Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice

Diabetes

Volumn 60, Issue 6, 2011, Pages 1770-1778

  Xie, Zhonglin ^a   Lau, Kai ^b   Eby, Bonnie ^b   Lozano, Pedro ^b   He, Chaoyong ^a   Pennington, Becky ^b   Li, Hongliang ^a   Rathi, Shradha ^b   Dong, Yunzhou ^a   Tian, Rong ^c   Kem, David ^a,b   Zou, Ming Hui ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMP ACTIVATED PROTEIN KINASE ALPHA1; AMP ACTIVATED PROTEIN KINASE ALPHA2; BECLIN 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN; POLYUBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGY; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DIABETIC CARDIOMYOPATHY; DISEASE EXACERBATION; ENZYME ACTIVITY; ENZYME REPRESSION; GENE OVEREXPRESSION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CELL; HEART PROTECTION; IN VIVO STUDY; MALE; MORTALITY; MOUSE; MUSCLE FIBRIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; BLOTTING, WESTERN; CARDIOMYOPATHIES; ECHOCARDIOGRAPHY; HYPOGLYCEMIC AGENTS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; METFORMIN; MICE; MICROSCOPY, ELECTRON, TRANSMISSION; MYOCARDIUM; MYOCYTES, CARDIAC; TUBEROUS SCLEROSIS;

EID: 79959385996     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db10-0351     Document Type: Article

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