylaxis Ann Allergy Asthma Immunol 102 2009 257 258
46. S.L. Spector, and R.A. Tan Effect of omalizumab on patients with chronic urticaria Ann Allergy Asthma Immunol 99 2007 190 193 (Pubitemid 47264781)
47. J.A. Boyce Successful treatment of cold-induced urticaria/anaphylaxis with anti-IgE J Allergy Clin Immunol 117 2006 1415 1418 (Pubitemid 43795744)
48. R.A. Sabroe Failure of omalizumab in cholinergic urticaria Clin Exp Dermatol 35 2010 e127 e129
49. A. Groffik, H. Mitzel-Kaoukhov, M. Magerl, M. Maurer, and P. Staubach Omalizumab - an effective and safe treatment of therapy-resistant chronic spontaneous urticaria Allergy 66 2011 303 305
50. M. Ferrer, P. Gamboa, and M.L. Sanz Omalizumab is effective in nonautoimmune urticaria J Allergy Clin Immunol 127 2011 1300 1302
51. R. Rocha, A.B. Vitor, and E. Trindade Omalizumab in the treatment of eosinophilic esophagitis and food allergy Eur J Pediatr 170 2011 1471 1474
52. S. Holgate, T. Casale, S. Wenzel, J. Bousquet, Y. Deniz, and C. Reisner The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation J Allergy Clin Immunol 115 2005 459 465 (Pubitemid 40341694)
53. F.M. Davis, L.A. Gossett, and K.L. Pinkston Can anti-IgE be used to treat allergy? Springer Semin Immunopathol 15 1993 51 73 (Pubitemid 23175440)
54. J.B. Chen, P.C. Wu, and A.F. Hung Unique epitopes on C epsilon mX in IgE-B cell receptors are potentially applicable for targeting IgE-committed B cells J Immunol 184 2010 1748 1756
55. P.J. Lowe, and D. Renard Omalizumab decreases IgE production in patients with allergic (IgE-mediated) asthma; PKPD analysis of a biomarker, total IgE Br J Clin Pharmacol 72 2011 306 320
56. R.A. Manz, A.E. Hauser, F. Hiepe, and A. Radbruch Maintenance of serum antibody levels Annu Rev Immunol 23 2005 367 386 (Pubitemid 40563174)
57. J. Corren, D. Diaz-Sanchez, and A. Saxon Effects of omalizumab, a humanized monoclonal anti-IgE antibody, on nasal reactivity to allergen and local IgE synthesis Ann Allergy Asthma Immunol 93 2004 243 248 (Pubitemid 39280527)
58. A. Lim, S. Luderschmidt, and A. Weidinger The IgE repertoire in PBMCs of atopic patients is characterized by individual rearrangements without variable region of the heavy immunoglobulin chain bias J Allergy Clin Immunol 120 2007 696 706 (Pubitemid 47334838)
59. S.S. Saini, D.W. MacGlashan Jr., and S.A. Sterbinsky Down-regulation of human basophil IgE and FC epsilon RI alpha surface densities and mediator release by anti-IgE-infusions is reversible in vitro and in vivo J Immunol 162 1999 5624 5630 (Pubitemid 29307177)
60. J. Liu, P. Lester, S. Builder, and S.J. Shire Characterization of complex formation by humanized anti-IgE monoclonal antibody and monoclonal human IgE Biochemistry 34 1995 10474 10482
61. J. Corne, R. Djukanovic, and L. Thomas The effect of intravenous administration of a chimeric anti-IgE antibody on serum IgE levels in atopic subjects: efficacy, safety, and pharmacokinetics J Clin Invest 99 1997 879 887 (Pubitemid 27123624)
62. B. Demeule, S.J. Shire, and J. Liu A therapeutic antibody and its antigen form different complexes in serum than in phosphate-buffered saline: a study by analytical ultracentrifugation Anal Biochem 388 2009 279 287
63. T.B. Casale, I.L. Bernstein, and W.W. Busse Use of an anti-IgE humanized monoclonal antibody in ragweed-induced allergic rhinitis J Allergy Clin Immunol 100 1997 110 121 (Pubitemid 27328539)
64. C.L. Hsu, Y.Y. Shiung, B.L. Lin, H.Y. Chang, and T.W. Chang Accumulated immune complexes of IgE and omalizumab trap allergens in an in vitro model Int Immunopharmacol 10 2010 533 539
65. M. Metz, P. Bergmann, T. Zuberbier, and M. Maurer Successful treatment of cholinergic urticaria with anti-immunoglobulin E therapy Allergy 63 2008 247 249