Burden of infection and insulin resistance in healthy middle-aged men

Diabetes Care

Volumn 29, Issue 5, 2006, Pages 1058-1064

  Fernández Real, José Manuel ^a   López Bermejo, Abel ^a   Vendrell, Joan ^b   Ferri, Maria José ^a   Recasens, Mónica ^a   Ricart, Wifredo ^a  

^a GIRONA BIOMEDICAL RESEARCH INSTITUTE IDIBGI   (Spain)

^b HOSPITAL UNIVERSITARI JOAN XXIII   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; HEPATITIS C ANTIBODY; IMMUNOGLOBULIN G; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2;

ARTICLE; ATHEROSCLEROSIS; BODY MASS; CHLAMYDOPHILA PNEUMONIAE; CHRONIC INFLAMMATION; CONTROLLED STUDY; DYSLIPIDEMIA; ENTEROVIRUS; ENZYME LINKED IMMUNOSORBENT ASSAY; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; HUMAN; INFECTION; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; MULTIVARIATE ANALYSIS; PATHOGENESIS; SCORING SYSTEM; SEROTYPE;

EID: 33746341831     PISSN: 01495992     EISSN: 01495992     Source Type: Journal    
DOI: 10.2337/dc05-2068     Document Type: Article

References (44)

1. Epstein SE, Zhou YF, Zhu J: Infection and atherosclerosis: emerging mechanistic paradigms. Circulation 100:e20-e28, 1999
2. Zhu J, Nieto FJ, Horne BD, Anderson JL, Muhlestein JB, Epstein SE: Prospective study of pathogen burden and risk of myocardial infarction or death. Circulation 103:45-51, 2001
3. Prasad A, Zhu J, Halcox JPJ, Waclawiw MA, Epstein SE, Quyyumi AA: Predisposition to atherosclerosis by infections: role of endothelial dysfunction. Circulation 106:184-190, 2002
4. Epstein SE: The multiple mechanisms by which infection may contribute to atherosclerosis development and course. Circ Res 90:2-4, 2002
5. Zhu J, Quyyumi AA, Norman JE, Csako G, Waclawiw MA, Shearer GM, Epstein SE: Effects of total pathogen burden on coronary artery disease risk and C-reactive protein levels. Am J Cardiol 85:140-146, 2000
6. Rupprecht HJ, Blankenberg S, Bickel C, Rippin G, Hafner G, Prellwitz W, Schlumberger W, Meyer J, the AutoGene Investigators: Impact of viral and bacterial infectious burden on long-term prognosis in patients with coronary artery disease. Circulation 104:25-31, 2001
7. Espinola-Klein C, Rupprecht HJ, Blankenberg S, Bickel C, Kopp H, Rippin G, Victor A, Hafner G, Schlumberger W, Meyer J, the AtheroGene Investigators: Impact of infectious burden on extent and long-term prognosis of atherosclerosis. Circulation 105:15-21, 2002
8. Smieja M, Gnarpe J, Lonn E, Gnarpe H, Olsson G, Yi Q, Dzavik V, McQueen M, Yusuf S, the Heart Outcomes Prevention Evaluation (HOPE) Study Investigators: Multiple infections, subsequent cardiovascular events, and atherosclerotic progression in the Heart Outcome and Prevention Evaluation (HOPE) study. Circulation 107:251-257, 2003
9. Pussinen PJ, Nyyssonen K, Alfthan G, Salonen R, Laukkanen JA, Salonen JT: Serum antibody levels to Actinobacillus actinomycetemcomitans predict the risk for coronary heart disease. Arterioscler Thromb Vasc Biol 25:833-888, 2005
10. Visser MR, Tracy PB, Vercellotti GM, Goodman JL, White JG, Jacob HS: Enhanced thrombin generation and platelet binding on herpes simplex virus-infected endothelium. Proc Natl Acad Sci U S A 85: 8227-8230, 1988
11. Key NS, Vercellotti GM, Winkelmann JC, Moldow CF, Goodman JL, Esmon NL, Esmon CT, Jacob HS: Infection of vascular endothelial cells with herpes simplex virus enhances tissue factor activity and reduces thrombomodulin expression. Proc Natl Acad Sci U S A 87:7095-7099, 1990
12. Kol A, Sukhova GK, Lichtman AH, Libby P: Chlamydial heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor- and matrix metalloproteinase expression. Circulation 98:300-307, 1998
13. Dechend R, Maass M, Gieffers J, Dietz R, Scheidereit C, Leutz A, Gulba DC: Chlamydia pneumoniae infection of vascular smooth muscle and endothelial cells activates NF-B and induces tissue factor and PAI-1 expression: a potential link to accelerated arteriosclerosis. Circulation 100: 1369-1373, 1999
14. Wang CC, Goalstone ML, Draznin B: Molecular mechanisms of insulin resistance that impact cardiovascular biology. Diabetes 53:2735-2740, 2004
15. Kristensen BO, Andersen PL, Vestergaard BF, Andersen HM: Herpesvirus antibodies and vascular complications in essential hypertension. Acta Med Scand 212:375-377, 1982
16. Sun Y, Pei W, Wu Y, Yang Y: An association of herpes simplex virus type 1 infection with type 2 diabetes. Diabetes Care 28:435-436, 2005
17. Sun Y, Pei W, Wu Y, Jing Z, Zhang J, Wang G: Herpes simplex virus type 2 infection is a risk factor for hypertension. Hypertens Res 27:541-544, 2004
18. Roberts BW, Cech I: Association of type 2 diabetes mellitus and seroprevalence for cytomegalovirus. South Med J 98:686-692, 2005
19. Sun YH, Pei WD, Wu YJ, Wang GG: [Association of herpes simplex virus type 2 infection with dyslipidemia in Chinese] (Abstract). Zhonghua Yi Xue Za Zhi 83:1774-1777, 2003 [in Chinese]
20. Leinonen M, Saikku P: Interaction of Chlamydia pneumoniae infection with other risk factors of atherosclerosis. Am Heart J 138:S504-S506, 1999
21. Laurila A, Bloigu A, Nayha S, Hassi J, Leinonen M, Saikku P: Chronic Chlamydia pneumoniae infection is associated with a serum lipid profile known to be a risk factor for atherosclerosis. Arterioscler Thromb Vasc Biol 17:2910-2913, 1997
22. Murray LJ, O'Reilly DP, Ong GM, O'Neill C, Evans AE, Bamford KB: Chlamydia pneumoniae antibodies are associated with an atherogenic lipid profile. Heart 8:239-244, 1999
23. Muller J, Moller DS, Kjaer M, Nyvad O, Larsen NA, Pedersen EB: Chlamydia pneumoniae DNA in peripheral blood mononuclear cells in healthy control subjects and patients with diabetes mellitus, acute coronary syndrome, stroke, and arterial hypertension. Scand J Infect Dis 35:704-712, 2003
24. Fernández-Real JM, Ricart W: Insulin resistance and chronic cardiovascular inflammatory syndrome. Endocr Rev 24:278 -301, 2003
25. Roivainen M, Alfthan G, Jousilahti P, Kimpimaki M, Hovi T, Tuomilehto J: Enterovirus infections as a possible risk factor for myocardial infarction. Circulation 98:2534-2537, 1998
26. Fernandez-Real JM, Broch M, Ricart W, Casamitjana R, Gutierrez C, Vendrell J, Richart C: Plasma levels of the soluble fraction of tumor necrosis factor receptor 2 and insulin resistance. Diabetes 47:1757-1762, 1998
27. Shintani Y, Fujie H, Miyoshi H, Tsutsumi T, Tsukamoto K, Kimura S, Moriya K, Koike K: Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance. Gastroenterology 126:840-848, 2004
28. Toplak H, Wascher TC, Weber K, Lauermann T, Reisinger EC, Bahadori B, Tilz GP, Haller EM: [Increased prevalence of serum IgA Chlamydia antibodies in obesity] Acta Med Austriaca 22:23-24, 1995 [in German]
29. Ekesbo R, Nilsson PM, Lindholm LH, Persson K, Wadstrom T: Combined seropositivity for H. pylori and C. pneumoniae is associated with age, obesity and social factors. J Cardiovasc Risk 7:191-195, 2000
30. Falck G, Gnarpe J, Hansson LO, Svardsudd K, Gnarpe H: Comparison of individuals with and without specific IgA antibodies to Chlamydia pneumoniae: respiratory morbidity and the metabolic syndrome. Chest 122:1587-1593, 2002
31. Yudkin JS, Stehouwer CD, Emeis JJ, Coppack SW: C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol 19:972-978, 1999
32. el-Reshaid K, al-Mofti S, Stepic NR: Induction of insulin resistance by autoantibodies to insulin receptors following on an acute Coxsackie B4 infection. Diabetes Res Clin Pract 25:207-210, 1994
33. Hilleman MR: Strategies and mechanisms for host and pathogen survival in acute and persistent viral infections. Proc Natl Acad Sci U S A 101 (Suppl. 2):14560-14566, 2004
34. Sweet JM, Hume DA: Endotoxin signal transduction in macrophages. J Leukoc Biol 60:8-26, 1996
35. Khanna KM, Lepisto AJ, Decman V, Hendricks RL: Immune control of herpes simplex virus during latency. Curr Opin Immunol 16:463-469, 2004
36. Posavad CM, Huang ML, Barcy S, Koelle DM, Corey L: Long term persistence of herpes simplex virus-specific CD8+ CTL in persons with frequently recurring genital herpes. J Immunol 165:1146-1152, 2000
37. Ward ME: The immunobiology and immunopathology of chlamydial infections. APMIS 103:769-796, 1995
38. Beatty WL, Morrison RP, Byrne GI: Persistent chlamydiae: from cell culture to a paradigm for chlamydial pathogenesis. Microbiol Rev 58:686-699, 1994
39. Frisk G: Mechanisms of chronic enteroviral persistence in tissue. Curr Opin Infect Dis 14:251-256, 2001
40. Fernandez-Real JM, Ricart W: Insulin resistance and inflammation in an evolutionary perspective: the contribution of cytokine genotype/phenotype to thriftiness. Diabetologia 42:1367-1374, 1999
41. Xu F, Schillinger J, Sternberg M, Johnson RE, Lee FK, Nahmias AJ, Markowitz LE: Seroprevalence and coinfection with herpes simplex virus type 1 and type 2 in the United States, 1988-1994. J Infect Dis 185:1019-1024, 2002
42. Cook PJ, Honeybourne D: Clinical aspects of Chlamydia pneumoniae infection (Review). Presse Med 24:278-282, 1995
43. Lipp EK, Farrah SA, Rose JB: Assessment and impact of microbial fecal pollution and human enteric pathogens in a coastal community. Mar Pollut Bull 42:286-293, 2001
44. Finch CE, Crimmins EM: Inflammatory exposure and historical changes in human life-spans. Science 305:1736-1739, 2004