Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane

Journal of Pharmacology and Experimental Therapeutics

Volumn 306, Issue 2, 2003, Pages 703-708

  Kobayashi, Daisuke ^a,b,c   Nozawa, Takashi ^a,b,c   Imai, Kozue ^a   Nezu, Jun Ichi ^d   Tsuji, Akira ^b,c   Tamai, Ikumi ^a,c  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; ACETIC ACID; ANION; ESTRONE SULFATE; LACTIC ACID; ORGANIC ANION; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTING POLYPEPTIDE B; POLYPEPTIDE; PRAVASTATIN; UNCLASSIFIED DRUG;

ANION TRANSPORT; APICAL MEMBRANE; ARTICLE; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INTESTINE ABSORPTION; INTESTINE EPITHELIUM CELL; PH; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

BIOLOGICAL TRANSPORT; CARBON RADIOISOTOPES; CELL MEMBRANE; CELLS, CULTURED; ESTRONE; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOHISTOCHEMISTRY; INTESTINE, SMALL; ORGANIC ANION TRANSPORTERS; PRAVASTATIN; RADIOPHARMACEUTICALS; TIME FACTORS; TRITIUM;

EID: 0038637144     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.051300     Document Type: Article

References (36)

1. Bergwerk AJ, Shi XY, Ford AC, Kanai N, Jacquemin E, Burk RD, Bai S, Novikoff PM, Stieger B, Meier PJ, et al. (1996) Immunologic distribution of an organic anion transport protein in rat liver and kidney. Am J Physiol 271:G231-G238.
2. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
3. Dresser GK, Bailey DG, Leake BF, Schwarz UI, Dawson PA, Freeman DJ, and Kim RB (2002) Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine. Clin Pharmacol Ther 71:11-20.
4. Hagenbuch B and Meier PJ (2003) The superfamily of organic anion transporting polypeptides. Biochim Biophys Acta 1609:1-18.
5. Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang W-P, and Kirchgessner TG (1999) A novel human hepatic organic anion transporting polypeptide (OATP2). J Biol Chem 274:37161-37168.
6. Kanai N, Lu R, Bao Y, Wolkoff AW, and Schuster VL (1996) Transient expression of oatp organic anion transporter in mammalian cells: identification of candidate substrates. Am J Physiol 270:F319-F325.
7. Koga T, Shimada Y, Kuroda M, Tsujita Y, Hasegawa Y, and Yamazaki M (1990) Tissue-selective inhibition of cholesterol synthesis in vivo by pravastatin sodium, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. Biochim Biophys Acta 1045:115-120.
8. Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, and Meier PJ (2001) Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology 120:525-533.
9. König J, Cui Y, Nies AT, and Keppler D (2000a) A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. Am J Physiol 278:G156-G164.
10. König J, Cui Y, Nies AT, and Keppler D (2000b) Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. J Biol Chem 275:23161-23168.
11. Lilja JJ, Kivistö KT, and Neuvonen PJ (1999) Grapefruit juice increases serum concentrations of atrovastatin and has no effect on pravastatin. Clin Pharmacol Ther 66:118-127.
12. Nakai D, Nakagomi R, Furuta Y, Tokui T, Abe T, Ikeda T, and Nishimura K (2001) Human liver-specific organic anion transporter, LST-1, mediates uptake of pravastatin by human hepatocytes. J Pharmacol Exp Ther 297:861-867.
13. 4 and taurocholate. Biochem Biophys Res Commun 275:831-838.
14. Nozawa T, Nakajima M, Tamai I, Noda K, Nezu J, Sai Y, Tsuji A, and Yokoi T (2002) Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis. J Pharmacol Exp Ther 302:804-813.
15. Pan HY (1991) Clinical pharmacology of pravastatin, a selective inhibitor of HMG-CoA reductase. Eur J Clin Pharmacol 40:S15-S18.
16. 3-exchange. J Biol Chem 272:26340-26345.
17. Simanjuntak MT, Tamai I, Terasaki T, and Tsuji A (1990) Carrier-mediated uptake of nicotinic acid by rat intestinal brush-border membrane vesicles and relation to monocarboxylic acid transport. J Pharmacobio-Dyn 13:301-309.
18. Simanjuntak MT, Terasaki T, Tamai I, and Tsuji A (1991) Participation of monocarboxylic anion and bicarbonate exchange system for the transport of acetic acid and monocarboxylic acid drugs in the small intestinal brush-border membrane vesicles. J Pharmacobio-Dyn 14:501-508.
19. Singhvi SM, Pan HY, Morrison RA, and Willard DA (1990) Disposition of pravastatin sodium, a tissue-selective HMG-CoA reductase inhibitor, in healthy subjects. Br J Clin Pharmacol 29:239-243.
20. St-Pierre MV, Hagenbuch B, Ugele B, Meier PJ, and Stallmach T (2002) Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta. J Clin Endocrinol Metab 87:1856-1863.
21. Takanaga H, Maeda H, Yabuuchi H, Tamai I, Higashida H, and Tsuji A (1996) Nicotinic acid transport mediated by pH-dependent anion antiporter and proton cotransporter in rabbit intestinal brush-border membrane. J Pharm Pharmacol 48:1073-1077.
22. Takanaga H, Tamai I, Inaba S, Sai Y, Higashida H, Yamamoto H, and Tsuji A (1995) cDNA cloning and functional characterization of rat intestinal monocarboxylate transporter. Biochem Biophys Res Commun 217:370-377.
23. Takanaga H, Tamai I, and Tsuji A (1994) pH-dependent and carrier mediated transport of salicylic acid across Caco-2 cells. J Pharm Pharmacol 46:567-570.
24. +-coupled transport of L-carnitine via high-affinity carnitine transporter OCTN2 and its subcellular localization in kidney. Biochim Biophys Acta 1512: 273-284.
25. Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, and Tsuji A (2000a) Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun 273:251-260.
26. Tamai I, Nozawa T, Koshida M, Nezu J, Sai Y, and Tsuji A (2001b) Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C. Pharm Res (NY) 18:1262-1269.
27. Tamai I, Ogihara T, Takanaga H, Maeda H, and Tsuji A (2000b) Anion antiport mechanism is involved in transport of lactic acid across intestinal epithelial brush-border membrane. Biochim Biophys Acta 1468:285-292.
28. Tamai I, Sai Y, Ono A, Kido Y, Yabuuchi H, Takanaga H, Satoh E, Ogihara T, Amano O, Izeki S, and Tsuji A (1999) Immunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by the monocarboxylic acid transporter MCT1. J Pharm Pharmacol 51:1113-1121.
29. Tamai I, Takanaga H, Maeda H, Ogihara T, Yoneda M, and Tsuji A (1995a) Proton-cotransport of pravastatin across intestinal brush-border membrane. Pharm Res (NY) 12:1727-1732.
30. Tamai I, Tanakanga H, Maeda H, Sai Y, Ogihara H, Higashida H, and Tsuji A (1995b) Participation of a proton-cotransporter, MCT1, in the intestinal transport of monocarboxylic acids. Biochem Biophys Res Commun 214:482-489.
31. Tamai I, Yabuuchi H, Nezu J, Sai Y, Oku A, Shimane M, and Tsuji A (1997) Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1. FEBS Lett 419:107-111.
32. Triscari J, O'Donnell D, Zinny M, and Pan HY (1995) Gastrointestinal absorption of pravastatin in healthy subjects. J Clin Pharmacol 35:142-144.
33. +-cotransport mechanism versus pH-partition hypothesis. J Pharm Sci 79:1123-1124.
34. Tsuji A, Takanaga H, Tamai I, and Terasaki T (1994) Transcellular transport of benzoic acid across Caco-2 cells by a pH-dependent and carrier-mediated transport mechanism. Pharm Res (NY) 11:30-37.
35. Walters HC, Craddock AL, Fusegawa H, Willingham MC, and Dawson PA (2000) Expression, transport properties and chromosomal location of organic anion transporter subtype 3. Am J Physiol 279:G1188-G1200.
36. Yabuuchi H, Tamai I, Sai Y, and Tsuji A (1998) Possible role of anion exchanger AE2 as the intestinal monocarboxylic acid/anion antiporter. Pharm Res (NY) 15:411-416.