Different expression patterns of organic anion transporting polypeptides in osteosarcomas, bone metastases and aneurysmal bone cysts

Oncology Reports

Volumn 22, Issue 6, 2009, Pages 1485-1492

  Liedauer, Richard ^a   Svoboda, Martin ^a   Wlcek, Katrin ^c   Arrich, Ferdi ^a   Jäger, Walter ^c   Toma, Cyril ^a,b   Thalhammer, Theresia ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Prince Court Medical Centre ^*  (Malaysia)

^c UNIVERSITY OF VIENNA   (Austria)

Author keywords

Bone tumor; Drug uptake; Multidrug resistance; Organic anion transporting polypeptide

Indexed keywords

GLYCOPROTEIN P; MESSENGER RNA; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 1C1; ORGANIC ANION TRANSPORTER 2A1; ORGANIC ANION TRANSPORTER 2B1; ORGANIC ANION TRANSPORTER 3A1; ORGANIC ANION TRANSPORTER 4A1; ORGANIC ANION TRANSPORTER 4C1; ORGANIC ANION TRANSPORTER 5A1; PREGNANE X RECEPTOR; UNCLASSIFIED DRUG;

ADULT; ANEURYSMAL BONE CYST; ARTICLE; BONE MARROW CELL; BONE METASTASIS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE FUNCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; METASTASIS POTENTIAL; OSTEOBLAST; OSTEOSARCOMA; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADOLESCENT; ADULT; AGED; BONE CYSTS, ANEURYSMAL; BONE NEOPLASMS; BONE RESORPTION; CELL LINE, TUMOR; CHILD; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MIDDLE AGED; NEOPLASM METASTASIS; ORGANIC ANION TRANSPORTERS; OSTEOSARCOMA; TRANSCRIPTION, GENETIC;

EID: 70449371196     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000591     Document Type: Article

References (34)

1. Chou AJ, Geller DS and Gorlick R: Therapy for osteosarcoma: where do we go from here? Paediatr Drugs 10: 315-327, 2008.
2. Cottalorda J and Bourelle S: Modern concepts of primary aneurysmal bone cyst. Arch Orthop Trauma Surg 127: 105-114, 2007.
3. Clines GA and Guise TA: Molecular mechanisms and treatment of bone metastasis. Expert Rev Mol Med 6: e7, 2008.
4. Clark JC, Dass CR and Choong PF: A review of clinical and molecular prognostic factors in osteosarcoma. J Cancer Res Clin Oncol 134: 281-297, 2008.
5. Walters DK, Steinmann P, Langsam B, Schmutz S, Born W and Fuchs B: Identification of potential chemoresistance genes in osteosarcoma. Anticancer Res 28: 673-679, 2008.
6. Zhou SF: Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition 38: 802-832, 2008.
7. Hagenbuch B and Meier PJ: Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties. Pflugers Arch 447: 653-665, 2004.
8. Mikkaichi T, Suzuki T, Tanemoto M, Ito S and Abe T: The organic anion transporter (OATP) family. Drug Metab Pharmacokinet 19: 171-179, 2004.
9. Dobson PD and Kell DB: Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule? Nat Rev Drug Discov 7: 205-220, 2008.
10. Gallagher JC: Advances in bone biology and new treatments for bone loss. Maturitas 60: 65-69, 2008.
11. Hagenbuch B and Gui C: Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family. Xenobiotica 38: 778-801, 2008.
12. Hagenbuch B: Cellular entry of thyroid hormones by organic anion transporting polypeptides. Best Pract Res Clin Endocrinol Metab 21: 209-221, 2007.
13. Nomura T, Lu R, Pucci ML and Schuster VL: The two-step model of prostaglandin signal termination: in vitro reconstitution with the prostaglandin transporter and prostaglandin 15 dehydrogenase. Mol Pharmacol 65: 973-978, 2004.
14. Grube M, Köck K, Karner S, Reuther S, Ritter CA, Jedlitschky G and Kroemer HK: Modification of OATP2B1-mediated transport by steroid hormones. Mol Pharmacol 70: 1735-1741, 2006.
15. Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M and Tsuji A: Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun 273: 251-260, 2000.
16. Huber RD, Gao B, Sidler Pfändler MA, Zhang-Fu W, Leuthold S, Hagenbuch B, Folkers G, Meier PJ and Stieger B: Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain. Am J Physiol Cell Physiol 292: C795-C806, 2007.
17. Satoh F, Unno M, Nunoki K, Suzuki M, Hishinuma T, Goto J, Shimosegawa T, Matsuno S, Ito S and Abe T: Identification and characterization of novel rat and human gonad-specific organic anion transporters. Mol Endocrinol 17: 1203-1215, 2003.
18. Mikkaichi T, Suzuki T, Onogawa T, Tanemoto M, Mizutamari H, Okada M, Chaki T, Masuda S, Tokui T, Eto N, Abe M, Satoh F, Unno M, Hishinuma T, Inui K, Ito S, Goto J and Abe T: Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci USA 101: 3569-3574, 2004.
19. Lee SY, Williamson B, Caballero OL, Chen YT, Scanlan MJ, Ritter G, Jongeneel CV, Simpson AJ and Old LJ: Identification of the gonad-specific anion transporter SLCO6A1 as a cancer/testis (CT) antigen expressed in human lung cancer. Cancer Immun 4: 13, 2004.
20. Wlcek K, Svoboda M, Thalhammer T, Sellner F, Krupitza G and Jaeger W: Altered expression of organic anion transporter polypeptide (OATP) genes in human breast carcinoma. Cancer Biol Ther 7: 1450-1455, 2008.
21. Smith NF, Figg WD and Sparreboom A: Role of the liver-specific transporters OATP1B1 and OATP1B3 in governing drug elimination. Expert Opin Drug Metab Toxicol 1: 429-445, 2005.
22. Ballestero MR, Monte MJ, Briz O, Jimenez F, Gonzalez-San Martin F and Marin JJ: Expression of transporters potentially involved in the targeting of cytostatic bile acid derivatives to colon cancer and polyps. Biochem Pharmacol 72: 729-738, 2006.
23. Raisz LG: Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J Clin Invest 115: 3318-3325, 2005.
24. Biondi B and Cooper DS: The clinical significance of subclinical thyroid dysfunction. Endocr Rev 29: 76-131, 2008.
25. Hikiji H, Takato T, Shimizu T and Ishii S: The roles of prostanoids, leukotrienes, and platelet-activating factor in bone metabolism and disease. Prog Lipid Res 47: 107-126, 2008.
26. Svoboda M, Thalhammer T, Aust S, Arrich F, Assadian O and Toma CD: Estrogen sulfotransferase (SULT1E1) expression in benign and malignant human bone tumors. J Surg Oncol 95: 572-581, 2007.
27. Muller PY, Janovjak H, Miserez AR and Dobbie Z: Processing of gene expression data generated by quantitative real-time RT-PCR. Biotechniques 32: 1372-1379.
28. Ancona N, Maglietta R, Piepoli A, D'Addabbo A, Cotugno R, Savino M, Liuni S, Carella M, Pesole G and Perri F: On the statistical assessment of classifiers using DNA microarray data. BMC Bioinformatics 7: 387, 2006.
29. Harvey CB, O'Shea PJ, Scott AJ, Siebler T, Shalet SM, Samarut J, chassande O and Williams GR: Molecular mechanisms of thyroid hormone effects on bone growth and function. Mol Genet Metab 75: 17-30, 2002.
30. Jankowski CM, Gozansky WS, Kittelson JM, Van Pelt RE, Schwartz RS and Kohrt WM: Increases in bone mineral density in response to oral dehydroepiandrosterone replacement in older adults appear to be mediated by serum estrogens. J Clin Endocrinol Metab 93: 4767-4773, 2008.
31. Schuster VL: Prostaglandin transport. Prostaglandins and other lipid mediated ABC multidrug transporters: structure, function and role in chemoresistance. Pharmacogenomics 9: 105-127, 2008.
32. Chi Y, Pucci ML and Schuster VL: Dietary salt induces transcription of the prostaglandin transporter gene in renal collecting ducts. Am J Physiol Renal Physiol 295: F765-F771, 2008.
33. Eselgrim M, Grunert H, Kuhne T, Zoubek A, Kevric M, Bürger H, Jürgens H, Mayer-Steinacker R, Gosheger G and Bielack SS: Dose intensity of chemotherapy for osteosarcoma and outcome in the Cooperative Osteosarcoma Study Group (COSS) trials. Pediatr Blood Cancer 47: 42-50, 2006.
34. Gui C, Miao Y, Thompson L, Wahlgren B, Mock M, Stieger B and Hagenbuch B: Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. Eur J Pharmacol 584: 57-65, 2008.