AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells

Journal of Biological Chemistry

Volumn 279, Issue 46, 2004, Pages 47898-47905

  Zang, Mengwei ^a   Zuccollo, Adriana ^a   Hou, Xiuyun ^a   Nagata, Daisuke ^a   Walsh, Kenneth ^a   Herscovitz, Haya ^a   Brecher, Peter ^a   Ruderman, Neil B ^a   Cohen, Richard A ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CELLS; CHOLESTEROL; DRUG PRODUCTS; ENZYME INHIBITION; INSULIN; LIPIDS; MUSCLE; PROTEINS;

HEPATIC LIPIDS; METFORMINS; PHOSPHORYLATION; SKELETAL MUSCLES;

ENZYME KINETICS;

ACETYL COENZYME A CARBOXYLASE; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; METFORMIN; SERINE; THREONINE; TRIACYLGLYCEROL;

ALPHA CHAIN; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME REGULATION; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; INSULIN RESISTANCE; LIPID LIVER LEVEL; LIPID STORAGE; LIVER CELL CULTURE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ACETYL-COA CARBOXYLASE; CELL LINE, TUMOR; ENZYME ACTIVATION; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; LIPID METABOLISM; LIVER; METFORMIN; MULTIENZYME COMPLEXES; PROTEIN SUBUNITS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECOMBINANT FUSION PROTEINS;

EID: 9144271181     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M408149200     Document Type: Article

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