Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression

Science

Volumn 343, Issue 6175, 2014, Pages

  Fairfax, Benjamin P ^a   Humburg, Peter ^a   Makino, Seiko ^a   Naranbhai, Vivek ^a   Wong, Daniel ^a   Lau, Evelyn ^a   Jostins, Luke ^a   Plant, Katharine ^a   Andrews, Robert ^b   McGee, Chris ^b   Knight, Julian C ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; CD14 ANTIGEN; CHEMOKINE RECEPTOR CCR3; CYTOCHROME P450 1B1; GAMMA INTERFERON; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; INTERFERON REGULATORY FACTOR 2; LIPOPOLYSACCHARIDE; PROTEASOME; BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; CARD9 PROTEIN, HUMAN; CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; CYTOCHROME P 450 CYP1B1; CYTOCHROME P-450 CYP1B1; INDOLEAMINE 2,3 DIOXYGENASE; INDOLEAMINE 2,3 DIOXYGENASE 2, HUMAN; INDOLEAMINE 2,3-DIOXYGENASE 2, HUMAN; INTERFERON REGULATORY FACTOR; IRF2 PROTEIN, HUMAN; NFE2L3 PROTEIN, HUMAN; P2RY11 PROTEIN, HUMAN; PURINERGIC P2 RECEPTOR; UNSPECIFIC MONOOXYGENASE;

ENZYME ACTIVITY; GENE EXPRESSION; GENETIC VARIATION; IMMUNITY; MAJOR HISTOCOMPATIBILITY COMPLEX; PATHOLOGY; POLYSACCHARIDE; PUBLIC HEALTH;

ADULT; ARTICLE; CONTROLLED STUDY; CROHN DISEASE; FEMALE; GENE; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN EXPERIMENT; IDO2 GENE; IMMUNOSTIMULATION; INNATE IMMUNITY; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MIDDLE AGED; MONOCYTE; NORMAL HUMAN; P2RY11 GENE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RISK ASSESSMENT; TRANSCRIPTION INITIATION SITE; UPREGULATION; YOUNG ADULT; CHROMOSOME MAP; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM;

EUROPE;

ADULT; ANTIGENS, CD14; ARYL HYDROCARBON HYDROXYLASES; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; CARD SIGNALING ADAPTOR PROTEINS; CHROMOSOME MAPPING; CROHN DISEASE; FEMALE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; IMMUNITY, INNATE; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; INTERFERON REGULATORY FACTOR-2; INTERFERON REGULATORY FACTORS; INTERFERON-GAMMA; MALE; MIDDLE AGED; MONOCYTES; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; RECEPTORS, PURINERGIC P2; YOUNG ADULT;

EID: 84896742056     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1246949     Document Type: Article

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