Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 29, 2014, Pages 10574-10579

  Janzer, Andreas ^a   German, Natalie J ^a   Gonzalez Herrera, Karina N ^a   Asara, John M ^b   Haigis, Marcia C ^a   Struhl, Kevin ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Cancer metabolism; Glycolysis; Metabolic profiling; Metabolism

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE; BIGUANIDE DERIVATIVE; GLYCEROPHOSPHATE; LACTIC ACID; METFORMIN; PHENFORMIN; PROTEIN TYROSINE KINASE; TAMOXIFEN; TRICARBOXYLIC ACID;

ARTICLE; BREAST CANCER; CANCER STEM CELL; CELL METABOLISM; CELL TRANSFORMATION; GLYCOLYSIS; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

CANCER METABOLISM; GLYCOLYSIS; METABOLIC PROFILING; METABOLISM;

AMINOIMIDAZOLE CARBOXAMIDE; BIGUANIDES; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CITRIC ACID CYCLE; ENDOPLASMIC RETICULUM; FOLIC ACID; GLYCEROPHOSPHATES; GLYCOLYSIS; HUMANS; LACTATES; METABOLOME; METFORMIN; NEOPLASTIC STEM CELLS; NUCLEOTIDES; PHENFORMIN; RIBONUCLEOTIDES; SRC-FAMILY KINASES; TAMOXIFEN;

EID: 84904686912     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1409844111     Document Type: Article

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