Metformin induces renal medullary interstitial cell apoptosis in type 2 diabetic mice

Journal of Diabetes

Volumn 6, Issue 2, 2014, Pages 132-146

  Zheng, Senfeng ^a   Liu, Jia ^a   Han, Qifei ^a   Huang, Shizheng ^a   Su, Wen ^a   Fu, Jialin ^a   Jia, Xiao ^a   Du, Shengnan ^a   Zhou, Yunfeng ^a,b   Zhang, Xiaoyan ^a,b   Guan, Youfei ^a,b  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b Shenzhen University   (China)

Author keywords

AMP activated protein kinase; Apoptosis; Hypertonicity; Metformin; Renal medullary interstitial cells

Indexed keywords

AMP-ACTIVATED PROTEIN KINASE; APOPTOSIS; HYPERTONICITY; METFORMIN; RENAL MEDULLARY INTERSTITIAL CELLS;

ADENOSINE TRIPHOSPHATE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL SURVIVAL; CELLS, CULTURED; CYCLOOXYGENASE 2; DIABETES MELLITUS, TYPE 2; GENE EXPRESSION; HYPERTONIC SOLUTIONS; HYPOGLYCEMIC AGENTS; KIDNEY MEDULLA; METFORMIN; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; NF-KAPPA B; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; WATER DEPRIVATION;

EID: 84893349601     PISSN: 17530393     EISSN: 17530407     Source Type: Journal    
DOI: 10.1111/1753-0407.12105     Document Type: Article

References (33)

1. Danaei G, Finucane MM, Lu Y etal. National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: Systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. Lancet. 2011; 378: 31-40.
2. Kirpichnikov D, McFarlane SI, Sowers JR. Metformin: An update. Ann Intern Med. 2002; 137: 25-33.
3. Rojas LB, Gomes MB. Metformin: An old but still the best treatment for type 2 diabetes. Diabetol Metab Syndr. 2013; 5: 6.
4. Hawley SA, Gadalla AE, Olsen GS, Hardie DG. The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism. Diabetes. 2002; 51: 2420-2425.
5. Scheen AJ. Clinical pharmacokinetics of metformin. Clin Pharmacokinet. 1996; 30: 359-371.
6. von Mach MA, Gauer M, Meyer S etal. Antidiabetic medications in overdose: A comparison of the inquiries made to a regional poisons unit regarding original sulfonylureas, biguanides and insulin. Int J Clin Pharmacol Ther. 2006; 44: 51-56.
7. Pastor-Soler NM, Hallows KR. AMP-activated protein kinase regulation of kidney tubular transport. Curr Opin Nephrol Hypertens. 2012; 21: 523-533.
8. Han Q, Zhang X, Xue R etal. AMPK potentiates hypertonicity-induced apoptosis by suppressing NF-kappaB/COX-2 in medullary interstitial cells. J Am Soc Nephrol. 2011; 22: 1897-1911.
9. Vistica DT, Skehan P, Scudiero D, Monks A, Pittman A, Boyd MR. Tetrazolium-based assays for cellular viability: A critical examination of selected parameters affecting formazan production. Cancer Res. 1991; 51: 2515-2520.
10. Wang Y, Li J, Cui Y etal. CMTM3, located at the critical tumor suppressor locus 16q22.1, is silenced by CpG methylation in carcinomas and inhibits tumor cell growth through inducing apoptosis. Cancer Res. 2009; 69: 5194-5201.
11. Rao R, Hao CM, Breyer MD. Hypertonic stress activates glycogen synthase kinase 3beta-mediated apoptosis of renal medullary interstitial cells, suppressing an NF-kappaB-driven cyclooxygenase-2-dependent survival pathway. J Biol Chem. 2004; 279: 3949-3955.
12. Cheng HF, Zhang MZ, Harris RC. Nitric oxide stimulates cyclooxygenase-2 in cultured cTAL cells though a p38-dependent pathway. Am J Physiol Renal Physiol. 2006; 290: F1391-1397.
13. Hao CM, Redha R, Morrow J, Breyer MD. Peroxisome proliferator-activated receptor delta activation promotes cell survival following hypertonic stress. J Biol Chem. 2002; 277: 21341-21345.
14. Chen M, Li Y, Yang T, Wang Y, Bai Y, Xie X. ADMA induces monocyte adhesion via activation of chemokine receptors in cultured THP-1 cells. Cytokine. 2008; 43: 149-159.
15. Zhou G, Myers R, Li Y etal. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest. 2001; 108: 1167-1174.
16. Suwa M, Egashira T, Nakano H, Sasaki H, Kumagai S. Metformin increases the PGC-1alpha protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo. J Appl Physiol. 2006; 101: 1685-1692.
17. Hao CM, Yull F, Blackwell T, Komhoff M, Davis LS, Breyer MD. Dehydration activates an NF-kappaB-driven, COX2-dependent survival mechanism in renal medullary interstitial cells. J Clin Invest. 2000; 106: 973-982.
18. Schmidt-Nielsen B, Graves B, Roth J. Water removal and solute additions determining increases in renal medullary osmolality. Am J Physiol. 1983; 244: F472-482.
19. Viollet B, Foretz M. Revisiting the mechanisms of metformin action in the liver. Ann Endocrinol. 2013; 74: 123-129.
20. 2 stimulates expression of osmoprotective genes in MDCK cells and promotes survival under hypertonic conditions. J Physiol. 2007; 583: 287-297.
21. Yang T, Zhang A, Honeggar M etal. Hypertonic induction of COX-2 in collecting duct cells by reactive oxygen species of mitochondrial origin. J Biol Chem. 2005; 280: 34966-34973.
22. Zhou X, Ferraris JD, Burg MB. Mitochondrial reactive oxygen species contribute to high NaCl-induced activation of the transcription factor TonEBP/OREBP. Am J Physiol Renal Physiol. 2006; 290: F1169-F1176.
23. Vytla VS, Ochs RS. Metformin increases mitochondrial energy formation in l6 muscle cell cultures. J Biol Chem. 2013; 288: 20369-20377.
24. Hardie DG, Ross FA, Hawley SA. AMPK: A nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol. 2012; 13: 251-262.
25. Hawley SA, Davison M, Woods A etal. Characterization of the AMP-activated protein kinase kinase from rat liver and identification of theonine 172 as the major site at which it phosphorylates AMP-activated protein kinase. J Biol Chem. 1996; 271: 27879-27887.
26. Corton JM, Gillespie JG, Hawley SA, Hardie DG. 5-Aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? Eur J Biochem. 1995; 229: 558-565.
27. Liu J, Hou M, Yuan T etal. Enhanced cytotoxic effect of low doses of metformin combined with ionizing radiation on hepatoma cells via ATP deprivation and inhibition of DNA repair. Oncol Rep. 2012; 28: 1406-1412.
28. Ashour AE, Sayed-Ahmed MM, Abd-Allah AR etal. Metformin rescues the myocardium from doxorubicin-induced energy starvation and mitochondrial damage in rats. Oxid Med Cell Longev. 2012; 2012: 434195.
29. Stephenne X, Foretz M, Taleux N etal. Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status. Diabetologia. 2011; 54: 3101-3110.
30. Batandier C, Guigas B, Detaille D etal. The ROS production induced by a reverse-electron flux at respiratory-chain complex 1 is hampered by metformin. J Bioenerg Biomembr. 2006; 38: 33-42.
31. Owen MR, Doran E, Halestrap AP. Evidence that metformin exerts its anti-diabetic effects though inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J. 2000; 348: 607-614.
32. Lee SD, Choi SY, Lim SW etal. TonEBP stimulates multiple cellular pathways for adaptation to hypertonic stress: Organic osmolyte-dependent and -independent pathways. Am J Physiol Renal Physiol. 2011; 300: F707-F715.
33. Zhao X, Zmijewski JW, Lorne E etal. Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2008; 295: L497-504.