High expression of steroid sulfatase mRNA predicts poor prognosis in patients with estrogen receptor-positive breast cancer

Clinical Cancer Research

Volumn 9, Issue 6, 2003, Pages 2288-2293

  Miyoshi, Yasuo ^a   Ando, Akiko ^a   Hasegawa, Seiichi ^a   Ishitobi, Makoto ^a   Taguchi, Tetsuya ^a   Tamaki, Yasuhiro ^a   Noguchi, Shinzaburo ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; AROMATASE; CYCLOPHOSPHAMIDE; EPIRUBICIN; ESTROGEN RECEPTOR; FLUOROURACIL; MESSENGER RNA; METHOTREXATE; STERYL SULFATASE; SULFATASE; TAMOXIFEN; TESTOSTERONE 17BETA DEHYDROGENASE;

ARTICLE; BREAST CANCER; CANCER GRADING; CANCER INVASION; CONCENTRATION RESPONSE; ENZYME REGULATION; FEMALE; HISTOPATHOLOGY; HUMAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MULTIVARIATE ANALYSIS; POLYMERASE CHAIN REACTION; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; QUANTITATIVE DIAGNOSIS; RNA ANALYSIS; STATISTICAL SIGNIFICANCE; TUMOR GROWTH;

17-HYDROXYSTEROID DEHYDROGENASES; AROMATASE; BREAST NEOPLASMS; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; MULTIVARIATE ANALYSIS; PROGNOSIS; RECEPTORS, ESTROGEN; RNA, MESSENGER; STERYL-SULFATASE;

EID: 0038175996     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Thomas, D. B. Do hormones cause cancer? Cancer (Phila.), 53: 595-604, 1984.
2. Vihko, R., and Apter, D. Endogenous steroids in the pathophysiology of breast cancer. Crit. Rev. Oncol. Hematol., 9: 1-16, 1989.
3. Miller, W. R., and O'Neill, J. The importance of local synthesis of estrogen within the breast. Steroids, 50: 537-548, 1987.
4. O'Neill, J. S., Elton, R. A., and Miller, W. R. Aromatase activity in adipose tissue from breast quadrants: a link with tumour site. Br. Med. J. (Clin. Res. Ed.), 296: 741-743, 1988.
5. Reed, M. J., Aherne, G. W., Ghilchik, M. W., Patel, S., and Chakraborty, J. Concentrations of oestrone and 4-hydroxyandrostenedione in malignant and normal breast tissues. Int. J. Cancer, 49: 562-565, 1991.
6. MacIndoe, J. H. The hydrolysis of estrone sulfate and dehydroepiandrosterone sulfate by MCF-7 human breast cancer cells. Endocrinology, 123: 1281-1287, 1988.
7. Prost, O., Turrel, M. O., Dahan, N., Craveur, C., and Adessi, G. L. Estrone and dehydroepiandrosterone sulfatase activities and plasma estrone sulfate levels in human breast carcinoma. Cancer Res., 44: 661-664, 1984.
8. Abul-Hajj, Y. J., Iverson, R., and Kiang, D. T. Related articles aromatization of androgens by human breast cancer. Steroids, 33: 205-222, 1979.
9. Lipton, A., Santner, S. J., Santen, R. J., Harvey, H. A., Feil, P. D., White-Hershey, D., Bartholomen, M. J., and Antle, C. E. Aromatase activity in primary and metastatic human breast cancer. Cancer (Phila.), 59: 779-782, 1987.
10. Perel, E., Daniilescu, D., Kharlip, L., Blackstein, M., and Killinger, D. W. Steroid modulation of aromatase activity in human cultured breast carcinoma cells. J. Steroid Biochem., 29: 393-399, 1988.
11. Abul-Hajj, Y. J. Relationship between estrogen receptors, 17 beta-hydroxysteroid dehydrogenase and estrogen content in human breast cancer. Steroids, 34: 217-225, 1979.
12. Vermeulen, A., Deslypere, J. P., Paridaens, R., Leclercq, G., Roy, F., and Heuson, J. C. Aromatase, 17 β-hydroxysteroid dehydrogenase and intratissular sex hormone concentrations in cancerous and normal glandular breast tissue in postmenopausal women. Eur. J. Cancer Clin. Oncol., 22: 515-225, 1986.
13. Utsumi, T., Yoshimura, N., Takeuchi, S., Ando, J., Maruta, M., Maeda, K., and Harada, N. Steroid sulfatase expression is an independent predictor of recurrence in human breast cancer. Cancer Res., 59: 377-381, 1999.
14. Gunnarsson, C., Olsson, B. M., and Stal, O. Abnormal expression of 17β-hydroxysteroid dehydrogenases in breast cancer predicts late recurrence. Cancer Res., 61: 8448-8451, 2001.
15. Le Doussal, V., Tubiana-Hulin, M., Friedman, S., Hacene, K., Spyratos, F., and Brunet, M. Prognostic value of histologic grade nuclear components of Scarff-Bloom-Richardson (SBR). An improved score modification based on a multivariate analysis of 1262 invasive ductal breast carcinomas. Cancer (Phila.), 64: 1914-1921, 1989.
16. Goldhirsch, A., Wood, W. C., Senn, H. J., Glick, J. H., and Gelber, R. D. Fifth international conference on adjuvant therapy of breast cancer, St. Gallen, March 1995. International Consensus Panel on the Treatment of Primary Breast Cancer. Eur. J. Cancer, 31A: 1754-1759, 1995.
17. Adjuvant Therapy of Primary Breast Cancer, 6th international conference. Olma Messen St. Gallen, February 25-28, 1998. Eur. J. Cancer, 34 (Suppl. 1): S3-S45, 1998.
18. Miyoshi, Y., Ando, A., Shiba, E., Taguchi, T., Tamaki, T., and Noguchi, S. Involvement of up-regulation of 17β-hydroxysteroid dehydrogenase type 1 in maintenance of intratumoral high estradiole levels in postmenopausal breast cancers. Int. J. Cancer, 94: 685-689, 2001.
19. Iwao, K., Miyoshi, Y., Egawa, C., Ikeda, N., Tsukamoto, F., and Noguchi, S. Quantitative analysis of estrogen receptor-α and -β messenger RNA expression in breast carcinoma by real-time polymerase chain reaction. Cancer (Phila.), 89: 1732-1738, 2000.
20. James, M. R., Skaar, T. C., Lee, R. Y., MacPherson, A., Zwiebel, J. A., Ahluwalia, B. S., Ampy, F., and Clarke, R. Constitutive expression of the steroid sulfatase gene supports the growth of MCF-7 human breast cancer cells in vitro and in vivo. Endocrinology, 142: 1497-1505, 2001.
21. Klijn, J. G., Blamey, R. W., Boccardo, F., Tominaga, T., Duchateau, L., and Sylvester, R. Combined tamoxifen and luteinizing hormone-releasing hormone (LHRH) agonist versus LHRH agonist alone in premenopausal advanced breast cancer: a meta-analysis of four randomized trials. J. Clin. Oncol., 19: 343-353, 2001.
22. Silva, M. C., Rowlands, M. G., Dowsett, M., Gusterson, B., McKinna, J. A., Fryatt, I., and Coombes, R. C. Intratumoral aromatase as a prognostic factor in human breast carcinoma. Cancer Res., 49: 2588-2591, 1989.
23. Lipton, A., Santen, R. J., Santner, S. J., Harvey, H. A., Sanders, S. I., and Matthews, Y. L. Prognostic value of breast cancer aromatase. Cancer (Phila.), 70: 1951-1955, 1992.
24. Miller, W. R. Biology of aromatase inhibitors: pharmacology/endocrinology within the breast. Endocr. Relat. Cancer, 6: 187-195, 1999.
25. Meeting highlights: International Consensus Panel on the Treatment of Primary Breast Cancer. Seventh international conference on Adjuvant Therapy of Primary Breast Cancer. J. Clin. Oncol., 19: 3817-3827, 2001.
26. Goldhirsch, A., Glick, J. H., Gelber, R. D., Coates, A. S., and Senn, H. J. National Institutes of Health Consensus Development Conference statement: adjuvant therapy for breast cancer. November 1-3, 2000. J. Natl. Cancer Inst. Monogr., 30: 5-15, 2001.
27. Robertson, J., Buzdar, A., Nabholtz, J., Thurliman, B., Bonneterre, J., Euler, M., Steinberg, M., and Webster, A. Anastrozole (Arimidex™) versus tamoxifen as first-line therapy for advanced breast cancer (ABC) in post-menopausal (PM) women: prospective combined analysis from two international trials. Second European Breast Cancer Conference, September 26-30, Brussels, 2000.
28. Miller, W. R. Aromatase activity in breast tissue. J. Steroid Biochem. Mol. Biol., 39: 783-790, 1991.
29. Miller, W. R., Mullen, P., Telford, J., and Dixon, J. M. Clinical importance of intratumoral aromatase. Breast Cancer Res. Treat., 49 (Suppl. 1): S27-S32, 1998.
30. Vermeulen, A., Deslypere, J. P., Paridaens, R., Leclercq, G., Roy, F., and Heuson, J. C. Aromatase, 17 β-hydroxysteroid dehydrogenase and intratissular sex hormone concentrations in cancerous and normal glandular breast tissue in postmenopausal women. Eur. J. Cancer Clin. Oncol., 22: 515-525, 1986.
31. Clarke, R., Leonessa, F., Welch, J. N., and Skaar, T. C. Cellular and molecular pharmacology of antiestrogen action and resistance. Pharmacol. Rev., 53: 25-71, 2001.
32. Sasano, H., Nagura, H., Harada, N., Goukon, Y., and Kimura, M. Immunolocalization of aromatase and other steroidogenic enzymes in human breast disorders. Hum. Pathol., 25: 530-535, 1994.
33. Newman, S. P., Purohit, A., Ghilchik, M. W., Potter, B. V. L., and Reed, M. J. Regulation of steroid sulphatase expression and activity in breast cancer. J. Steroid Biochem. Mol. Biol., 75: 259-264, 2000.
34. Santner, S. J., Pauley, R. J., Tait, L., Kaseta, J., and Santen, R. J. Aromatase activity and expression in breast cancer and benign breast tissue stromal cells. J. Clin. Endocrinol. Metab., 82: 200-208, 1997.
35. Pasqualini, J. R., Chetrite, G., and Nestour, E. L. Control and expression of oestrone sulphatase activities in human breast cancer. J. Endocrinol., 150 (Suppl.): S99-S105, 1996.