Effect of helical conformation and side chain structure on γ-secretase inhibition by β-peptide foldamers: Insight into substrate recognition

Journal of Medicinal Chemistry

Volumn 56, Issue 4, 2013, Pages 1443-1454

  Imamura, Yuki ^a   Umezawa, Naoki ^a   Osawa, Satoko ^b   Shimada, Naoaki ^b   Higo, Takuya ^b   Yokoshima, Satoshi ^b   Fukuyama, Tohru ^b   Iwatsubo, Takeshi ^b,c,d   Kato, Nobuki ^a   Tomita, Taisuke ^b,c   Higuchi, Tsunehiko ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; FUNCTIONAL GROUP; GAMMA SECRETASE; PRESENILIN 1;

ARTICLE; CONFORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; HYDROPHILICITY; MOLECULAR DOCKING; PHOTOAFFINITY LABELING; PROTEIN STRUCTURE; PROTEIN SYNTHESIS;

EID: 84874590103     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301306c     Document Type: Article

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