An oligopeptide transporter is expressed at high levels in the pancreatic carcinoma cell lines AsPc-1 and Capan-2

Cancer Research

Volumn 58, Issue 3, 1998, Pages 519-525

  Gonzalez, Deborah E ^a   Covitz, Kuang Ming Y ^b   Sadée, Wolfgang ^b   Mrsny, Randall J ^a  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BESTATIN; CARRIER PROTEIN; DIPEPTIDE; GLYCINE; GLYCOSYLATED PROTEIN; GLYCYLPROLINE; GLYCYLSARCOSINE; OLIGOPEPTIDE; PHENYLGLUTAMIC ACID; PHENYLGLYCINE; TETRAPEPTIDE; TRIGLYCINE; TRIPEPTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CARCINOMA CELL; CHO CELL; CONTROLLED STUDY; HUMAN; HUMAN CELL; NONHUMAN; PANCREAS CARCINOMA; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; TRANSPORT KINETICS;

ADENOCARCINOMA; ANIMALS; BIOLOGICAL TRANSPORT; CARCINOMA; CARRIER PROTEINS; CHO CELLS; COLONIC NEOPLASMS; CRICETINAE; CRICETULUS; DIPEPTIDES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYDROGEN-ION CONCENTRATION; INTESTINAL ABSORPTION; KINETICS; NEOPLASM PROTEINS; OLIGOPEPTIDES; PANCREATIC NEOPLASMS; POLYMERASE CHAIN REACTION; RECOMBINANT FUSION PROTEINS; SYMPORTERS; TUMOR CELLS, CULTURED;

EID: 0032005174     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Boring, C. C., Squires, T. S., and Tong, T. Cancer statistics. CA Cancer J. Clin., 43: 7-26, 1993.
2. Scarpa, A., Capelli, P., Villanueva, A., Zamboni, G., Lluìs, F., Accolla, R., Mariuzzi, G., and Capellà, G. Pancreatic cancer in Europe: Ki-ras gene mutation pattern shows geographical differences. Int. J. Cancer, 57: 167-171, 1994.
3. Hruban, R. H., van Mansfeld, A. O. M., Offerhaus, G. J. A., van Weering, D. H. J., Allison, D. C., Goodman, S. N., Kensler, T. W., Bose, K. K., Cameron, J. L., and Bos, J. L. K-ras oncogene activation in adenocarcinomas of the human pancreas: a study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization. Am. J. Pathol., 143: 545-554, 1993.
4. Suwa, H., Yoshimura, T., Yamaguchi, N., Kanehira, K., Manabe, T., Imamura, M., Hiai, H., and Fukumoto, M. K-ras and p53 alterations in genomic DNA and transcripts of human pancreatic adenocarcinoma cell lines. Jpn. J. Cancer Res., 85: 1005-1014, 1994.
5. Berrozpe, G., Schaeffer, J., Pienado, M. A., Real, F. X., and Perucho, M. Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer. Int. J. Cancer, 58: 185-191, 1994.
6. Oikawa, T., Kusuhara, M., Ishikawa, S., Hitomi, J., Kono, A., Iwanaga, T., and Yamaguchi, K. Production of endothelin-1 and thrombomodulin by human pancreatic cancer cells. Br. J. Cancer, 69: 1059-1064, 1994.
7. Fei, Y-J., Kanai, Y., Nussberger, S., Ganapathy, V., Leibach, F. H., Romero, M. F., Singh, S. K., Boron, W. F., and Hediger, M. A. Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature (Lond.), 368: 563-566, 1994.
8. +/peptide cotransporter. J. Biol Chem., 270: 6456-6463, 1995.
9. Lombardo, Y. B., Morse, E. L., and Adibi, S. A. Specificity and mechanism of influence of amino acid residues on hepatic clearance of oligopeptides. J. Biol. Chem., 263: 12920-12926, 1988.
10. Ramamoorthy, S., Liu, W., Ma, Y-Y., Yang-Feng, T. L., Ganapathy, V., and Leibach, F. H. Proton/peptide cotransporter (PEPT 2) from human kidney: functional characterization and chromosomal localization. Biochim. Biophys. Acta, 1240: 1-4, 1995.
11. + coupled transport of p.o. cephalosporins via dipeptide carriers in rabbit intestinal brush-border membranes: difference of transport characteristics between cefixime and cephradine. J. Pharmacol. Exp. Ther., 247: 235-241, 1988.
12. Thwaites, D. T., Cavet, M., Hirst, B. H., and Simmons, N. L. Angiotensin-converting enzyme (ACE) inhibitor transport in human intestinal epithelial (Caco-2) cells. Br. J. Pharmacol., 114: 981-986, 1995.
13. Takano, M., Tomita, Y., Katsura, T., Yasuhara, M., Inui, K-I., and Hori, R. Bestatin transport in rabbit intestinal brush-border membrane vesicles. Biochem. Pharmacol., 47: 1089-1090, 1994.
14. Tamai, I., Tomizawa, N., Kadowaki, A., Terasaki, T., Nakayama, K., Higashida, H., and Tsuji, A. Functional expression of intestinal dipeptide/β-lactam antibiotic transporter in Xenopus laevis oocytes. Biochem. Pharmacol., 48: 881-888, 1994.
15. Ardalan, B., Ucar, A., Reddy, R., Livingstone, A. S., Markoe, A., Schwade, J., Richman, S. P., and Donofrio, K. Phase I trial of low dose N-phosphonacetyl-L-aspartic acid and high dose 5-fluorouracil administered concomitantly with radiation therapy for unresectable localized adenocarcinoma of the pancreas. Cancer (Phila.), 74: 1869-1873, 1994.
16. Kupczyk-Subotkowska, L., Tamura, K., Pal, D., Sakaeda, T., Siahaan, T. J., Stella, V. J., and Borchardt, R. T. Derivatives of melphalan designed to enhance drug accumulation in cancer cells. J. Drug Targeting, 4: 359-370, 1997.
17. Rubas, W., Villagran, J., Cromwell, M., McLeod, A., Wassenberg, J., and Mrsny, R. Correlation of solute flux across Caco-2 monolayers and colonie tissue in vitro. S.T.P. Pharm. Sci., 5: 93-97, 1995.
18. Covitz, K-M. Y., Amidon, G. L., and Sadée, W. Human dipeptide transporter, hPEPT1, stably transfected into Chinese hamster ovary cells. Pharm. Res., 13: 1631-1634, 1996.
19. Wang, H-Y., Lipfert, L., Malbon, C. C., and Bahouth, S. Site-directed anti-peptide antibodies define the topography of the β-adrenergic receptor. J. Biol. Chem., 264: 14424-14431, 1989.
20. +-coupled oligopeptide transporter hPEPT1. J. Biol. Chem., 271: 5430-5437, 1996.
21. Saito, H., and Inui, K-I. Dipeptide transporters in apical and basolateral membranes in the human intestinal cell line Caco-2. Am. J. Physiol., 265: G289-G294, 1993.
22. +-coupled absorption. Br. J. Pharmacol., 113: 1050-1056, 1994.
23. + cotransport system in Caco-2 human colon carcinoma cell line. Biochem. J., 299: 253-260, 1994.
24. Hefta, S. A., Hefta, L. J. F., Lee, T. D., Paxton, R. J., and Shively, J. E. Carcinoembryonic antigen is anchored to membrane by covalent attachment to a glycosylphosphatidylinositol moiety: identification of the ethanolamine linkage site. Proc. Natl. Acad. Sci. USA, 85: 4648-4652, 1988.
25. Yamanaka, Y., Friess, H., Kobrin, M. S., Büchler, M., Kunz, J., Beger, H. G., and Korc, M. Overexpression of HER2/neu oncogene in human pancreatic carcinoma. Hum. Pathol., 24: 1127-1134, 1993.
26. Friess, H., Yamanaka, Y., Büchler, M., Kobrin, M. S., Tahara, E., and Korc, M. Cripto, a member of the epidermal growth factor family, is over-expressed in human pancreatic cancer and chronic pancreatitis. Int. J. Cancer, 56: 668-674, 1994.
27. Murer, H., Hopfer, U., and Kinne, R. Sodium/proton antiport in brush-border-membrane vesicles isolated from rat small intestine and kidney. Biochem. J., 154: 597-604, 1976.
28. Lucas, M. L., Blair, J. A., Cooper, B. T., and Cooke, W. T. Relationship of the amino acid micro-climate in rat and human intestine to malabsorption. Biochem. Soc. Trans., 4: 154-156, 1976.