IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism

Cancer Research

Volumn 74, Issue 12, 2014, Pages 3317-3331

  Grassian, Alexandra R ^a,g   Parker, Seth J ^d   Davidson, Shawn M ^c   Divakaruni, Ajit S ^e   Green, Courtney R ^d   Zhang, Xiamei ^a   Slocum, Kelly L ^a   Pu, Minying ^a   Lin, Fallon ^a   Vickers, Chad ^a   Joud Caldwell, Carol ^a   Chung, Franklin ^a   Yin, Hong ^a   Handly, Erika D ^d   Straub, Christopher ^a   Growney, Joseph D ^a   Vander Heiden, Matthew G ^b,c   Murphy, Anne N ^e   Pagliarini, Raymond ^a   Metallo, Christian M ^d,f  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b KOCH INSTITUTE FOR INTEGRATIVE CANCER RESEARCH   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^e University of California San Diego   (United States)

^f UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^g EPIZYME INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CITRIC ACID; GLUTAMINE; ISOCITRATE DEHYDROGENASE 1; ISOCITRATE DEHYDROGENASE 2;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOXYLATION; CELL GROWTH; CELL HYPOXIA; CELL METABOLISM; CELL PROLIFERATION; CELLULAR STRESS RESPONSE; CITRIC ACID CYCLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVITY; ENZYME INHIBITION; GENE MUTATION; HUMAN; HUMAN CELL; IDH1 GENE; METABOLIC FLUX ANALYSIS; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PRIORITY JOURNAL; RESPIRATORY CHAIN;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL HYPOXIA; CITRIC ACID CYCLE; ENZYME INHIBITORS; GLUTAMINE; HCT116 CELLS; HUMANS; ISOCITRATE DEHYDROGENASE; MICE; MITOCHONDRIA; MUTATION, MISSENSE; OXIDATION-REDUCTION; STRESS, PHYSIOLOGICAL; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84903489573     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-14-0772-T     Document Type: Article

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