Expression of transporters potentially involved in the targeting of cytostatic bile acid derivatives to colon cancer and polyps

Biochemical Pharmacology

Volumn 72, Issue 6, 2006, Pages 729-738

  Ballestero, Maria R ^a   Monte, Maria J ^a   Briz, Oscar ^a   Jimenez, Felipe ^b   Martin, Francisco Gonzalez San ^b   Marin, Jose J G ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

^b HOSPITAL UNIVERSITARIO DE SALAMANCA   (Spain)

Author keywords

ASBT; Chemotherapy; Gut; Intestine; Resistance; Tumor

Indexed keywords

ABC TRANSPORTER; BILE ACID; CISPLATIN; DIAMMINE URSODEOXYCHOLATE PLATINUM; GENE PRODUCT; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; PROTEIN ASBT; PROTEIN OATP8; PROTEIN OCT1; PROTEIN OST ALPHA; RNA; TAUROCHOLIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CANCER RESISTANCE; CANCER TISSUE; CELL TRANSPORT; COLON; COLON CANCER; COLON POLYP; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOSTASIS; DRUG MECHANISM; DRUG TARGETING; DRUG UPTAKE; FEMALE; GENE EXPRESSION; GENE IDENTIFICATION; HETEROZYGOTE; HUMAN; HUMAN TISSUE; ILEUM; IN VITRO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; XENOPUS LAEVIS;

ANIMALS; BILE ACIDS AND SALTS; COLONIC NEOPLASMS; DRUG DELIVERY SYSTEMS; HUMANS; MEMBRANE TRANSPORT PROTEINS; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; ORGANIC CATION TRANSPORTER 1; ORGANOPLATINUM COMPOUNDS; POLYPS; SYMPORTERS; URSODEOXYCHOLIC ACID; XENOPUS LAEVIS;

EID: 33747178997     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.06.007     Document Type: Article

References (34)

1. Jarnagin W.R., Ruo L., Little S.A., Klimstra D., D'Angelica M., DeMatteo R.P., et al. Patterns of initial disease recurrence after resection of gallbladder carcinoma and hilar cholangiocarcinoma: implications for adjuvant therapeutic strategies. Cancer 98 (2003) 1689-1700
2. O'Connell J.B., Maggard M.A., Liu J.H., Etzioni D.A., Livingston E.H., and Ko C.Y. Rates of colon and rectal cancers are increasing in young adults. Am Surg 69 (2003) 866-872
3. Si M.S., Amersi F., Golish S.R., Ortiz J.A., Zaky J., Finklestein D., et al. Prevalence of metastases in hepatocellular carcinoma: risk factors and impact on survival. Am Surg 69 (2003) 879-885
4. Marin J.J.G., Romero M.R., Vallejo M., and Monte M.J. Targeting of cytostatic bile acid derivatives toward tumours of the enterohepatic circuit. Cancer Ther 3 (2005) 57-64
5. Dominguez M.F., Macias R.I.R., Izco-Basurko I., de la Fuente A., Pascual M.J., Criado J.M., et al. Low in vivo toxicity of a novel cisplatin-ursodeoxycholic derivative (Bamet-UD2) with enhanced cytostatic activity versus liver tumors. J Pharmacol Exp Ther 297 (2001) 1106-1112
6. Monte M.J., Ballestero M.R., Briz O., Perez M.J., and Marin J.J.G. Proapoptotic effect on normal and tumor intestinal cells of cytostatic drugs with enterohepatic organotropism. J Pharmacol Exp Ther 315 (2005) 24-35
7. Craddock A.L., Love M.W., Daniel R.W., Kirby L.C., Walters H.C., Wong M.H., et al. Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. Am J Physiol 274 (1998) G157-G169
8. +/bile acid cotransporter. J Lipid Res 40 (1999) 2158-2168
9. Hagenbuch B., and Meier P.J. Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties. Pflugers Arch 447 (2004) 653-665
10. Kullak-Ublick G.A., Ismair M.G., Stieger B., Landmann L., Huber R., Pizzagalli F., et al. Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology 120 (2001) 525-533
11. Van Montfoort J.E., Hagenbuch B., Fattinger K.E., Müller M., Groothuis G.M.M., Meijer D.K.F., et al. Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations. J Pharmacol Exp Ther 291 (1999) 147-152
12. Koepsell H. Organic cation transporters in intestine, kidney, liver, and brain. Ann Rev Physiol 60 (1998) 243-266
13. Dawson P.A., Hubbert M., Haywood J., Craddock A.L., Zerangue N., Christian W.V., et al. The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter. J Biol Chem 280 (2005) 6960-6968
14. Smit J.W., Schinkel A.H., Muller M., Weert B., and Meijer D.K.F. Contribution of the murine mdr1a P-glycoprotein to hepatobiliary and intestinal elimination of cationic drugs as measured in mice with an mdr1a gene disruption. Hepatology 27 (1998) 1056-1063
15. Minemura M., Tanimura H., and Tabor E. Overexpression of multidrug resistance genes MDR1 and cMOAT in human hepatocellular carcinoma and hepatoblastoma cell lines. Int J Oncol 15 (1999) 559-563
16. Leonard G.D., Fojo T., and Bates S.E. The role of ABC transporters in clinical practice. Oncologist 8 (2003) 411-424
17. Criado J.J., Dominguez M.F., Medarde M., Fernandez E.R., Macias R.I.R., and Marin J.J.G. Structural characterization, kinetic studies, and in vitro biological activity of new cis-diamminebis-cholylglycinate (O,O′) Pt(II) and cis-diamminebis-ursodeoxycholate (O,O′) Pt(II) complexes. Bioconjug Chem 11 (2000) 167-174
18. Briz O., Serrano M.A., Rebollo N., Hagenbuch B., Meier P.J., Koepsell H., et al. Carriers involved in targeting the cytostatic bile acid-cisplatin derivatives cis-diammine-chloro-cholylglycinate-platinum(II) and cis-diammine-bisursodeoxycholate-platinum(II) toward liver cells. Mol Pharmacol 61 (2002) 853-860
19. Tsuji A. Tissue selective drug delivery utilizing carrier-mediated transport systems. J Control Release 62 (1999) 239-244
20. Ho N.F.H. Utilizing bile acid carrier mechanisms to enhance liver and small intestine absorption. Ann N Y Acad Sci 507 (1987) 315-329
21. Wess G., Kramer W., and Han X.B. Synthesis and biological activity of bile acid-derived HMG-CoA reductase inhibitors. The role of 21 methyl in recognition of HMG-CoA reductase and the ileal bile acid transport system. J Med Chem 37 (1994) 3240-3246
22. Kramer W., Wess G., Schubert G., Bickel M., Gribig F., Gutjahr U., et al. Liver-specific drug targeting by coupling to bile acids. J Biol Chem 267 (1992) 18598-18604
23. Marin J.J.G., Herrera M.C., Palomero M.F., Macias R.I.R., Monte M.J., El-Mir M.Y., et al. Rat liver transport and biotransformation of a cytostatic complex of bis-cholylglycinate and platinum(II). J Hepatol 28 (1998) 417-425
24. Criado J.J., Herrera M.C., Palomero M.F., Medarde M., Rodriguez E., and Marin J.J.G. Synthesis and characterization of a new bile acid and platinum(II) complex with cytostatic activity. J Lipid Res 38 (1997) 1022-1032
25. Criado J.J., Macias R.I.R., Medarde M., Monte M.J., Serrano M.A., and Marin J.J.G. Synthesis and characterization of the new cytostatic complex cis-diammineplatinum (II)-chlorocholylglycinate. Bioconjug Chem 8 (1997) 453-458
26. Macias R.I.R., El-Mir M.Y., Monte M.J., Serrano M.A., Garcia M.J., and Marin J.J.G. Cholephilic characteristics of a new cytostatic complex of cisplatin with glycocholate (Bamet-R2). J Control Release 57 (1999) 161-169
27. Marin J.J.G., Macias R.I.R., Criado J.J., Bueno A., Monte M.J., and Serrano M.A. DNA interaction and cytostatic activity of the new liver organotropic complex of cisplatin with glycocholic acid: Bamet-R2. Int J Cancer 78 (1998) 346-352
28. Larena M.G., Martinez-Diez M.C., Monte M.J., Dominguez M.F., Pascual M.P., and Marin J.J.G. Liver organotropism and biotransformation of a novel platinum-ursodeoxycholate derivative, Bamet-UD2, with enhanced antitumor activity. J Drug Target 9 (2000) 185-200
29. Van Montfoort J.E., Müller M., Groothuis G.M.M., Meijer D.K.F., Koepsell H., and Meier P.J. Comparison of "type I" and "type II" organic cation transport by organic cation transporters and organic anion-transporting polypeptides. J Pharmacol Exp Ther 298 (2001) 110-115
30. Hirohashi T., Suzuki H., Takikawa H., and Sugiyama Y. ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3). J Biol Chem 275 (2000) 2905-2910
31. Zeng H., Liu G., Rea P.A., and Kruh G.D. Transport of amphipathic anions by human multidrug resistance protein 3. Cancer Res 60 (2000) 4779-4784
32. Kusuhara H., Suzuki H., and Sugiyama Y. The role of P-glycoprotein and canalicular multispecific organic anion transporter in the hepatobiliary excretion of drugs. J Pharm Sci 87 (1998) 1025-1040
33. Cui Y., Konig J., Buchholz J.K., Spring H., Leier I., and Keppler D. Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. Mol Pharmacol 55 (1999) 929-937
34. Hinoshita E., Uchiumi T., Taguchi K., Kinukawa N., Tsuneyoshi M., Maehara Y., et al. Increased expression of an ATP-binding cassette superfamily transporter, multidrug resistance protein 2, in human colorectal carcinomas. Clin Cancer Res 6 (2000) 2401-2407