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Volumn 35, Issue 3, 2015, Pages 525-534

Human experimental endotoxemia in modeling the pathophysiology, genomics, and therapeutics of innate immunity in complex cardiometabolic diseases

Author keywords

Chemotactic; Cytokines; Immune system; Inflammation; Metabolic syndrome X

Indexed keywords

ESCHERICHIA COLI ENDOTOXIN; GLUCOSE; LIPOPROTEIN; AUTACOID; BIOLOGICAL MARKER; GLUCOSE BLOOD LEVEL; LIPID;

EID: 84920396283     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.114.304455     Document Type: Review
Times cited : (53)

References (139)
  • 2
    • 0034601309 scopus 로고    scopus 로고
    • Innate immunity
    • Medzhitov R, Janeway C Jr. Innate immunity. N Engl J Med. 2000;343:338-344. doi: 10.1056/NEJM200008033430506.
    • (2000) N Engl J Med , vol.343 , pp. 338-344
    • Medzhitov, R.1    Janeway, C.2
  • 3
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell. 2006;124:783-801. doi: 10.1016/j.cell.2006.02.015.
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 4
    • 1442275317 scopus 로고    scopus 로고
    • Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes
    • Pickup JC. Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care. 2004;27:813-823.
    • (2004) Diabetes Care , vol.27 , pp. 813-823
    • Pickup, J.C.1
  • 5
    • 12444341944 scopus 로고    scopus 로고
    • Toll-like receptors in innate immunity
    • Takeda K, Akira S. Toll-like receptors in innate immunity. Int Immunol. 2005;17:1-14. doi: 10.1093/intimm/dxh186.
    • (2005) Int Immunol , vol.17 , pp. 1-14
    • Takeda, K.1    Akira, S.2
  • 6
    • 79960152357 scopus 로고    scopus 로고
    • Toll-like receptors
    • Moresco EM, LaVine D, Beutler B. Toll-like receptors. Curr Biol. 2011;21:R488-R493. doi: 10.1016/j.cub.2011.05.039.
    • (2011) Curr Biol , vol.21 , pp. R488-R493
    • Moresco, E.M.1    LaVine, D.2    Beutler, B.3
  • 7
    • 33846245059 scopus 로고    scopus 로고
    • Translational mini-review series on Tolllike receptors: Networks regulated by Toll-like receptors mediate innate and adaptive immunity
    • Parker LC, Prince LR, Sabroe I. Translational mini-review series on Tolllike receptors: networks regulated by Toll-like receptors mediate innate and adaptive immunity. Clin Exp Immunol. 2007;147:199-207. doi: 10.1111/j.1365-2249.2006.03203.x.
    • (2007) Clin Exp Immunol , vol.147 , pp. 199-207
    • Parker, L.C.1    Prince, L.R.2    Sabroe, I.3
  • 8
    • 65549164068 scopus 로고    scopus 로고
    • Roles of NF-kappaB in health and disease: Mechanisms and therapeutic potential
    • Wong ET, Tergaonkar V. Roles of NF-kappaB in health and disease: mechanisms and therapeutic potential. Clin Sci (Lond). 2009;116:451-465. doi: 10.1042/CS20080502.
    • (2009) Clin Sci (Lond) , vol.116 , pp. 451-465
    • Wong, E.T.1    Tergaonkar, V.2
  • 11
    • 0028965644 scopus 로고
    • Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin
    • Ulevitch RJ, Tobias PS. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. Annu Rev Immunol. 1995;13:437-457. doi: 10.1146/annurev.iy.13.040195.002253.
    • (1995) Annu Rev Immunol , vol.13 , pp. 437-457
    • Ulevitch, R.J.1    Tobias, P.S.2
  • 13
    • 67649422321 scopus 로고    scopus 로고
    • Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer
    • O'Neill LA, Bryant CE, Doyle SL. Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer. Pharmacol Rev. 2009;61:177-197. doi: 10.1124/pr.109.001073.
    • (2009) Pharmacol Rev , vol.61 , pp. 177-197
    • O'Neill, L.A.1    Bryant, C.E.2    Doyle, S.L.3
  • 15
    • 5444254408 scopus 로고    scopus 로고
    • Toll-like receptors in the pathogenesis of human disease
    • Cook DN, Pisetsky DS, Schwartz DA. Toll-like receptors in the pathogenesis of human disease. Nat Immunol. 2004;5:975-979. doi: 10.1038/ ni1116.
    • (2004) Nat Immunol , vol.5 , pp. 975-979
    • Cook, D.N.1    Pisetsky, D.S.2    Schwartz, D.A.3
  • 18
    • 33750584214 scopus 로고    scopus 로고
    • TLR4 links innate immunity and fatty acid-induced insulin resistance
    • Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest. 2006;116:3015-3025. doi: 10.1172/JCI28898.
    • (2006) J Clin Invest , vol.116 , pp. 3015-3025
    • Shi, H.1    Kokoeva, M.V.2    Inouye, K.3    Tzameli, I.4    Yin, H.5    Flier, J.S.6
  • 19
    • 3242710174 scopus 로고    scopus 로고
    • Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E
    • Michelsen KS, Wong MH, Shah PK, Zhang W, Yano J, Doherty TM, Akira S, Rajavashisth TB, Arditi M. Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc Natl Acad Sci U S A. 2004;101:10679-10684. doi: 10.1073/pnas.0403249101.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 10679-10684
    • Michelsen, K.S.1    Wong, M.H.2    Shah, P.K.3    Zhang, W.4    Yano, J.5    Doherty, T.M.6    Akira, S.7    Rajavashisth, T.B.8    Arditi, M.9
  • 21
    • 33745861300 scopus 로고    scopus 로고
    • Inflammation and insulin resistance
    • Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. J Clin Invest. 2006;116:1793-1801. doi: 10.1172/JCI29069.
    • (2006) J Clin Invest , vol.116 , pp. 1793-1801
    • Shoelson, S.E.1    Lee, J.2    Goldfine, A.B.3
  • 22
    • 0346880505 scopus 로고    scopus 로고
    • Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance
    • Shoelson SE, Lee J, Yuan M. Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance. Int J Obes Relat Metab Disord. 2003;27(suppl 3):S49-S52. doi: 10.1038/ sj.ijo.0802501.
    • (2003) Int J Obes Relat Metab Disord , vol.27 , pp. S49-S52
    • Shoelson, S.E.1    Lee, J.2    Yuan, M.3
  • 23
    • 34547535297 scopus 로고    scopus 로고
    • Mechanisms of disease: Toll-like receptors in cardiovascular disease
    • Frantz S, Ertl G, Bauersachs J. Mechanisms of disease: toll-like receptors in cardiovascular disease. Nat Clin Pract Cardiovasc Med. 2007;4:444-454. doi: 10.1038/ncpcardio0938.
    • (2007) Nat Clin Pract Cardiovasc Med , vol.4 , pp. 444-454
    • Frantz, S.1    Ertl, G.2    Bauersachs, J.3
  • 25
    • 0016908453 scopus 로고
    • Biology of endotoxin
    • Elin RJ, Wolff SM. Biology of endotoxin. Annu Rev Med. 1976;27:127-141. doi: 10.1146/annurev.me.27.020176.001015.
    • (1976) Annu Rev Med , vol.27 , pp. 127-141
    • Elin, R.J.1    Wolff, S.M.2
  • 27
    • 0031606321 scopus 로고    scopus 로고
    • Animal models of sepsis and shock: A review and lessons learned
    • Deitch EA. Animal models of sepsis and shock: a review and lessons learned. Shock. 1998;9:1-11.
    • (1998) Shock , vol.9 , pp. 1-11
    • Deitch, E.A.1
  • 28
    • 0033257553 scopus 로고    scopus 로고
    • Endotoxin, sepsis, and the primrose path
    • O'Reilly M, Newcomb DE, Remick D. Endotoxin, sepsis, and the primrose path. Shock. 1999;12:411-420.
    • (1999) Shock , vol.12 , pp. 411-420
    • O'Reilly, M.1    Newcomb, D.E.2    Remick, D.3
  • 34
    • 84869750897 scopus 로고    scopus 로고
    • Experimental human endotoxemia: A model of the systemic inflammatory response syndrome?
    • Calvano SE, Coyle SM. Experimental human endotoxemia: a model of the systemic inflammatory response syndrome? Surg Infect (Larchmt). 2012;13:293-299. doi: 10.1089/sur.2012.155.
    • (2012) Surg Infect (Larchmt) , vol.13 , pp. 293-299
    • Calvano, S.E.1    Coyle, S.M.2
  • 35
    • 33646800894 scopus 로고    scopus 로고
    • Evaluation of endotoxin models for the study of sepsis
    • Remick DG, Ward PA. Evaluation of endotoxin models for the study of sepsis. Shock. 2005;24(suppl 1):7-11.
    • (2005) Shock , vol.24 , pp. 7-11
    • Remick, D.G.1    Ward, P.A.2
  • 38
    • 33751249013 scopus 로고    scopus 로고
    • Gender influences in vivo human responses to endotoxin
    • Coyle SM, Calvano SE, Lowry SF. Gender influences in vivo human responses to endotoxin. Shock. 2006;26:538-543. doi: 10.1097/01. shk.0000232589.39001.4d.
    • (2006) Shock , vol.26 , pp. 538-543
    • Coyle, S.M.1    Calvano, S.E.2    Lowry, S.F.3
  • 40
    • 0038322493 scopus 로고    scopus 로고
    • Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans
    • Starkie R, Ostrowski SR, Jauffred S, Febbraio M, Pedersen BK. Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans. FASEB J. 2003;17:884-886. doi: 10.1096/fj.02-0670fje.
    • (2003) FASEB J , vol.17 , pp. 884-886
    • Starkie, R.1    Ostrowski, S.R.2    Jauffred, S.3    Febbraio, M.4    Pedersen, B.K.5
  • 41
    • 34147128114 scopus 로고    scopus 로고
    • Human models of low-grade inflammation: Bolus versus continuous infusion of endotoxin
    • Taudorf S, Krabbe KS, Berg RM, Pedersen BK, Møller K. Human models of low-grade inflammation: bolus versus continuous infusion of endotoxin. Clin Vaccine Immunol. 2007;14:250-255. doi: 10.1128/CVI.00380-06.
    • (2007) Clin Vaccine Immunol , vol.14 , pp. 250-255
    • Taudorf, S.1    Krabbe, K.S.2    Berg, R.M.3    Pedersen, B.K.4    Møller, K.5
  • 42
    • 0028931724 scopus 로고
    • Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance
    • Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest. 1995;95:2409-2415. doi: 10.1172/JCI117936.
    • (1995) J Clin Invest , vol.95 , pp. 2409-2415
    • Hotamisligil, G.S.1    Arner, P.2    Caro, J.F.3    Atkinson, R.L.4    Spiegelman, B.M.5
  • 44
    • 33846201363 scopus 로고    scopus 로고
    • Release of interleukins and other inflammatory cytokines by human adipose tissue is enhanced in obesity and primarily due to the nonfat cells
    • Fain JN. Release of interleukins and other inflammatory cytokines by human adipose tissue is enhanced in obesity and primarily due to the nonfat cells. Vitam Horm. 2006;74:443-477. doi: 10.1016/ S0083-6729(06)74018-3.
    • (2006) Vitam Horm , vol.74 , pp. 443-477
    • Fain, J.N.1
  • 46
    • 84872834256 scopus 로고    scopus 로고
    • Metabolic endotoxaemia: Is it more than just a gut feeling?
    • Piya MK, Harte AL, McTernan PG. Metabolic endotoxaemia: is it more than just a gut feeling? Curr Opin Lipidol. 2013;24:78-85. doi: 10.1097/ MOL.0b013e32835b4431.
    • (2013) Curr Opin Lipidol , vol.24 , pp. 78-85
    • Piya, M.K.1    Harte, A.L.2    McTernan, P.G.3
  • 47
    • 84872161044 scopus 로고    scopus 로고
    • The gut microbiota, obesity and insulin resistance
    • Shen J, Obin MS, Zhao L. The gut microbiota, obesity and insulin resistance. Mol Aspects Med. 2013;34:39-58. doi: 10.1016/j.mam.2012.11.001.
    • (2013) Mol Aspects Med , vol.34 , pp. 39-58
    • Shen, J.1    Obin, M.S.2    Zhao, L.3
  • 51
    • 34347399563 scopus 로고    scopus 로고
    • Metabolic endotoxemia initiates obesity and insulin resistance
    • Cani PD, Amar J, Iglesias MA, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007;56:1761-1772. doi: 10.2337/ db06-1491.
    • (2007) Diabetes , vol.56 , pp. 1761-1772
    • Cani, P.D.1    Amar, J.2    Iglesias, M.A.3
  • 52
    • 84877331372 scopus 로고    scopus 로고
    • Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis
    • Koeth RA, Wang Z, Levison BS, et al. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med. 2013;19:576-585. doi: 10.1038/nm.3145.
    • (2013) Nat Med , vol.19 , pp. 576-585
    • Koeth, R.A.1    Wang, Z.2    Levison, B.S.3
  • 54
    • 80053618114 scopus 로고    scopus 로고
    • Linking long-term dietary patterns with gut microbial enterotypes
    • Wu GD, Chen J, Hoffmann C, et al. Linking long-term dietary patterns with gut microbial enterotypes. Science. 2011;334:105-108. doi: 10.1126/ science.1208344.
    • (2011) Science , vol.334 , pp. 105-108
    • Wu, G.D.1    Chen, J.2    Hoffmann, C.3
  • 55
    • 33845901507 scopus 로고    scopus 로고
    • Microbial ecology: Human gut microbes associated with obesity
    • Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Microbial ecology: human gut microbes associated with obesity. Nature. 2006;444:1022-1023. doi: 10.1038/4441022a.
    • (2006) Nature , vol.444 , pp. 1022-1023
    • Ley, R.E.1    Turnbaugh, P.J.2    Klein, S.3    Gordon, J.I.4
  • 56
    • 79959199187 scopus 로고    scopus 로고
    • Intestinal microbiota in inflammation and insulin resistance: Relevance to humans
    • De Bandt JP, Waligora-Dupriet AJ, Butel MJ. Intestinal microbiota in inflammation and insulin resistance: relevance to humans. Curr Opin Clin Nutr Metab Care. 2011;14:334-340. doi: 10.1097/ MCO.0b013e328347924a.
    • (2011) Curr Opin Clin Nutr Metab Care , vol.14 , pp. 334-340
    • De Bandt, J.P.1    Waligora-Dupriet, A.J.2    Butel, M.J.3
  • 57
    • 84863870958 scopus 로고    scopus 로고
    • Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity
    • Cani PD, Osto M, Geurts L, Everard A. Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity. Gut Microbes. 2012;3:279-288. doi: 10.4161/gmic.19625.
    • (2012) Gut Microbes , vol.3 , pp. 279-288
    • Cani, P.D.1    Osto, M.2    Geurts, L.3    Everard, A.4
  • 61
    • 82455171885 scopus 로고    scopus 로고
    • Involvement of tissue bacteria in the onset of diabetes in humans: Evidence for a concept
    • Amar J, Serino M, Lange C, et al; D.E.S.I.R. Study Group. Involvement of tissue bacteria in the onset of diabetes in humans: evidence for a concept. Diabetologia. 2011;54:3055-3061. doi: 10.1007/s00125-011-2329-8.
    • (2011) Diabetologia , vol.54 , pp. 3055-3061
    • Amar, J.1    Serino, M.2    Lange, C.3
  • 68
    • 0026716993 scopus 로고
    • Lipids, lipoproteins, triglyceride clearance, and cytokines in human immunodeficiency virus infection and the acquired immunodeficiency syndrome
    • Grunfeld C, Pang M, Doerrler W, Shigenaga JK, Jensen P, Feingold KR. Lipids, lipoproteins, triglyceride clearance, and cytokines in human immunodeficiency virus infection and the acquired immunodeficiency syndrome. J Clin Endocrinol Metab. 1992;74:1045-1052. doi: 10.1210/ jcem.74.5.1373735.
    • (1992) J Clin Endocrinol Metab , vol.74 , pp. 1045-1052
    • Grunfeld, C.1    Pang, M.2    Doerrler, W.3    Shigenaga, J.K.4    Jensen, P.5    Feingold, K.R.6
  • 69
    • 33947166873 scopus 로고    scopus 로고
    • HDL cholesterol transport during inflammation
    • van der Westhuyzen DR, de Beer FC, Webb NR. HDL cholesterol transport during inflammation. Curr Opin Lipidol. 2007;18:147-151. doi: 10.1097/MOL.0b013e328051b4fe.
    • (2007) Curr Opin Lipidol , vol.18 , pp. 147-151
    • Van Der, W.D.R.1    De Beer, F.C.2    Webb, N.R.3
  • 70
    • 3042606551 scopus 로고    scopus 로고
    • Thematic review series: The pathogenesis of atherosclerosis. Effects of infection and inflammation on lipid and lipoprotein metabolism: Mechanisms and consequences to the host
    • Khovidhunkit W, Kim MS, Memon RA, Shigenaga JK, Moser AH, Feingold KR, Grunfeld C. Thematic review series: the pathogenesis of atherosclerosis. Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host. J Lipid Res. 2004;45:1169-1196. doi: 10.1194/jlr.R300019-JLR200.
    • (2004) J Lipid Res , vol.45 , pp. 1169-1196
    • Khovidhunkit, W.1    Kim, M.S.2    Memon, R.A.3    Shigenaga, J.K.4    Moser, A.H.5    Feingold, K.R.6    Grunfeld, C.7
  • 72
    • 34250214537 scopus 로고    scopus 로고
    • Molecular regulation of macrophage reverse cholesterol transport
    • Wang X, Rader DJ. Molecular regulation of macrophage reverse cholesterol transport. Curr Opin Cardiol. 2007;22:368-372. doi: 10.1097/ HCO.0b013e3281ec5113.
    • (2007) Curr Opin Cardiol , vol.22 , pp. 368-372
    • Wang, X.1    Rader, D.J.2
  • 75
    • 40149083940 scopus 로고    scopus 로고
    • Endothelial lipase is increased in vivo by inflammation in humans
    • Badellino KO, Wolfe ML, Reilly MP, Rader DJ. Endothelial lipase is increased in vivo by inflammation in humans. Circulation. 2008;117:678-685. doi: 10.1161/CIRCULATIONAHA.107.707349.
    • (2008) Circulation , vol.117 , pp. 678-685
    • Badellino, K.O.1    Wolfe, M.L.2    Reilly, M.P.3    Rader, D.J.4
  • 77
    • 44449123689 scopus 로고    scopus 로고
    • Obesity-related changes in high-density lipoprotein metabolism
    • Mooradian AD, Haas MJ, Wehmeier KR, Wong NC. Obesity-related changes in high-density lipoprotein metabolism. Obesity (Silver Spring). 2008;16:1152-1160. doi: 10.1038/oby.2008.202.
    • (2008) Obesity (Silver Spring) , vol.16 , pp. 1152-1160
    • Mooradian, A.D.1    Haas, M.J.2    Wehmeier, K.R.3    Wong, N.C.4
  • 80
    • 0028859490 scopus 로고
    • Anti-inflammatory HDL becomes pro-inflammatory during the acute phase response. Loss of protective effect of HDL against LDL oxidation in aortic wall cell cocultures
    • Van Lenten BJ, Hama SY, de Beer FC, Stafforini DM, McIntyre TM, Prescott SM, La Du BN, Fogelman AM, Navab M. Anti-inflammatory HDL becomes pro-inflammatory during the acute phase response. Loss of protective effect of HDL against LDL oxidation in aortic wall cell cocultures. J Clin Invest. 1995;96:2758-2767. doi: 10.1172/JCI118345.
    • (1995) J Clin Invest , vol.96 , pp. 2758-2767
    • Van Lenten, B.J.1    Hama, S.Y.2    De Beer, F.C.3    Stafforini, D.M.4    McIntyre, T.M.5    Prescott, S.M.6    La Du, B.N.7    Fogelman, A.M.8    Navab, M.9
  • 82
    • 34249283440 scopus 로고    scopus 로고
    • Gender differences in the innate immune response and vascular reactivity following the administration of endotoxin to human volunteers
    • van Eijk LT, Dorresteijn MJ, Smits P, van der Hoeven JG, Netea MG, Pickkers P. Gender differences in the innate immune response and vascular reactivity following the administration of endotoxin to human volunteers. Crit Care Med. 2007;35:1464-1469. doi: 10.1097/01. CCM.0000266534.14262.E8.
    • (2007) Crit Care Med , vol.35 , pp. 1464-1469
    • Van Eijk, L.T.1    Dorresteijn, M.J.2    Smits, P.3    Van Der Hoeven, J.G.4    Netea, M.G.5    Pickkers, P.6
  • 83
    • 84900329074 scopus 로고    scopus 로고
    • Pronounced inflammatory response to endotoxaemia during nighttime: A randomised cross-over trial
    • Alamili M, Bendtzen K, Lykkesfeldt J, Rosenberg J, Gögenur I. Pronounced inflammatory response to endotoxaemia during nighttime: a randomised cross-over trial. PLoS One. 2014;9:e87413. doi: 10.1371/ journal.pone.0087413.
    • (2014) PLoS One , vol.9 , pp. e87413
    • Alamili, M.1    Bendtzen, K.2    Lykkesfeldt, J.3    Rosenberg, J.4    Gögenur, I.5
  • 85
    • 0037190065 scopus 로고    scopus 로고
    • Inflammatory biomarkers, hormone replacement therapy, and incident coronary heart disease: Prospective analysis from the Women's Health Initiative observational study
    • Pradhan AD, Manson JE, Rossouw JE, Siscovick DS, Mouton CP, Rifai N, Wallace RB, Jackson RD, Pettinger MB, Ridker PM. Inflammatory biomarkers, hormone replacement therapy, and incident coronary heart disease: prospective analysis from the Women's Health Initiative observational study. JAMA. 2002;288:980-987.
    • (2002) JAMA , vol.288 , pp. 980-987
    • Pradhan, A.D.1    Manson, J.E.2    Rossouw, J.E.3    Siscovick, D.S.4    Mouton, C.P.5    Rifai, N.6    Wallace, R.B.7    Jackson, R.D.8    Pettinger, M.B.9    Ridker, P.M.10
  • 86
    • 84861790964 scopus 로고    scopus 로고
    • The dynamic range of the human metabolome revealed by challenges
    • Krug S, Kastenmüller G, Stückler F, et al. The dynamic range of the human metabolome revealed by challenges. FASEB J. 2012;26:2607-2619. doi: 10.1096/fj.11-198093.
    • (2012) FASEB J , vol.26 , pp. 2607-2619
    • Krug, S.1    Kastenmüller, G.2    Stückler, F.3
  • 87
    • 84939874843 scopus 로고    scopus 로고
    • Phenotypic flexibility as key factor in the human nutrition and health relationship
    • van Ommen B, van der Greef J, Ordovas JM, Daniel H. Phenotypic flexibility as key factor in the human nutrition and health relationship. Genes Nutr. 2014;9:423. doi: 10.1007/s12263-014-0423-5.
    • (2014) Genes Nutr , vol.9 , pp. 423
    • Van Ommen, B.1    Van Der, G.J.2    Ordovas, J.M.3    Daniel, H.4
  • 88
    • 80053298540 scopus 로고    scopus 로고
    • Determinants of inflammatory markers in a bi-ethnic population
    • Paalani M, Lee JW, Haddad E, Tonstad S. Determinants of inflammatory markers in a bi-ethnic population. Ethn Dis. 2011;21:142-149.
    • (2011) Ethn Dis , vol.21 , pp. 142-149
    • Paalani, M.1    Lee, J.W.2    Haddad, E.3    Tonstad, S.4
  • 89
    • 84860601964 scopus 로고    scopus 로고
    • Ethnicity, plasma phospholipid fatty acid composition and inflammatory/endothelial activation biomarkers in the Multi-Ethnic Study of Atherosclerosis (MESA)
    • Steffen BT, Steffen LM, Tracy R, Siscovick D, Jacobs D, Liu K, He K, Hanson NQ, Nettleton JA, Tsai MY. Ethnicity, plasma phospholipid fatty acid composition and inflammatory/endothelial activation biomarkers in the Multi-Ethnic Study of Atherosclerosis (MESA). Eur J Clin Nutr. 2012;66:600-605. doi: 10.1038/ejcn.2011.215.
    • (2012) Eur J Clin Nutr , vol.66 , pp. 600-605
    • Steffen, B.T.1    Steffen, L.M.2    Tracy, R.3    Siscovick, D.4    Jacobs, D.5    Liu, K.6    He, K.7    Hanson, N.Q.8    Nettleton, J.A.9    Tsai, M.Y.10
  • 93
    • 77949756362 scopus 로고    scopus 로고
    • Genome-wide association studies in pharmacogenomics
    • Daly AK. Genome-wide association studies in pharmacogenomics. Nat Rev Genet. 2010;11:241-246. doi: 10.1038/nrg2751.
    • (2010) Nat Rev Genet , vol.11 , pp. 241-246
    • Daly, A.K.1
  • 95
    • 84858433310 scopus 로고    scopus 로고
    • Personal omics profiling reveals dynamic molecular and medical phenotypes
    • Chen R, Mias GI, Li-Pook-Than J, et al. Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell. 2012;148:1293-1307. doi: 10.1016/j.cell.2012.02.009.
    • (2012) Cell , vol.148 , pp. 1293-1307
    • Chen, R.1    Mias, G.I.2    Li-Pook-Than, J.3
  • 96
    • 75649139205 scopus 로고    scopus 로고
    • Murine responses to endotoxin: Another dirty little secret?
    • Munford RS. Murine responses to endotoxin: another dirty little secret? J Infect Dis. 2010;201:175-177. doi: 10.1086/649558.
    • (2010) J Infect Dis , vol.201 , pp. 175-177
    • Munford, R.S.1
  • 97
    • 60649083141 scopus 로고    scopus 로고
    • LPS response and tolerance in the zebrafish (Danio rerio)
    • Novoa B, Bowman TV, Zon L, Figueras A. LPS response and tolerance in the zebrafish (Danio rerio). Fish Shellfish Immunol. 2009;26:326-331. doi: 10.1016/j.fsi.2008.12.004.
    • (2009) Fish Shellfish Immunol , vol.26 , pp. 326-331
    • Novoa, B.1    Bowman, T.V.2    Zon, L.3    Figueras, A.4
  • 98
    • 84874457770 scopus 로고    scopus 로고
    • Genomic responses in mouse models poorly mimic human inflammatory diseases
    • Inflammation and Host Response to Injury, Large Scale Collaborative Research Program
    • Seok J, Warren HS, Cuenca AG, et al; Inflammation and Host Response to Injury, Large Scale Collaborative Research Program. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A. 2013;110:3507-3512. doi: 10.1073/pnas.1222878110.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 3507-3512
    • Seok, J.1    Warren, H.S.2    Cuenca, A.G.3
  • 99
    • 84921727957 scopus 로고    scopus 로고
    • Genomic responses in mouse models greatly mimic human inflammatory diseases
    • published online ahead of print August 4, 2014
    • Takao K, Miyakawa T. Genomic responses in mouse models greatly mimic human inflammatory diseases [published online ahead of print August 4, 2014]. Proc Natl Acad Sci U S A. doi: 10.1073/pnas.1401965111.
    • Proc Natl Acad Sci U S A
    • Takao, K.1    Miyakawa, T.2
  • 101
    • 84896759364 scopus 로고    scopus 로고
    • Common genetic variants modulate pathogen-sensing responses in human dendritic cells
    • Lee MN, Ye C, Villani AC, et al. Common genetic variants modulate pathogen-sensing responses in human dendritic cells. Science. 2014;343:1246980. doi: 10.1126/science.1246980.
    • (2014) Science , vol.343 , pp. 1246980
    • Lee, M.N.1    Ye, C.2    Villani, A.C.3
  • 104
    • 0035503202 scopus 로고    scopus 로고
    • The influence of tumor necrosis factor-alpha and interleukin-10 gene promoter polymorphism on the inflammatory response in experimental human endotoxemia
    • Fijen JW, Tulleken JE, Hepkema BG, van der Werf TS, Ligtenberg JJ, Zijlstra JG. The influence of tumor necrosis factor-alpha and interleukin-10 gene promoter polymorphism on the inflammatory response in experimental human endotoxemia. Clin Infect Dis. 2001;33:1601-1603. doi: 10.1086/323197.
    • (2001) Clin Infect Dis , vol.33 , pp. 1601-1603
    • Fijen, J.W.1    Tulleken, J.E.2    Hepkema, B.G.3    Van Der Werf, T.S.4    Ligtenberg, J.J.5    Zijlstra, J.G.6
  • 105
    • 1642492772 scopus 로고    scopus 로고
    • The interleukin-6 G(-174)C promoter polymorphism does not determine plasma interleukin-6 concentrations in experimental endotoxemia in humans
    • Endler G, Marsik C, Joukhadar C, Marculescu R, Mayr F, Mannhalter C, Wagner OF, Jilma B. The interleukin-6 G(-174)C promoter polymorphism does not determine plasma interleukin-6 concentrations in experimental endotoxemia in humans. Clin Chem. 2004;50:195-200. doi: 10.1373/clinchem.2003.022459.
    • (2004) Clin Chem , vol.50 , pp. 195-200
    • Endler, G.1    Marsik, C.2    Joukhadar, C.3    Marculescu, R.4    Mayr, F.5    Mannhalter, C.6    Wagner, O.F.7    Jilma, B.8
  • 106
    • 27144509163 scopus 로고    scopus 로고
    • Inflamm and Host Response to Injury Large Scale Collab Res. Program. A network-based analysis of systemic inflammation in humans
    • Calvano SE, Xiao W, Richards DR, et al; Inflamm and Host Response to Injury Large Scale Collab. Res. Program. A network-based analysis of systemic inflammation in humans. Nature. 2005;437:1032-1037. doi: 10.1038/nature03985.
    • (2005) Nature , vol.437 , pp. 1032-1037
    • Calvano, S.E.1    Xiao, W.2    Richards, D.R.3
  • 110
    • 0037007683 scopus 로고    scopus 로고
    • Treatment of ankylosing spondylitis by inhibition of tumor necrosis factor alpha
    • Gorman JD, Sack KE, Davis JC Jr. Treatment of ankylosing spondylitis by inhibition of tumor necrosis factor alpha. N Engl J Med. 2002;346:1349-1356. doi: 10.1056/NEJMoa012664.
    • (2002) N Engl J Med , vol.346 , pp. 1349-1356
    • Gorman, J.D.1    Sack, K.E.2    Davis, J.C.3
  • 111
    • 79151481493 scopus 로고    scopus 로고
    • Gout therapeutics: New drugs for an old disease
    • Burns CM, Wortmann RL. Gout therapeutics: new drugs for an old disease. Lancet. 2011;377:165-177. doi: 10.1016/S0140-6736(10)60665-4.
    • (2011) Lancet , vol.377 , pp. 165-177
    • Burns, C.M.1    Wortmann, R.L.2
  • 113
    • 4544384060 scopus 로고    scopus 로고
    • Experimental human endotoxemia is associated with depression of load-independent contractility indices: Prevention by the lipid a analogue E5531
    • Kumar A, Bunnell E, Lynn M, Anel R, Habet K, Neumann A, Parrillo JE. Experimental human endotoxemia is associated with depression of load-independent contractility indices: prevention by the lipid a analogue E5531. Chest. 2004;126:860-867. doi: 10.1378/chest.126.3.860.
    • (2004) Chest , vol.126 , pp. 860-867
    • Kumar, A.1    Bunnell, E.2    Lynn, M.3    Anel, R.4    Habet, K.5    Neumann, A.6    Parrillo, J.E.7
  • 117
    • 0034053007 scopus 로고    scopus 로고
    • Interleukin 10 inhibits the release of CC chemokines during human endotoxemia
    • Olszyna DP, Pajkrt D, Lauw FN, van Deventer SJ, van Der Poll T. Interleukin 10 inhibits the release of CC chemokines during human endotoxemia. J Infect Dis. 2000;181:613-620. doi: 10.1086/315275.
    • (2000) J Infect Dis , vol.181 , pp. 613-620
    • Olszyna, D.P.1    Pajkrt, D.2    Lauw, F.N.3    Van Deventer, S.J.4    Van Der Poll, T.5
  • 118
    • 0028811230 scopus 로고
    • Effects of recombinant dimeric TNF receptor on human inflammatory responses following intravenous endotoxin administration
    • Suffredini AF, Reda D, Banks SM, Tropea M, Agosti JM, Miller R. Effects of recombinant dimeric TNF receptor on human inflammatory responses following intravenous endotoxin administration. J Immunol. 1995;155:5038-5045.
    • (1995) J Immunol , vol.155 , pp. 5038-5045
    • Suffredini, A.F.1    Reda, D.2    Banks, S.M.3    Tropea, M.4    Agosti, J.M.5    Miller, R.6
  • 120
    • 35349001343 scopus 로고    scopus 로고
    • Thalidomide suppressed interleukin-6 but not tumor necrosis factor-alpha in volunteers with experimental endotoxemia
    • Shannon E, Noveck R, Sandoval F, Kamath B, Kearney M. Thalidomide suppressed interleukin-6 but not tumor necrosis factor-alpha in volunteers with experimental endotoxemia. Transl Res. 2007;150:275-280. doi: 10.1016/j.trsl.2007.05.003.
    • (2007) Transl Res , vol.150 , pp. 275-280
    • Shannon, E.1    Noveck, R.2    Sandoval, F.3    Kamath, B.4    Kearney, M.5
  • 123
  • 125
    • 84897584542 scopus 로고    scopus 로고
    • Omega-3 PUFA supplementation and the response to evoked endotoxemia in healthy volunteers
    • Ferguson JF, Mulvey CK, Patel PN, et al. Omega-3 PUFA supplementation and the response to evoked endotoxemia in healthy volunteers. Mol Nutr Food Res. 2014;58:601-613. doi: 10.1002/mnfr.201300368.
    • (2014) Mol Nutr Food Res , vol.58 , pp. 601-613
    • Ferguson, J.F.1    Mulvey, C.K.2    Patel, P.N.3
  • 127
    • 33846640524 scopus 로고    scopus 로고
    • Effects of fish oil on the neuro-endocrine responses to an endotoxin challenge in healthy volunteers
    • Michaeli B, Berger MM, Revelly JP, Tappy L, Chioléro R. Effects of fish oil on the neuro-endocrine responses to an endotoxin challenge in healthy volunteers. Clin Nutr. 2007;26:70-77. doi: 10.1016/j. clnu.2006.06.001.
    • (2007) Clin Nutr , vol.26 , pp. 70-77
    • Michaeli, B.1    Berger, M.M.2    Revelly, J.P.3    Tappy, L.4    Chioléro, R.5
  • 128
    • 84955673724 scopus 로고    scopus 로고
    • Dietary isoflavone intake is associated with evoked responses to inflammatory cardiometabolic stimuli and improved glucose homeostasis in healthy volunteers
    • Ferguson JF, Ryan MF, Gibney ER, Brennan L, Roche HM, Reilly MP. Dietary isoflavone intake is associated with evoked responses to inflammatory cardiometabolic stimuli and improved glucose homeostasis in healthy volunteers. Nutr Metab Cardiovasc Dis. 2014;24:996-1003. doi: 10.1016/j.numecd.2014.03.010.
    • (2014) Nutr Metab Cardiovasc Dis , vol.24 , pp. 996-1003
    • Ferguson, J.F.1    Ryan, M.F.2    Gibney, E.R.3    Brennan, L.4    Roche, H.M.5    Reilly, M.P.6
  • 130
    • 84896395172 scopus 로고    scopus 로고
    • MMP-8 genotypes influence the inflammatory response in human endotoxemia
    • Rella JM, Jilma B, Fabry A, Kaynar AM, Mayr FB. MMP-8 genotypes influence the inflammatory response in human endotoxemia. Inflammation. 2014;37:451-456. doi: 10.1007/s10753-013-9758-0.
    • (2014) Inflammation , vol.37 , pp. 451-456
    • Rella, J.M.1    Jilma, B.2    Fabry, A.3    Kaynar, A.M.4    Mayr, F.B.5
  • 131
    • 34547947060 scopus 로고    scopus 로고
    • The fibrinogen -148 C/T polymorphism influences inflammatory response in experimental endotoxemia in vivo
    • Kovar FM, Marsik C, Jilma B, Mannhalter C, Quehenberger P, Handler S, Wagner OF, Endler G. The fibrinogen -148 C/T polymorphism influences inflammatory response in experimental endotoxemia in vivo. Thromb Res. 2007;120:727-731. doi: 10.1016/j.thromres.2006.12.007.
    • (2007) Thromb Res , vol.120 , pp. 727-731
    • Kovar, F.M.1    Marsik, C.2    Jilma, B.3    Mannhalter, C.4    Quehenberger, P.5    Handler, S.6    Wagner, O.F.7    Endler, G.8
  • 132
    • 33749139712 scopus 로고    scopus 로고
    • The C-reactive protein (+)1444C/T alteration modulates the inflammation and coagulation response in human endotoxemia
    • Marsik C, Sunder-Plassmann R, Jilma B, Kovar FM, Mannhalter C, Wagner O, Rumpold H, Endler G. The C-reactive protein (+)1444C/T alteration modulates the inflammation and coagulation response in human endotoxemia. Clin Chem. 2006;52:1952-1957. doi: 10.1373/ clinchem.2006.069823.
    • (2006) Clin Chem , vol.52 , pp. 1952-1957
    • Marsik, C.1    Sunder-Plassmann, R.2    Jilma, B.3    Kovar, F.M.4    Mannhalter, C.5    Wagner, O.6    Rumpold, H.7    Endler, G.8
  • 133
    • 27444446627 scopus 로고    scopus 로고
    • The Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms influence the late inflammatory response in human endotoxemia
    • Marsik C, Jilma B, Joukhadar C, Mannhalter C, Wagner O, Endler G. The Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms influence the late inflammatory response in human endotoxemia. Clin Chem. 2005;51:2178-2180. doi: 10.1373/clinchem.2005.051649.
    • (2005) Clin Chem , vol.51 , pp. 2178-2180
    • Marsik, C.1    Jilma, B.2    Joukhadar, C.3    Mannhalter, C.4    Wagner, O.5    Endler, G.6
  • 134
    • 33847039081 scopus 로고    scopus 로고
    • The tumor necrosis factor alpha -308 G/A polymorphism does not influence inflammation and coagulation response in human endotoxemia
    • Kovar FM, Marsik C, Cvitko T, Wagner OF, Jilma B, Endler G. The tumor necrosis factor alpha -308 G/A polymorphism does not influence inflammation and coagulation response in human endotoxemia. Shock. 2007;27:238-241. doi: 10.1097/01.shk.0000239768.64786.3a.
    • (2007) Shock , vol.27 , pp. 238-241
    • Kovar, F.M.1    Marsik, C.2    Cvitko, T.3    Wagner, O.F.4    Jilma, B.5    Endler, G.6
  • 135
    • 67650433962 scopus 로고    scopus 로고
    • Development of endotoxin tolerance in humans in vivo
    • Draisma A, Pickkers P, Bouw MP, van der Hoeven JG. Development of endotoxin tolerance in humans in vivo. Crit Care Med. 2009;37:1261-1267. doi: 10.1097/CCM.0b013e31819c3c67.
    • (2009) Crit Care Med , vol.37 , pp. 1261-1267
    • Draisma, A.1    Pickkers, P.2    Bouw, M.P.3    Van Der Hoeven, J.G.4
  • 136
    • 68049084831 scopus 로고    scopus 로고
    • Microcirculation and vascular reactivity during endotoxemia and endotoxin tolerance in humans
    • Draisma A, Bemelmans R, van der Hoeven JG, Spronk P, Pickkers P. Microcirculation and vascular reactivity during endotoxemia and endotoxin tolerance in humans. Shock. 2009;31:581-585. doi: 10.1097/ SHK.0b013e318193e187.
    • (2009) Shock , vol.31 , pp. 581-585
    • Draisma, A.1    Bemelmans, R.2    Van Der Hoeven, J.G.3    Spronk, P.4    Pickkers, P.5
  • 139
    • 0029796138 scopus 로고    scopus 로고
    • Effects of recombinant soluble type I interleukin-1 receptor on human inflammatory responses to endotoxin
    • Preas HL II, Reda D, Tropea M, Vandivier RW, Banks SM, Agosti JM, Suffredini AF. Effects of recombinant soluble type I interleukin-1 receptor on human inflammatory responses to endotoxin. Blood. 1996;88:2465-2472.
    • (1996) Blood , vol.88 , pp. 2465-2472
    • Preas HL, I.I.1    Reda, D.2    Tropea, M.3    Vandivier, R.W.4    Banks, S.M.5    Agosti, J.M.6    Suffredini, A.F.7


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