-
1
-
-
79960140546
-
Solute carrier transporters as targets for drug delivery and pharmacological intervention for chemotherapy
-
Nakanishi T, Tamai I. Solute carrier transporters as targets for drug delivery and pharmacological intervention for chemotherapy. J Pharm Sci 2011; 100: 3731-3750. doi:10.1002/jps.22576
-
(2011)
J Pharm Sci
, vol.100
, pp. 3731-3750
-
-
Nakanishi, T.1
Tamai, I.2
-
2
-
-
79955775731
-
Putative transport mechanism and intracellular fate of trans-1-amino-3-18 F-fluorocyclobutanecarboxylic acid in human prostate cancer
-
Okudaira H, Shikano N, Nishii R, et al. Putative transport mechanism and intracellular fate of trans-1-amino-3-18 F-fluorocyclobutanecarboxylic acid in human prostate cancer. J Nucl Med 2011; 52: 822-829. doi:10.2967/jnumed.110.086074
-
(2011)
J Nucl Med
, vol.52
, pp. 822-829
-
-
Okudaira, H.1
Shikano, N.2
Nishii, R.3
-
3
-
-
77954757238
-
Impact of system L amino acid transporter 1 (LAT1) on proliferation of human ovarian cancer cells: A possible target for combination therapy with anti-proliferative aminopeptidase inhibitors
-
Fan X, Ross DD, Arakawa H, Ganapathy V, Tamai I, Nakanishi T. Impact of system L amino acid transporter 1 (LAT1) on proliferation of human ovarian cancer cells: a possible target for combination therapy with anti-proliferative aminopeptidase inhibitors. Biochem Pharmacol 2010; 80: 811-818. doi:10.1016/j.bcp.2010.05.021
-
(2010)
Biochem Pharmacol
, vol.80
, pp. 811-818
-
-
Fan, X.1
Ross, D.D.2
Arakawa, H.3
Ganapathy, V.4
Tamai, I.5
Nakanishi, T.6
-
4
-
-
59049087460
-
Bidirectional transport of amino acids regulates mTOR and autophagy
-
Nicklin P, Bergman P, Zhang B, et al. Bidirectional transport of amino acids regulates mTOR and autophagy. Cell 2009; 136: 521-534. doi:10.1016/j. cell.2008.11.044
-
(2009)
Cell
, vol.136
, Issue.521-534
-
-
Nicklin, P.1
Bergman, P.2
Zhang, B.3
-
5
-
-
0030805221
-
Carrier- mediated transport of oligopeptides in the human fibrosarcoma cell line HT1080
-
Nakanishi T, Tamai I, Sai Y, Sasaki T, Tsuji A. Carrier- mediated transport of oligopeptides in the human fibrosarcoma cell line HT1080. Cancer Res 1997; 57: 4118-4122
-
(1997)
Cancer Res
, vol.57
, pp. 4118-4122
-
-
Nakanishi, T.1
Tamai, I.2
Sai, Y.3
Sasaki, T.4
Tsuji, A.5
-
6
-
-
0033813664
-
Cancer cell-targeted drug delivery utilizing oligopeptide transport activity
-
Nakanishi T, Tamai I, Takaki A, Tsuji A. Cancer cell-targeted drug delivery utilizing oligopeptide transport activity. Int J Cancer 2000; 88: 274-280. doi:10.1002/1097-0215(20001015)88:2274::aidijc20 3.0.co;2-5
-
(2000)
Int J Cancer
, vol.88
, pp. 274-280
-
-
Nakanishi, T.1
Tamai, I.2
Takaki, A.3
Tsuji, A.4
-
7
-
-
0032005174
-
An oligopeptide transporter is expressed at high levels in the pancreatic carcinoma cell lines AsPc-1 and Capan-2
-
Gonzalez DE, Covitz K-MY, SadeeW,Mrsny RJ. An oligopeptide transporter is expressed at high levels in the pancreatic carcinoma cell lines AsPc-1 and Capan-2. Cancer Res 1998; 58: 519-525
-
(1998)
Cancer Res
, vol.58
, pp. 519-525
-
-
Gonzalez, D.E.1
Covitz, K.-M.Y.2
Sadee, W.3
Mrsny, R.J.4
-
8
-
-
70350048926
-
Impact of OATP transporters on pharmacokinetics
-
Kalliokoski A, Niemi M. Impact of OATP transporters on pharmacokinetics. Br J Pharmacol 2009; 158: 693-705. doi:10.1111/j.1476-5381.2009.00430.x
-
(2009)
Br J Pharmacol
, vol.158
, pp. 693-705
-
-
Kalliokoski, A.1
Niemi, M.2
-
9
-
-
0037870111
-
Clinical role of FDG PET in evaluation of cancer patients
-
Kostakoglu L, Agress H Jr, Goldsmith SJ. Clinical role of FDG PET in evaluation of cancer patients. Radiographics 2003; 23: 315-340. doi:10.1148/ rg.232025705
-
(2003)
Radiographics
, vol.23
, pp. 315-340
-
-
Kostakoglu, L.1
Agress, H.2
Goldsmith, S.J.3
-
10
-
-
52549133776
-
Non-natural amino acids for tumor imaging using positron emission tomography and single photon emission computed tomography
-
McConathy J, Goodman M. Non-natural amino acids for tumor imaging using positron emission tomography and single photon emission computed tomography. Cancer Metastasis Rev 2008; 27: 555-573. doi:10.1007/s10555-008-9154-7
-
(2008)
Cancer Metastasis Rev
, vol.27
, pp. 555-573
-
-
McConathy, J.1
Goodman, M.2
-
11
-
-
42049085310
-
Cancer detection using a PET tracer, 11C-glycylsarcosine, targeted to H+/peptide transporter
-
Mitsuoka K, Miyoshi S, Kato Y, et al. Cancer detection using a PET tracer, 11C-glycylsarcosine, targeted to H+/peptide transporter. J Nucl Med 2008; 49: 615-622. doi:10.2967/jnumed.107.048231
-
(2008)
J Nucl Med
, vol.49
, pp. 615-622
-
-
Mitsuoka, K.1
Miyoshi, S.2
Kato, Y.3
-
12
-
-
57749111596
-
Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond
-
Ganapathy V, Thangaraju M, Prasad PD. Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond. Pharmacol Ther 2009; 121: 29-40. doi:10.1016/j.pharmthera.2008.09.005
-
(2009)
Pharmacol Ther
, vol.121
, pp. 29-40
-
-
Ganapathy, V.1
Thangaraju, M.2
Prasad, P.D.3
-
13
-
-
0028140393
-
Expression cloning of a rat liver Na(+)-independent organic anion transporter
-
Jacquemin E, Hagenbuch B, Stieger B, Wolkoff AW, Meier PJ. Expression cloning of a rat liver Na(+)-independent organic anion transporter. Proc Natl Acad Sci U S A 1994; 91: 133-137
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 133-137
-
-
Jacquemin, E.1
Hagenbuch, B.2
Stieger, B.3
Wolkoff, A.W.4
Meier, P.J.5
-
14
-
-
0037427972
-
The superfamily of organic anion transporting polypeptides
-
Hagenbuch B, Meier PJ. The superfamily of organic anion transporting polypeptides. Biochim Biophys Acta Biomembr 2003; 1609: 1-18. doi:10.1016/S0005-2736(02)00633-8
-
(2003)
Biochim Biophys Acta Biomembr
, vol.1609
, pp. 1-18
-
-
Hagenbuch, B.1
Meier, P.J.2
-
15
-
-
1242272736
-
Organic anion transporting polypeptides of the OATP/SLC21 family: Phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties
-
Hagenbuch B,Meier PJ.Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties. Pflugers Arch 2004; V447: 653-665. doi:10.1007/s00424-003-1168-y
-
(2004)
Pflugers Arch
, vol.447
, pp. 653-665
-
-
Hagenbuch, B.1
Meier, P.J.2
-
16
-
-
84857769037
-
Genetic polymorphisms of OATP transporters and their impact on intestinal absorption and hepatic disposition of drugs
-
Nakanishi T, Tamai I. Genetic polymorphisms of OATP transporters and their impact on intestinal absorption and hepatic disposition of drugs. Drug Metab Pharmacokinet 2012; 27: 106-121. doi:10.2133/dmpk.DMPK-11-RV-099
-
(2012)
Drug Metab Pharmacokinet
, vol.27
, pp. 106-121
-
-
Nakanishi, T.1
Tamai, I.2
-
17
-
-
78649656801
-
Uptake transporters of the human OATP family
-
Fromm MF, Kim RB, König J (eds) Springer: Berlin, Heidelberg
-
König J. Uptake transporters of the human OATP family. In Drug Transporters, Fromm MF, Kim RB, König J (eds). Springer: Berlin, Heidelberg, 2011; 1-28
-
(2011)
Drug Transporters
, pp. 1-28
-
-
König, J.1
-
18
-
-
79955017453
-
Long evolutionary conservation and considerable tissue specificity of several atypical solute carrier transporters
-
Sreedharan S, Stephansson O, Schioth HB, Fredriksson R. Long evolutionary conservation and considerable tissue specificity of several atypical solute carrier transporters. Gene 2011; 478: 11-18. doi:10.1016/j.gene.2010.10.011
-
(2011)
Gene
, vol.478
, pp. 11-18
-
-
Sreedharan, S.1
Stephansson, O.2
Schioth, H.B.3
Fredriksson, R.4
-
19
-
-
0040368659
-
Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1
-
Abe T, Kakyo M, Tokui T, et al. Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J Biol Chem 1999; 274: 17159-17163. doi:10.1074/jbc.274.24.17159
-
(1999)
J Biol Chem
, vol.274
, pp. 17159-17163
-
-
Abe, T.1
Kakyo, M.2
Tokui, T.3
-
20
-
-
0033601257
-
A novel human hepatic organic anion transporting polypeptide (OATP2)
-
Hsiang B, Zhu Y, Wang Z, et al. A novel human hepatic organic anion transporting polypeptide (OATP2). J Biol Chem 1999; 274: 37161-37168. doi:10.1074/jbc.274.52.37161
-
(1999)
J Biol Chem
, vol.274
, pp. 37161-37168
-
-
Hsiang, B.1
Zhu, Y.2
Wang, Z.3
-
21
-
-
0037733365
-
A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane
-
König J, Cui Y, Nies AT, Keppler D. A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. Am J Physiol Gastrointest Liver Physiol 2000; 278: G156-G164
-
(2000)
Am J Physiol Gastrointest Liver Physiol
, vol.278
, pp. G156-G164
-
-
König, J.1
Cui, Y.2
Nies, A.T.3
Keppler, D.4
-
22
-
-
0035125407
-
Organic anion-transporting polypeptide B (OATPB) and its functional comparison with three other OATPs of human liver
-
Kullak-Ublick GA, Ismair MG, Stieger B, et al. Organic anion-transporting polypeptide B (OATPB) and its functional comparison with three other OATPs of human liver. Gastroenterology 2001; 120: 525-533. doi:10.1053/gast.2001.21176
-
(2001)
Gastroenterology
, vol.120
, pp. 525-533
-
-
Kullak-Ublick, G.A.1
Ismair, M.G.2
Stieger, B.3
-
23
-
-
33646205286
-
Effects of organic anion transporting polypeptide 1B1 haplotype on pharmacokinetics of pravastatin, valsartan, and temocapril
-
Maeda K, Ieiri I, Yasuda K, et al. Effects of organic anion transporting polypeptide 1B1 haplotype on pharmacokinetics of pravastatin, valsartan, and temocapril. Clin Pharmacol Ther 2006; 79: 427-439. doi:10.1016/j.clpt.2006.01.011
-
(2006)
Clin Pharmacol Ther
, vol.79
, pp. 427-439
-
-
Maeda, K.1
Ieiri, I.2
Yasuda, K.3
-
24
-
-
58149313047
-
Identification and species similarity of OATP transporters responsible for hepatic uptake of beta-lactam antibiotics
-
Nakakariya M, Shimada T, Irokawa M, Maeda T, Tamai I. Identification and species similarity of OATP transporters responsible for hepatic uptake of beta-lactam antibiotics. Drug Metab Pharmacokinet 2008; 23: 347-355. doi:10.2133/ dmpk.23.347
-
(2008)
Drug Metab Pharmacokinet
, vol.23
, pp. 347-355
-
-
Nakakariya, M.1
Shimada, T.2
Irokawa, M.3
Maeda, T.4
Tamai, I.5
-
26
-
-
41549168190
-
Investigation of the inhibitory effects of various drugs on the hepatic uptake of fexofenadine in humans
-
Matsushima S, Maeda K, Ishiguro N, Igarashi T, Sugiyama Y. Investigation of the inhibitory effects of various drugs on the hepatic uptake of fexofenadine in humans. Drug Metab Dispos 2008; 36: 663-669. doi:10.1124/dmd.107.017814
-
(2008)
Drug Metab Dispos
, vol.36
, pp. 663-669
-
-
Matsushima, S.1
Maeda, K.2
Ishiguro, N.3
Igarashi, T.4
Sugiyama, Y.5
-
27
-
-
14044260589
-
Role of organic anion transporter OATP1B1 (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10-hydroxycamptothecin: In vitro evidence and effect of single nucleotide polymorphisms
-
Nozawa T, Minami H, Sugiura S, Tsuji A, Tamai I. Role of organic anion transporter OATP1B1 (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10-hydroxycamptothecin: in vitro evidence and effect of single nucleotide polymorphisms. Drug Metab Dispos 2005; 33: 434-439. doi:10.1124/dmd.104.001909
-
(2005)
Drug Metab Dispos
, vol.33
, pp. 434-439
-
-
Nozawa, T.1
Minami, H.2
Sugiura, S.3
Tsuji, A.4
Tamai, I.5
-
28
-
-
63949084512
-
Life-threatening toxicities in a patient with UGT1A16/28 and SLCO1B115/15 genotypes after irinotecanbased chemotherapy
-
Takane H, Kawamoto K, Sasaki T, et al. Life-threatening toxicities in a patient with UGT1A16/28 and SLCO1B1 15/15 genotypes after irinotecanbased chemotherapy. Cancer Chemother Pharmacol 2009; 63: 1165-1169. doi:10.1007/s00280-008-0864-x
-
(2009)
Cancer Chemother Pharmacol
, vol.63
, pp. 1165-1169
-
-
Takane, H.1
Kawamoto, K.2
Sasaki, T.3
-
29
-
-
0037218382
-
Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors
-
Wang X, Furukawa T, Nitanda T, et al. Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors. Mol Pharmacol 2003; 63: 65-72
-
(2003)
Mol Pharmacol
, vol.63
, pp. 65-72
-
-
Wang, X.1
Furukawa, T.2
Nitanda, T.3
-
30
-
-
59649117206
-
Methotrexate pharmacokinetics in transgenic mice with liver-specific expression of human organic anion-transporting polypeptide 1B1 (SLCO1B1
-
van de Steeg E, van der Kruijssen CMM, Wagenaar E, et al. Methotrexate pharmacokinetics in transgenic mice with liver-specific expression of human organic anion-transporting polypeptide 1B1 (SLCO1B1). Drug Metab Dispos 2009; 37: 277-281. doi:10.1124/dmd.108.024315
-
(2009)
Drug Metab Dispos
, vol.37
, pp. 277-281
-
-
Van De Steeg, E.1
Van Der Kruijssen Cmm2
Wagenaar, E.3
-
31
-
-
33644543341
-
Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics
-
Katz DA, Carr R, Grimm DR, et al. Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics. Clin Pharmacol Ther 2006; 79: 186-196
-
(2006)
Clin Pharmacol Ther
, vol.79
, pp. 186-196
-
-
Katz, D.A.1
Carr, R.2
Grimm, D.R.3
-
32
-
-
0035006408
-
LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers
-
Abe T, Unno M, Onogawa T, et al. LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology 2001; 120: 1689-1699
-
(2001)
Gastroenterology
, vol.120
, pp. 1689-1699
-
-
Abe, T.1
Unno, M.2
Onogawa, T.3
-
33
-
-
0034725617
-
Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide
-
König J, CuiY,NiesAT, KepplerD. Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. J Biol Chem 2000; 275: 23161-23168. doi:10.1074/jbc.M001448200
-
(2000)
J Biol Chem
, vol.275
, pp. 23161-23168
-
-
König, J.1
Cui, Y.2
Nies, A.T.3
Keppler, D.4
-
34
-
-
4644364576
-
Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans
-
Hirano M, Maeda K, Shitara Y, Sugiyama Y. Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans. J Pharmacol Exp Ther 2004; 311: 139-146. doi:10.1124/jpet.104.068056
-
(2004)
J Pharmacol Exp Ther
, vol.311
, pp. 139-146
-
-
Hirano, M.1
Maeda, K.2
Shitara, Y.3
Sugiyama, Y.4
-
35
-
-
3242765929
-
Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8
-
Letschert K, Keppler D, König J. Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8). Pharmacogenetics 2004; 14: 441-452
-
(2004)
Pharmacogenetics
, vol.14
, pp. 441-452
-
-
Letschert, K.1
Keppler, D.2
König, J.3
-
36
-
-
50349085911
-
Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in caucasian patients with androgen-independent prostatic cancer
-
Hamada A, Sissung T, Price DK, et al. Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in caucasian patients with androgen-independent prostatic cancer. Clin Cancer Res 2008; 14: 3312-3318. doi:10.1158/1078- 0432.ccr-07-4118
-
(2008)
Clin Cancer Res
, vol.14
, pp. 3312-3318
-
-
Hamada, A.1
Sissung, T.2
Price, D.K.3
-
37
-
-
0034754481
-
Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver
-
Ismair MG, Stieger B, Cattori V, et al. Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver. Gastroenterology 2001; 121: 1185-1190
-
(2001)
Gastroenterology
, vol.121
, pp. 1185-1190
-
-
Ismair, M.G.1
Stieger, B.2
Cattori, V.3
-
38
-
-
0034709561
-
Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family
-
Tamai I, Nezu J-I, Uchino H, et al. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun 2000; 273: 251-260. doi:10.1006/bbrc.2000.2922
-
(2000)
Biochem Biophys Res Commun
, vol.273
, pp. 251-260
-
-
Tamai, I.1
Nezu, J.-I.2
Uchino, H.3
-
39
-
-
0038637144
-
Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane
-
Kobayashi D, Nozawa T, Imai K, Nezu J-I, Tsuji A, Tamai I. Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane. J Pharmacol Exp Ther 2003; 306: 703-708. doi:10.1124/jpet.103.051300
-
(2003)
J Pharmacol Exp Ther
, vol.306
, pp. 703-708
-
-
Kobayashi, D.1
Nozawa, T.2
Imai, K.3
Nezu, J.-I.4
Tsuji, A.5
Tamai, I.6
-
40
-
-
12344333505
-
Localization of organic anion transporting polypeptides in the rat and human ciliary body epithelium
-
Gao B, Huber RD, Wenzel A, et al. Localization of organic anion transporting polypeptides in the rat and human ciliary body epithelium. Exp Eye Res 2005; 80: 61-72. doi:10.1016/j.exer.2004.08.013
-
(2005)
Exp Eye Res
, vol.80
, pp. 61-72
-
-
Gao, B.1
Huber, R.D.2
Wenzel, A.3
-
41
-
-
84859712703
-
Oral drug delivery utilizing intestinal OATP transporters
-
Tamai I. Oral drug delivery utilizing intestinal OATP transporters. Adv Drug Deliv Rev 2012; 64: 508-514. doi:10.1016/j.addr.2011.07.007
-
(2012)
Adv Drug Deliv Rev
, vol.64
, pp. 508-514
-
-
Tamai, I.1
-
42
-
-
33845524038
-
Organic anion transporting polypeptide 2B1 is a high-affinity transporter for atorvastatin and is expressed in the human heart
-
Grube M, Kock K, Oswald S, et al. Organic anion transporting polypeptide 2B1 is a high-affinity transporter for atorvastatin and is expressed in the human heart. Clin Pharmacol Ther 2006; 80: 607-620. doi:10.1016/j.clpt.2006.09.010
-
(2006)
Clin Pharmacol Ther
, vol.80
, pp. 607-620
-
-
Grube, M.1
Kock, K.2
Oswald, S.3
-
43
-
-
0029091022
-
Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver
-
Kullak-Ublick GA, Hagenbuch B, Stieger B, et al. Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology 1995; 109: 1274-1282. doi:10.1016/0016-5085(95)90588-X
-
(1995)
Gastroenterology
, vol.109
, pp. 1274-1282
-
-
Kullak-Ublick, G.A.1
Hagenbuch, B.2
Stieger, B.3
-
44
-
-
77957903556
-
Influence of the flavonoids apigenin, kaempferol, and quercetin on the function of organic anion transporting polypeptides 1A2 and 2B1
-
Mandery K, Bujok K, Schmidt I, et al. Influence of the flavonoids apigenin, kaempferol, and quercetin on the function of organic anion transporting polypeptides 1A2 and 2B1. Biochem Pharmacol 2010; 80: 1746-1753. doi:10.1016/j.bcp.2010.08.008
-
(2010)
Biochem Pharmacol
, vol.80
, pp. 1746-1753
-
-
Mandery, K.1
Bujok, K.2
Schmidt, I.3
-
45
-
-
33847662941
-
Intestinal drug transporter expression and the impact of grapefruit juice in humans
-
Glaeser H, Bailey DG, Dresser GK, et al. Intestinal drug transporter expression and the impact of grapefruit juice in humans. Clin Pharmacol Ther 2007; 81: 362-370. doi:10.1038/sj.clpt.6100056
-
(2007)
Clin Pharmacol Ther
, vol.81
, pp. 362-370
-
-
Glaeser, H.1
Bailey, D.G.2
Dresser, G.K.3
-
46
-
-
84883017256
-
LC-MS/MS-based quantification of clinically relevant intestinal uptake and efflux transporter proteins
-
Groer C, Bruck S, Lai Y, et al. LC-MS/MS-based quantification of clinically relevant intestinal uptake and efflux transporter proteins. J Pharm Biomed Anal 2013; 85: 253-261. doi:10.1016/j.jpba.2013.07.031
-
(2013)
J Pharm Biomed Anal
, vol.85
, pp. 253-261
-
-
Groer, C.1
Bruck, S.2
Lai, Y.3
-
47
-
-
0033932502
-
Organic aniontransporting polypeptides mediate transport of opioid peptides across blood-brain barrier
-
Gao B, Hagenbuch B, Kullak-Ublick GA, Benke D, Aguzzi A, Meier PJ. Organic aniontransporting polypeptides mediate transport of opioid peptides across blood-brain barrier. J Pharmacol Exp Ther 2000; 294: 73-79
-
(2000)
J Pharmacol Exp Ther
, vol.294
, pp. 73-79
-
-
Gao, B.1
Hagenbuch, B.2
Kullak-Ublick, G.A.3
Benke, D.4
Aguzzi, A.5
Meier, P.J.6
-
48
-
-
0036793106
-
Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter
-
Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, Meier PJ. Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol 2002; 16: 2283-2296. doi:10.1210/me.2001-0309
-
(2002)
Mol Endocrinol
, vol.16
, pp. 2283-2296
-
-
Pizzagalli, F.1
Hagenbuch, B.2
Stieger, B.3
Klenk, U.4
Folkers, G.5
Meier, P.J.6
-
49
-
-
0029739973
-
Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT
-
Lu R, Kanai N, Bao Y, Schuster VL. Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT). J Clin Invest 1996; 98: 1142-1149. doi:10.1172/JCI118897
-
(1996)
J Clin Invest
, vol.98
, pp. 1142-1149
-
-
Lu, R.1
Kanai, N.2
Bao, Y.3
Schuster, V.L.4
-
50
-
-
0036080556
-
Prostaglandin transporter PGT is expressed in cell types that synthesize and release prostanoids
-
Bao Y, Pucci ML, Chan BS, Lu R, Ito S, Schuster VL. Prostaglandin transporter PGT is expressed in cell types that synthesize and release prostanoids. Am J Physiol Renal Physiol 2002; 282: F1103-F1110. doi:10.1152/ajprenal.00152.2001
-
(2002)
Am J Physiol Renal Physiol
, vol.282
, pp. F1103-F1110
-
-
Bao, Y.1
Pucci, M.L.2
Chan, B.S.3
Lu, R.4
Ito, S.5
Schuster, V.L.6
-
51
-
-
1842532964
-
The twostep model of prostaglandin signal termination: In vitro reconstitution with the prostaglandin transporter and prostaglandin 15 dehydrogenase
-
Nomura T, Lu R, Pucci ML, Schuster VL. The twostep model of prostaglandin signal termination: in vitro reconstitution with the prostaglandin transporter and prostaglandin 15 dehydrogenase. Mol Pharmacol 2004; 65: 973-978. doi:10.1124/mol.65.4.973
-
(2004)
Mol Pharmacol
, vol.65
, pp. 973-978
-
-
Nomura, T.1
Lu, R.2
Pucci, M.L.3
Schuster, V.L.4
-
52
-
-
84878801522
-
A role of prostaglandin transporter in regulating PGE2 release from human bronchial epithelial BEAS-2B cells in response to LPS
-
Shirasaka Y, Shichiri M, Kasai T, et al. A role of prostaglandin transporter in regulating PGE2 release from human bronchial epithelial BEAS-2B cells in response to LPS. J Endocrinol 2013; 217: 265-274. doi:10.1530/JOE-12-0339
-
(2013)
J Endocrinol
, vol.217
, pp. 265-274
-
-
Shirasaka, Y.1
Shichiri, M.2
Kasai, T.3
-
53
-
-
0037289789
-
Active influx transport is mediated by members of the organic anion transporting polypeptide family in human epidermal keratinocytes
-
Schiffer R, Neis M, Holler D, et al. Active influx transport is mediated by members of the organic anion transporting polypeptide family in human epidermal keratinocytes. J Invest Dermatol 2003; 120: 285-291. doi:10.1046/j.1523-1747.2003.12031.x
-
(2003)
J Invest Dermatol
, vol.120
, pp. 285-291
-
-
Schiffer, R.1
Neis, M.2
Holler, D.3
-
54
-
-
0242497239
-
Molecular characterization of human and rat organic anion transporter OATP-D
-
Adachi H, Suzuki T, Abe M, et al. Molecular characterization of human and rat organic anion transporter OATP-D. Am J Physiol Renal Physiol 2003; 285: F1188-F1197. doi:10.1152/ajprenal.00402.2002
-
(2003)
Am J Physiol Renal Physiol
, vol.285
, pp. F1188-F1197
-
-
Adachi, H.1
Suzuki, T.2
Abe, M.3
-
55
-
-
33847069574
-
Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain
-
Huber RD, Gao B, Pfandler MS, et al. Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain. Am J Physiol Cell Physiol 2007; 292: C795-C806. doi:10.1152/ajpcell.00597.2005
-
(2007)
Am J Physiol Cell Physiol
, vol.292
, pp. C795-C806
-
-
Huber, R.D.1
Gao, B.2
Pfandler, M.S.3
-
56
-
-
17744376593
-
Identification of thyroid hormone transporters in humans: Different molecules are involved in a tissue-specific manner
-
Fujiwara K, Adachi H, Nishio T, et al. Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. Endocrinology 2001; 142: 2005-2012. doi:10.1210/en.142.5.2005
-
(2001)
Endocrinology
, vol.142
, pp. 2005-2012
-
-
Fujiwara, K.1
Adachi, H.2
Nishio, T.3
-
57
-
-
0037586412
-
Expression of organic anion transporting polypeptide e (OATP-E) in human placenta
-
Sato K, Sugawara J, Sato T, et al. Expression of organic anion transporting polypeptide E (OATP-E) in human placenta. Placenta 2003; 24: 144-148
-
(2003)
Placenta
, vol.24
, pp. 144-148
-
-
Sato, K.1
Sugawara, J.2
Sato, T.3
-
58
-
-
12144288563
-
Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney
-
cMikkaichi T, Suzuki T, Onogawa T, et al. Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci U S A 2004; 101: 3569-3574. doi:10.1073/pnas.0304987101
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 3569-3574
-
-
Mikkaichi, T.1
Suzuki, T.2
Onogawa, T.3
-
59
-
-
72049086464
-
SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation
-
Toyohara T, Suzuki T, Morimoto R, et al. SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation. J Am Soc Nephrol 2009; 20: 2546-2555. doi:10.1681/ASN.2009070696
-
(2009)
J Am Soc Nephrol
, vol.20
, pp. 2546-2555
-
-
Toyohara, T.1
Suzuki, T.2
Morimoto, R.3
-
60
-
-
54049145153
-
Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters
-
Okabe M, Szakacs G, Reimers MA, et al. Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters. Mol Cancer Ther 2008; 7: 3081-3091. doi:10.1158/ 1535-7163.mct-08-0539
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 3081-3091
-
-
Okabe, M.1
Szakacs, G.2
Reimers, M.A.3
-
61
-
-
70449371196
-
Different expression patterns of organic anion transporting polypeptides in osteosarcomas, bone metastases and aneurysmal bone cysts
-
Iedauer R, Svoboda M, Wlcek K, et al. Different expression patterns of organic anion transporting polypeptides in osteosarcomas, bone metastases and aneurysmal bone cysts. Oncol Rep 2009; 22: 1485-1492
-
(2009)
Oncol Rep
, vol.22
, pp. 1485-1492
-
-
Iedauer, R.1
Svoboda, M.2
Wlcek, K.3
-
62
-
-
58149161886
-
Altered expression of organic anion transporter polypeptide (OATP) genes in human breast carcinoma
-
Wlcek K, Svoboda M, Sellner F, Krupitza G, Jaeger W, Thalhammer T. Altered expression of organic anion transporter polypeptide (OATP) genes in human breast carcinoma. Cancer Biol Ther 2008; 7: 1450-1455
-
(2008)
Cancer Biol Ther
, vol.7
, pp. 1450-1455
-
-
Wlcek, K.1
Svoboda, M.2
Sellner, F.3
Krupitza, G.4
Jaeger, W.5
Thalhammer, T.6
-
63
-
-
84893421449
-
Organic anion transporting polypeptide 5A1 (OATP5A1) in small cell lung cancer (SCLC) cells: Possible involvement in chemoresistance to satraplatin
-
Olszewski-Hamilton U, Svoboda M, Thalhammer T, Buxhofer-Ausch V, Geissler K, Hamilton G. Organic anion transporting polypeptide 5A1 (OATP5A1) in small cell lung cancer (SCLC) cells: possible involvement in chemoresistance to satraplatin. Biomark Cancer 2011; 3: 31-40. doi:10.4137/BIC.S7151
-
(2011)
Biomark Cancer
, vol.3
, pp. 31-40
-
-
Olszewski-Hamilton, U.1
Svoboda, M.2
Thalhammer, T.3
Buxhofer-Ausch, V.4
Geissler, K.5
Hamilton, G.6
-
64
-
-
79952783538
-
The analysis of organic anion transporting polypeptide (OATP) mRNA and protein patterns in primary and metastatic liver cancer
-
Wlcek K, Svoboda M, Riha J, et al. The analysis of organic anion transporting polypeptide (OATP) mRNA and protein patterns in primary and metastatic liver cancer. Cancer Biol Ther 2011; 11: 801-811
-
(2011)
Cancer Biol Ther
, vol.11
, pp. 801-811
-
-
Wlcek, K.1
Svoboda, M.2
Riha, J.3
-
65
-
-
84893406370
-
Characterization of SLCO5A1/OATP5A1, a solute carrier transport protein with non-classical function
-
Sebastian K, Detro-Dassen S, Rinis N, et al. Characterization of SLCO5A1/OATP5A1, a solute carrier transport protein with non-classical function. PLoS One 2013; 8: e83257. doi:10.1371/journal. pone.0083257
-
(2013)
PLoS One
, vol.8
, pp. e83257
-
-
Sebastian, K.1
Detro-Dassen, S.2
Rinis, N.3
-
66
-
-
12444339784
-
Identification and characterization of novel rat and human gonad-specific organic anion transporters
-
Suzuki T, Onogawa T, Asano N, et al. Identification and characterization of novel rat and human gonad-specific organic anion transporters. Mol Endocrinol 2003; 17: 1203-1215. doi:10.1210/ me.2002-0304
-
(2003)
Mol Endocrinol
, vol.17
, pp. 1203-1215
-
-
Suzuki, T.1
Onogawa, T.2
Asano, N.3
-
67
-
-
12344334809
-
Identification of the gonad-specific anion transporter SLCO6A1 as a cancer/testis (CT) antigen expressed in human lung cancer
-
Lee SY,Williamson B, Caballero OL, et al. Identification of the gonad-specific anion transporter SLCO6A1 as a cancer/testis (CT) antigen expressed in human lung cancer. Cancer Immun 2004; 4: 13
-
(2004)
Cancer Immun
, vol.4
, pp. 13
-
-
Lee Sywilliamson, B.1
Caballero, O.L.2
-
69
-
-
17044428337
-
Steroid sulfatase: Molecular biology, regulation, and inhibition
-
Reed MJ, Purohit A,Woo LWL, Newman SP, Potter BVL. Steroid sulfatase: molecular biology, regulation, and inhibition. Endocr Rev 2005; 26: 171-202. doi:10.1210/er.2004-0003
-
(2005)
Endocr Rev
, vol.26
, pp. 171-202
-
-
Reed, M.J.1
Awoo Lwl, P.2
Newman, S.P.3
Bvl, P.4
-
70
-
-
0031027687
-
Characterization of structural and functional properties of human 17 beta-hydroxysteroid dehydrogenase type 1 using recombinant enzymes and site-directed mutagenesis
-
Puranen T, Poutanen M, Ghosh D, Vihko P, Vihko R. Characterization of structural and functional properties of human 17 beta-hydroxysteroid dehydrogenase type 1 using recombinant enzymes and site-directed mutagenesis. Mol Endocrinol 1997; 11: 77-86
-
(1997)
Mol Endocrinol
, vol.11
, pp. 77-86
-
-
Puranen, T.1
Poutanen, M.2
Ghosh, D.3
Vihko, P.4
Vihko, R.5
-
71
-
-
0036924550
-
Systemic distribution of steroid sulfatase and estrogen sulfotransferase in human adult and fetal tissues
-
Miki Y, Nakata T, Suzuki T, et al. Systemic distribution of steroid sulfatase and estrogen sulfotransferase in human adult and fetal tissues. J Clin Endocrinol Metab 2002; 87: 5760-5768
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 5760-5768
-
-
Miki, Y.1
Nakata, T.2
Suzuki, T.3
-
72
-
-
0015323450
-
Estrone sulfate: Production rate and metabolism in man
-
Ruder HJ, Loriaux L, Lipsett MB. Estrone sulfate: production rate and metabolism in man. J Clin Invest 1972; 51: 1020-1033. doi:10.1172/JCI106862
-
(1972)
J Clin Invest
, vol.51
, pp. 1020-1033
-
-
Ruder, H.J.1
Loriaux, L.2
Lipsett, M.B.3
-
73
-
-
0034210051
-
Elevated steroid sulfatase expression in breast cancers
-
Utsumi T, Yoshimura N, Takeuchi S, Maruta M, Maeda K, Harada N. Elevated steroid sulfatase expression in breast cancers. J Steroid Biochem Mol Biol 2000; 73: 141-145
-
(2000)
J Steroid Biochem Mol Biol
, vol.73
, pp. 141-145
-
-
Utsumi, T.1
Yoshimura, N.2
Takeuchi, S.3
Maruta, M.4
Maeda, K.5
Harada, N.6
-
74
-
-
0038175996
-
High expression of steroid sulfatase mRNA predicts poor prognosis in patients with estrogen receptorpositive breast cancer
-
Miyoshi Y, Ando A, Hasegawa S, et al. High expression of steroid sulfatase mRNA predicts poor prognosis in patients with estrogen receptorpositive breast cancer. Clin Cancer Res 2003; 9: 2288-2293
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2288-2293
-
-
Miyoshi, Y.1
Ando, A.2
Hasegawa, S.3
-
75
-
-
7044253796
-
Intratumoural mRNA expression of genes from the oestradiol metabolic pathway and clinical and histopathological parameters of breast cancer
-
Yoshimura N, Harada N, Bukholm I, Karesen R, Borresen-Dale AL, Kristensen VN. Intratumoural mRNA expression of genes from the oestradiol metabolic pathway and clinical and histopathological parameters of breast cancer. Breast Cancer Res 2004; 6: R46-R55. doi:10.1186/bcr746
-
(2004)
Breast Cancer Res
, vol.6
, pp. R46-R55
-
-
Yoshimura, N.1
Harada, N.2
Bukholm, I.3
Karesen, R.4
Borresen-Dale, A.L.5
Kristensen, V.N.6
-
76
-
-
10044292945
-
Involvement of estrone-3-sulfate transporters in proliferation of hormone-dependent breast cancer cells
-
Nozawa T, Suzuki M, Takahashi K, et al. Involvement of estrone-3-sulfate transporters in proliferation of hormone-dependent breast cancer cells. J Pharmacol Exp Ther 2004; 311: 1032-1037. doi:10.1124/jpet.104.071522
-
(2004)
J Pharmacol Exp Ther
, vol.311
, pp. 1032-1037
-
-
Nozawa, T.1
Suzuki, M.2
Takahashi, K.3
-
77
-
-
25144466905
-
Suppression of cell proliferation by inhibition of estrone-3-sulfate transporter in estrogen-dependent breast cancer cells
-
Nozawa T, Suzuki M, Yabuuchi H, Irokawa M, Tsuji A, Tamai I. Suppression of cell proliferation by inhibition of estrone-3-sulfate transporter in estrogen-dependent breast cancer cells. Pharm Res 2005; 22: 1634-1641. doi:10.1007/s11095-005- 7096-0
-
(2005)
Pharm Res
, vol.22
, pp. 1634-1641
-
-
Nozawa, T.1
Suzuki, M.2
Yabuuchi, H.3
Irokawa, M.4
Tsuji, A.5
Tamai, I.6
-
78
-
-
31644436285
-
Expression of the steroid and xenobiotic receptor and its possible target gene, organic anion transporting polypeptide-A, in human breast carcinoma
-
Miki Y, Suzuki T, Kitada K, et al. Expression of the steroid and xenobiotic receptor and its possible target gene, organic anion transporting polypeptide-A, in human breast carcinoma. Cancer Res 2006; 66: 535-542. doi:10.1158/0008-5472. can-05-1070
-
(2006)
Cancer Res
, vol.66
, pp. 535-542
-
-
Miki, Y.1
Suzuki, T.2
Kitada, K.3
-
79
-
-
56449083452
-
Interplay between the nuclear receptor pregnane X receptor and the uptake transporter organic anion transporter polypeptide 1A2 selectively enhances estrogen effects in breast cancer
-
Meyer zu Schwabedissen HE, Tirona RG, Yip CS, Ho RH, Kim RB. Interplay between the nuclear receptor pregnane X receptor and the uptake transporter organic anion transporter polypeptide 1A2 selectively enhances estrogen effects in breast cancer. Cancer Res 2008; 68: 9338-9347. doi:10.1158/0008-5472.can-08-0265
-
(2008)
Cancer Res
, vol.68
, pp. 9338-9347
-
-
Meyer Zu Schwabedissen, H.E.1
Tirona, R.G.2
Yip, C.S.3
Ho, R.H.4
Kim, R.B.5
-
80
-
-
84864149247
-
Differential role of organic anion-transporting polypeptides in estrone-3-sulphate uptake by breast epithelial cells and breast cancer cells
-
Banerjee N, Allen C, Bendayan R. Differential role of organic anion-transporting polypeptides in estrone-3-sulphate uptake by breast epithelial cells and breast cancer cells. J Pharmacol Exp Ther 2012; 342: 510-519. doi:10.1124/jpet.112.192344
-
(2012)
J Pharmacol Exp Ther
, vol.342
, pp. 510-519
-
-
Banerjee, N.1
Allen, C.2
Bendayan, R.3
-
81
-
-
0041381393
-
Identification of steroid sulfate transport processes in the human mammary gland
-
Pizzagalli F, Varga Z, Huber RD, Folkers G, Meier PJ, St-Pierre MV. Identification of steroid sulfate transport processes in the human mammary gland. J Clin Endocrinol Metab 2003; 88: 3902-3912. doi:10.1210/jc.2003-030174
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 3902-3912
-
-
Pizzagalli, F.1
Varga, Z.2
Huber, R.D.3
Folkers, G.4
Meier, P.J.5
St-Pierre, M.V.6
-
82
-
-
77957272593
-
Uptake transporter organic anion transporting polypeptide 1B3 contributes to the growth of estrogen-dependent breast cancer
-
Maeda T, Irokawa M, Arakawa H, et al. Uptake transporter organic anion transporting polypeptide 1B3 contributes to the growth of estrogen-dependent breast cancer. J Steroid Biochem Mol Biol 2010; 122: 180-185. doi:10.1016/j.jsbmb.2010.06.014
-
(2010)
J Steroid Biochem Mol Biol
, vol.122
, pp. 180-185
-
-
Maeda, T.1
Irokawa, M.2
Arakawa, H.3
-
83
-
-
84878091737
-
Estrone-3-sulphate, a potential novel ligand for targeting breast cancers
-
Banerjee N, Fonge H, Mikhail A, Reilly RM, Bendayan R, Allen C. Estrone-3-sulphate, a potential novel ligand for targeting breast cancers. PLoS One 2013; 8: e64069. doi:10.1371/ journal.pone.0064069
-
(2013)
PLoS One
, vol.8
, pp. e64069
-
-
Banerjee, N.1
Fonge, H.2
Mikhail, A.3
Reilly, R.M.4
Bendayan, R.5
Allen, C.6
-
84
-
-
78650989996
-
Polymorphisms of the nuclear receptor pregnane X receptor and organic anion transporter polypeptides 1A2, 1B1, 1B3, and 2B1 are not associated with breast cancer risk
-
Justenhoven C, Schaeffeler E, Winter S, et al. Polymorphisms of the nuclear receptor pregnane X receptor and organic anion transporter polypeptides 1A2, 1B1, 1B3, and 2B1 are not associated with breast cancer risk. Breast Cancer Res Treat 2011; 125: 563-569. doi:10.1007/s10549- 010-1046-1
-
(2011)
Breast Cancer Res Treat
, vol.125
, pp. 563-569
-
-
Justenhoven, C.1
Schaeffeler, E.2
Winter, S.3
-
85
-
-
33845942044
-
The role of STS and OATP-B mRNA expression in predicting the clinical outcome in human breast cancer
-
Al SW, Mokbel R, Salhab M, Jiang W, Reed M, Mokbel K. The role of STS and OATP-B mRNA expression in predicting the clinical outcome in human breast cancer. Anticancer Res 2006; 26: 4985-4990
-
(2006)
Anticancer Res
, vol.26
, pp. 4985-4990
-
-
Al, S.W.1
Mokbel, R.2
Salhab, M.3
Jiang, W.4
Reed, M.5
Mokbel, K.6
-
86
-
-
79952757686
-
Expression and localization of the uptake transporters OATP2B1 OATP3A1 and OATP5A1 in non-malignant and malignant breast tissue
-
Kindla J, Rau TT, Jung R, et al. Expression and localization of the uptake transporters OATP2B1, OATP3A1 and OATP5A1 in non-malignant and malignant breast tissue. Cancer Biol Ther 2011; 11: 584-591. DOI: 10.4161/cbt.11.6.14533
-
(2011)
Cancer Biol Ther
, vol.11
, pp. 584-591
-
-
Kindla, J.1
Rau, T.T.2
Jung, R.3
-
87
-
-
34548165578
-
Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma
-
Muto M, Onogawa T, Suzuki T, et al. Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma. Cancer Sci 2007; 98: 1570-1576. doi:10.1111/j.1349-7006.2007.00570.x
-
(2007)
Cancer Sci
, vol.98
, pp. 1570-1576
-
-
Muto, M.1
Onogawa, T.2
Suzuki, T.3
-
88
-
-
34447551019
-
Hormonal therapy for prostate cancer
-
Brawer MK. Hormonal therapy for prostate cancer. Rev Urol 2006; 8: S35-S47
-
(2006)
Rev Urol
, vol.8
, pp. S35-S47
-
-
Brawer, M.K.1
-
89
-
-
79951511609
-
Blockade of testicular and adrenal androgens in prostate cancer treatment
-
Labrie F. Blockade of testicular and adrenal androgens in prostate cancer treatment. Nat Rev Urol 2011; 8: 73-85. doi:10.1038/nrurol.2010.231
-
(2011)
Nat Rev Urol
, vol.8
, pp. 73-85
-
-
Labrie, F.1
-
90
-
-
0033655573
-
Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes
-
LeCluyse EL, Madan A, Hamilton G, Carroll K, DeHaan R, Parkinson A. Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes. J Biochem Mol Toxicol 2000; 14: 177-188. doi: 10.1002/(sici)1099-0461(2000)144177::aid-jbt13.0.co;2-4
-
J Biochem Mol Toxicol 2000
, vol.14
, pp. 177-188
-
-
Lecluyse, E.L.1
Madan, A.2
Hamilton, G.3
Carroll, K.4
Dehaan, R.5
Parkinson, A.6
-
91
-
-
0029011116
-
Mutation of the androgen-receptor gene in metastatic androgenindependent prostate cancer
-
Taplin M-E, Bubley GJ, Shuster TD, et al. Mutation of the androgen-receptor gene in metastatic androgenindependent prostate cancer.NEng JMed 1995; 332: 1393-1398. doi:10.1056/NEJM199505253322101
-
(1995)
NEng JMed
, vol.332
, pp. 1393-1398
-
-
Taplin, M.-E.1
Bubley, G.J.2
Shuster, T.D.3
-
92
-
-
0035496220
-
The development of androgen-independent prostate cancer
-
Feldman BJ, Feldman D. The development of androgen-independent prostate cancer. Nat Rev Cancer 2001; 1: 34-45
-
(2001)
Nat Rev Cancer
, vol.1
, pp. 34-45
-
-
Feldman, B.J.1
Feldman, D.2
-
93
-
-
79955781090
-
Expression of SLCO transport genes in castrationresistant prostate cancer and impact of genetic variation in SLCO1B3 and SLCO2B1 on prostate cancer outcomes
-
Wright JL, Kwon EM, Ostrander EA, et al. Expression of SLCO transport genes in castrationresistant prostate cancer and impact of genetic variation in SLCO1B3 and SLCO2B1 on prostate cancer outcomes. Cancer Epidemiol Biomarkers Prev 2011; 20: 619-627. doi:10.1158/1055-9965.epi-10-1023
-
(2011)
Cancer Epidemiol Biomarkers Prev
, vol.20
, pp. 619-627
-
-
Wright, J.L.1
Kwon, E.M.2
Ostrander, E.A.3
-
94
-
-
79956268032
-
Expression of OATP family members in hormone-related cancers: Potential markers of progression
-
Pressler H, Sissung TM, Venzon D, Price DK, Figg WD. Expression of OATP family members in hormone-related cancers: potential markers of progression. PLoS One 2011; 6: e20372. doi:10.1371/journal.pone.0020372
-
(2011)
PLoS One
, vol.6
, pp. e20372
-
-
Pressler, H.1
Sissung, T.M.2
Venzon, D.3
Price, D.K.4
Figg, W.D.5
-
95
-
-
79959294088
-
SLCO2B1 and SLCO1B3 may determine time to progression for patients receiving androgen deprivation therapy for prostate cancer
-
Yang M, Xie W, Mostaghel E, et al. SLCO2B1 and SLCO1B3 may determine time to progression for patients receiving androgen deprivation therapy for prostate cancer. J Clin Oncol 2011; 29: 2565-2573. doi:10.1200/JCO.2010.31.2405
-
(2011)
J Clin Oncol
, vol.29
, pp. 2565-2573
-
-
Yang, M.1
Xie, W.2
Mostaghel, E.3
-
96
-
-
0032513049
-
Dehydroepiandrosterone sulfate (DHEAS): Identification of a carrier protein in human liver and brain
-
Kullak-Ublick G-A, Fisch T, Oswald M, et al. Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain. FEBS Lett 1998; 424: 173-176. doi:10.1016/ s0014-5793(98)00168-9
-
(1998)
FEBS Lett
, vol.424
, pp. 173-176
-
-
Kullak-Ublick, G.-A.1
Fisch, T.2
Oswald, M.3
-
97
-
-
0035971239
-
Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6
-
Cui Y, König J, Leier I, Buchholz U, Keppler D. Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. J Biol Chem 2001; 276: 9626-9630. doi:10.1074/jbc. M004968200
-
(2001)
J Biol Chem
, vol.276
, pp. 9626-9630
-
-
Cui, Y.1
König, J.2
Leier, I.3
Buchholz, U.4
Keppler, D.5
-
98
-
-
0030739131
-
Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging
-
Labrie F, Bélanger A, Cusan L, Gomez J-L, Candas B. Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging. J Clin Endocrinol Metab 1997; 82: 2396-2402. doi:10.1210/jc.82.8.2396
-
(1997)
J Clin Endocrinol Metab
, vol.82
, pp. 2396-2402
-
-
Labrie, F.1
Bélanger, A.2
Cusan, L.3
Gomez, J.-L.4
Candas, B.5
-
99
-
-
84866125863
-
Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: Possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions
-
Arakawa H, Nakanishi T, Yanagihara C, et al. Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions. Biochem Pharmacol 2012; 84: 1070-1077. doi:10.1016/j. bcp.2012.07.026
-
(2012)
Biochem Pharmacol
, vol.84
, pp. 1070-1077
-
-
Arakawa, H.1
Nakanishi, T.2
Yanagihara, C.3
-
100
-
-
0029554030
-
Metabolism of dehydroepiandrosterone
-
Longcope C. Metabolism of dehydroepiandrosterone. Ann N Y Acad Sci 1995; 774: 143-148. doi:10.1111/j.1749-6632.1995.tb17378.x
-
(1995)
Ann N y Acad Sci
, vol.774
, pp. 143-148
-
-
Longcope, C.1
-
101
-
-
34548165578
-
Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma
-
Muto M, Onogawa T, Suzuki T, et al. Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma. Cancer Sci 2007; 98: 1570-1576. doi:10.1111/j.1349-7006.2007.00570.x
-
(2007)
Cancer Sci
, vol.98
, pp. 1570-1576
-
-
Muto, M.1
Onogawa, T.2
Suzuki, T.3
-
102
-
-
57749102685
-
Overexpression of OATP1B3 confers apoptotic resistance in colon cancer
-
LeeW, Belkhiri A, Lockhart AC, et al. Overexpression of OATP1B3 confers apoptotic resistance in colon cancer. Cancer Res 2008; 68: 10315-10323. doi:10.1158/0008-5472.can-08-1984
-
(2008)
Cancer Res
, vol.68
, pp. 10315-10323
-
-
Lee, W.1
Belkhiri, A.2
Lockhart, A.C.3
-
103
-
-
78649823151
-
Organic anion transporting polypeptide 1B3 (OATP1B3) is overexpressed in colorectal tumors and is a predictor of clinical outcome
-
Lockhart AC, Harris E, Lafleur BJ, et al. Organic anion transporting polypeptide 1B3 (OATP1B3) is overexpressed in colorectal tumors and is a predictor of clinical outcome. Clin Exp Gastroenterol 2008; 1: 1-7
-
(2008)
Clin Exp Gastroenterol
, vol.1
, pp. 1-7
-
-
Lockhart, A.C.1
Harris, E.2
Lafleur, B.J.3
-
104
-
-
25144491657
-
Identification of OATP1B3 as a high-affinity hepatocellular transporter of paclitaxel
-
Smith NF, Acharya MR, Desai N, Figg W, Sparreboom A. Identification of OATP1B3 as a high-affinity hepatocellular transporter of paclitaxel. Cancer Biol Ther 2005; 4: 815-818
-
(2005)
Cancer Biol Ther
, vol.4
, pp. 815-818
-
-
Smith, N.F.1
Acharya, M.R.2
Desai, N.3
Figg, W.4
Sparreboom, A.5
-
105
-
-
38349059946
-
Rapid screening of antineoplastic candidates for the human organic anion transporter OATP1B3 substrates using fluorescent probes
-
Yamaguchi H, Kobayashi M, Okada M, et al. Rapid screening of antineoplastic candidates for the human organic anion transporter OATP1B3 substrates using fluorescent probes. Cancer Lett 2008; 260: 163-169
-
(2008)
Cancer Lett
, vol.260
, pp. 163-169
-
-
Yamaguchi, H.1
Kobayashi, M.2
Okada, M.3
-
106
-
-
58549108591
-
Pharmacogenetic pathway analysis of docetaxel elimination
-
Baker SD, Verweij J, Cusatis GA, et al. Pharmacogenetic pathway analysis of docetaxel elimination. Clin Pharmacol Ther 2008; 85: 155-163
-
(2008)
Clin Pharmacol Ther
, vol.85
, pp. 155-163
-
-
Baker, S.D.1
Verweij, J.2
Cusatis, G.A.3
-
107
-
-
33747178997
-
Expression of transporters potentially involved in the targeting of cytostatic bile acid derivatives to colon cancer and polyps
-
Ballestero MR, Monte MJ, Briz O, Jimenez F, Gonzalez-San Martin F, Marin JJ. Expression of transporters potentially involved in the targeting of cytostatic bile acid derivatives to colon cancer and polyps. Biochem Pharmacol 2006; 72: 729-738. doi:10.1016/j.bcp.2006.06.007
-
(2006)
Biochem Pharmacol
, vol.72
, pp. 729-738
-
-
Ballestero, M.R.1
Monte, M.J.2
Briz, O.3
Jimenez, F.4
Gonzalez-San Martin, F.5
Marin, J.J.6
-
108
-
-
84872165084
-
A cancer-specific variant of the SLCO1B3 gene encodes a novel human organic anion transporting polypeptide 1B3 (OATP1B3) localized mainly in the cytoplasm of colon and pancreatic cancer cells
-
Thakkar N, Kim K, Jang ER, et al. A cancer-specific variant of the SLCO1B3 gene encodes a novel human organic anion transporting polypeptide 1B3 (OATP1B3) localized mainly in the cytoplasm of colon and pancreatic cancer cells. Mol Pharm 2013; 10: 406-416. doi:10.1021/mp3005353
-
(2013)
Mol Pharm
, vol.10
, pp. 406-416
-
-
Thakkar, N.1
Kim, K.2
Jang, E.R.3
-
109
-
-
84885190041
-
Role of hypoxia inducible factor-1alpha in the regulation of the cancer-specific variant of organic anion transporting polypeptide 1B3 (OATP1B3), in colon and pancreatic cancer
-
Han S, Kim K, Thakkar N, Kim D, Lee W. Role of hypoxia inducible factor-1alpha in the regulation of the cancer-specific variant of organic anion transporting polypeptide 1B3 (OATP1B3), in colon and pancreatic cancer. Biochem Pharmacol 2013; 86: 816-823. doi:10.1016/j.bcp.2013.07.020
-
(2013)
Biochem Pharmacol
, vol.86
, pp. 816-823
-
-
Han, S.1
Kim, K.2
Thakkar, N.3
Kim, D.4
Lee, W.5
-
110
-
-
84857443229
-
Identification of a new organic anion transporting polypeptide 1B3 mRNA isoform primarily expressed in human cancerous tissues and cells
-
Nagai M, Furihata T, Matsumoto S, et al. Identification of a new organic anion transporting polypeptide 1B3 mRNA isoform primarily expressed in human cancerous tissues and cells. Biochem Biophys Res Commun 2012; 418: 818-823. doi:10.1016/j.bbrc.2012.01.115
-
(2012)
Biochem Biophys Res Commun
, vol.418
, pp. 818-823
-
-
Nagai, M.1
Furihata, T.2
Matsumoto, S.3
-
111
-
-
84862679663
-
Transporter function and cyclic AMP turnover in normal colonic mucosa from patients with and without colorectal neoplasia
-
Kleberg K, Jensen GM, Christensen DP, et al. Transporter function and cyclic AMP turnover in normal colonic mucosa from patients with and without colorectal neoplasia. BMC Gastroenterol 2012; 12: 78. doi:10.1186/1471-230X-12-78
-
(2012)
BMC Gastroenterol
, vol.12
, pp. 78
-
-
Kleberg, K.1
Jensen, G.M.2
Christensen, D.P.3
-
112
-
-
57249086646
-
Regulation of prostaglandin transporters in colorectal neoplasia
-
Holla VR, Backlund MG, Yang P, Newman RA, DuBois RN. Regulation of prostaglandin transporters in colorectal neoplasia. Cancer Prev Res (Phila) 2008; 1: 93-99. doi:10.1158/1940-6207. CAPR-07-0009
-
(2008)
Cancer Prev Res (Phila)
, vol.1
, pp. 93-99
-
-
Holla, V.R.1
Backlund, M.G.2
Yang, P.3
Newman, R.A.4
Dubois, R.N.5
-
113
-
-
0345700691
-
Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma
-
CuiY,Konig J,NiesAT, et al. Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma. Lab Invest 2003; 83: 527-538
-
(2003)
Lab Invest
, vol.83
, pp. 527-538
-
-
Cui, Y.1
Konig, J.2
Nies, A.T.3
-
114
-
-
1642491778
-
The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3b in hepatocellular carcinoma
-
Vavricka SR, Jung D, Fried M, Grutzner U, Meier PJ, Kullak-Ublick GA. The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3b in hepatocellular carcinoma. J Hepatol 2004; 40: 212-218
-
(2004)
J Hepatol
, vol.40
, pp. 212-218
-
-
Vavricka, S.R.1
Jung, D.2
Fried, M.3
Grutzner, U.4
Meier, P.J.5
Kullak-Ublick, G.A.6
-
115
-
-
77952722303
-
Hepatocellular carcinoma: Hepatocyte-selective enhancement at gadoxetic acid-enhanced MR imaging - Correlation with expression of sinusoidal and canalicular transporters and bile accumulation
-
Tsuboyama T, Onishi H, Kim T, et al. Hepatocellular carcinoma: hepatocyte-selective enhancement at gadoxetic acid-enhanced MR imaging - correlation with expression of sinusoidal and canalicular transporters and bile accumulation. Radiology 2010; 255: 824-833. doi:10.1148/ radiol.10091557
-
(2010)
Radiology
, vol.255
, pp. 824-833
-
-
Tsuboyama, T.1
Onishi, H.2
Kim, T.3
-
116
-
-
68149084824
-
Expression of OATP1B3 determines uptake of Gd-EOB-DTPA in hepatocellular carcinoma
-
Narita M, Hatano E, Arizono S, et al. Expression of OATP1B3 determines uptake of Gd-EOB-DTPA in hepatocellular carcinoma. J Gastroenterol 2009; 44: 793-798. doi:10.1007/s00535-009-0056-4
-
(2009)
J Gastroenterol
, vol.44
, pp. 793-798
-
-
Narita, M.1
Hatano, E.2
Arizono, S.3
-
117
-
-
80052425120
-
OATP 1B1/1B3 expression in hepatocellular carcinomas treated with orthotopic liver transplantation
-
Vasuri F, Golfieri R, Fiorentino M, et al. OATP 1B1/1B3 expression in hepatocellular carcinomas treated with orthotopic liver transplantation. Virchows Arch 2011; 459: 141-146. doi:10.1007/ s00428-011-1099-5
-
(2011)
Virchows Arch
, vol.459
, pp. 141-146
-
-
Vasuri, F.1
Golfieri, R.2
Fiorentino, M.3
-
118
-
-
77953776261
-
Hepatic uptake of the magnetic resonance imaging contrast agent Gd-EOB-DTPA: Role of human organic anion transporters
-
Leonhardt M, Keiser M, Oswald S, et al. Hepatic uptake of the magnetic resonance imaging contrast agent Gd-EOB-DTPA: role of human organic anion transporters. Drug Metab Dispos 2010; 38: 1024-1028. doi:10.1124/dmd.110.032862
-
(2010)
Drug Metab Dispos
, vol.38
, pp. 1024-1028
-
-
Leonhardt, M.1
Keiser, M.2
Oswald, S.3
-
119
-
-
79955494794
-
Expression of organic anion-transporting polypeptides 1B3, 1B1, and 1A2 in human pancreatic cancer reveals a new class of potential therapeutic targets
-
Kounnis V, Ioachim E, Svoboda M, et al. Expression of organic anion-transporting polypeptides 1B3, 1B1, and 1A2 in human pancreatic cancer reveals a new class of potential therapeutic targets. Onco Targets Ther 2011; 4: 27-32. doi:10.2147/ OTT.S16706
-
(2011)
Onco Targets Ther
, vol.4
, pp. 27-32
-
-
Kounnis, V.1
Ioachim, E.2
Svoboda, M.3
-
120
-
-
84883275439
-
Organic anion transporting polypeptides expressed in pancreatic cancer may serve as potential diagnostic markers and therapeutic targets for early stage adenocarcinomas
-
Hays A, Apte U, Hagenbuch B. Organic anion transporting polypeptides expressed in pancreatic cancer may serve as potential diagnostic markers and therapeutic targets for early stage adenocarcinomas. Pharm Res 2013; 30: 2260-2269. doi:10.1007/s11095-012-0962-7
-
(2013)
Pharm Res
, vol.30
, pp. 2260-2269
-
-
Hays, A.1
Apte, U.2
Hagenbuch, B.3
-
121
-
-
80052675543
-
Expression of organic anion-transporting polypeptides 1B1 and 1B3 in ovarian cancer cells: Relevance for paclitaxel transport
-
Svoboda M, Wlcek K, Taferner B, et al. Expression of organic anion-transporting polypeptides 1B1 and 1B3 in ovarian cancer cells: relevance for paclitaxel transport. Biomed Pharmacother 2011; 65: 417-426. doi:10.1016/j.biopha.2011.04.031
-
(2011)
Biomed Pharmacother
, vol.65
, pp. 417-426
-
-
Svoboda, M.1
Wlcek, K.2
Taferner, B.3
-
122
-
-
29244441701
-
ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier
-
Bronger H, König J, Kopplow K, et al. ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier. Cancer Res 2005; 65: 11419-11428. doi:10.1158/0008-5472.can-05-1271
-
(2005)
Cancer Res
, vol.65
, pp. 11419-11428
-
-
Bronger, H.1
König, J.2
Kopplow, K.3
-
123
-
-
3542992126
-
Rosuvastatin pharmacokinetics in heart transplant recipients administered an antirejection regimen including cyclosporine
-
Simonson SG, Raza A, Martin PD, et al. Rosuvastatin pharmacokinetics in heart transplant recipients administered an antirejection regimen including cyclosporine. Clin Pharmacol Ther 2004; 76: 167-177
-
(2004)
Clin Pharmacol Ther
, vol.76
, pp. 167-177
-
-
Simonson, S.G.1
Raza, A.2
Martin, P.D.3
-
124
-
-
33645816996
-
OATP1B1, OATP1B3, and MRP2 are involved in hepatobiliary transport of olmesartan, a novel angiotensin II blocker
-
Nakagomi-Hagihara R, Nakai D, Kawai K, et al. OATP1B1, OATP1B3, and MRP2 are involved in hepatobiliary transport of olmesartan, a novel angiotensin II blocker. Drug Metab Dispos 2006; 34: 862-869. doi:10.1124/dmd.105.008888
-
(2006)
Drug Metab Dispos
, vol.34
, pp. 862-869
-
-
Nakagomi-Hagihara, R.1
Nakai, D.2
Kawai, K.3
-
125
-
-
33646536542
-
Drug and bile acid transporters in rosuvastatin hepatic uptake: Function, expression, and pharmacogenetics
-
Ho RH, Tirona RG, Leake BF, et al. Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics. Gastroenterology 2006; 130: 1793-1806
-
(2006)
Gastroenterology
, vol.130
, pp. 1793-1806
-
-
Ho, R.H.1
Tirona, R.G.2
Leake, B.F.3
-
126
-
-
36348943537
-
Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1- receptor
-
Yamada A, Maeda K, Kamiyama E, et al. Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1- receptor. Drug Metab Dispos 2007; 35: 2166-2176. doi:10.1124/dmd.107.017459
-
(2007)
Drug Metab Dispos
, vol.35
, pp. 2166-2176
-
-
Yamada, A.1
Maeda, K.2
Kamiyama, E.3
-
127
-
-
0036293982
-
Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver
-
Vavricka SR, Van Montfoort J, Ha HR, Meier PJ, Fattinger K. Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology 2002; 36: 164-172. doi:10.1053/jhep.2002.34133
-
(2002)
Hepatology
, vol.36
, pp. 164-172
-
-
Vavricka, S.R.1
Van Montfoort, J.2
Ha, H.R.3
Meier, P.J.4
Fattinger, K.5
-
128
-
-
84858072531
-
Impact of testosterone on the expression of organic anion transporting polypeptides (OATP-1A2, OATP-2B1, OATP-3A1) in malignant and non-malignant human breast cells in vitro
-
Stute P, Reichenbach A, Szuwart T, Kiesel L, Gotte M. Impact of testosterone on the expression of organic anion transporting polypeptides (OATP-1A2, OATP-2B1, OATP-3A1) in malignant and non-malignant human breast cells in vitro. Maturitas 2012; 71: 376-384. doi:10.1016/ j.maturitas.2011.12.020
-
(2012)
Maturitas
, vol.71
, pp. 376-384
-
-
Stute, P.1
Reichenbach, A.2
Szuwart, T.3
Kiesel, L.4
Gotte, M.5
-
129
-
-
1642457252
-
Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human
-
Nozawa T, Imai K, Nezu J-I, Tsuji A, Tamai I. Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human. J Pharmacol Exp Ther 2004; 308: 438-445. doi:10.1124/jpet.103.060194
-
(2004)
J Pharmacol Exp Ther
, vol.308
, pp. 438-445
-
-
Nozawa, T.1
Imai, K.2
Nezu, J.-I.3
Tsuji, A.4
Tamai, I.5
-
130
-
-
73949086125
-
Species difference in the effect of grapefruit juice on intestinal absorption of talinolol between human and rat
-
Shirasaka Y, Kuraoka E, Spahn-Langguth H, Nakanishi T, Langguth P, Tamai I. Species difference in the effect of grapefruit juice on intestinal absorption of talinolol between human and rat. J Pharmacol Exp Ther 2010; 332: 181-189. doi:10.1124/jpet.109.159756
-
(2010)
J Pharmacol Exp Ther
, vol.332
, pp. 181-189
-
-
Shirasaka, Y.1
Kuraoka, E.2
Spahn-Langguth, H.3
Nakanishi, T.4
Langguth, P.5
Tamai, I.6
|