Identification and species similarity of OATP transporters responsible for hepatic uptake of β-lactam antibiotics

Drug Metabolism and Pharmacokinetics

Volumn 23, Issue 5, 2008, Pages 347-355

  Nakakariya, Masanori ^a   Shimada, Taiki ^a   Irokawa, Masanori ^a   Maeda, Tomoji ^a,b   Tamai, Ikumi ^a,c  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b IWATE MEDICAL UNIVERSITY   (Japan)

^c KANAZAWA UNIVERSITY   (Japan)

Author keywords

CCK 8, cholecystokinin octapeptide; cRNA, complementary RNA; E13S, estrone 3 sulfate; OAT, organic anion transporter; OATP, organic anion transporting polypeptide; RAF, relative activity factor

Indexed keywords

CEFADROXIL; CEFDITOREN; CEFMETAZOLE; CEFOPERAZONE; CHOLECYSTOKININ OCTAPEPTIDE; ESTRONE SULFATE; NAFCILLIN; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 1A4; ORGANIC ANION TRANSPORTER 1B1; ORGANIC ANION TRANSPORTER 1B3; UNCLASSIFIED DRUG; ANILIDE; BENZOIC ACID DERIVATIVE; BETA LACTAM; SLCO1A4 PROTEIN, RAT; SLCO1B1 PROTEIN, HUMAN; SLCO1B3 PROTEIN, HUMAN; SLCO2B1 PROTEIN, HUMAN; T 3095; T 3157;

ANIMAL CELL; ARTICLE; BASOLATERAL MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG TRANSPORT; DRUG UPTAKE; HUMAN; HUMAN CELL; LIVER CELL; LIVER CLEARANCE; NONHUMAN; SPECIES DIFFERENCE; XENOPUS; ANIMAL; CRYOPRESERVATION; DRUG ANTAGONISM; KINETICS; LIVER; METABOLISM; OOCYTE; RAT; XENOPUS LAEVIS;

ANILIDES; ANIMALS; BENZOIC ACIDS; BETA-LACTAMS; CRYOPRESERVATION; HEPATOCYTES; HUMANS; KINETICS; LIVER; NAFCILLIN; OOCYTES; ORGANIC ANION TRANSPORTERS; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; RATS; SINCALIDE; XENOPUS LAEVIS;

EID: 58149313047     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.23.347     Document Type: Article

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