TLR4 gene variants modify endotoxin effects on asthma

Journal of Allergy and Clinical Immunology

Volumn 112, Issue 2, 2003, Pages 323-330

  Werner, Monika ^a   Topp, Rebekka ^a   Wimmer, Katrin ^a   Richter, Kai ^b   Bischof, Wolfgang ^c   Wjst, Matthias ^a   Heinrich, Joachim ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b KRANKENHAUS GROSSHANSDORF   (Germany)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Asthma; ECRHS; Endotoxin; Gene polymorphism; TLR4

Indexed keywords

ENDOTOXIN; HOUSE DUST ALLERGEN; TOLL LIKE RECEPTOR 4;

ADULT; ARTICLE; ASTHMA; CONTROLLED STUDY; CORRELATION ANALYSIS; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; EUROPE; FEMALE; FOLLOW UP; GENE FUNCTION; GENETIC CORRELATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC VARIABILITY; HOUSE DUST; HUMAN; IMMUNOMODULATION; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; NONPARAMETRIC TEST; PREVALENCE; PRIORITY JOURNAL; RECEPTOR GENE; RECOMBINANT GENE; RISK ASSESSMENT; WHEEZING;

EID: 0043031387     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2003.1648     Document Type: Article

References (37)

1. Michel O, Ginanni R, Duchateau J, Vertongen F, Le Bon B, Sergysels R. Domestic endotoxin exposure and clinical severity of asthma. Clin Exp Allergy 1991;21:441-8.
2. Douwes J, Heederik D. Epidemiologic investigations of endotoxins. Int J Occ Env Health 1997;3:S26-S31.
3. Park JH, Gold DR, Spiegelman DL, Burge HA, Milton DK. House dust endotoxin and wheeze in the first year of life. Am J Respir Crit Care Med 2001;163:322-8.
4. Gehring U, Bolte G, Borte M, Bischof W, Fahlhusch B, Wichmann HE. et al. Exposure to endotoxin decreases the risk of atopic eczema in infancy: a cohort study [published erratum appears in J Allergy Clin Immunol 2002;109:648]. J Allergy Clin Immunol 2001;108:847-54.
5. Martinez FD, Holt PG. Role of microbial burden in aetiology of allergy and asthma. Lancet 1999;354 Suppl 2:SII12-5.
6. Reed CE, Milton DK. Endotoxin-stimulated innate immunity: a contributing factor for asthma. J Allergy Clin Immunol 2001;108:157-66.
7. Douwes J, Pearce N, Heederik D. Does environmental endotoxin exposure prevent asthma? Thorax 2002;57:86-90.
8. Braun-Fahrlander C, Riedler J, Herz U, Eder W, Waser M, Grize L, et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med 2002;347:869-77.
9. Gehring U, Bischof W, Fahlbusch B, Wichmann HE, Heinrich J. House dust endotoxin and allergic sensitisation in children. Am J Respir Crit Care Med 2002;166:939-44.
10. Bischof W, Koch A, Gehring U, Fahlhusch B, Wichmann HE, Heinrich J. Predictors of high endotoxin concentrations in the settled dust of German homes. Indoor Air 2002;12:2-9.
11. Heinrich J, Gehring U, Douwes J, Koch A, Fahlbusch B, Bischof W, et al. Pets and vermin are associated with high endotoxin levels in house dust. Clin Exp Allergy 2001;31:1839-45.
12. Michel O, Kips J, Duchateau J, Vertongen F, Robert L, Collet H, et al. Severity of asthma is related to endotoxin in house dust. Am J Respir Crit Care Med 1996;154:1641-6.
13. Michel O, Ginanni R, Le Bon B, Content J, Duchateau J, Sergysels R. Inflammatory response to acute inhalation of endotoxin in asthmatic patients. Am Rev Respir Dis 1992;146:352-7.
14. Sandstrom T, Bjermer L, Rylander R. Lipopolysaccharide (LPS) inhalation in healthy subjects increases neutrophils, lymphocytes and fibronectin levels in bronchoalveolar lavage fluid. Eur Respir J 1992;5:992-6.
15. Michel O, Nagy AM, Schroeven M, Duchateau J, Neve J, Fondu P, et al. Dose-response relationship to inhaled endotoxin in normal subjects. Am J Respir Crit Care Med 1997;156:1157-64.
16. Dubin W, Martin TR, Swoveland P, Leturcq DJ, Moriarty AM, Tobias PS, et al. Asthma and endotoxin: lipopolysaccharide-binding protein and soluble CD14 in bronchoalveolar compartment. Am J Physiol 1996;270:L736-44.
17. Kline JN, Cowden JD, Hunninghake GW, Schutte BC, Watt JL, Wohlford-Lenane CL, et al. Variable airway responsiveness to inhaled lipopolysaccharide. Am J Respir Crit Care Med 1999;160:297-303.
18. Michel O, Dentener M, Corazza F, Buurman W, Rylander R. Healthy subjects express differences in clinical responses to inhaled lipopolysaccharide that are related with inflammation and with atopy. J Allergy Clin Immunol 2001;107:797-804.
19. Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997;388:394-7.
20. Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, et al. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 2000;25:187-91.
21. Kiechl S, Lorenz E, Reindl M, Wiedermann CJ, Oherhollenzer F, Bonora E, et al. Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med 2002;347:185-92.
22. Burney PG, Luczynska C, Chinn S, Jarvis D. The European Community Respiratory Health Survey. Eur Respir J 1994;7:954-60.
23. Nowak D, Heinrich J, Jorres R, Wassmer G, Berger J, Beck E, et al. Prevalence of respiratory symptoms, bronchial hyperresponsiveness and atopy among adults: west and east Germany. Eur Respir J 1996;9:2541-52.
24. Quanjer PH, Tammeling GH, Cotes JE, Pedersen OF, Peslin R, Yernault JC. Lung volumes and forced ventilatory flows. Eur Respir J 1993;6:5-40.
25. Chinn S. Comparing and combining studies of bronchial responsiveness. Thorax 2002;57:393-5.
26. Gehring U, Heinrich J, Jacob B, Richter K, Fahlbusch B, Schlenvoigt G, et al. Respiratory symptoms in relation to indoor exposure to mite and cat allergens and endotoxins. Indoor Factors and Genetics in Asthma (INGA) Study Group. Eur Respir J 2001;18:555-63.
27. Dabbagh K, Dahl ME, Stepick-Biek P, Lewis DB. Toll-like receptor 4 is required for optimal development of Th2 immune responses: role of dendritic cells. J Immunol 2002;168:4524-30.
28. Kopp EB, Medzhitov R. The Toll-receptor family and control of innate immunity. Curr Opin Immunol 1999;11:13-8.
29. Medzhitov R. Toll-like receptors and innate immunity. Nat Rev Immunol 2001;1:135-45.
30. Douwes J, Gibson P, Pekkanen J, Pearce N. Non-eosinophilic asthma: importance and possible mechanisms. Thorax 2002;57:643-8.
31. Kurt-Jones EA, Popova L, Kwinn L, Haynes LM, Jones LP, Tripp RA, et al. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol 2000;1:398-401.
32. O'Neill LA. Toll-like receptor signal transduction and the tailoring of innate immunity: a role for Mal? Trends Immunol 2002;23:296-300.
33. Gereda JE, Leung DY, Thatayatikom A, Streib JE, Price MR, Klinnert MD, et al. Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma. Lancet 2000;355:1680-3.
34. Heinrich J, Bolte G, Hölscher B, Douwes J, Lehmann I, Fahlbusch B, et al. Allergens and endotoxin on mothers mattresses and total immunoglobulin E in cord blood of neonates. Eur Respir J 2002;20:617-23.
35. Lauener RP, Birchler T, Adamski J, Braun-Fahrländer C, Bufe A, Herz U, et al. Expression of CD14 and Toll-like receptor 2 in farmers and non-farmers' children. Lancet 2002;360:465-6.
36. Jansen DF, Rijcken B, Schouten JP, Kraan J, Weiss ST, Timens W, et al. The relationship of skin test positivity, high serum total IgE levels, and peripheral blood eosinophilia to symptomatic and asymptomatic airway hyperresponsiveness. Am J Respir Crit Care Med 1999;159:924-31.
37. Park JH, Spiegelman DL, Burge HA, Gold DR, Chew GL, Milton DK. Longitudinal study of dust and airborne endotoxin in the home. Environ Health Perspect 2000;108:1023-8.