Intestinal microbiota in inflammation and insulin resistance: Relevance to humans

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 14, Issue 4, 2011, Pages 334-340

  De Bandt, Jean Pascal ^a,c   Waligora Dupriet, Anne Judith ^b   Butel, Marie José ^b  

^a Département de Biologie Expérimentale temp Métabolique et Clinique ^*  (France)

^b Faculte de Medecine Paris   (France)

^c HÔTEL DIEU   (France)

Author keywords

gut microbiota; gut permeability; lipopolysaccharide; obesity

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; ENDOTOXIN; INSULIN; PLACEBO; PREBIOTIC AGENT; PROBIOTIC AGENT; ROSIGLITAZONE; SERUM AMYLOID A; SHORT CHAIN FATTY ACID; TETRAHYDROLIPSTATIN;

BACTERIAL COLONIZATION; BACTERIAL TRANSLOCATION; CLOSTRIDIUM; CLOSTRIDIUM LEPTUM; CYTOKINE PRODUCTION; DIET THERAPY; ENDOTOXEMIA; ENERGY METABOLISM; GLYCEMIC CONTROL; HEPATITIS; HUMAN; IMMUNE RESPONSE; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTESTINE FLORA; INTESTINE MUCOSA PERMEABILITY; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; NONALCOHOLIC FATTY LIVER; NONHUMAN; OBESITY; PREVOTELLACEAE; REVIEW; WEIGHT GAIN;

ADIPOKINES; ANIMALS; BACTEROIDETES; FATTY ACIDS, NONESTERIFIED; GASTROINTESTINAL TRACT; HUMANS; INFLAMMATION; INSULIN RESISTANCE; INTESTINES; METAGENOME; OBESITY; WEIGHT GAIN; WEIGHT LOSS;

EID: 79959199187     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0b013e328347924a     Document Type: Review

References (46)

1. Shi H, Kokoeva MV, Inouye K, et al. TLR4 links innate immunity and fatty acidinduced insulin resistance. J Clin Invest 2006; 116:3015-3025. (Pubitemid 44684486)
2. Fasano A. Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer. Physiol Rev 2011; 91:151-175.
3. Round JL, Mazmanian SK. The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol 2009; 9:313-323.
4. Neish AS. Microbes in gastrointestinal health and disease. Gastroenterology 2009; 136:65-80.
5. Fujimura KE, Slusher NA, Cabana MD, Lynch SV. Role of the gut microbiota in defining human health. Expert Rev Anti Infect Ther 2010; 8:435-454.
6. Backhed F, Ding H, Wang T, et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci 2004; 101:15718-15723. (Pubitemid 39473554)
7. Koren O, Spor A, Felin J, et al. Microbes and Health Sackler Colloquium: human oral, gut, and plaque microbiota in patients with atherosclerosis. Proc Natl Acad Sci USA 2010 [Epub ahead of print].
8. Ley RE, Backhed F, Turnbaugh P, et al. Obesity alters gut microbial ecology. Proc Natl Acad Sci USA 2005; 102:11070-11075. (Pubitemid 41105994)
9. Turnbaugh PJ, Ley RE, Mahowald MA, et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006; 444:1027-1031. (Pubitemid 46018515)
10. Turnbaugh PJ, Backhed F, Fulton L, Gordon JI. Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe 2008; 3:213-223. (Pubitemid 351494716)
11. Backhed F, Manchester JK, Semenkovich CF, Gordon JI. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc Natl Acad Sci USA 2007; 104:979-984. (Pubitemid 46154722)
12. Gao Z, Yin J, Zhang J, et al. Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes 2009; 58:1509-1517.
13. Maslowski KM, Vieira AT, Ng A, et al. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 2009; 461:1282-1286.
14. Atarashi K, Tanoue T, Shima T, et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Science 2011; 331:337.
15. Ivanov II, Atarashi K, Manel N, et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 2009; 139:485-498.
16. Reigstad CS, Östergren Lundén G, Felin J, Bäckhed F. Regulation of serum amyloid A3 (SAA3) in mouse colonic epithelium and adipose tissue by the intestinal microbiota. PLoS One 2009; 4:e5842.
17. Ding S, Chi MM, Scull BP, et al. High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse. PLoS ONE 2010; 5:e12191.
18. Cani PD, Amar J, Iglesias MA, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 2007; 56:1761-1772. (Pubitemid 47025442)
19. Haub S, Kanuri G, Volynets V, et al. Serotonin reuptake transporter (SERT) plays a critical role in the onset of fructose-induced hepatic steatosis in mice. Am J Physiol Gastrointest Liver Physiol 2010; 298: G335-G344.
20. Brun P, Castagliuolo I, Leo VD, et al. Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol 2007; 292:G518-G525.
21. Cani PD, Bibiloni R, Knauf C, et al. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 2008; 57:1470-1481.
22. Membrez M, Blancher F, Jaquet M, et al. Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice. FASEB J 2008; 22:2416-2426. (Pubitemid 351948659)
23. Li Z, Yang S, Lin H, et al. Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology 2003; 37:343-350. (Pubitemid 36152533)
24. Ma X, Hua J, Li Z. Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells. J Hepatol 2008; 49:821-830.
25. Cani PD, Neyrinck AM, Fava F, et al. Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia 2007; 50:2374-2383. (Pubitemid 47512397)
26. Cani PD, Possemiers S, Van de Wiele T, et al. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut 2009; 58:1091-1103.
27. Muccioli GG, Naslain D, Bäckhed F, et al. The endocannabinoid system links gut microbiota to adipogenesis. Mol Syst Biol 2010; 6:392.
28. Schwiertz A, Taras D, Schä fer K, et al. Microbiota and SCFA in lean and overweight healthy subjects. Obesity (Silver Spring) 2010; 18:190-195.
29. Zhang H, DiBaise JK, Zuccolo A, et al. Human gut microbiota in obesity and after gastric bypass. Proc Natl Acad Sci USA 2009; 106:2365-2370.
30. Turnbaugh PJ, Hamady M, Yatsunenko T, et al. A core gut microbiome in obese and lean twins. Nature 2009; 457:480-484.
31. Armougom F, Henry M, Vialettes B, et al. Monitoring bacterial community of human gut microbiota reveals an increase in Lactobacillus in obese patients and Methanogens in anorexic patients. PLoS One 2009; 4: e7125.
32. Brignardello J, Morales P, Diaz E, et al. Pilot study: alterations of intestinal microbiota in obese humans are not associated with colonic inflammation or disturbances of barrier function. Aliment Pharmacol Ther 2010; 32:1307-1314.
33. Duncan SH, Lobley GE, Holtrop G, et al. Human colonic microbiota associated with diet, obesity and weight loss. Int J Obes (Lond) 2008; 32:1720-1724.
34. Furet JP, Kong LC, Tap J, et al. Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers. Diabetes 2010; 59:3049-3057.
35. Larsen N, Vogensen FK, van den Berg FW, et al. Gut microbiota in human adults with type 2 diabetes differs from nondiabetic adults. PLoS One 2010; 5:e9085.
36. Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Microbial ecology: human gut microbes associated with obesity. Nature 2006; 444:1022-1023. (Pubitemid 46018512)
37. Collado MC, Isolauri E, Laitinen K, Salminen S. Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women. Am J Clin Nutr 2008; 88:894-899.
38. Santacruz A, Collado MC, García-Valdés L, et al. Gut microbiota composition is associated with body weight, weight gain and biochemical parameters in pregnant women. Br J Nutr 2010; 104:83-92.
39. Kalliomä ki M, Collado MC, Salminen S, Isolauri E. Early differences in fecal microbiota composition in children may predict overweight. Am J Clin Nutr 2008; 87:534-538. (Pubitemid 351364532)
40. Balamurugan R, George G, Kabeerdoss J, et al. Quantitative differences in intestinal Faecalibacterium prausnitzii in obese Indian children. Br J Nutr 2010; 103:335-338.
41. Nadal I, Santacruz A, Marcos A, et al. Shifts in clostridia, bacteroides and immunoglobulin-coating fecal bacteria associated with weight loss in obese adolescents. Int J Obes (Lond) 2009; 33:758-767.
42. Thuny F, Richet H, Casalta JP, et al. Vancomycin treatment of infective endocarditis is linked with recently acquired obesity. PLoS One 2010; 5:e9074.
43. Al-AttasOS, Al-Daghri NM, Al-Rubeaan K, et al. Changes in endotoxin levels in T2DM subjects on antidiabetic therapies. Cardiovasc Diabetol 2009; 8:20.
44. Harte AL, da Silva NF, Creely SJ, et al. Elevated endotoxin levels in nonalcoholic fatty liver disease. J Inflamm (Lond) 2010; 7:15.
45. Creely SJ,McTernan PG, Kusminski CM, et al. Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes. Am J Physiol Endocrinol Metab 2007; 292:E740-E747. (Pubitemid 46411051)
46. Pendyala S, Neff LM, Suárez-Fariñas M, Holt PR. Diet-induced weight loss reduces colorectal inflammation: implications for colorectal carcinogenesis. Am J Clin Nutr 2011; 93:234-242.