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Volumn 2, Issue 9, 2012, Pages 778-790

Investigating metformin for cancer prevention and treatment: The end of the beginning

Author keywords

[No Author keywords available]

Indexed keywords

BIGUANIDE; CYTOCHROME; INSULIN; METFORMIN;

EID: 84866322945     PISSN: 21598274     EISSN: 21598290     Source Type: Journal    
DOI: 10.1158/2159-8290.CD-12-0263     Document Type: Review
Times cited : (433)

References (122)
  • 1
    • 0034783579 scopus 로고    scopus 로고
    • The blooming of the French lilac
    • Witters LA. The blooming of the French lilac. J Clin Invest 2001; 108: 1105-7.
    • (2001) J Clin Invest , vol.108 , pp. 1105-1107
    • Witters, L.A.1
  • 4
    • 33751284806 scopus 로고    scopus 로고
    • Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells
    • Zakikhani M, Dowling R, Fantus IG, Sonenberg N, Pollak M. Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res 2006; 66: 10269-73.
    • (2006) Cancer Res , vol.66 , pp. 10269-10273
    • Zakikhani, M.1    Dowling, R.2    Fantus, I.G.3    Sonenberg, N.4    Pollak, M.5
  • 5
    • 84857640868 scopus 로고    scopus 로고
    • The insulin and insulin-like growth factor receptor family in neoplasia: An update
    • Pollak M. The insulin and insulin-like growth factor receptor family in neoplasia: an update. Nat Rev Cancer 2012; 12: 159-69.
    • (2012) Nat Rev Cancer , vol.12 , pp. 159-169
    • Pollak, M.1
  • 6
    • 84864056422 scopus 로고    scopus 로고
    • Metformin: A diabetes drug for cancer, or a cancer drug for diabetics?
    • Martin M, Marais R. Metformin: a diabetes drug for cancer, or a cancer drug for diabetics? J Clin Oncol 2012; 30: 2698-700.
    • (2012) J Clin Oncol , vol.30 , pp. 2698-2700
    • Martin, M.1    Marais, R.2
  • 7
    • 77956401999 scopus 로고    scopus 로고
    • Metformin and other biguanides in oncology: Advancing the research agenda
    • Pollak M. Metformin and other biguanides in oncology: advancing the research agenda. Cancer Prev Res (Phila) 2010; 3: 1060-5.
    • (2010) Cancer Prev Res (Phila) , vol.3 , pp. 1060-1065
    • Pollak, M.1
  • 9
    • 84255178432 scopus 로고    scopus 로고
    • Diabetes, cancer, and metformin: Connections of metabolism and cell proliferation
    • Gallagher EJ, LeRoith D. Diabetes, cancer, and metformin: connections of metabolism and cell proliferation. Ann N Y Acad Sci 2011; 1243: 54-68.
    • (2011) Ann N Y Acad Sci , vol.1243 , pp. 54-68
    • Gallagher, E.J.1    LeRoith, D.2
  • 10
    • 84875437348 scopus 로고    scopus 로고
    • Targeting metabolism for cancer treatment and prevention: Metformin, an old drug with multi-faceted effects
    • Jun 4: [Epub ahead of print]
    • Pierotti MA, Berrino F, Gariboldi M, Melani C, Mogavero A, Negri T, et al. Targeting metabolism for cancer treatment and prevention: metformin, an old drug with multi-faceted effects. Oncogene. 2012 Jun 4: [Epub ahead of print].
    • (2012) Oncogene
    • Pierotti, M.A.1    Berrino, F.2    Gariboldi, M.3    Melani, C.4    Mogavero, A.5    Negri, T.6
  • 12
    • 80054935612 scopus 로고    scopus 로고
    • Mammalian MATE (SLC47A) transport proteins: Impact on efflux of endogenous substrates and xenobiotics
    • Damme K, Nies AT, Schaeffeler E, Schwab M. Mammalian MATE (SLC47A) transport proteins: impact on efflux of endogenous substrates and xenobiotics. Drug Metab Rev 2011; 43: 499-523.
    • (2011) Drug Metab Rev , vol.43 , pp. 499-523
    • Damme, K.1    Nies, A.T.2    Schaeffeler, E.3    Schwab, M.4
  • 13
    • 34248156160 scopus 로고    scopus 로고
    • Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action
    • Shu Y, Sheardown SA, Brown C, Owen RP, Zhang S, Castro RA, et al. Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J Clin Invest 2007; 117: 1422-31.
    • (2007) J Clin Invest , vol.117 , pp. 1422-1431
    • Shu, Y.1    Sheardown, S.A.2    Brown, C.3    Owen, R.P.4    Zhang, S.5    Castro, R.A.6
  • 15
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009; 324: 1029-33.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 16
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 2008; 7: 11-20.
    • (2008) Cell Metab , vol.7 , pp. 11-20
    • DeBerardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 17
    • 80052242132 scopus 로고    scopus 로고
    • Targeting cancer metabolism: A therapeutic window opens
    • Vander Heiden MG. Targeting cancer metabolism: a therapeutic window opens. Nat Rev Drug Discov 2011; 10: 671-84.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 671-684
    • vander Heiden, M.G.1
  • 18
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogramming: A cancer hallmark even warburg did not anticipate
    • Ward PS, Thompson CB. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell 2012; 21: 297-308.
    • (2012) Cancer Cell , vol.21 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 20
    • 79955398591 scopus 로고    scopus 로고
    • Otto Warburg's contributions to current concepts of cancer metabolism
    • Koppenol WH, Bounds PL, Dang CV. Otto Warburg's contributions to current concepts of cancer metabolism. Nat Rev Cancer 2011; 11: 325-37.
    • (2011) Nat Rev Cancer , vol.11 , pp. 325-337
    • Koppenol, W.H.1    Bounds, P.L.2    Dang, C.V.3
  • 23
    • 77649311383 scopus 로고    scopus 로고
    • Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans healthspan via AMPK, LKB1, and SKN-1
    • Onken B, Driscoll M. Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans healthspan via AMPK, LKB1, and SKN-1. PLoS One 2010; 5: e8758.
    • (2010) PLoS One , vol.5
    • Onken, B.1    Driscoll, M.2
  • 24
    • 84857720818 scopus 로고    scopus 로고
    • Repurposing approved and abandoned drugs for the treatment and prevention of cancer through public-private partnership
    • Weir SJ, DeGennaro LJ, Austin CP. Repurposing approved and abandoned drugs for the treatment and prevention of cancer through public-private partnership. Cancer Res 2012; 72: 1055-8.
    • (2012) Cancer Res , vol.72 , pp. 1055-1058
    • Weir, S.J.1    DeGennaro, L.J.2    Austin, C.P.3
  • 25
    • 84862215222 scopus 로고    scopus 로고
    • Cancer occurrence in Danish diabetic patients: Duration and insulin effects
    • Carstensen B, Witte DR, Friis S. Cancer occurrence in Danish diabetic patients: duration and insulin effects. Diabetologia 2012; 55: 948-58.
    • (2012) Diabetologia , vol.55 , pp. 948-958
    • Carstensen, B.1    Witte, D.R.2    Friis, S.3
  • 26
    • 84858695046 scopus 로고    scopus 로고
    • Cancer risk in diabetic patients treated with metformin: A systematic review and metaanalysis
    • Noto H, Goto A, Tsujimoto T, Noda M. Cancer risk in diabetic patients treated with metformin: a systematic review and metaanalysis. PLoS One 2012; 7: e33411.
    • (2012) PLoS One , vol.7
    • Noto, H.1    Goto, A.2    Tsujimoto, T.3    Noda, M.4
  • 28
    • 84855432249 scopus 로고    scopus 로고
    • Risk of hepatocellular carcinoma in diabetic patients and risk reduction associated with anti-diabetic therapy: A population-based cohort study
    • Lai SW, Chen PC, Liao KF, Muo CH, Lin CC, Sung FC. Risk of hepatocellular carcinoma in diabetic patients and risk reduction associated with anti-diabetic therapy: a population-based cohort study. Am J Gastroenterol 2012; 107: 46-52.
    • (2012) Am J Gastroenterol , vol.107 , pp. 46-52
    • Lai, S.W.1    Chen, P.C.2    Liao, K.F.3    Muo, C.H.4    Lin, C.C.5    Sung, F.C.6
  • 30
    • 84861127026 scopus 로고    scopus 로고
    • Metformin use is associated with better survival of diabetic patients with pancreatic cancer
    • Sadeghi N, Abbruzzese JL, Yeung S-CJ, Hassan M, Li D. Metformin use is associated with better survival of diabetic patients with pancreatic cancer. Clin Cancer Res 2012; 18: 2905-12.
    • (2012) Clin Cancer Res , vol.18 , pp. 2905-2912
    • Sadeghi, N.1    Abbruzzese, J.L.2    Yeung, S.-C.J.3    Hassan, M.4    Li, D.5
  • 31
    • 67749144226 scopus 로고    scopus 로고
    • Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer
    • Jiralerspong S, Palla SL, Giordano SH, Meric-Bernstam F, Liedtke C, Barnett CM, et al. Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. J Clin Oncol 2009; 27: 3297-302.
    • (2009) J Clin Oncol , vol.27 , pp. 3297-3302
    • Jiralerspong, S.1    Palla, S.L.2    Giordano, S.H.3    Meric-Bernstam, F.4    Liedtke, C.5    Barnett, C.M.6
  • 32
    • 84866323234 scopus 로고    scopus 로고
    • Examining the effects of metformin on survival outcome in stage II/ III colorectal cancer patients with diabetes mellitus
    • (abstr 3589)
    • Lee GE, Aung T, Lim KH, Tan WS, Tai WMD, Suhaimi N-AB, et al. Examining the effects of metformin on survival outcome in stage II/ III colorectal cancer patients with diabetes mellitus. J Clin Oncol 30: 2012 (suppl; abstr 3589).
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Lee, G.E.1    Aung, T.2    Lim, K.H.3    Tan, W.S.4    Tai, W.M.D.5    Suhaimi, N.-A.B.6
  • 33
    • 84861152001 scopus 로고    scopus 로고
    • Metformin and pancreatic cancer: A clue requiring investigation
    • Pollak M. Metformin and pancreatic cancer: a clue requiring investigation. Clin Cancer Res 2012; 18: 2723-5.
    • (2012) Clin Cancer Res , vol.18 , pp. 2723-2725
    • Pollak, M.1
  • 34
    • 84859631091 scopus 로고    scopus 로고
    • Survival advantage observed with the use of metformin in patients with type II diabetes and colorectal cancer
    • Garrett CR, Hassabo HM, Bhadkamkar NA, Wen S, Baladandayuthapani V, Kee BK, et al. Survival advantage observed with the use of metformin in patients with type II diabetes and colorectal cancer. Br J Cancer 2012; 106: 1374-8.
    • (2012) Br J Cancer , vol.106 , pp. 1374-1378
    • Garrett, C.R.1    Hassabo, H.M.2    Bhadkamkar, N.A.3    Wen, S.4    Baladandayuthapani, V.5    Kee, B.K.6
  • 35
    • 84859029647 scopus 로고    scopus 로고
    • Mortality after incident cancer in people with and without type 2 diabetes: Impact of metformin on survival
    • Currie CJ, Poole CD, Jenkins-Jones S, Gale EA, Johnson JA, Morgan CL. Mortality after incident cancer in people with and without type 2 diabetes: impact of metformin on survival. Diabetes Care 2012; 35: 299-304.
    • (2012) Diabetes Care , vol.35 , pp. 299-304
    • Currie, C.J.1    Poole, C.D.2    Jenkins-Jones, S.3    Gale, E.A.4    Johnson, J.A.5    Morgan, C.L.6
  • 37
    • 84857372409 scopus 로고    scopus 로고
    • Effect of metformin on survival outcomes in diabetic patients with triple receptor-negative breast cancer
    • Bayraktar S, Hernadez-Aya LF, Lei X, Meric-Bernstam F, Litton JK, Hsu L, et al. Effect of metformin on survival outcomes in diabetic patients with triple receptor-negative breast cancer. Cancer 2012; 118: 1202-11.
    • (2012) Cancer , vol.118 , pp. 1202-1211
    • Bayraktar, S.1    Hernadez-Aya, L.F.2    Lei, X.3    Meric-Bernstam, F.4    Litton, J.K.5    Hsu, L.6
  • 38
    • 84892808887 scopus 로고    scopus 로고
    • Diabetes, metformin use, and colorectal cancer survival in women: A retrospective cohort study
    • (abstr e14005)
    • Cossor FI, Adams-Campbell LL, Chlebowski RT, Gunter MJ, Johnson K, Martell RE, et al. Diabetes, metformin use, and colorectal cancer survival in women: A retrospective cohort study. J Clin Oncol 30: 2012 (suppl; abstr e14005).
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Cossor, F.I.1    Adams-Campbell, L.L.2    Chlebowski, R.T.3    Gunter, M.J.4    Johnson, K.5    Martell, R.E.6
  • 39
    • 84857073798 scopus 로고    scopus 로고
    • Use of metformin is not associated with a decreased risk of colorectal cancer: A casecontrol analysis
    • Bodmer M, Becker C, Meier C, Jick SS, Meier CR. Use of metformin is not associated with a decreased risk of colorectal cancer: a casecontrol analysis. Cancer Epidemiol Biomarkers Prev 2012; 21: 280-6.
    • (2012) Cancer Epidemiol Biomarkers Prev , vol.21 , pp. 280-286
    • Bodmer, M.1    Becker, C.2    Meier, C.3    Jick, S.S.4    Meier, C.R.5
  • 40
    • 84862064131 scopus 로고    scopus 로고
    • Statin use as a moderator of metformin effect on risk for prostate cancer among type 2 diabetic patients
    • Lehman DM, Lorenzo C, Hernandez J, Wang CP. Statin use as a moderator of metformin effect on risk for prostate cancer among type 2 diabetic patients. Diabetes Care 2012; 35: 1002-7.
    • (2012) Diabetes Care , vol.35 , pp. 1002-1007
    • Lehman, D.M.1    Lorenzo, C.2    Hernandez, J.3    Wang, C.P.4
  • 41
    • 79960295006 scopus 로고    scopus 로고
    • Proton pump inhibitors inhibit metformin uptake by organic cation transporters (OCTs)
    • Nies AT, Hofmann U, Resch C, Schaeffeler E, Rius M, Schwab M. Proton pump inhibitors inhibit metformin uptake by organic cation transporters (OCTs). PLoS One 2011; 6: e22163.
    • (2011) PLoS One , vol.6
    • Nies, A.T.1    Hofmann, U.2    Resch, C.3    Schaeffeler, E.4    Rius, M.5    Schwab, M.6
  • 43
    • 28844433635 scopus 로고    scopus 로고
    • The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
    • Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, et al. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 2005; 310: 1642-6.
    • (2005) Science , vol.310 , pp. 1642-1646
    • Shaw, R.J.1    Lamia, K.A.2    Vasquez, D.3    Koo, S.H.4    Bardeesy, N.5    Depinho, R.A.6
  • 44
    • 77954933558 scopus 로고    scopus 로고
    • Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
    • Foretz M, Hebrard S, Leclerc J, Zarrinpashneh E, Soty M, Mithieux G, et al. Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. J Clin Invest 2010; 120: 2355-69.
    • (2010) J Clin Invest , vol.120 , pp. 2355-2369
    • Foretz, M.1    Hebrard, S.2    Leclerc, J.3    Zarrinpashneh, E.4    Soty, M.5    Mithieux, G.6
  • 45
    • 0034773404 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in mechanism of metformin action
    • Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 2001; 108: 1167-74.
    • (2001) J Clin Invest , vol.108 , pp. 1167-1174
    • Zhou, G.1    Myers, R.2    Li, Y.3    Chen, Y.4    Shen, X.5    Fenyk-Melody, J.6
  • 46
    • 48449084609 scopus 로고    scopus 로고
    • Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: A mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action
    • Turner N, Li JY, Gosby A, To SW, Cheng Z, Miyoshi H, et al. Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action. Diabetes 2008; 57: 1414-8.
    • (2008) Diabetes , vol.57 , pp. 1414-1418
    • Turner, N.1    Li, J.Y.2    Gosby, A.3    To, S.W.4    Cheng, Z.5    Miyoshi, H.6
  • 47
    • 0034659785 scopus 로고    scopus 로고
    • Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
    • Owen MR, Doran E, Halestrap AP. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J 2000; 348: 607-14.
    • (2000) Biochem J , vol.348 , pp. 607-614
    • Owen, M.R.1    Doran, E.2    Halestrap, A.P.3
  • 48
    • 0034614420 scopus 로고    scopus 로고
    • Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I
    • El Mir MY, Nogueira V, Fontaine E, Averet N, Rigoulet M, Leverve X. Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. J Biol Chem 2000; 275: 223-8.
    • (2000) J Biol Chem , vol.275 , pp. 223-228
    • El Mir, M.Y.1    Nogueira, V.2    Fontaine, E.3    Averet, N.4    Rigoulet, M.5    Leverve, X.6
  • 49
    • 73049161724 scopus 로고
    • A study of the action of hypoglycemiaproducing biguanide and sulfonylurea compounds on oxidative phosphorylation
    • Falcone AB, Mao RL, Shrago E. A study of the action of hypoglycemiaproducing biguanide and sulfonylurea compounds on oxidative phosphorylation. J Biol Chem 1962; 237: 904-9.
    • (1962) J Biol Chem , vol.237 , pp. 904-909
    • Falcone, A.B.1    Mao, R.L.2    Shrago, E.3
  • 51
    • 80052068980 scopus 로고    scopus 로고
    • Structure of the membrane domain of respiratory complex I
    • Efremov RG, Sazanov LA. Structure of the membrane domain of respiratory complex I. Nature 2011; 476: 414-20.
    • (2011) Nature , vol.476 , pp. 414-420
    • Efremov, R.G.1    Sazanov, L.A.2
  • 52
    • 73849114263 scopus 로고    scopus 로고
    • Towards the molecular mechanism of respiratory complex I
    • Hirst J. Towards the molecular mechanism of respiratory complex I. Biochem J 2010; 425: 327-39.
    • (2010) Biochem J , vol.425 , pp. 327-339
    • Hirst, J.1
  • 53
    • 84858782079 scopus 로고    scopus 로고
    • AMPK: A nutrient and energy sensor that maintains energy homeostasis
    • Hardie DG, Ross FA, Hawley SA. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol 2012; 13: 251-62.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 251-262
    • Hardie, D.G.1    Ross, F.A.2    Hawley, S.A.3
  • 56
    • 67749111502 scopus 로고    scopus 로고
    • The LKB1-AMPK pathway: Metabolism and growth control in tumour suppression
    • Shackelford DB, Shaw RJ. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat Rev Cancer 2009; 9: 563-75.
    • (2009) Nat Rev Cancer , vol.9 , pp. 563-575
    • Shackelford, D.B.1    Shaw, R.J.2
  • 57
    • 77953589054 scopus 로고    scopus 로고
    • Metformin blocks the stimulative effect of a high energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid acid synthase
    • Algire C, Amrein L, Zakikhani M, Panasci L, Pollak M. Metformin blocks the stimulative effect of a high energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid acid synthase. Endocr Relat Cancer 2010; 17: 351-60.
    • (2010) Endocr Relat Cancer , vol.17 , pp. 351-360
    • Algire, C.1    Amrein, L.2    Zakikhani, M.3    Panasci, L.4    Pollak, M.5
  • 58
    • 0032511053 scopus 로고    scopus 로고
    • AMP-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase gene in rat hepatocytes
    • Foretz M, Carling D, Guichard C, Ferre P, Foufelle F. AMP-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase gene in rat hepatocytes. J Biol Chem 1998; 273: 14767-71.
    • (1998) J Biol Chem , vol.273 , pp. 14767-14771
    • Foretz, M.1    Carling, D.2    Guichard, C.3    Ferre, P.4    Foufelle, F.5
  • 59
    • 84863763440 scopus 로고    scopus 로고
    • AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress
    • Jeon S-M, Chandel NS, Hay N. AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress. Nature 2012; 485: 661-5.
    • (2012) Nature , vol.485 , pp. 661-665
    • Jeon, S.-M.1    Chandel, N.S.2    Hay, N.3
  • 60
    • 79956260998 scopus 로고    scopus 로고
    • Combination therapy with vemurafenib (PLX4032/RG7204) and metformin in melanoma cell lines with distinct driver mutations
    • Niehr F, von Euw E, Attar N, Guo D, Matsunaga D, Sazegar H, et al. Combination therapy with vemurafenib (PLX4032/RG7204) and metformin in melanoma cell lines with distinct driver mutations. J Transl Med 2011; 9: 76.
    • (2011) J Transl Med , vol.9 , pp. 76
    • Niehr, F.1    von Euw, E.2    Attar, N.3    Guo, D.4    Matsunaga, D.5    Sazegar, H.6
  • 61
    • 84864059240 scopus 로고    scopus 로고
    • Metformin accelerates the growth of BRAFV600E-driven melanoma by upregulating VEGF-A
    • Martin MJ, Hayward R, Viros A, Marais R. Metformin accelerates the growth of BRAFV600E-driven melanoma by upregulating VEGF-A. Cancer Discov 2012; 2: 344-55.
    • (2012) Cancer Discov , vol.2 , pp. 344-355
    • Martin, M.J.1    Hayward, R.2    Viros, A.3    Marais, R.4
  • 64
    • 79952538201 scopus 로고    scopus 로고
    • Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo
    • Algire C, Amrein L, Bazile M, David S, Zakikhani M, Pollak M. Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo. Oncogene 2011; 30: 1174-82.
    • (2011) Oncogene , vol.30 , pp. 1174-1182
    • Algire, C.1    Amrein, L.2    Bazile, M.3    David, S.4    Zakikhani, M.5    Pollak, M.6
  • 65
    • 34547114031 scopus 로고    scopus 로고
    • Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth
    • Buzzai M, Jones RG, Amaravadi RK, Lum JJ, DeBerardinis RJ, Zhao F, et al. Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res 2007; 67: 6745-52.
    • (2007) Cancer Res , vol.67 , pp. 6745-6752
    • Buzzai, M.1    Jones, R.G.2    Amaravadi, R.K.3    Lum, J.J.4    DeBerardinis, R.J.5    Zhao, F.6
  • 66
    • 84873613396 scopus 로고    scopus 로고
    • Dual effects of metformin on breast cancer proliferation in a randomized trial
    • (abstr 519)
    • Decensi A, Pollak MN, Puntoni M, Gandini S, Cazzaniga M, Pruneri G, et al. Dual effects of metformin on breast cancer proliferation in a randomized trial. J Clin Oncol 30: 2012 (suppl; abstr 519).
    • J Clin Oncol , vol.30 , Issue.SUPPL. , pp. 2012
    • Decensi, A.1    Pollak, M.N.2    Puntoni, M.3    Gandini, S.4    Cazzaniga, M.5    Pruneri, G.6
  • 67
    • 33744514139 scopus 로고    scopus 로고
    • Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome
    • Cool B, Zinker B, Chiou W, Kifle L, Cao N, Perham M, et al. Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab 2006; 3: 403-16.
    • (2006) Cell Metab , vol.3 , pp. 403-416
    • Cool, B.1    Zinker, B.2    Chiou, W.3    Kifle, L.4    Cao, N.5    Perham, M.6
  • 69
    • 84855987831 scopus 로고    scopus 로고
    • Reductive carboxylation supports growth in tumour cells with defective mitochondria
    • Mullen AR, Wheaton WW, Jin ES, Chen PH, Sullivan LB, Cheng T, et al. Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature 2011; 481: 385-8.
    • (2011) Nature , vol.481 , pp. 385-388
    • Mullen, A.R.1    Wheaton, W.W.2    Jin, E.S.3    Chen, P.H.4    Sullivan, L.B.5    Cheng, T.6
  • 70
    • 81755184076 scopus 로고    scopus 로고
    • Metformin represses self-renewal of the human breast carcinoma stem cells via inhibition of estrogen receptor-mediated OCT4 expression
    • Jung JW, Park SB, Lee SJ, Seo MS, Trosko JE, Kang KS. Metformin represses self-renewal of the human breast carcinoma stem cells via inhibition of estrogen receptor-mediated OCT4 expression. PLoS One 2011; 6: e28068.
    • (2011) PLoS One , vol.6
    • Jung, J.W.1    Park, S.B.2    Lee, S.J.3    Seo, M.S.4    Trosko, J.E.5    Kang, K.S.6
  • 71
    • 79952121979 scopus 로고    scopus 로고
    • Inducible formation of breast cancer stem cells and their dynamic equilibrium with nonstem cancer cells via IL6 secretion
    • Iliopoulos D, Hirsch HA, Wang G, Struhl K. Inducible formation of breast cancer stem cells and their dynamic equilibrium with nonstem cancer cells via IL6 secretion. Proc Natl Acad Sci U S A 2011; 108: 1397-402.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 1397-1402
    • Iliopoulos, D.1    Hirsch, H.A.2    Wang, G.3    Struhl, K.4
  • 72
    • 84865798995 scopus 로고    scopus 로고
    • Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC
    • Blandino G, Valerio M, Cioce M, Mori F, Casadei L, Pulito C, et al. Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC. Nat Commun 2012; 3: 865.
    • (2012) Nat Commun , vol.3 , pp. 865
    • Blandino, G.1    Valerio, M.2    Cioce, M.3    Mori, F.4    Casadei, L.5    Pulito, C.6
  • 73
    • 79958756136 scopus 로고    scopus 로고
    • Promoter-specific effects of metformin on aromatase transcript expression
    • Samarajeewa NU, Ham S, Yang F, Simpson ER, Brown KA. Promoter-specific effects of metformin on aromatase transcript expression. Steroids 2011; 76: 768-71.
    • (2011) Steroids , vol.76 , pp. 768-771
    • Samarajeewa, N.U.1    Ham, S.2    Yang, F.3    Simpson, E.R.4    Brown, K.A.5
  • 74
    • 79551489371 scopus 로고    scopus 로고
    • Metformin inhibits P-glycoprotein expression via the NF-kappaB pathway and CRE transcriptional activity through AMPK activation
    • Kim HG, Hien TT, Han EH, Hwang YP, Choi JH, Kang KW, et al. Metformin inhibits P-glycoprotein expression via the NF-kappaB pathway and CRE transcriptional activity through AMPK activation. Br J Pharmacol 2011; 162: 1096-108.
    • (2011) Br J Pharmacol , vol.162 , pp. 1096-1108
    • Kim, H.G.1    Hien, T.T.2    Han, E.H.3    Hwang, Y.P.4    Choi, J.H.5    Kang, K.W.6
  • 77
    • 84866332524 scopus 로고    scopus 로고
    • Differences in metformin transporter expression between breast tumor and breast cancer cell lines: Selecting a relevant breast cancer cell model for metformin therapy [abstract]
    • In: Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; 2012. Abstract nr LB-345
    • Zhang Y, Everett RS, Thakker DR. Differences in metformin transporter expression between breast tumor and breast cancer cell lines: selecting a relevant breast cancer cell model for metformin therapy [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; 2012. Abstract nr LB-345.
    • (2012) Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research
    • Zhang, Y.1    Everett, R.S.2    Thakker, D.R.3
  • 78
    • 84862001123 scopus 로고    scopus 로고
    • Defining the contribution of AMPK and PKCs in the regulation of glucose uptake by metformin in skeletal muscle cells
    • Turban S, Stretton C, Drouin O, Green CJ, Watson ML, Gray A, et al. Defining the contribution of AMPK and PKCs in the regulation of glucose uptake by metformin in skeletal muscle cells. J Biol Chem 2012; 287: 20088-99.
    • (2012) J Biol Chem , vol.287 , pp. 20088-20099
    • Turban, S.1    Stretton, C.2    Drouin, O.3    Green, C.J.4    Watson, M.L.5    Gray, A.6
  • 79
    • 80053932300 scopus 로고    scopus 로고
    • Randomized trial of tamoxifen versus combined tamoxifen and octreotide LAR therapy in the adjuvant treatment of early-stage breast cancer in postmenopausal women: NCIC CTG MA.14
    • Pritchard KI, Shepherd LE, Chapman JW, Norris BD, Cantin J, Goss PE, et al. Randomized trial of tamoxifen versus combined tamoxifen and octreotide LAR therapy in the adjuvant treatment of early-stage breast cancer in postmenopausal women: NCIC CTG MA.14. J Clin Oncol 2011; 29: 3869-76.
    • (2011) J Clin Oncol , vol.29 , pp. 3869-3876
    • Pritchard, K.I.1    Shepherd, L.E.2    Chapman, J.W.3    Norris, B.D.4    Cantin, J.5    Goss, P.E.6
  • 80
    • 84855604629 scopus 로고    scopus 로고
    • Insulin-and obesity-related variables in early-stage breast cancer: Correlations and time course of prognostic associations
    • Goodwin PJ, Ennis M, Pritchard KI, Trudeau ME, Koo J, Taylor SK, et al. Insulin-and obesity-related variables in early-stage breast cancer: correlations and time course of prognostic associations. J Clin Oncol 2012; 30: 164-71.
    • (2012) J Clin Oncol , vol.30 , pp. 164-171
    • Goodwin, P.J.1    Ennis, M.2    Pritchard, K.I.3    Trudeau, M.E.4    Koo, J.5    Taylor, S.K.6
  • 82
    • 58249092146 scopus 로고    scopus 로고
    • Insulin, the insulin-like growth factor axis, and mortality in patients with nonmetastatic colorectal cancer
    • Wolpin BM, Meyerhardt JA, Chan AT, Ng K, Chan JA, Wu K, et al. Insulin, the insulin-like growth factor axis, and mortality in patients with nonmetastatic colorectal cancer. J Clin Oncol 2009; 27: 176-85.
    • (2009) J Clin Oncol , vol.27 , pp. 176-185
    • Wolpin, B.M.1    Meyerhardt, J.A.2    Chan, A.T.3    Ng, K.4    Chan, J.A.5    Wu, K.6
  • 83
    • 54349083481 scopus 로고    scopus 로고
    • Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: A long-term survival analysis
    • Ma J, Li H, Giovannucci E, Mucci L, Qiu W, Nguyen P, et al. Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis. Lancet Oncol 2008; 9: 1039-47.
    • (2008) Lancet Oncol , vol.9 , pp. 1039-1047
    • Ma, J.1    Li, H.2    Giovannucci, E.3    Mucci, L.4    Qiu, W.5    Nguyen, P.6
  • 84
    • 38449105596 scopus 로고    scopus 로고
    • Association of diet-induced hyperinsulinemia with accelerated growth of prostate cancer (LNCaP) xenografts
    • Venkateswaran V, Haddad AQ, Fleshner NE, Fan R, Sugar LM, Nam R, et al. Association of diet-induced hyperinsulinemia with accelerated growth of prostate cancer (LNCaP) xenografts. J Natl Cancer Inst 2007; 99: 1793-800.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 1793-1800
    • Venkateswaran, V.1    Haddad, A.Q.2    Fleshner, N.E.3    Fan, R.4    Sugar, L.M.5    Nam, R.6
  • 85
    • 84855426420 scopus 로고    scopus 로고
    • Hyperinsulinemia enhances c-Myc-mediated mammary tumor development and advances metastatic progression to the lung in a mouse model of type 2 diabetes
    • Ferguson RD, Novosyadlyy R, Fierz Y, Alikhani N, Sun H, Yakar S, et al. Hyperinsulinemia enhances c-Myc-mediated mammary tumor development and advances metastatic progression to the lung in a mouse model of type 2 diabetes. Breast Cancer Res 2012; 14: R8.
    • (2012) Breast Cancer Res , vol.14
    • Ferguson, R.D.1    Novosyadlyy, R.2    Fierz, Y.3    Alikhani, N.4    Sun, H.5    Yakar, S.6
  • 86
  • 88
    • 84861155928 scopus 로고    scopus 로고
    • Effect of different doses of metformin on serum testosterone and insulin in non-diabetic women with breast cancer: A randomized study
    • Campagnoli C, Pasanisi P, Abba C, Ambroggio S, Biglia N, Brucato T, et al. Effect of different doses of metformin on serum testosterone and insulin in non-diabetic women with breast cancer: a randomized study. Clin Breast Cancer 2012; 12: 175-82.
    • (2012) Clin Breast Cancer , vol.12 , pp. 175-182
    • Campagnoli, C.1    Pasanisi, P.2    Abba, C.3    Ambroggio, S.4    Biglia, N.5    Brucato, T.6
  • 89
    • 79151478459 scopus 로고    scopus 로고
    • Evaluation of metformin in early breast cancer: A modification of the traditional paradigm for clinical testing of anticancer agents
    • Goodwin PJ, Stambolic V, Lemieux J, Chen BE, Parulekar WR, Gelmon KA, et al. Evaluation of metformin in early breast cancer: a modification of the traditional paradigm for clinical testing of anticancer agents. Breast Cancer Res Treat 2011; 126: 215-20.
    • (2011) Breast Cancer Res Treat , vol.126 , pp. 215-220
    • Goodwin, P.J.1    Stambolic, V.2    Lemieux, J.3    Chen, B.E.4    Parulekar, W.R.5    Gelmon, K.A.6
  • 90
    • 84868257500 scopus 로고    scopus 로고
    • The ORIGIN Trial Investigators. Basal insulin and cardiovascular and other outcomes in dysglycemia
    • Jun 11. [Epub ahead of print]
    • The ORIGIN Trial Investigators. Basal insulin and cardiovascular and other outcomes in dysglycemia. N Engl J Med. 2012 Jun 11. [Epub ahead of print].
    • (2012) N Engl J Med.
  • 91
    • 33646029746 scopus 로고    scopus 로고
    • Insulin sensitivity during combined androgen blockade for prostate cancer
    • Smith MR, Lee H, Nathan DM. Insulin sensitivity during combined androgen blockade for prostate cancer. J Clin Endocrinol Metab 2006; 91: 1305-8.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 1305-1308
    • Smith, M.R.1    Lee, H.2    Nathan, D.M.3
  • 94
    • 84862907716 scopus 로고    scopus 로고
    • IGF-1/insulin receptor kinase inhibition by BMS-536924 is better tolerated than alloxan-induced hypoinsulinemia and more effective than metformin in the treatment of experimental insulin responsive breast cancer
    • Dool C, Mashhedi H, Zakikhani M, David S, Zhao Y, Birman E, et al. IGF-1/insulin receptor kinase inhibition by BMS-536924 is better tolerated than alloxan-induced hypoinsulinemia and more effective than metformin in the treatment of experimental insulin responsive breast cancer. Endocr Relat Cancer 2011; 18: 699-709.
    • (2011) Endocr Relat Cancer , vol.18 , pp. 699-709
    • Dool, C.1    Mashhedi, H.2    Zakikhani, M.3    David, S.4    Zhao, Y.5    Birman, E.6
  • 95
    • 84866335179 scopus 로고    scopus 로고
    • Elevated insulin can reduce effectiveness of PI3K inhibitors: Rationale for co-targeting the insulin receptor family and PI3K [abstract]
    • In: Jul 7-10; Barcelona, Spain. Nottingham, United Kingdom: EACR; 2012. Abstract nr 636
    • Blouin M-J, Zhao Y, Birman E, Pollak M. Elevated insulin can reduce effectiveness of PI3K inhibitors: rationale for co-targeting the insulin receptor family and PI3K [abstract]. In: Proceedings of the 22nd Meeting of the European Association for Cancer Research (EACR); 2012 Jul 7-10; Barcelona, Spain. Nottingham, United Kingdom: EACR; 2012. Abstract nr 636.
    • (2012) Proceedings of the 22nd Meeting of the European Association for Cancer Research (EACR)
    • Blouin, M.-J.1    Zhao, Y.2    Birman, E.3    Pollak, M.4
  • 97
    • 84873612937 scopus 로고    scopus 로고
    • Effects of metformin on markers of insulin resistance and on breast cancer proliferation: The putative role of IGFBP-1 as a predictive biomarker [abstract]
    • In: Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; 2012. Abstract nr 30
    • Johansson HA, Decensi A, Puntoni M, Cazzaniga M, Pruneri G, Serrano D, et al. Effects of metformin on markers of insulin resistance and on breast cancer proliferation: the putative role of IGFBP-1 as a predictive biomarker [abstract]. In: Proceedings of the 103rd Annual Meeting of American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; 2012. Abstract nr 30.
    • (2012) Proceedings of the 103rd Annual Meeting of American Association for Cancer Research
    • Johansson, H.A.1    Decensi, A.2    Puntoni, M.3    Cazzaniga, M.4    Pruneri, G.5    Serrano, D.6
  • 99
    • 79959764729 scopus 로고    scopus 로고
    • Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1
    • Ben SI, Regazzetti C, Robert G, Laurent K, Marchand-Brustel Y, Auberger P, et al. Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1. Cancer Res 2011; 71: 4366-72.
    • (2011) Cancer Res , vol.71 , pp. 4366-4372
    • Ben, S.I.1    Regazzetti, C.2    Robert, G.3    Laurent, K.4    Marchand-Brustel, Y.5    Auberger, P.6
  • 100
    • 84862740754 scopus 로고    scopus 로고
    • Hyperactivation of 4E-binding protein 1 as a mediator of biguanideinduced cytotoxicity during glucose deprivation
    • Matsuo J, Tsukumo Y, Saito S, Tsukahara S, Sakurai J, Sato S, et al. Hyperactivation of 4E-binding protein 1 as a mediator of biguanideinduced cytotoxicity during glucose deprivation. Mol Cancer Ther 2012; 11: 1082-91.
    • (2012) Mol Cancer Ther , vol.11 , pp. 1082-1091
    • Matsuo, J.1    Tsukumo, Y.2    Saito, S.3    Tsukahara, S.4    Sakurai, J.5    Sato, S.6
  • 102
    • 84859117806 scopus 로고    scopus 로고
    • Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity
    • Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, et al. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science 2012; 335: 1638-43.
    • (2012) Science , vol.335 , pp. 1638-1643
    • Lamming, D.W.1    Ye, L.2    Katajisto, P.3    Goncalves, M.D.4    Saitoh, M.5    Stevens, D.M.6
  • 103
    • 77955287742 scopus 로고    scopus 로고
    • Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner
    • Kalender A, Selvaraj A, Kim SY, Gulati P, Brule S, Viollet B, et al. Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. Cell Metab 2010; 11: 390-401.
    • (2010) Cell Metab , vol.11 , pp. 390-401
    • Kalender, A.1    Selvaraj, A.2    Kim, S.Y.3    Gulati, P.4    Brule, S.5    Viollet, B.6
  • 104
    • 79960845901 scopus 로고    scopus 로고
    • Evidence for biological effects of metformin in operable breast cancer: A pre-operative, window-of-opportunity, randomized trial
    • Hadad S, Iwamoto T, Jordan L, Purdie C, Bray S, Baker L, et al. Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial. Breast Cancer Res Treat 2011; 128: 783-94.
    • (2011) Breast Cancer Res Treat , vol.128 , pp. 783-794
    • Hadad, S.1    Iwamoto, T.2    Jordan, L.3    Purdie, C.4    Bray, S.5    Baker, L.6
  • 105
    • 80051495503 scopus 로고    scopus 로고
    • Lapatinib activity in premalignant lesions and HER-2-positive cancer of the breast in a randomized, placebocontrolled presurgical trial
    • Decensi A, Puntoni M, Pruneri G, Guerrieri-Gonzaga A, Lazzeroni M, Serrano D, et al. Lapatinib activity in premalignant lesions and HER-2-positive cancer of the breast in a randomized, placebocontrolled presurgical trial. Cancer Prev Res (Phila) 2011; 4: 1181-9.
    • (2011) Cancer Prev Res (Phila) , vol.4 , pp. 1181-1189
    • Decensi, A.1    Puntoni, M.2    Pruneri, G.3    Guerrieri-Gonzaga, A.4    Lazzeroni, M.5    Serrano, D.6
  • 106
    • 0038467378 scopus 로고    scopus 로고
    • A randomized trial of low-dose tamoxifen on breast cancer proliferation and blood estrogenic biomarkers
    • Decensi A, Robertson C, Viale G, Pigatto F, Johansson H, Kisanga ER, et al. A randomized trial of low-dose tamoxifen on breast cancer proliferation and blood estrogenic biomarkers. J Natl Cancer Inst 2003; 95: 779-90.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 779-790
    • Decensi, A.1    Robertson, C.2    Viale, G.3    Pigatto, F.4    Johansson, H.5    Kisanga, E.R.6
  • 107
    • 84873608739 scopus 로고    scopus 로고
    • Metformin in early breast cancer: A prospective, open-label, neoadjuvant "window of opportunity" study
    • (abstr 1019)
    • Niraula S, Dowling RJO, Enis M, Chang M, Done S, Hood N, et al. Metformin in early breast cancer: A prospective, open-label, neoadjuvant "window of opportunity" study. J Clin Oncol 30; 2012 (suppl; abstr 1019).
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Niraula, S.1    Dowling, R.J.O.2    Enis, M.3    Chang, M.4    Done, S.5    Hood, N.6
  • 110
    • 80051714418 scopus 로고    scopus 로고
    • Metformin abolishes increased tumor 18F-2-fluoro-2-deoxy-D-glucose uptake associated with a high-energy diet
    • Mashhedi H, Blouin M-J, Zakikhani M, David S, Zhao Y, Bazile M, et al. Metformin abolishes increased tumor 18F-2-fluoro-2-deoxy-D-glucose uptake associated with a high-energy diet. Cell Cycle 2011; 10: 2770-8.
    • (2011) Cell Cycle , vol.10 , pp. 2770-2778
    • Mashhedi, H.1    Blouin, M.-J.2    Zakikhani, M.3    David, S.4    Zhao, Y.5    Bazile, M.6
  • 112
    • 84863614868 scopus 로고    scopus 로고
    • Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation
    • Wang J, Gallagher D, Devito LM, Cancino GI, Tsui D, He L, et al. Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation. Cell Stem Cell 2012; 11: 23-35.
    • (2012) Cell Stem Cell , vol.11 , pp. 23-35
    • Wang, J.1    Gallagher, D.2    Devito, L.M.3    Cancino, G.I.4    Tsui, D.5    He, L.6
  • 113
    • 84856740961 scopus 로고    scopus 로고
    • Oral pharmacologic treatment of type 2 diabetes mellitus: A clinical practice guideline from the American College of Physicians
    • Qaseem A, Humphrey LL, Sweet DE, Starkey M, Shekelle P. Oral pharmacologic treatment of type 2 diabetes mellitus: a clinical practice guideline from the American College of Physicians. Ann Intern Med 2012; 156: 218-31.
    • (2012) Ann Intern Med , vol.156 , pp. 218-231
    • Qaseem, A.1    Humphrey, L.L.2    Sweet, D.E.3    Starkey, M.4    Shekelle, P.5
  • 114
    • 84865411135 scopus 로고    scopus 로고
    • Diabetes and cancer (2): Evaluating the impact of diabetes on mortality in patients with cancer
    • Renehan AG, Yeh HC, Johnson JA, Wild SH, Gale EA, Moller H. Diabetes and cancer (2): evaluating the impact of diabetes on mortality in patients with cancer. Diabetologia 2012; 55: 1619-32.
    • (2012) Diabetologia , vol.55 , pp. 1619-1632
    • Renehan, A.G.1    Yeh, H.C.2    Johnson, J.A.3    Wild, S.H.4    Gale, E.A.5    Moller, H.6
  • 115
    • 84863601615 scopus 로고    scopus 로고
    • Metformin for liver cancer prevention in patients with type 2 diabetes: A systematic review and meta-analysis
    • Zhang ZJ, Zheng ZJ, Shi R, Su Q, Jiang Q, Kip KE. Metformin for liver cancer prevention in patients with type 2 diabetes: a systematic review and meta-analysis. J Clin Endocrinol Metab 2012; 97: 2347-53.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 2347-2353
    • Zhang, Z.J.1    Zheng, Z.J.2    Shi, R.3    Su, Q.4    Jiang, Q.5    Kip, K.E.6
  • 117
    • 79955490053 scopus 로고    scopus 로고
    • Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types
    • Iliopoulos D, Hirsch HA, Struhl K. Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types. Cancer Res 2011; 71: 3196-201.
    • (2011) Cancer Res , vol.71 , pp. 3196-3201
    • Iliopoulos, D.1    Hirsch, H.A.2    Struhl, K.3
  • 118
    • 83355163333 scopus 로고    scopus 로고
    • Dual inhibition of tumor energy pathway by 2-deoxy glucose and metformin is effective against a broad spectrum of preclinical cancer models
    • Cheong JH, Park ES, Liang J, Dennison JB, Tsavachidou D, Nguyen-Charles C, et al. Dual inhibition of tumor energy pathway by 2-deoxy glucose and metformin is effective against a broad spectrum of preclinical cancer models. Mol Cancer Ther 2011; 10: 2350-62.
    • (2011) Mol Cancer Ther , vol.10 , pp. 2350-2362
    • Cheong, J.H.1    Park, E.S.2    Liang, J.3    Dennison, J.B.4    Tsavachidou, D.5    Nguyen-Charles, C.6
  • 119
    • 77950191479 scopus 로고    scopus 로고
    • Targeting cancer cell metabolism: The combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells
    • Ben SI, Laurent K, Giuliano S, Larbret F, Ponzio G, Gounon P, et al. Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells. Cancer Res 2010; 70: 2465-75.
    • (2010) Cancer Res , vol.70 , pp. 2465-2475
    • Ben, S.I.1    Laurent, K.2    Giuliano, S.3    Larbret, F.4    Ponzio, G.5    Gounon, P.6
  • 120
    • 80053640489 scopus 로고    scopus 로고
    • CD147 subunit of lactate/H +symporters MCT1 and hypoxiainducible MCT4 is critical for energetics and growth of glycolytic tumors
    • Le Floch R, Chiche J, Marchiq I, Naiken T, Ilk K, Murray C M, et al. CD147 subunit of lactate/H +symporters MCT1 and hypoxiainducible MCT4 is critical for energetics and growth of glycolytic tumors. Proc Natl Acad Sci U S A 2011; 108: 16663-8.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 16663-16668
    • Le Floch, R.1    Chiche, J.2    Marchiq, I.3    Naiken, T.4    Ilk, K.5    Murray, C.M.6
  • 122
    • 84866314550 scopus 로고    scopus 로고
    • Effect of dietary energy balance modulation on the ability of metformin to inhibit skin tumor promotion [abstract]
    • In: Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; 2012. Abstract nr 1010
    • Checkley A, Moore T, Rho O, DiGiovanni J. Effect of dietary energy balance modulation on the ability of metformin to inhibit skin tumor promotion [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; 2012. Abstract nr 1010.
    • (2012) Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research
    • Checkley, A.1    Moore, T.2    Rho, O.3    DiGiovanni, J.4


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