Inhibition of γ-secretase activity by a monoclonal antibody against the extracellular hydrophilic loop of presenilin 1

Biochemistry

Volumn 52, Issue 1, 2013, Pages 61-69

  Takagi Niidome, Shizuka ^a   Osawa, Satoko ^a   Tomita, Taisuke ^a,b   Iwatsubo, Takeshi ^a,b,c  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICANCER DRUG; CANCER CELLS; CATALYTIC SUBUNITS; EXTRACELLULAR; INTRAMEMBRANE PROTEOLYSIS; LOOP REGIONS; MOLECULAR TARGETS; PRESENILINS; SECRETASES; TRANS-MEMBRANE DOMAINS;

ACTIVATION ANALYSIS; HYDROPHILICITY; PROTEINS;

MONOCLONAL ANTIBODIES;

GAMMA SECRETASE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 9D11; NOTCH RECEPTOR; PRESENILIN 1; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROPHILICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT; SIGNAL TRANSDUCTION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTIBODIES, MONOCLONAL; CATALYTIC DOMAIN; CELL LINE; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; PRESENILIN-1; PROTEIN STRUCTURE, TERTIARY; RATS;

EID: 84872119708     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi301252r     Document Type: Article

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