-
1
-
-
84255172344
-
Mapping the road forward in Alzheimer's disease
-
Holtzman, D.M., Goate, A., Kelly, J., and Sperling, R. (2011) Mapping the road forward in Alzheimer's disease. Sci. Transl. Med. 3, 114ps148
-
(2011)
Sci. Transl. Med.
, vol.3
, pp. 114ps148
-
-
Holtzman, D.M.1
Goate, A.2
Kelly, J.3
Sperling, R.4
-
2
-
-
76849086405
-
The secretases: Enzymes with therapeutic potential in Alzheimer disease
-
De Strooper, B., Vassar, R., and Golde, T. (2010) The secretases: enzymes with therapeutic potential in Alzheimer disease. Nat. Rev. Neurol. 6, 99-107
-
(2010)
Nat. Rev. Neurol.
, vol.6
, pp. 99-107
-
-
De Strooper, B.1
Vassar, R.2
Golde, T.3
-
3
-
-
0028169925
-
Visualization of A beta 42(43) and A beta 40 in senile plaques with endspecific A beta monoclonals: Evidence that an initially deposited species is A beta 42(43)
-
Iwatsubo, T., Odaka, A., Suzuki, N., Mizusawa, H., Nukina, N., and Ihara, Y. (1994) Visualization of A beta 42(43) and A beta 40 in senile plaques with endspecific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). Neuron 13, 45-53
-
(1994)
Neuron
, vol.13
, pp. 45-53
-
-
Iwatsubo, T.1
Odaka, A.2
Suzuki, N.3
Mizusawa, H.4
Nukina, N.5
Ihara, Y.6
-
4
-
-
84878256048
-
Structural biology of presenilins and signal peptide peptidases
-
Tomita, T. and Iwatsubo, T. (2013) Structural biology of presenilins and signal peptide peptidases. J. Biol. Chem. 288, 14673-14680
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 14673-14680
-
-
Tomita, T.1
Iwatsubo, T.2
-
5
-
-
0029004341
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
-
Sherrington, R., Rogaev, E.I., Liang, Y., Rogaeva, E.A., Levesque, G, Ikeda, M., Chi, H., Lin, C, Li, G, Holman, K., Tsuda, T., Mar, L., Foncin, J.F., Bruni, A.C., Montesi, M.P., Sorbi, S., Rainero, I., Pinessi, L., Nee, L., Chumakov, I., Pollen, D., Brookes, A., Sanseau, P., Polinsky, R.J., Wasco, W., Da Silva, H.A., Haines, J.L., Perkicak-Vance, M.A., Tanzi, R.E., Roses, A.D., Fraser, P.E., Rommens, J.M., and St George-Hyslop, P.H. (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375, 754-760
-
(1995)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
Rogaeva, E.A.4
Levesque, G.5
Ikeda, M.6
Chi, H.7
Lin, C.8
Li, G.9
Holman, K.10
Tsuda, T.11
Mar, L.12
Foncin, J.F.13
Bruni, A.C.14
Montesi, M.P.15
Sorbi, S.16
Rainero, I.17
Pinessi, L.18
Nee, L.19
Chumakov, I.20
Pollen, D.21
Brookes, A.22
Sanseau, P.23
Polinsky, R.J.24
Wasco, W.25
Da Silva, H.A.26
Haines, J.L.27
Perkicak-Vance, M.A.28
Tanzi, R.E.29
Roses, A.D.30
Fraser, P.E.31
Rommens, J.M.32
St George-Hyslop, P.H.33
more..
-
6
-
-
12644258498
-
The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue
-
Tomita, T., Maruyama, K., Saido, T.C., Kume, H., Shinozaki, K., Tokuhiro, S., Capell, A., Walter, J., Grunberg, J., Haass, C, Iwatsubo, T., and Obata, K. (1997) The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue. Proc. Natl Acad. Sci. USA 94, 2025-2030
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 2025-2030
-
-
Tomita, T.1
Maruyama, K.2
Saido, T.C.3
Kume, H.4
Shinozaki, K.5
Tokuhiro, S.6
Capell, A.7
Walter, J.8
Grunberg, J.9
Haass, C.10
Iwatsubo, T.11
Obata, K.12
-
7
-
-
0030293676
-
Familial Alzheimer's disease-linked presenilin 1 variants elevate abeta1-42/1-40 ratio in vitro and in vivo
-
Borchelt, D.R., Thinakaran, G, Eckman, C.B., Lee, M.K., Davenport, F., Ratovitsky, T., Prada, CM, Kim, G, Seekins, S., Yager, D., Slunt, H.H., Wang, R., Seeger, M., Levey, A.I., Gandy, S.E., Copeland, N.G, Jenkins, N.A., Price, D.L., Younkin, S.G, and Sisodia, S.S. (1996) Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron 17, 1005-1013
-
(1996)
Neuron
, vol.17
, pp. 1005-1013
-
-
Borchelt, D.R.1
Thinakaran, G.2
Eckman, C.B.3
Lee, M.K.4
Davenport, F.5
Ratovitsky, T.6
Prada, C.M.7
Kim, G.8
Seekins, S.9
Yager, D.10
Slunt, H.H.11
Wang, R.12
Seeger, M.13
Levey, A.I.14
Gandy, S.E.15
Copeland, N.G.16
Jenkins, N.A.17
Price, D.L.18
Younkin, S.G.19
Sisodia, S.S.20
more..
-
8
-
-
0030779784
-
Skeletal and CNS defects in presenilin-1-deficient mice
-
Shen, J., Bronson, R.T., Chen, D.F., Xia, W., Selkoe, D.J., and Tonegawa, S. (1997) Skeletal and CNS defects in Presenilin-1-deficient mice. Cell 89, 629-639
-
(1997)
Cell
, vol.89
, pp. 629-639
-
-
Shen, J.1
Bronson, R.T.2
Chen, D.F.3
Xia, W.4
Selkoe, D.J.5
Tonegawa, S.6
-
9
-
-
17744401440
-
Presenilin 1 is required for notch1 and DII1 expression in the paraxial mesoderm
-
Wong, P.C., Zheng, H., Chen, H., Becher, M.W., Sirinathsinghji, D.J., Trumbauer, M.E., Chen, H.Y., Price, D.L., Van der Ploeg, L.H., and Sisodia, S.S. (1997) Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm. Nature 387, 288-292
-
(1997)
Nature
, vol.387
, pp. 288-292
-
-
Wong, P.C.1
Zheng, H.2
Chen, H.3
Becher, M.W.4
Sirinathsinghji, D.J.5
Trumbauer, M.E.6
Chen, H.Y.7
Price, D.L.8
Van Der Ploeg, L.H.9
Sisodia, S.S.10
-
10
-
-
0033535553
-
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
-
Wolfe, M.S., Xia, W., Ostaszewski, B.L., Diehl, T.S., Kimberly, W.T., and Selkoe, D.J. (1999) Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature 398, 513-517
-
(1999)
Nature
, vol.398
, pp. 513-517
-
-
Wolfe, M.S.1
Xia, W.2
Ostaszewski, B.L.3
Diehl, T.S.4
Kimberly, W.T.5
Selkoe, D.J.6
-
11
-
-
0033780472
-
Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1
-
Esler, W.P., Kimberly, W.T., Ostaszewski, B.L., Diehl, T.S., Moore, C.L., Tsai, J.Y., Rahmati, T., Xia, W., Selkoe, D.J., and Wolfe, M.S. (2000) Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1. Nat. Cell Biol. 2, 428-434
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 428-434
-
-
Esler, W.P.1
Kimberly, W.T.2
Ostaszewski, B.L.3
Diehl, T.S.4
Moore, C.L.5
Tsai, J.Y.6
Rahmati, T.7
Xia, W.8
Selkoe, D.J.9
Wolfe, M.S.10
-
12
-
-
0034621824
-
Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1
-
Li, Y.M., Xu, M., Lai, M.T., Huang, Q., Castro, J.L., DiMuzio-Mower, J., Harrison, T., Lellis, C, Nadin, A., Neduvelil, J.G, Register, R.B., Sardana, M.K., Shearman, M.S., Smith, A.L., Shi, X.P., Yin, K.C., Shafer, J.A., and Gardell, S.J. (2000) Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1. Nature 405, 689-694
-
(2000)
Nature
, vol.405
, pp. 689-694
-
-
Li, Y.M.1
Xu, M.2
Lai, M.T.3
Huang, Q.4
Castro, J.L.5
DiMuzio-Mower, J.6
Harrison, T.7
Lellis, C.8
Nadin, A.9
Neduvelil, J.G.10
Register, R.B.11
Sardana, M.K.12
Shearman, M.S.13
Smith, A.L.14
Shi, X.P.15
Yin, K.C.16
Shafer, J.A.17
Gardell, S.J.18
-
13
-
-
70349558522
-
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
-
Harold, D., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Hamshere, M.L., Pahwa, J.S., Moskvina, V., Dowzell, K, Williams, A., Jones, N., Thomas, C, Stretton, A., Morgan, A.R., Lovestone, S., Powell, J., Proitsi, P., Lupton, M.K., Brayne, C, Rubinsztein, D.C., Gill, M., Lawlor, B., Lynch, A., Morgan, K, Brown, K.S., Passmore, P.A., Craig, D., McGuinness, B., Todd, S., Holmes, C, Mann, D., Smith, A.D., Love, S., Kehoe, P.G, Hardy, J., Mead, S., Fox, N., Rossor, M., Collinge, J., Maier, W., Jessen, F., Schurmann, B., Heun, R., van den Bussche, H., Heuser, I., Kornhuber, J., Wiltfang, J., Dichgans, M., Frolich, L., Hampel, H., Hull, M., Rujescu, D., Goate, A.M., Kauwe, J.S., Cruchaga, C, Nowotny, P., Morris, J.C., Mayo, K., Sleegers, K., Bettens, K., Engelborghs, S., De Deyn, P.P., Van Broeckhoven, C, Livingston, G, Bass, N.J., Gurling, H., McQuillin, A., Gwilliam, R., Deloukas, P., Al-Chalabi, A., Shaw, C.E., Tsolaki, M., Singleton, A.B., Guerreiro, R., Muhleisen, T.W., Nothen, M.M., Moebus, S., Jockel, K.H., Klopp, N., Wichmann, H.E., Carrasquillo, M.M., Pankratz, V.S., Younkin, S.G, Holmans, P.A., O'Donovan, M., Owen, M.J., and Williams, J. (2009) Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat. Genet. 41, 1088-1093
-
(2009)
Nat. Genet.
, vol.41
, pp. 1088-1093
-
-
Harold, D.1
Abraham, R.2
Hollingworth, P.3
Sims, R.4
Gerrish, A.5
Hamshere, M.L.6
Pahwa, J.S.7
Moskvina, V.8
Dowzell, K.9
Williams, A.10
Jones, N.11
Thomas, C.12
Stretton, A.13
Morgan, A.R.14
Lovestone, S.15
Powell, J.16
Proitsi, P.17
Lupton, M.K.18
Brayne, C.19
Rubinsztein, D.C.20
Gill, M.21
Lawlor, B.22
Lynch, A.23
Morgan, K.24
Brown, K.S.25
Passmore, P.A.26
Craig, D.27
McGuinness, B.28
Todd, S.29
Holmes, C.30
Mann, D.31
Smith, A.D.32
Love, S.33
Kehoe, P.G.34
Hardy, J.35
Mead, S.36
Fox, N.37
Rossor, M.38
Collinge, J.39
Maier, W.40
Jessen, F.41
Schurmann, B.42
Heun, R.43
Van Den Bussche, H.44
Heuser, I.45
Kornhuber, J.46
Wiltfang, J.47
Dichgans, M.48
Frolich, L.49
Hampel, H.50
Hull, M.51
Rujescu, D.52
Goate, A.M.53
Kauwe, J.S.54
Cruchaga, C.55
Nowotny, P.56
Morris, J.C.57
Mayo, K.58
Sleegers, K.59
Bettens, K.60
Engelborghs, S.61
De Deyn, P.P.62
Van Broeckhoven, C.63
Livingston, G.64
Bass, N.J.65
Gurling, H.66
McQuillin, A.67
Gwilliam, R.68
Deloukas, P.69
Al-Chalabi, A.70
Shaw, C.E.71
Tsolaki, M.72
Singleton, A.B.73
Guerreiro, R.74
Muhleisen, T.W.75
Nothen, M.M.76
Moebus, S.77
Jockel, K.H.78
Klopp, N.79
Wichmann, H.E.80
Carrasquillo, M.M.81
Pankratz, V.S.82
Younkin, S.G.83
Holmans, P.A.84
O'Donovan, M.85
Owen, M.J.86
Williams, J.87
more..
-
14
-
-
84896898403
-
Decreased CALM expression reduces abeta42 to total abeta ratio through clathrin-mediated endocytosis of gamma-secretase
-
Kanatsu, K, Morohashi, Y., Suzuki, M., Kuroda, H., Watanabe, T., Tomita, T., and Iwatsubo, T. (2014) Decreased CALM expression reduces Abeta42 to total Abeta ratio through clathrin-mediated endocytosis of gamma-secretase. Nat. Commun. 5, 3386
-
(2014)
Nat. Commun.
, vol.5
, pp. 3386
-
-
Kanatsu, K.1
Morohashi, Y.2
Suzuki, M.3
Kuroda, H.4
Watanabe, T.5
Tomita, T.6
Iwatsubo, T.7
-
15
-
-
0033778262
-
Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases
-
Steiner, H., Kostka, M., Romig, H., Basset, G, Pesold, B., Hardy, J., Capell, A., Meyn, L., Grim, M.L., Baumeister, R., Fechteler, K., and Haass, C (2000) Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases. Nat. Cell Biol. 2, 848-851
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 848-851
-
-
Steiner, H.1
Kostka, M.2
Romig, H.3
Basset, G.4
Pesold, B.5
Hardy, J.6
Capell, A.7
Meyn, L.8
Grim, M.L.9
Baumeister, R.10
Fechteler, K.11
Haass, C.12
-
16
-
-
0037150672
-
Identification of signal peptide peptidase, a presenilin-type aspartic protease
-
Weihofen, A., Binns, K, Lemberg, M.K., Ashman, K, and Martoglio, B. (2002) Identification of signal peptide peptidase, a presenilin-type aspartic protease. Science 296, 2215-2218
-
(2002)
Science
, vol.296
, pp. 2215-2218
-
-
Weihofen, A.1
Binns, K.2
Lemberg, M.K.3
Ashman, K.4
Martoglio, B.5
-
17
-
-
0034618715
-
Nicastrin modulates presenilin-mediated notch/ glp-1 signal transduction and betaAPP processing
-
Yu, G, Nishimura, M., Arawaka, S., Levitan, D., Zhang, L., Tandon, A., Song, Y.Q., Rogaeva, E., Chen, F., Kawarai, T., Supala, A., Levesque, L., Yu, H., Yang, D.S., Holmes, E., Milman, P., Liang, Y., Zhang, D.M., Xu, D.H., Sato, C, Rogaev, E., Smith, M., Janus, C, Zhang, Y., Aebersold, R., Farrer, L.S., Sorbi, S., Bruni, A., Fraser, P., and St George-Hyslop, P. (2000) Nicastrin modulates presenilin-mediated notch/ glp-1 signal transduction and betaAPP processing. Nature 407, 48-54
-
(2000)
Nature
, vol.407
, pp. 48-54
-
-
Yu, G.1
Nishimura, M.2
Arawaka, S.3
Levitan, D.4
Zhang, L.5
Tandon, A.6
Song, Y.Q.7
Rogaeva, E.8
Chen, F.9
Kawarai, T.10
Supala, A.11
Levesque, L.12
Yu, H.13
Yang, D.S.14
Holmes, E.15
Milman, P.16
Liang, Y.17
Zhang, D.M.18
Xu, D.H.19
Sato, C.20
Rogaev, E.21
Smith, M.22
Janus, C.23
Zhang, Y.24
Aebersold, R.25
Farrer, L.S.26
Sorbi, S.27
Bruni, A.28
Fraser, P.29
St George-Hyslop, P.30
more..
-
18
-
-
18444417998
-
Aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation
-
Francis, R., McGrath, G, Zhang, J., Ruddy, D.A., Sym, M., Apfeld, J., Nicoll, M., Maxwell, M., Hai, B., Ellis, M.C, Parks, A.L., Xu, W., Li, J., Gurney, M., Myers, R.L., Himes, CS., Hiebsch, R., Ruble, C, Nye, J.S., and Curtis, D. (2002) aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev. Cell 3, 85-97
-
(2002)
Dev. Cell
, vol.3
, pp. 85-97
-
-
Francis, R.1
McGrath, G.2
Zhang, J.3
Ruddy, D.A.4
Sym, M.5
Apfeld, J.6
Nicoll, M.7
Maxwell, M.8
Hai, B.9
Ellis, M.C.10
Parks, A.L.11
Xu, W.12
Li, J.13
Gurney, M.14
Myers, R.L.15
Himes, C.S.16
Hiebsch, R.17
Ruble, C.18
Nye, J.S.19
Curtis, D.20
more..
-
19
-
-
0037468759
-
The role of presenilin cofactors in the gamma-secretase complex
-
Takasugi, N., Tomita, T., Hayashi, I., Tsuruoka, M., Niimura, M., Takahashi, Y., Thinakaran, G., and Iwatsubo, T. (2003) The role of presenilin cofactors in the gamma-secretase complex. Nature 422, 438-441
-
(2003)
Nature
, vol.422
, pp. 438-441
-
-
Takasugi, N.1
Tomita, T.2
Hayashi, I.3
Tsuruoka, M.4
Niimura, M.5
Takahashi, Y.6
Thinakaran, G.7
Iwatsubo, T.8
-
20
-
-
0038664363
-
Reconstitution of gamma-secretase activity
-
Edbauer, D., Winkler, E., Regula, J.T., Pesold, B., Steiner, H., and Haass, C. (2003) Reconstitution of gamma-secretase activity. Nat. Cell Biol. 5, 486-488
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 486-488
-
-
Edbauer, D.1
Winkler, E.2
Regula, J.T.3
Pesold, B.4
Steiner, H.5
Haass, C.6
-
21
-
-
0038652102
-
Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2
-
Kimberly, W.T., LaVoie, M.J., Ostaszewski, B.L., Ye, W., Wolfe, M.S., and Selkoe, D.J. (2003) Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. Proc. Natl Acad. Sci. USA 100, 6382-6387
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 6382-6387
-
-
Kimberly, W.T.1
LaVoie, M.J.2
Ostaszewski, B.L.3
Ye, W.4
Wolfe, M.S.5
Selkoe, D.J.6
-
22
-
-
15844425969
-
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
-
Thinakaran, G, Borchelt, D.R., Lee, M.K., Slunt, H.H., Spitzer, L., Kim, G, Ratovitsky, T., Davenport, F., Nordstedt, C, Seeger, M., Hardy, J., Levey, A.I., Gandy, S.E., Jenkins, N.A., Copeland, N.G, Price, D.L., and Sisodia, S.S. (1996) Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron 17, 181-190
-
(1996)
Neuron
, vol.17
, pp. 181-190
-
-
Thinakaran, G.1
Borchelt, D.R.2
Lee, M.K.3
Slunt, H.H.4
Spitzer, L.5
Kim, G.6
Ratovitsky, T.7
Davenport, F.8
Nordstedt, C.9
Seeger, M.10
Hardy, J.11
Levey, A.I.12
Gandy, S.E.13
Jenkins, N.A.14
Copeland, N.G.15
Price, D.L.16
Sisodia, S.S.17
-
23
-
-
36349024875
-
Active gamma-secretase complexes contain only one of each component
-
Sato, T., Diehl, T.S., Narayanan, S., Funamoto, S., Ihara, Y., De Strooper, B., Steiner, H., Haass, C, and Wolfe, M.S. (2007) Active gamma-secretase complexes contain only one of each component. J. Biol. Chem. 282, 33985-33993
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 33985-33993
-
-
Sato, T.1
Diehl, T.S.2
Narayanan, S.3
Funamoto, S.4
Ihara, Y.5
De Strooper, B.6
Steiner, H.7
Haass, C.8
Wolfe, M.S.9
-
24
-
-
78650718960
-
Activation and intrinsic gamma-secretase activity of presenilin 1
-
Ahn, K., Shelton, C.C., Tian, Y., Zhang, X., Gilchrist, M.L., Sisodia, S.S., and Li, Y.M. (2010) Activation and intrinsic gamma-secretase activity of presenilin 1. Proc. Natl Acad. Sci. USA 107, 21435-21440
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 21435-21440
-
-
Ahn, K.1
Shelton, C.C.2
Tian, Y.3
Zhang, X.4
Gilchrist, M.L.5
Sisodia, S.S.6
Li, Y.M.7
-
25
-
-
84885172858
-
Gamma-secretase inhibitors and modulators
-
Golde, T.E., Koo, E.H., Felsenstein, K.M., Osborne, B.A., and Miele, L. (2013) gamma-Secretase inhibitors and modulators. Biochim. Biophys. Acta 1828, 2898-2907
-
(2013)
Biochim. Biophys. Acta
, vol.1828
, pp. 2898-2907
-
-
Golde, T.E.1
Koo, E.H.2
Felsenstein, K.M.3
Osborne, B.A.4
Miele, L.5
-
27
-
-
0141509025
-
Designed helical peptides inhibit an intramembrane protease
-
Das, C, Berezovska, O., Diehl, T.S., Genet, C, Buldyrev, I., Tsai, J.Y., Hyman, B.T., and Wolfe, M.S. (2003) Designed helical peptides inhibit an intramembrane protease. J. Am. Chem. Soc. 125, 11794-11795
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 11794-11795
-
-
Das, C.1
Berezovska, O.2
Diehl, T.S.3
Genet, C.4
Buldyrev, I.5
Tsai, J.Y.6
Hyman, B.T.7
Wolfe, M.S.8
-
28
-
-
67650513893
-
Inhibition of gamma-secretase activity by helical betapeptide foldamers
-
Imamura, Y., Watanabe, N, Umezawa, N, Iwatsubo, T., Kato, N, Tomita, T., and Higuchi, T. (2009) Inhibition of gamma-secretase activity by helical betapeptide foldamers. J. Am. Chem. Soc. 131, 7353-7359
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 7353-7359
-
-
Imamura, Y.1
Watanabe, N.2
Umezawa, N.3
Iwatsubo, T.4
Kato, N.5
Tomita, T.6
Higuchi, T.7
-
29
-
-
14744267675
-
The initial substrate-binding site of gamma-secretase is located on presenilin near the active site
-
Kornilova, A.Y., Bihel, F., Das, C, and Wolfe, M.S. (2005) The initial substrate-binding site of gamma-secretase is located on presenilin near the active site. Proc. Natl Acad. Sci. USA 102, 3230-3235
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 3230-3235
-
-
Kornilova, A.Y.1
Bihel, F.2
Das, C.3
Wolfe, M.S.4
-
30
-
-
77953782609
-
Functional analysis of the transmembrane domains of presenilin 1: Participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase
-
Watanabe, N, Takagi, S., Tominaga, A., Tomita, T., and Iwatsubo, T. (2010) Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase. J. Biol. Chem. 285, 19738-19746
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 19738-19746
-
-
Watanabe, N.1
Takagi, S.2
Tominaga, A.3
Tomita, T.4
Iwatsubo, T.5
-
31
-
-
46749127360
-
The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase
-
Sato, C, Takagi, S., Tomita, T., and Iwatsubo, T. (2008) The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase. J. Neurosci. 28, 6264-6271
-
(2008)
J. Neurosci.
, vol.28
, pp. 6264-6271
-
-
Sato, C.1
Takagi, S.2
Tomita, T.3
Iwatsubo, T.4
-
32
-
-
84874590103
-
Effect of helical conformation and side chain structure on gammasecretase inhibition by beta-peptide foldamers: Insight into substrate recognition
-
Imamura, Y., Umezawa, N, Osawa, S., Shimada, N, Higo, T., Yokoshima, S., Fukuyama, T., Iwatsubo, T., Kato, N, Tomita, T., and Higuchi, T. (2013) Effect of helical conformation and side chain structure on gammasecretase inhibition by beta-peptide foldamers: insight into substrate recognition. J. Med. Chem. 56, 1443-1454
-
(2013)
J. Med. Chem.
, vol.56
, pp. 1443-1454
-
-
Imamura, Y.1
Umezawa, N.2
Osawa, S.3
Shimada, N.4
Higo, T.5
Yokoshima, S.6
Fukuyama, T.7
Iwatsubo, T.8
Kato, N.9
Tomita, T.10
Higuchi, T.11
-
33
-
-
76249118271
-
An APP inhibitory domain containing the flemish mutation residue modulates gamma-secretase activity for abeta production
-
Tian, Y., Bassit, B., Chau, D., and Li, Y.M. (2010) An APP inhibitory domain containing the Flemish mutation residue modulates gamma-secretase activity for Abeta production. Nat. Struct. Mol. Biol. 17, 151-158
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 151-158
-
-
Tian, Y.1
Bassit, B.2
Chau, D.3
Li, Y.M.4
-
34
-
-
23744491374
-
Nicastrin functions as a gamma-secretasesubstrate receptor
-
Shah, S., Lee, S.F., Tabuchi, K, Hao, Y.H., Yu, C, LaPlant, Q., Ball, H, Dann, CE. 3rd, Sudhof, T., and Yu, G. (2005) Nicastrin functions as a gamma-secretasesubstrate receptor. Cell 122, 435-447
-
(2005)
Cell
, vol.122
, pp. 435-447
-
-
Shah, S.1
Lee, S.F.2
Tabuchi, K.3
Hao, Y.H.4
Yu, C.5
LaPlant, Q.6
Ball, H.7
Dann, C.E.8
Sudhof, T.9
Yu, G.10
-
35
-
-
19944430034
-
Longer forms of amyloid beta protein: Implications for the mechanism of intramembrane cleavage by gamma-secretase
-
Qi-Takahara, Y., Morishima-Kawashima, M., Tanimura, Y., Dolios, G, Hirotani, N., Horikoshi, Y., Kametani, F., Maeda, M., Saido, T.C., Wang, R., and Ihara, Y. (2005) Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase. J. Neurosci. 25, 436-445
-
(2005)
J. Neurosci.
, vol.25
, pp. 436-445
-
-
Qi-Takahara, Y.1
Morishima-Kawashima, M.2
Tanimura, Y.3
Dolios, G.4
Hirotani, N.5
Horikoshi, Y.6
Kametani, F.7
Maeda, M.8
Saido, T.C.9
Wang, R.10
Ihara, Y.11
-
36
-
-
0035929554
-
Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of notch
-
Gu, Y., Misonou, H, Sato, T., Dohmae, N, Takio, K, and Ihara, Y. (2001) Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch. J. Biol. Chem. 276, 35235-35238
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 35235-35238
-
-
Gu, Y.1
Misonou, H.2
Sato, T.3
Dohmae, N.4
Takio, K.5
Ihara, Y.6
-
37
-
-
84873143698
-
Gamma-secretase modulators and presenilin 1 mutants act differently on presenilin/gammasecretase function to cleave abeta42 and abeta43
-
Okochi, M., Tagami, S., Yanagida, K, Takami, M., Kodama, T.S., Mori, K, Nakayama, T., Ihara, Y., and Takeda, M. (2013) gamma-secretase modulators and presenilin 1 mutants act differently on presenilin/gammasecretase function to cleave Abeta42 and Abeta43. Cell Rep. 3, 42-51
-
(2013)
Cell Rep.
, vol.3
, pp. 42-51
-
-
Okochi, M.1
Tagami, S.2
Yanagida, K.3
Takami, M.4
Kodama, T.S.5
Mori, K.6
Nakayama, T.7
Ihara, Y.8
Takeda, M.9
-
38
-
-
0033167066
-
Twentynine missense mutations linked with familial Alzheimer's disease alter the processing of presenilin 1
-
Murayama, O., Murayama, M., Honda, T., Sun, X., Nihonmatsu, N, and Takashima, A. (1999) Twentynine missense mutations linked with familial Alzheimer's disease alter the processing of presenilin 1. Progr. Neuro-psychopharmacol. Biol. Psychiatr. 23, 905-913
-
(1999)
Progr. Neuro-psychopharmacol. Biol. Psychiatr.
, vol.23
, pp. 905-913
-
-
Murayama, O.1
Murayama, M.2
Honda, T.3
Sun, X.4
Nihonmatsu, N.5
Takashima, A.6
-
39
-
-
33745700370
-
Mean ageof-onset of familial Alzheimer disease caused by presenilin mutations correlates with both increased abeta42 and decreased abeta40
-
Kumar-Singh, S., Theuns, J., Van Broeck, B., Pirici, D., Vennekens, K, Corsmit, E., Cruts, M., Dermaut, B., Wang, R., and Van Broeckhoven, C. (2006) Mean ageof-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40. Hum. Mutat. 27, 686-695
-
(2006)
Hum. Mutat.
, vol.27
, pp. 686-695
-
-
Kumar-Singh, S.1
Theuns, J.2
Van Broeck, B.3
Pirici, D.4
Vennekens, K.5
Corsmit, E.6
Cruts, M.7
Dermaut, B.8
Wang, R.9
Van Broeckhoven, C.10
-
40
-
-
84861194622
-
The mechanism of gammaSecretase dysfunction in familial Alzheimer disease
-
Chavez-Gutierrez, L., Bammens, L., Benilova, I., Vandersteen, A., Benurwar, M., Borgers, M., Lismont, S., Zhou, L., Van Cleynenbreugel, S., Esselmann, H., Wiltfang, J., Serneels, L., Karran, E., Gijsen, H, Schymkowitz, J., Rousseau, F., Broersen, K, and De Strooper, B. (2012) The mechanism of gammaSecretase dysfunction in familial Alzheimer disease. EMBO J. 31, 2261-2274
-
(2012)
EMBO J
, vol.31
, pp. 2261-2274
-
-
Chavez-Gutierrez, L.1
Bammens, L.2
Benilova, I.3
Vandersteen, A.4
Benurwar, M.5
Borgers, M.6
Lismont, S.7
Zhou, L.8
Van Cleynenbreugel, S.9
Esselmann, H.10
Wiltfang, J.11
Serneels, L.12
Karran, E.13
Gijsen, H.14
Schymkowitz, J.15
Rousseau, F.16
Broersen, K.17
De Strooper, B.18
-
41
-
-
84880712325
-
A phase 3 trial of semagacestat for treatment of Alzheimer's disease
-
Doody, R.S., Raman, R., Farlow, M., Iwatsubo, T., Vellas, B., Joffe, S., Kieburtz, K, He, F., Sun, X., Thomas, R.G, Aisen, P.S., Alzheimer's Disease Cooperative Study Steering, C, Siemers, E., Sethuraman, G, Mohs, R., and Semagacestat Study, G (2013) A phase 3 trial of semagacestat for treatment of Alzheimer's disease. New Engl. J. Med. 369, 341-350
-
(2013)
New Engl. J. Med.
, vol.369
, pp. 341-350
-
-
Semagacestat Study, G,1
Doody, R.S.2
Raman, R.3
Farlow, M.4
Iwatsubo, T.5
Vellas, B.6
Joffe, S.7
Kieburtz, K.8
He, F.9
Sun, X.10
Thomas, R.G.11
Aisen, P.S.12
Siemers, E.13
Sethuraman, G.14
Mohs, R.15
-
42
-
-
84877762179
-
Development and mechanism of gamma-secretase modulators for Alzheimer's disease
-
Crump, C.J., Johnson, D.S., and Li, Y.M. (2013) Development and mechanism of gamma-secretase modulators for Alzheimer's disease. Biochemistry 52, 3197-3216
-
(2013)
Biochemistry
, vol.52
, pp. 3197-3216
-
-
Crump, C.J.1
Johnson, D.S.2
Li, Y.M.3
-
43
-
-
0035829592
-
A subset of NSAIDs lower amyloidogenic abeta42 independently of cyclooxygenase activity
-
Weggen, S., Eriksen, J.L., Das, P., Sagi, S.A., Wang, R., Pietrzik, C.U., Findlay, K.A., Smith, T.E., Murphy, M.P., Bulter, T., Kang, D.E., Marquez-Sterling, N, Golde, T.E., and Koo, E.H. (2001) A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature 414, 212-216
-
(2001)
Nature
, vol.414
, pp. 212-216
-
-
Weggen, S.1
Eriksen, J.L.2
Das, P.3
Sagi, S.A.4
Wang, R.5
Pietrzik, C.U.6
Findlay, K.A.7
Smith, T.E.8
Murphy, M.P.9
Bulter, T.10
Kang, D.E.11
Marquez-Sterling, N.12
Golde, T.E.13
Koo, E.H.14
-
44
-
-
33744949267
-
C-terminal fragment of presenilin is the molecular target of a dipeptidic gamma-secretase-specific inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester)
-
Morohashi, Y., Kan, T., Tominari, Y., Fuwa, H, Okamura, Y., Watanabe, N, Sato, C, Natsugari, H, Fukuyama, T., Iwatsubo, T., and Tomita, T. (2006) C-terminal fragment of presenilin is the molecular target of a dipeptidic gamma-secretase-specific inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester). J. Biol. Chem. 281, 14670-14676
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 14670-14676
-
-
Morohashi, Y.1
Kan, T.2
Tominari, Y.3
Fuwa, H.4
Okamura, Y.5
Watanabe, N.6
Sato, C.7
Natsugari, H.8
Fukuyama, T.9
Iwatsubo, T.10
Tomita, T.11
-
45
-
-
34547597126
-
Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic gamma-secretase inhibitors
-
Fuwa, H., Takahashi, Y., Konno, Y., Watanabe, N., Miyashita, H., Sasaki, M., Natsugari, H., Kan, T., Fukuyama, T., Tomita, T., and Iwatsubo, T. (2007) Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic gamma-secretase inhibitors. ACS Chem. Biol. 2, 408-418
-
(2007)
ACS Chem. Biol.
, vol.2
, pp. 408-418
-
-
Fuwa, H.1
Takahashi, Y.2
Konno, Y.3
Watanabe, N.4
Miyashita, H.5
Sasaki, M.6
Natsugari, H.7
Kan, T.8
Fukuyama, T.9
Tomita, T.10
Iwatsubo, T.11
-
46
-
-
82455167920
-
Phenylpiperidine-type gamma-secretase modulators target the transmembrane domain 1 of presenilin 1
-
Ohki, Y., Higo, T., Uemura, K., Shimada, N., Osawa, S., Berezovska, O., Yokoshima, S., Fukuyama, T., Tomita, T., and Iwatsubo, T. (2011) Phenylpiperidine-type gamma-secretase modulators target the transmembrane domain 1 of presenilin 1. EMBO J. 30, 4815-4824
-
(2011)
EMBO J
, vol.30
, pp. 4815-4824
-
-
Ohki, Y.1
Higo, T.2
Uemura, K.3
Shimada, N.4
Osawa, S.5
Berezovska, O.6
Yokoshima, S.7
Fukuyama, T.8
Tomita, T.9
Iwatsubo, T.10
-
47
-
-
84904613573
-
Allosteric regulation of gamma-secretase activity by a phenylimidazole-type gamma-secretase modulator
-
Takeo, K., Tanimura, S., Shinoda, T., Osawa, S., Zahariev, I.K., Takegami, N., Ishizuka-Katsura, Y., Shinya, N., Takagi-Niidome, S., Tominaga, A., Ohsawa, N., Kimura-Someya, T., Shirouzu, M., Yokoshima, S., Yokoyama, S., Fukuyama, T., Tomita, T., and Iwatsubo, T. (2014) Allosteric regulation of gamma-secretase activity by a phenylimidazole-type gamma-secretase modulator. Proc. Natl Acad. Sci. USA 111, 10544-10549
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. 10544-10549
-
-
Takeo, K.1
Tanimura, S.2
Shinoda, T.3
Osawa, S.4
Zahariev, I.K.5
Takegami, N.6
Ishizuka-Katsura, Y.7
Shinya, N.8
Takagi-Niidome, S.9
Tominaga, A.10
Ohsawa, N.11
Kimura-Someya, T.12
Shirouzu, M.13
Yokoshima, S.14
Yokoyama, S.15
Fukuyama, T.16
Tomita, T.17
Iwatsubo, T.18
-
48
-
-
84885187600
-
Protein trafficking and maturation regulate intramembrane proteolysis
-
Morohashi, Y. and Tomita, T. (2013) Protein trafficking and maturation regulate intramembrane proteolysis. Biochim. Biophys. Acta 1828, 2855-2861
-
(2013)
Biochim. Biophys. Acta
, vol.1828
, pp. 2855-2861
-
-
Morohashi, Y.1
Tomita, T.2
-
49
-
-
36849055107
-
Biogenesis of gammasecretase early in the secretory pathway
-
Kim, J., Kleizen, B., Choy, R., Thinakaran, G., Sisodia, S.S., and Schekman, R.W. (2007) Biogenesis of gammasecretase early in the secretory pathway. J. Cell Biol. 179, 951-963
-
(2007)
J. Cell Biol.
, vol.179
, pp. 951-963
-
-
Kim, J.1
Kleizen, B.2
Choy, R.3
Thinakaran, G.4
Sisodia, S.S.5
Schekman, R.W.6
-
50
-
-
84856966635
-
Neutralization of the gammasecretase activity by monoclonal antibody against extracellular domain of nicastrin
-
Hayashi, I., Takatori, S., Urano, Y., Miyake, Y., Takagi, J., Sakata-Yanagimoto, M., Iwanari, H., Osawa, S., Morohashi, Y., Li, T., Wong, P.C., Chiba, S., Kodama, T., Hamakubo, T., Tomita, T., and Iwatsubo, T. (2012) Neutralization of the gammasecretase activity by monoclonal antibody against extracellular domain of nicastrin. Oncogene 31, 787-798
-
(2012)
Oncogene
, vol.31
, pp. 787-798
-
-
Hayashi, I.1
Takatori, S.2
Urano, Y.3
Miyake, Y.4
Takagi, J.5
Sakata-Yanagimoto, M.6
Iwanari, H.7
Osawa, S.8
Morohashi, Y.9
Li, T.10
Wong, P.C.11
Chiba, S.12
Kodama, T.13
Hamakubo, T.14
Tomita, T.15
Iwatsubo, T.16
-
51
-
-
70449523262
-
Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains
-
Wakabayashi, T., Craessaerts, K, Bammens, L., Bentahir, M., Borgions, F., Herdewijn, P., Staes, A., Timmerman, E., Vandekerckhove, J., Rubinstein, E., Boucheix, C, Gevaert, K, and De Strooper, B. (2009) Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains. Nat. Cell Biol. 11, 1340-1346
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 1340-1346
-
-
Wakabayashi, T.1
Craessaerts, K.2
Bammens, L.3
Bentahir, M.4
Borgions, F.5
Herdewijn, P.6
Staes, A.7
Timmerman, E.8
Vandekerckhove, J.9
Rubinstein, E.10
Boucheix, C.11
Gevaert, K.12
De Strooper, B.13
-
52
-
-
84872074765
-
Alzheimer's gamma-secretase under arrestin
-
Wolfe, M.S. (2013) Alzheimer's gamma-secretase under arrestin. Nat. Med. 19, 22-24
-
(2013)
Nat. Med.
, vol.19
, pp. 22-24
-
-
Wolfe, M.S.1
-
53
-
-
84864392474
-
Contribution of the gamma-secretase subunits to the formation of catalytic pore of presenilin 1 protein
-
Takeo, K, Watanabe, N., Tomita, T., and Iwatsubo, T. (2012) Contribution of the gamma-secretase subunits to the formation of catalytic pore of presenilin 1 protein. J. Biol. Chem. 287, 25834-25843
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 25834-25843
-
-
Takeo, K.1
Watanabe, N.2
Tomita, T.3
Iwatsubo, T.4
-
54
-
-
78649393418
-
Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the gamma-secretase
-
Takagi, S., Tominaga, A., Sato, C, Tomita, T., and Iwatsubo, T. (2010) Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the gamma-secretase. J. Neurosci. 30, 15943-15950
-
(2010)
J. Neurosci.
, vol.30
, pp. 15943-15950
-
-
Takagi, S.1
Tominaga, A.2
Sato, C.3
Tomita, T.4
Iwatsubo, T.5
-
55
-
-
33751087756
-
Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines
-
Sato, C, Morohashi, Y., Tomita, T., and Iwatsubo, T. (2006) Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines. J. Neurosci. 26, 12081-12088
-
(2006)
J. Neurosci.
, vol.26
, pp. 12081-12088
-
-
Sato, C.1
Morohashi, Y.2
Tomita, T.3
Iwatsubo, T.4
-
56
-
-
84904560883
-
Three-dimensional structure of human gammasecretase
-
Lu, P., Bai, X.-C, Ma, D., Xie, T., Yan, C, Sun, L., Yang, G., Zhao, Y., Zhou, R., Scheres, S.H.W., and Shi, Y. (2014) Three-dimensional structure of human gammasecretase. Nature 512, 166-170
-
(2014)
Nature
, vol.512
, pp. 166-170
-
-
Lu, P.1
Bai, X.-C.2
Ma, D.3
Xie, T.4
Yan, C.5
Sun, L.6
Yang, G.7
Zhao, Y.8
Zhou, R.9
Scheres, S.H.W.10
Shi, Y.11
-
57
-
-
84871725890
-
Structure of a presenilin family intramembrane aspartate protease
-
Li, X., Dang, S., Yan, C, Gong, X., Wang, J., and Shi, Y. (2013) Structure of a presenilin family intramembrane aspartate protease. Nature 493, 56-61
-
(2013)
Nature
, vol.493
, pp. 56-61
-
-
Li, X.1
Dang, S.2
Yan, C.3
Gong, X.4
Wang, J.5
Shi, Y.6
-
58
-
-
79960918054
-
The crystal structure of GXGD membrane protease FlaK
-
Hu, J., Xue, Y., Lee, S., and Ha, Y. (2011) The crystal structure of GXGD membrane protease FlaK. Nature 475, 528-531
-
(2011)
Nature
, vol.475
, pp. 528-531
-
-
Hu, J.1
Xue, Y.2
Lee, S.3
Ha, Y.4
-
59
-
-
84872119708
-
Inhibition of gamma-secretase activity by a monoclonal antibody against the extracellular hydrophilic loop of presenilin 1
-
Takagi-Niidome, S., Osawa, S., Tomita, T., and Iwatsubo, T. (2013) Inhibition of gamma-secretase activity by a monoclonal antibody against the extracellular hydrophilic loop of presenilin 1. Biochemistry 52, 61-69
-
(2013)
Biochemistry
, vol.52
, pp. 61-69
-
-
Takagi-Niidome, S.1
Osawa, S.2
Tomita, T.3
Iwatsubo, T.4
-
60
-
-
84893421984
-
Substrate ectodomain is critical for substrate preference and inhibition of gamma-secretase
-
Funamoto, S., Sasaki, T., Ishihara, S., Nobuhara, M., Nakano, M., Watanabe-Takahashi, M., Saito, T., Kakuda, N., Miyasaka, T., Nishikawa, K, Saido, T.C., and Ihara, Y. (2013) Substrate ectodomain is critical for substrate preference and inhibition of gamma-secretase. Nat. Commun. 4, 2529
-
(2013)
Nat. Commun.
, vol.4
, pp. 2529
-
-
Funamoto, S.1
Sasaki, T.2
Ishihara, S.3
Nobuhara, M.4
Nakano, M.5
Watanabe-Takahashi, M.6
Saito, T.7
Kakuda, N.8
Miyasaka, T.9
Nishikawa, K.10
Saido, T.C.11
Ihara, Y.12
|