Metformin inhibits mitochondrial permeability transition and cell death: A pharmacological in vitro study

Biochemical Journal

Volumn 382, Issue 3, 2004, Pages 877-884

  Guigas, Bruno ^a   Detaille, Dominique ^a   Chauvin, Christiane ^a   Batandier, Cécile ^a   De Oliveira, Frédéric ^a   Fontaine, Eric ^a   Leverve, Xavier ^a  

^a INSERM   (France)

Author keywords

Cell death; Complex 1; Metformin; Mitochondria; Oxidative stress; Permeability transition pore (PTP)

Indexed keywords

ANTIBIOTICS; CELLS; MECHANICAL PERMEABILITY; OXIDATION; PROBABILITY;

CELL DEATH; CELLULAR EFFECTS; METFORMIN; MITOCHONDRIAL PERMEABILITY TRANSITION;

DRUG DOSAGE;

CALCIUM; CYCLOSPORIN A; CYTOCHROME C; METFORMIN; PROPIDIUM IODIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); TERT BUTYL HYDROPEROXIDE; TRYPAN BLUE;

ARTICLE; CANCER CELL CULTURE; CELL DEATH; CELL MEMBRANE PERMEABILITY; CELL RESPIRATION; CELL STRAIN KB; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME RELEASE; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL;

CELL DEATH; CITRATE (SI)-SYNTHASE; CYTOCHROMES C; ELECTRON TRANSPORT COMPLEX I; HUMANS; HYPOGLYCEMIC AGENTS; INTRACELLULAR MEMBRANES; ION CHANNELS; KB CELLS; METFORMIN; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; OXYGEN CONSUMPTION; PERMEABILITY;

EID: 4744355266     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20040885     Document Type: Article

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