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Volumn 377, Issue 9760, 2011, Pages 165-177

Gout therapeutics: New drugs for an old disease

Author keywords

[No Author keywords available]

Indexed keywords

ALLOPURINOL; CANAKINUMAB; FEBUXOSTAT; PEGLOTICASE; PLACEBO; RDEA 594; RDEA 806; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; RILONACEPT; UNCLASSIFIED DRUG;

EID: 79151481493     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(10)60665-4     Document Type: Review
Times cited : (207)

References (99)
  • 1
    • 0001223338 scopus 로고
    • Identification of urate crystals in gouty synovial fluid
    • DJ McCarty Jr, JL Hollander Identification of urate crystals in gouty synovial fluid Ann Intern Med 54 1961 452 460
    • (1961) Ann Intern Med , vol.54 , pp. 452-460
    • McCarty Jr., D.J.1    Hollander, J.L.2
  • 2
    • 3442899325 scopus 로고    scopus 로고
    • Increasing prevalence of gout and hyperuricemia over 10 years among older adults in a managed care population
    • KL Wallace, AA Riedel, N Joseph-Ridge, R Wortmann Increasing prevalence of gout and hyperuricemia over 10 years among older adults in a managed care population J Rheumatol 31 2004 1582 1587
    • (2004) J Rheumatol , vol.31 , pp. 1582-1587
    • Wallace, K.L.1    Riedel, A.A.2    Joseph-Ridge, N.3    Wortmann, R.4
  • 3
    • 33745230455 scopus 로고    scopus 로고
    • Epidemiology, risk factors, and lifestyle modifications for gout
    • KG Saag, H Choi Epidemiology, risk factors, and lifestyle modifications for gout Arthritis Res Ther 8 2006 S2
    • (2006) Arthritis Res Ther , vol.8 , pp. 2
    • Saag, K.G.1    Choi, H.2
  • 5
    • 46849088805 scopus 로고    scopus 로고
    • Gout in the UK and Germany: Prevalence, comorbidities and management in general practice 2000-2005
    • L Annemans, E Spaepen, M Gaskin Gout in the UK and Germany: prevalence, comorbidities and management in general practice 2000-2005 Ann Rheum Dis 67 2008 960 966
    • (2008) Ann Rheum Dis , vol.67 , pp. 960-966
    • Annemans, L.1    Spaepen, E.2    Gaskin, M.3
  • 6
    • 33846974015 scopus 로고    scopus 로고
    • Validity of gout diagnoses in administrative data
    • LR Harrold, K Saag, RA Yood Validity of gout diagnoses in administrative data Arthritis Rheum 57 2007 103 108
    • (2007) Arthritis Rheum , vol.57 , pp. 103-108
    • Harrold, L.R.1    Saag, K.2    Yood, R.A.3
  • 8
    • 0037449776 scopus 로고    scopus 로고
    • An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition
    • K Okamoto, BT Eger, T Nishino, S Kondo, EF Pai, T Nishino An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition J Biol Chem 278 2003 1848 1855
    • (2003) J Biol Chem , vol.278 , pp. 1848-1855
    • Okamoto, K.1    Eger, B.T.2    Nishino, T.3    Kondo, S.4    Pai, E.F.5    Nishino, T.6
  • 9
    • 10344260696 scopus 로고    scopus 로고
    • Febuxostat (TMX-67), a novel, nonpurine, selective inhibitor of xanthine oxidase, is safe and decreases serum urate in healthy volunteers
    • MA Becker, J Kisicki, R Khosravan Febuxostat (TMX-67), a novel, nonpurine, selective inhibitor of xanthine oxidase, is safe and decreases serum urate in healthy volunteers Nucleosides Nucleotides Nucleic Acids 23 2004 1111 1116
    • (2004) Nucleosides Nucleotides Nucleic Acids , vol.23 , pp. 1111-1116
    • Becker, M.A.1    Kisicki, J.2    Khosravan, R.3
  • 10
    • 13444257733 scopus 로고    scopus 로고
    • Selectivity of febuxostat, a novel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase
    • Y Takano, K Hase-Aoki, H Horiuchi Selectivity of febuxostat, a novel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase Life Sci 76 2005 1835 1847
    • (2005) Life Sci , vol.76 , pp. 1835-1847
    • Takano, Y.1    Hase-Aoki, K.2    Horiuchi, H.3
  • 11
    • 10344222996 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of febuxostat (TMX-67), a non-purine selective inhibitor of xanthine oxidase/xanthine dehydrogenase (NPSIXO) in patients with gout and/or hyperuricemia
    • K Komoriya, S Hoshide, K Takeda Pharmacokinetics and pharmacodynamics of febuxostat (TMX-67), a non-purine selective inhibitor of xanthine oxidase/xanthine dehydrogenase (NPSIXO) in patients with gout and/or hyperuricemia Nucleosides Nucleotides Nucleic Acids 23 2004 1119 1122
    • (2004) Nucleosides Nucleotides Nucleic Acids , vol.23 , pp. 1119-1122
    • Komoriya, K.1    Hoshide, S.2    Takeda, K.3
  • 12
    • 33746865996 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics and safety of febuxostat, a non-purine selective inhibitor of xanthine oxidase, in a dose escalation study in healthy subjects
    • R Khosravan, BA Grabowski, JT Wu, N Joseph-Ridge, L Vernillet Pharmacokinetics, pharmacodynamics and safety of febuxostat, a non-purine selective inhibitor of xanthine oxidase, in a dose escalation study in healthy subjects Clin Pharmacokinet 45 2006 821 841
    • (2006) Clin Pharmacokinet , vol.45 , pp. 821-841
    • Khosravan, R.1    Grabowski, B.A.2    Wu, J.T.3    Joseph-Ridge, N.4    Vernillet, L.5
  • 13
    • 17144396355 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of febuxostat, a new selective nonpurine inhibitor of xanthine oxidase, in subjects with renal impairment
    • MD Mayer, R Khosravan, L Vernillet, JT Wu, N Joseph-Ridge, DJ Mulford Pharmacokinetics and pharmacodynamics of febuxostat, a new selective nonpurine inhibitor of xanthine oxidase, in subjects with renal impairment Am J Ther 12 2005 22 34
    • (2005) Am J Ther , vol.12 , pp. 22-34
    • Mayer, M.D.1    Khosravan, R.2    Vernillet, L.3    Wu, J.T.4    Joseph-Ridge, N.5    Mulford, D.J.6
  • 14
    • 14944345365 scopus 로고    scopus 로고
    • Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase: A twenty-eight-day, multicenter, phase II, randomized, double-blind, placebo-controlled, dose-response clinical trial examining safety and efficacy in patients with gout
    • MA Becker, HR Schumacher Jr, RL Wortmann Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase: a twenty-eight-day, multicenter, phase II, randomized, double-blind, placebo-controlled, dose-response clinical trial examining safety and efficacy in patients with gout Arthritis Rheum 52 2005 916 923
    • (2005) Arthritis Rheum , vol.52 , pp. 916-923
    • Becker, M.A.1    Schumacher Jr., H.R.2    Wortmann, R.L.3
  • 15
    • 28944437578 scopus 로고    scopus 로고
    • Febuxostat compared with allopurinol in patients with hyperuricemia and gout
    • MA Becker, HR Schumacher Jr, RL Wortmann Febuxostat compared with allopurinol in patients with hyperuricemia and gout N Engl J Med 353 2005 2450 2461
    • (2005) N Engl J Med , vol.353 , pp. 2450-2461
    • Becker, M.A.1    Schumacher Jr., H.R.2    Wortmann, R.L.3
  • 16
    • 56049101851 scopus 로고    scopus 로고
    • Effects of febuxostat versus allopurinol and placebo in reducing serum urate in subjects with hyperuricemia and gout: A 28-week, phase III, randomized, double-blind, parallel group trial
    • HR Schumacher, MA Becker, RL Wortmann Effects of febuxostat versus allopurinol and placebo in reducing serum urate in subjects with hyperuricemia and gout: a 28-week, phase III, randomized, double-blind, parallel group trial Arthritis Care Res 59 2008 1540 1548
    • (2008) Arthritis Care Res , vol.59 , pp. 1540-1548
    • Schumacher, H.R.1    Becker, M.A.2    Wortmann, R.L.3
  • 17
    • 62349114811 scopus 로고    scopus 로고
    • A phase 3 randomized, controlled, multicenter, double-blind trial (RCT) comparing efficacy and safety of daily febuxostat (FEB) and allopurinol (ALLO) in subjects with gout
    • M Becker, HR Schumacher Jr, L Espinoza A phase 3 randomized, controlled, multicenter, double-blind trial (RCT) comparing efficacy and safety of daily febuxostat (FEB) and allopurinol (ALLO) in subjects with gout Arthritis Rheum 58 2008 S4029 S4030
    • (2008) Arthritis Rheum , vol.58
    • Becker, M.1    Schumacher Jr., H.R.2    Espinoza, L.3
  • 18
    • 0028120906 scopus 로고
    • Collaborative overview of randomised trials of antiplatelet therapy - I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients
    • Collaborative overview of randomised trials of antiplatelet therapy - I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients BMJ 308 1994 81 106
    • (1994) BMJ , vol.308 , pp. 81-106
  • 20
    • 67149083327 scopus 로고    scopus 로고
    • Clinical efficacy and safety of successful longterm urate lowering with febuxostat or allopurinol in subjects with gout
    • MA Becker, HR Schumacher, PA MacDonald, L Lloyd, C Lademacher Clinical efficacy and safety of successful longterm urate lowering with febuxostat or allopurinol in subjects with gout J Rheumatol 36 2009 1273 1282
    • (2009) J Rheumatol , vol.36 , pp. 1273-1282
    • Becker, M.A.1    Schumacher, H.R.2    MacDonald, P.A.3    Lloyd, L.4    Lademacher, C.5
  • 21
    • 70350664784 scopus 로고    scopus 로고
    • European Medicines Agency
    • European Medicines Agency CHMP assessment report for Adenuric http://www.emea.europa.eu/humandocs/PDFs/EPAR/adenuric/H-777-en6.pdf 2008 (accessed Feb 1, 2010).
    • (2008) CHMP Assessment Report for Adenuric
  • 22
    • 29644447615 scopus 로고    scopus 로고
    • The effect of mild and moderate hepatic impairment on pharmacokinetics, pharmacodynamics, and safety of febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase
    • R Khosravan, BA Grabowski, MD Mayer, JT Wu, N Joseph-Ridge, L Vernillet The effect of mild and moderate hepatic impairment on pharmacokinetics, pharmacodynamics, and safety of febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase J Clin Pharmacol 46 2006 88 102
    • (2006) J Clin Pharmacol , vol.46 , pp. 88-102
    • Khosravan, R.1    Grabowski, B.A.2    Mayer, M.D.3    Wu, J.T.4    Joseph-Ridge, N.5    Vernillet, L.6
  • 23
    • 33746891140 scopus 로고    scopus 로고
    • Effect of concomitant administration of febuxostat and colchicine on pharmacokinetics of febuxostat and colchicine at steady state
    • R Khosravan, MD Mayer, JT Wu Effect of concomitant administration of febuxostat and colchicine on pharmacokinetics of febuxostat and colchicine at steady state Arthritis Rheum 52 2005 S102 S103
    • (2005) Arthritis Rheum , vol.52
    • Khosravan, R.1    Mayer, M.D.2    Wu, J.T.3
  • 24
    • 22744431650 scopus 로고    scopus 로고
    • Effect of febuxostat on pharmacokinetics of desipramine, a CYP2D6 substrate, in healthy subjects
    • RP Khosravan, KB Erdman, LPP Vernillet Effect of febuxostat on pharmacokinetics of desipramine, a CYP2D6 substrate, in healthy subjects Clin Pharmacol Ther 77 2005 P43
    • (2005) Clin Pharmacol Ther , vol.77 , pp. 43
    • Khosravan, R.P.1    Erdman, K.B.2    Vernillet, L.P.P.3
  • 25
    • 33845647397 scopus 로고    scopus 로고
    • Effect of hydrochlorothiazide on pharmacokinetics and pharmacodynamics of febuxostat
    • BA Grabowski, R Khosravan, JT Wu Effect of hydrochlorothiazide on pharmacokinetics and pharmacodynamics of febuxostat Arthritis Rheum 52 2005 S103 S104
    • (2005) Arthritis Rheum , vol.52
    • Grabowski, B.A.1    Khosravan, R.2    Wu, J.T.3
  • 26
    • 33745926837 scopus 로고    scopus 로고
    • Pharmacokinetic interactions of concomitant administration of febuxostat and NSAIDs
    • R Khosravan, JT Wu, N Joseph-Ridge Pharmacokinetic interactions of concomitant administration of febuxostat and NSAIDs J Clin Pharmacol 46 2006 855 866
    • (2006) J Clin Pharmacol , vol.46 , pp. 855-866
    • Khosravan, R.1    Wu, J.T.2    Joseph-Ridge, N.3
  • 27
    • 42249100324 scopus 로고    scopus 로고
    • In vitro drug-drug interaction studies with febuxostat, a novel non-purine selective inhibitor of xanthine oxidase: Plasma protein binding, identification of metabolic enzymes and cytochrome P450 inhibition
    • M Mukoyoshi, S Nishimura, S Hoshide In vitro drug-drug interaction studies with febuxostat, a novel non-purine selective inhibitor of xanthine oxidase: plasma protein binding, identification of metabolic enzymes and cytochrome P450 inhibition Xenobiotica 38 2008 496 510
    • (2008) Xenobiotica , vol.38 , pp. 496-510
    • Mukoyoshi, M.1    Nishimura, S.2    Hoshide, S.3
  • 28
    • 70349729203 scopus 로고    scopus 로고
    • Allopurinol intolerant patients treated with febuxostat for 4 years
    • MA Becker, HR Schumacher, RL Wortmann Allopurinol intolerant patients treated with febuxostat for 4 years Arthritis Rheum 54 2006 S646
    • (2006) Arthritis Rheum , vol.54 , pp. 646
    • Becker, M.A.1    Schumacher, H.R.2    Wortmann, R.L.3
  • 29
  • 30
    • 0014236095 scopus 로고
    • Urate-oxydase d'Aspergillus flavus: I. Obtention, purification, propriétés
    • P Laboureur, C Langlois Urate-oxydase d'Aspergillus flavus: I. Obtention, purification, propriétés Bull Soc Chim Biol 50 1968 811 825
    • (1968) Bull Soc Chim Biol , vol.50 , pp. 811-825
    • Laboureur, P.1    Langlois, C.2
  • 31
    • 16944364892 scopus 로고    scopus 로고
    • Urate oxidase in prevention and treatment of hyperuricemia associated with lymphoid malignancies
    • C-H Pui, MV Relling, F Lascombes Urate oxidase in prevention and treatment of hyperuricemia associated with lymphoid malignancies Leukemia 11 1997 1813 1816
    • (1997) Leukemia , vol.11 , pp. 1813-1816
    • Pui, C.-H.1    Relling, M.V.2    Lascombes, F.3
  • 33
    • 0026480313 scopus 로고
    • High-level production of a peroxisomal enzyme: Aspergillus flavus uricase accumulates intracellularly and is active in Saccharomyces cerevisiae
    • P Leplatois, B Le Douarin, G Loison High-level production of a peroxisomal enzyme: Aspergillus flavus uricase accumulates intracellularly and is active in Saccharomyces cerevisiae Gene 122 1992 139 145
    • (1992) Gene , vol.122 , pp. 139-145
    • Leplatois, P.1    Le Douarin, B.2    Loison, G.3
  • 34
    • 0037352829 scopus 로고    scopus 로고
    • Elitek-rasburicase: An effective means to prevent and treat hyperuricemia associated with tumor lysis syndrome, a Meeting Report, Dallas, Texas, January 2002
    • PM Navolanic, C-H Pui, RA Larson Elitek-rasburicase: an effective means to prevent and treat hyperuricemia associated with tumor lysis syndrome, a Meeting Report, Dallas, Texas, January 2002 Leukemia 17 2003 499 514
    • (2003) Leukemia , vol.17 , pp. 499-514
    • Navolanic, P.M.1    Pui, C.-H.2    Larson, R.A.3
  • 36
    • 33744963408 scopus 로고    scopus 로고
    • Successful treatment with rasburicase of a tophaceous gout in a patient allergic to allopurinol
    • P Richette, T Bardin Successful treatment with rasburicase of a tophaceous gout in a patient allergic to allopurinol Nat Clin Pract Rheumatol 2 2006 338 342
    • (2006) Nat Clin Pract Rheumatol , vol.2 , pp. 338-342
    • Richette, P.1    Bardin, T.2
  • 37
    • 35148881765 scopus 로고    scopus 로고
    • Rasburicase for tophaceous gout not treatable with allopurinol: An exploratory study
    • P Richette, C Briere, V Honene-Claviert, D Loeuille, T Bardin Rasburicase for tophaceous gout not treatable with allopurinol: An exploratory study J Rheumatol 34 2007 1093 1098
    • (2007) J Rheumatol , vol.34 , pp. 1093-1098
    • Richette, P.1    Briere, C.2    Honene-Claviert, V.3    Loeuille, D.4    Bardin, T.5
  • 38
    • 35148836815 scopus 로고    scopus 로고
    • Learning how and when to employ uricase as bridge therapy in refractory gout
    • R Terkeltaub Learning how and when to employ uricase as bridge therapy in refractory gout J Rheumatol 34 2007 1955 1958
    • (2007) J Rheumatol , vol.34 , pp. 1955-1958
    • Terkeltaub, R.1
  • 39
    • 36549089052 scopus 로고    scopus 로고
    • PEG-uricase in the management of treatment-resistant gout and hyperuricemia
    • MR Sherman, MGP Saifer, F Perez-Ruiz PEG-uricase in the management of treatment-resistant gout and hyperuricemia Adv Drug Deliv Rev 60 2008 59 68
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 59-68
    • Sherman, M.R.1    Saifer, M.G.P.2    Perez-Ruiz, F.3
  • 40
    • 33947119693 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of intravenous PEGylated recombinant mammalian urate oxidase in patients with refractory gout
    • JS Sundy, NJ Ganson, SJ Kelly Pharmacokinetics and pharmacodynamics of intravenous PEGylated recombinant mammalian urate oxidase in patients with refractory gout Arthritis Rheum 56 2007 1021 1028
    • (2007) Arthritis Rheum , vol.56 , pp. 1021-1028
    • Sundy, J.S.1    Ganson, N.J.2    Kelly, S.J.3
  • 41
    • 33746995205 scopus 로고    scopus 로고
    • Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase i trial of subcutaneous PEGylated urate oxidase
    • NJ Ganson, SJ Kelly, E Scarlett, JS Sundy, MS Hershfield Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase Arthritis Res Ther 8 2006 R12
    • (2006) Arthritis Res Ther , vol.8 , pp. 12
    • Ganson, N.J.1    Kelly, S.J.2    Scarlett, E.3    Sundy, J.S.4    Hershfield, M.S.5
  • 42
    • 51849118368 scopus 로고    scopus 로고
    • Reduction of plasma urate levels following treatment with multiple doses of pegloticase (polyethylene glycol-conjugated uricase) in patients with treatment-failure gout
    • JS Sundy, MA Becker, HSB Baraf Reduction of plasma urate levels following treatment with multiple doses of pegloticase (polyethylene glycol-conjugated uricase) in patients with treatment-failure gout Arthritis Rheum 58 2008 2882 2891
    • (2008) Arthritis Rheum , vol.58 , pp. 2882-2891
    • Sundy, J.S.1    Becker, M.A.2    Baraf, H.S.B.3
  • 43
    • 55849118787 scopus 로고    scopus 로고
    • Resolution of gouty tophi after twelve weeks of pegloticase treatment
    • HS Baraf, AK Matsumoto, AN Maroli, RW Waltrip Resolution of gouty tophi after twelve weeks of pegloticase treatment Arthritis Rheum 58 2008 3632 3634
    • (2008) Arthritis Rheum , vol.58 , pp. 3632-3634
    • Baraf, H.S.1    Matsumoto, A.K.2    Maroli, A.N.3    Waltrip, R.W.4
  • 44
    • 78651098292 scopus 로고    scopus 로고
    • Efficacy and safety of intravenous pegloticase (PGL) in treatment failure gout (TFG): Results from GOUT1 and GOUT2
    • JS Sundy, HS Baraf, MA Becker Efficacy and safety of intravenous pegloticase (PGL) in treatment failure gout (TFG): results from GOUT1 and GOUT2 Ann Rheum Dis 68 2009 318
    • (2009) Ann Rheum Dis , vol.68 , pp. 318
    • Sundy, J.S.1    Baraf, H.S.2    Becker, M.A.3
  • 45
    • 62349123738 scopus 로고    scopus 로고
    • Tophus response to pegloticase (PGL) therapy: Pooled results from GOUT1 and GOUT2, PGL phase 3 randomized, double blind, placebo-controlled trials
    • HS Baraf, MA Becker, NL Edwards Tophus response to pegloticase (PGL) therapy: pooled results from GOUT1 and GOUT2, PGL phase 3 randomized, double blind, placebo-controlled trials Arthritis Rheum 58 2008 S176
    • (2008) Arthritis Rheum , vol.58 , pp. 176
    • Baraf, H.S.1    Becker, M.A.2    Edwards, N.L.3
  • 46
    • 62349101752 scopus 로고    scopus 로고
    • Improvement in health-related quality of life (HRQL) and disability index in treatment failure gout (TFG) after pegloticase (PGL) therapy: Pooled results from GOUT1 and GOUT2, phase 3, randomized, double blind, placebo (PBO)-controlled trials
    • NL Edwards, HS Baraf, MA Becker Improvement in health-related quality of life (HRQL) and disability index in treatment failure gout (TFG) after pegloticase (PGL) therapy: pooled results from GOUT1 and GOUT2, phase 3, randomized, double blind, placebo (PBO)-controlled trials Arthritis Rheum 58 2008 S178
    • (2008) Arthritis Rheum , vol.58 , pp. 178
    • Edwards, N.L.1    Baraf, H.S.2    Becker, M.A.3
  • 47
    • 62349121751 scopus 로고    scopus 로고
    • Immunoreactivity and clinical response to pegloticase (PGL): Pooled data from GOUT1 and GOUT2, PGL phase 3 randomized, double blind, placebo-controlled trials
    • MA Becker, EL Treadwell, HS Baraf Immunoreactivity and clinical response to pegloticase (PGL): pooled data from GOUT1 and GOUT2, PGL phase 3 randomized, double blind, placebo-controlled trials Arthritis Rheum 58 2008 S880
    • (2008) Arthritis Rheum , vol.58 , pp. 880
    • Becker, M.A.1    Treadwell, E.L.2    Baraf, H.S.3
  • 48
    • 77953477599 scopus 로고    scopus 로고
    • Routine serum uric acid (SUA) monitoring predicts antibody-mediated loss of response and infusion reaction risk during pegloticase therapy
    • D Wright, JS Sundy, T Rosario-Jansen Routine serum uric acid (SUA) monitoring predicts antibody-mediated loss of response and infusion reaction risk during pegloticase therapy Arthritis Rheum 60 2009 S413
    • (2009) Arthritis Rheum , vol.60 , pp. 413
    • Wright, D.1    Sundy, J.S.2    Rosario-Jansen, T.3
  • 49
    • 84859439093 scopus 로고    scopus 로고
    • US Food and Drug Administration
    • US Food and Drug Administration Briefing Document for the Arthritis Advisory Committee Meeting http://www.fda.gov/downloads/AdvisoryCommittees/ CommitteesMeetings Materials/Drugs/ArthritisDrugsAdvisoryCommittee/UCM165714.pdf (accessed Feb 15, 2010).
    • Briefing Document for the Arthritis Advisory Committee Meeting
  • 51
    • 79151472070 scopus 로고
    • Disposition of uric acid in primary gout
    • J.B. Wyngaarden W.N. Kelley Grune & Stratton New York
    • JB Wyngaarden, WN Kelley Disposition of uric acid in primary gout JB Wyngaarden WN Kelley Gout and hyperuricemia 1976 Grune & Stratton New York 149 157
    • (1976) Gout and Hyperuricemia , pp. 149-157
    • Wyngaarden, J.B.1    Kelley, W.N.2
  • 52
    • 0142031503 scopus 로고    scopus 로고
    • New standards for uric acid excretion: Evidence for an inducible transporter
    • PA Simkin New standards for uric acid excretion: evidence for an inducible transporter Arthritis Care Res 49 2003 735 736
    • (2003) Arthritis Care Res , vol.49 , pp. 735-736
    • Simkin, P.A.1
  • 53
    • 0037161834 scopus 로고    scopus 로고
    • Molecular identification of a renal urate anion exchanger that regulates blood urate levels
    • A Enomoto, H Kimura, A Chairoungdu Molecular identification of a renal urate anion exchanger that regulates blood urate levels Nature 417 2002 447 452
    • (2002) Nature , vol.417 , pp. 447-452
    • Enomoto, A.1    Kimura, H.2    Chairoungdu, A.3
  • 54
    • 46749102824 scopus 로고    scopus 로고
    • Urate transport across the apical membrane of renal proximal tubules
    • H Endou, N Anzai Urate transport across the apical membrane of renal proximal tubules Nucleosides Nucleotides Nucleic Acids 27 2008 578 584
    • (2008) Nucleosides Nucleotides Nucleic Acids , vol.27 , pp. 578-584
    • Endou, H.1    Anzai, N.2
  • 55
    • 33846692496 scopus 로고    scopus 로고
    • Human renal organic anion transporter 4 operates as an asymmetric urate transporter
    • Y Hagos, D Stein, B Ugele, G Burckhardt, A Bahn Human renal organic anion transporter 4 operates as an asymmetric urate transporter J Am Soc Nephrol 18 2007 430 439
    • (2007) J Am Soc Nephrol , vol.18 , pp. 430-439
    • Hagos, Y.1    Stein, D.2    Ugele, B.3    Burckhardt, G.4    Bahn, A.5
  • 56
    • 1942437498 scopus 로고    scopus 로고
    • Identification and characterization of human glucose transporter-like protein-9 (GLUT9): Alternative splicing alters trafficking
    • R Augustin, MO Carayannopoulos, LO Dowd, JE Phay, JF Moley, KH Moley Identification and characterization of human glucose transporter-like protein-9 (GLUT9): alternative splicing alters trafficking J Biol Chem 279 2004 16229 16236
    • (2004) J Biol Chem , vol.279 , pp. 16229-16236
    • Augustin, R.1    Carayannopoulos, M.O.2    Dowd, L.O.3    Phay, J.E.4    Moley, J.F.5    Moley, K.H.6
  • 57
    • 41349103917 scopus 로고    scopus 로고
    • SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout
    • V Vitart, I Rudan, C Hayward SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout Nat Genet 40 2008 437 442
    • (2008) Nat Genet , vol.40 , pp. 437-442
    • Vitart, V.1    Rudan, I.2    Hayward, C.3
  • 58
    • 55249096942 scopus 로고    scopus 로고
    • Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans
    • N Anzai, K Ichida, P Jutabha Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans J Biol Chem 283 2008 26834 26838
    • (2008) J Biol Chem , vol.283 , pp. 26834-26838
    • Anzai, N.1    Ichida, K.2    Jutabha, P.3
  • 59
    • 55949096514 scopus 로고    scopus 로고
    • SLC2A9 is a high-capacity urate transporter in humans
    • MJ Caulfield, PB Munroe, D O'Neill SLC2A9 is a high-capacity urate transporter in humans PLoS Med 5 2008 e197
    • (2008) PLoS Med , vol.5 , pp. 197
    • Caulfield, M.J.1    Munroe, P.B.2    O'Neill, D.3
  • 60
    • 61349163769 scopus 로고    scopus 로고
    • Crystal ball gazing: New therapeutic targets for hyperuricaemia and gout
    • N Dalbeth, T Merriman Crystal ball gazing: new therapeutic targets for hyperuricaemia and gout Rheumatology 48 2009 222 226
    • (2009) Rheumatology , vol.48 , pp. 222-226
    • Dalbeth, N.1    Merriman, T.2
  • 61
    • 70350219826 scopus 로고    scopus 로고
    • Safety and uric acid lowering effect in humans following multiple doses of RDEA806, a novel prodrug for the potential treatment of hyperuricemia
    • L Yeh, V Hingorani, K Manhard Safety and uric acid lowering effect in humans following multiple doses of RDEA806, a novel prodrug for the potential treatment of hyperuricemia Ann Rheum Dis 67 2008 248
    • (2008) Ann Rheum Dis , vol.67 , pp. 248
    • Yeh, L.1    Hingorani, V.2    Manhard, K.3
  • 62
    • 70350287158 scopus 로고    scopus 로고
    • Mode of action of RDEA594 as a uric acid lowering agent in humans following multiple doses of its prodrug, RDEA806
    • L Yeh, I Tamai, R Hamatake Mode of action of RDEA594 as a uric acid lowering agent in humans following multiple doses of its prodrug, RDEA806 Ann Rheum Dis 67 2008 249
    • (2008) Ann Rheum Dis , vol.67 , pp. 249
    • Yeh, L.1    Tamai, I.2    Hamatake, R.3
  • 63
    • 79151484250 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and serum uric acid lowering effect of RDEA594, a novel uricosuric agent, in healthy volunteers
    • L-T Yeh, Z Shen, B Kerr Safety, pharmacokinetics, and serum uric acid lowering effect of RDEA594, a novel uricosuric agent, in healthy volunteers Ann Rheum Dis 68 2009 320
    • (2009) Ann Rheum Dis , vol.68 , pp. 320
    • Yeh, L.-T.1    Shen, Z.2    Kerr, B.3
  • 64
    • 79151484250 scopus 로고    scopus 로고
    • RDEA594, a potent URAT1 inhibitor without affecting other important renal transporters OAT1 and OAT3
    • L-T Yeh, Z Shen, B Kerr RDEA594, a potent URAT1 inhibitor without affecting other important renal transporters OAT1 and OAT3 Ann Rheum Dis 68 2009 320
    • (2009) Ann Rheum Dis , vol.68 , pp. 320
    • Yeh, L.-T.1    Shen, Z.2    Kerr, B.3
  • 65
    • 79151483893 scopus 로고    scopus 로고
    • Evaluation of drug-drug interaction potential between RDEA594, allopurinol and febuxostat in preclinical species
    • X Yang, R Dick, V Borges Evaluation of drug-drug interaction potential between RDEA594, allopurinol and febuxostat in preclinical species Arthritis Rheum 60 2009 S412 S413
    • (2009) Arthritis Rheum , vol.60
    • Yang, X.1    Dick, R.2    Borges, V.3
  • 66
    • 79151483019 scopus 로고    scopus 로고
    • RDEA594, a novel uricosuric agent, significantly reduced serum urate levels and was well tolerated in a phase 2a pilot study in hyperuricemic gout patients
    • B Lasko, B Sheedy, V Hingorani RDEA594, a novel uricosuric agent, significantly reduced serum urate levels and was well tolerated in a phase 2a pilot study in hyperuricemic gout patients Arthritis Rheum 60 2009 S413 S414
    • (2009) Arthritis Rheum , vol.60
    • Lasko, B.1    Sheedy, B.2    Hingorani, V.3
  • 67
    • 0013919965 scopus 로고    scopus 로고
    • Effects of allopurinol, a xanthine oxidase inhibitor, and sulfinpyrazone upon the urinary and serum urate concentrations in eight patients with tophaceous gout
    • E Goldfarb, CJ Smythe Effects of allopurinol, a xanthine oxidase inhibitor, and sulfinpyrazone upon the urinary and serum urate concentrations in eight patients with tophaceous gout Arthritis Rheum 9 2007 414 423
    • (2007) Arthritis Rheum , vol.9 , pp. 414-423
    • Goldfarb, E.1    Smythe, C.J.2
  • 68
  • 69
    • 25444454295 scopus 로고    scopus 로고
    • Innate immunity conferred by Toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced inflammation
    • R Liu-Bryan, P Scott, A Sydlaske, DM Rose, R Terkeltaub Innate immunity conferred by Toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced inflammation Arthritis Rheum 52 2005 2936 2946
    • (2005) Arthritis Rheum , vol.52 , pp. 2936-2946
    • Liu-Bryan, R.1    Scott, P.2    Sydlaske, A.3    Rose, D.M.4    Terkeltaub, R.5
  • 70
    • 32944468985 scopus 로고    scopus 로고
    • Gout-associated uric acid crystal activate the NALP3 inflammasome
    • F Martinon, V Petrilli, A Mayor, A Tardivel, J Tschopp Gout-associated uric acid crystal activate the NALP3 inflammasome Nature 440 2006 237 241
    • (2006) Nature , vol.440 , pp. 237-241
    • Martinon, F.1    Petrilli, V.2    Mayor, A.3    Tardivel, A.4    Tschopp, J.5
  • 71
    • 0023178197 scopus 로고
    • Interleukin 1 (IL 1) as a mediator of crystal arthritis. Stimulation of T cell and synovial fibroblast mitogenesis by urate crystal-induced IL-1
    • FS Di Giovine, SE Malawista, G Nuki, GW Duff Interleukin 1 (IL 1) as a mediator of crystal arthritis. Stimulation of T cell and synovial fibroblast mitogenesis by urate crystal-induced IL-1 J Immunol 138 1987 3213 3218
    • (1987) J Immunol , vol.138 , pp. 3213-3218
    • Di Giovine, F.S.1    Malawista, S.E.2    Nuki, G.3    Duff, G.W.4
  • 72
    • 33746747096 scopus 로고    scopus 로고
    • MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals
    • CJ Chen, Y Shi, A Hearn MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals J Clin Invest 116 2006 2262 2271
    • (2006) J Clin Invest , vol.116 , pp. 2262-2271
    • Chen, C.J.1    Shi, Y.2    Hearn, A.3
  • 74
  • 75
    • 70349402166 scopus 로고    scopus 로고
    • The IL-1 inhibitor rilonacept in treatment of chronic gouty arthritis: Results of a placebo-controlled, monosequence crossover, nonrandomized, single-blind pilot study
    • R Terkeltaub, JS Sundy, HR Schumacher The IL-1 inhibitor rilonacept in treatment of chronic gouty arthritis: Results of a placebo-controlled, monosequence crossover, nonrandomized, single-blind pilot study Ann Rheum Dis 68 2009 1613 1617
    • (2009) Ann Rheum Dis , vol.68 , pp. 1613-1617
    • Terkeltaub, R.1    Sundy, J.S.2    Schumacher, H.R.3
  • 76
    • 77957675498 scopus 로고    scopus 로고
    • Placebo-controlled study of rilonacept for gout flare prophylaxis during initiation of urate-lowering therapy
    • HR Schumacher Jr, JS Sundy, R Terkeltaub Placebo-controlled study of rilonacept for gout flare prophylaxis during initiation of urate-lowering therapy Arthritis Rheum 60 2009 S410
    • (2009) Arthritis Rheum , vol.60 , pp. 410
    • Schumacher Jr., H.R.1    Sundy, J.S.2    Terkeltaub, R.3
  • 77
    • 79151475606 scopus 로고    scopus 로고
    • Canakinumab (ACZ885) vs. triamcinolone acetonide for treatment of acute flares and prevention of recurrent flares in gouty arthritis patients refractory to or contraindicated to NSAIDs and/or colchicine
    • A So, M De Meulemeester, T Shamim Canakinumab (ACZ885) vs. triamcinolone acetonide for treatment of acute flares and prevention of recurrent flares in gouty arthritis patients refractory to or contraindicated to NSAIDs and/or colchicine Arthritis Rheum 60 2009 LB4
    • (2009) Arthritis Rheum , vol.60 , pp. 4
    • So, A.1    De Meulemeester, M.2    Shamim, T.3
  • 78
    • 33745254724 scopus 로고    scopus 로고
    • The inflammatory process of gout and its treatment
    • BN Cronstein, R Terkeltaub The inflammatory process of gout and its treatment Arthritis Res Ther 8 2006 S3
    • (2006) Arthritis Res Ther , vol.8 , pp. 3
    • Cronstein, B.N.1    Terkeltaub, R.2
  • 79
    • 73349116225 scopus 로고    scopus 로고
    • Novel therapies for treatment of gout and hyperuricemia
    • R Terkeltaub Novel therapies for treatment of gout and hyperuricemia Arthritis Res Ther 11 2009 236
    • (2009) Arthritis Res Ther , vol.11 , pp. 236
    • Terkeltaub, R.1
  • 80
    • 40649127492 scopus 로고    scopus 로고
    • Gout in Ambulatory Care Settings in the United States
    • E Krishnan, D Lienesch, CK Kwoh Gout in Ambulatory Care Settings in the United States J Rheumatol 35 2008 498 501
    • (2008) J Rheumatol , vol.35 , pp. 498-501
    • Krishnan, E.1    Lienesch, D.2    Kwoh, C.K.3
  • 82
    • 33750374233 scopus 로고    scopus 로고
    • EULAR evidence based recommendations for gout. Part I: Diagnosis: report of a task force of the Standing committee for International Clinical Studies Including Therapeutics (ESCISIT)
    • W Zhang, M Doherty, E Pascual EULAR evidence based recommendations for gout. Part I: diagnosis: report of a task force of the Standing committee for International Clinical Studies Including Therapeutics (ESCISIT) Ann Rheum Dis 65 2006 1301 1311
    • (2006) Ann Rheum Dis , vol.65 , pp. 1301-1311
    • Zhang, W.1    Doherty, M.2    Pascual, E.3
  • 83
    • 33748608331 scopus 로고    scopus 로고
    • EULAR evidence bases recommendations for gout. Part II: Management: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)
    • W Zhang, M Doherty, T Bardin EULAR evidence bases recommendations for gout. Part II: management: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT) Ann Rheum Dis 65 2006 1312 1324
    • (2006) Ann Rheum Dis , vol.65 , pp. 1312-1324
    • Zhang, W.1    Doherty, M.2    Bardin, T.3
  • 84
    • 0033773721 scopus 로고    scopus 로고
    • The optimal use of allopurinol: An audit of allopurinol use in South Auckland
    • L Stamp, K Sharples, P Gow, B Raill The optimal use of allopurinol: an audit of allopurinol use in South Auckland Aust N Z J Med 30 2000 567 572
    • (2000) Aust N Z J Med , vol.30 , pp. 567-572
    • Stamp, L.1    Sharples, K.2    Gow, P.3    Raill, B.4
  • 86
    • 33745610176 scopus 로고    scopus 로고
    • Gout medication treatment patterns and adherence to standards of care from a managed care perspective
    • CA Sarawate, KK Brewer, W Yang Gout medication treatment patterns and adherence to standards of care from a managed care perspective Mayo Clin Proc 81 2006 925 934
    • (2006) Mayo Clin Proc , vol.81 , pp. 925-934
    • Sarawate, C.A.1    Brewer, K.K.2    Yang, W.3
  • 89
    • 40349110730 scopus 로고    scopus 로고
    • We can make gout management more successful now
    • MA Becker, S Chohan We can make gout management more successful now Curr Opin Rheumatol 20 2008 167 172
    • (2008) Curr Opin Rheumatol , vol.20 , pp. 167-172
    • Becker, M.A.1    Chohan, S.2
  • 90
    • 56049096712 scopus 로고    scopus 로고
    • Gout management: Let's get it right this time
    • JS Sundy Gout management: let's get it right this time Arthritis Care Res 59 2008 1535 1537
    • (2008) Arthritis Care Res , vol.59 , pp. 1535-1537
    • Sundy, J.S.1
  • 91
    • 0031662935 scopus 로고    scopus 로고
    • Efficacy of allopurinol and benzbromarone for the control of hyperuricemia: A pathogenic approach to the therapy of chronic primary gout
    • F Perez-Ruiz, A Alonso-Ruiz, M Calabozo, A Herrero-Beites, G Garcia-Erauskin, E Ruiz-Lucea Efficacy of allopurinol and benzbromarone for the control of hyperuricemia: a pathogenic approach to the therapy of chronic primary gout Ann Rheum Dis 57 1998 545 549
    • (1998) Ann Rheum Dis , vol.57 , pp. 545-549
    • Perez-Ruiz, F.1    Alonso-Ruiz, A.2    Calabozo, M.3    Herrero-Beites, A.4    Garcia-Erauskin, G.5    Ruiz-Lucea, E.6
  • 92
    • 33746717478 scopus 로고    scopus 로고
    • Dose adjustment of allopurinol according to creatinine clearance does not provide adequate control of hyperuricemia in patients with gout
    • N Dalbeth, S Kumar, L Stamp, P Gow Dose adjustment of allopurinol according to creatinine clearance does not provide adequate control of hyperuricemia in patients with gout J Rheumatol 33 2006 1646 1650
    • (2006) J Rheumatol , vol.33 , pp. 1646-1650
    • Dalbeth, N.1    Kumar, S.2    Stamp, L.3    Gow, P.4
  • 93
    • 34250724118 scopus 로고    scopus 로고
    • Lowering serum uric acid levels: What is the optimal target for improving clinical outcomes in gout?
    • F Perez-Ruiz, F Lioté Lowering serum uric acid levels: what is the optimal target for improving clinical outcomes in gout? Arthritis Care & Research 57 2007 1324 1328
    • (2007) Arthritis Care & Research , vol.57 , pp. 1324-1328
    • Perez-Ruiz, F.1    Lioté, F.2
  • 94
    • 0021366307 scopus 로고
    • Severe allopurinol toxicity: Description and guidelines for prevention in patients with renal insufficiency
    • KR Hande, RM Noone, WJ Stone Severe allopurinol toxicity: description and guidelines for prevention in patients with renal insufficiency Am J Med 76 1984 47 56
    • (1984) Am J Med , vol.76 , pp. 47-56
    • Hande, K.R.1    Noone, R.M.2    Stone, W.J.3
  • 95
    • 34748917556 scopus 로고    scopus 로고
    • Allopurinol dosing in renal impairment: Walking the tightrope between adequate urate lowering and adverse events
    • N Dalbeth, L Stamp Allopurinol dosing in renal impairment: walking the tightrope between adequate urate lowering and adverse events Semin Dial 20 2007 391 395
    • (2007) Semin Dial , vol.20 , pp. 391-395
    • Dalbeth, N.1    Stamp, L.2
  • 96
    • 0033668058 scopus 로고    scopus 로고
    • Improvement in renal function in patients with chronic gout after proper control of hyperuricemia and gouty bouts
    • F Perez-Ruiz, M Calabozo, AM Herrero-Beites, G García-Erauskin, JI Pijoan Improvement in renal function in patients with chronic gout after proper control of hyperuricemia and gouty bouts Nephron 86 2000 287 291
    • (2000) Nephron , vol.86 , pp. 287-291
    • Perez-Ruiz, F.1    Calabozo, M.2    Herrero-Beites, A.M.3    García-Erauskin, G.4    Pijoan, J.I.5
  • 97
    • 29244447160 scopus 로고    scopus 로고
    • Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid
    • YP Siu, KT Leung, MK Tong, TH Kwan Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid Am J Kidney Dis 47 2006 51 59
    • (2006) Am J Kidney Dis , vol.47 , pp. 51-59
    • Siu, Y.P.1    Leung, K.T.2    Tong, M.K.3    Kwan, T.H.4
  • 99
    • 79151484078 scopus 로고    scopus 로고
    • Increasing allopurinol dose above the recommended range is effective and safe in chronic gout, including in those with renal impairment - A pilot study
    • L Stamp, JL O'Donnell, M Zhang, C Frampton, M Barclay, PT Chapman Increasing allopurinol dose above the recommended range is effective and safe in chronic gout, including in those with renal impairment - a pilot study Arthritis Rheum 60 2009 S729
    • (2009) Arthritis Rheum , vol.60 , pp. 729
    • Stamp, L.1    O'Donnell, J.L.2    Zhang, M.3    Frampton, C.4    Barclay, M.5    Chapman, P.T.6


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