The influence of tumor necrosis factor-α and interleukin-10 gene promoter polymorphism on the inflammatory response in experimental human endotoxemia

Clinical Infectious Diseases

Volumn 33, Issue 9, 2001, Pages 1601-1603

  Fijen, J W ^a   Tulleken, J E ^a   Hepkema, B G ^b   Van der Werf, T S ^a   Ligtenberg, J J M ^a   Zijlstra, J G ^a  

^a Intensive and Respiratory Care Unit   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; CYTOKINE PRODUCTION; DNA POLYMORPHISM; ENDOTOXEMIA; HUMAN; INFLAMMATION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROMOTER REGION;

ADULT; ENDOTOXEMIA; HUMANS; INTERLEUKIN-10; MALE; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035503202     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/323197     Document Type: Article

References (12)

1. Tumour necrosis factor (TNF) gene polymorphism influences TNF-alpha production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans
2. Variation in the tumor necrosis factor-alpha gene promoter region may be associated with death from meningococcal disease
3. Association of TNF2, a TNF-alpha promoter polymorphism, with septic shock susceptibility and mortality: A multicenter study
4. Genetic influence on cytokine production and fatal meningococcal disease
5. -308 Tumor necrosis factor (TNF) polymorphism is not associated with survival in severe sepsis and is unrelated to lipopolysaccharide inducibility of the human TNF promoter
6. Why immunomodulatory therapies have not worked in sepsis
7. Interleukin-10 (IL-10) genotypes in inflammatory bowel disease
8. Are differences in interleukin 10 production associated with joint damage?
9. Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: A marker for prognosis and future therapeutic options
10. Leukocyte activation and cytokine production during experimental endotoxemia
11. Secretion of tumour necrosis factor alpha and lymphotoxin alpha in relation to polymorphisms in the TNF genes and HLA-DR alleles: Relevance for inflammatory bowel disease
12. Anti-inflammatory cytokine profile and mortality in febrile patients