Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter

Molecular Endocrinology

Volumn 16, Issue 10, 2002, Pages 2283-2296

  Pizzagalli, F ^a   Hagenbuch, B ^a   Stieger, B ^a   Klenk, U ^b   Folkers, G ^c   Meier, P J ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b Swiss Federal Institute of Technology ^*

^c ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BROMSULFOPHTHALEIN; CARRIER PROTEIN; DEXTROTHYROXINE; DIIODOTHYRONINE; ESTRADIOL 17 GLUCURONIDE; ESTRONE SULFATE; ORGANIC ANION TRANSPORTING POLYPEPTIDE; THYROXINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BRAIN; BRAIN REGION; CHROMOSOME 12P; CONTROLLED STUDY; GENE LOCATION; HORMONE TRANSPORT; HUMAN; HUMAN CELL; HUMAN TISSUE; LEYDIG CELL; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FAMILY; STEREOSPECIFICITY; TESTIS;

AMINO ACID SEQUENCE; ANIMALS; BRAIN; CHO CELLS; CHROMOSOMES, HUMAN, PAIR 12; CLONING, MOLECULAR; CRICETINAE; DIIODOTHYRONINES; ESTRADIOL; ESTRONE; FEMALE; HUMANS; LEYDIG CELLS; MALE; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; OOCYTES; ORGAN SPECIFICITY; ORGANIC ANION TRANSPORTERS; SEQUENCE HOMOLOGY, AMINO ACID; SULFOBROMOPHTHALEIN; TESTIS; THYROXINE; TRIIODOTHYRONINE; XENOPUS;

RODENTIA;

EID: 0036793106     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2001-0309     Document Type: Article

References (39)

1. Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B 2001 Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology 120:525-533
2. Meier PJ, Eckhardt U, Schroeder A, Hagenbuch B, Stieger B 1997 Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver. Hepatology 26:1667-1677
3. Reichel C, Gao B, van Montfoort J, Cattori V, Rahner C, Hagenbuch B, Stieger B, Kamisako T, Meier PJ 1999 Localization and function of the organic anion-transporting polypeptide Oatp2 in rat liver. Gastroenterology 117:688-695
4. Cattori V, van Montfoort JE, Stieger B, Landmann L, Meijer DKF, Winterhalter KE, Meier PJ, Hagenbuch B 2001 Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3. Pflügers Arch 443:188-195
5. Fujiwara K, Adachi H, Nishio T, Unno M, Tokui T, Okabe M, Onogawa T, Suzuki T, Asano N, Tanemoto M, Seki M, Shiiba K, Suzuki M, Kondo Y, Nunoki K, Shimosegawa T, Iinuma K, Ito S, Matsuno S, Abe T 2001 Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. Endocrinology 142:2005-2012
6. Abe T, Kakyo M, Tokui T, Nakagomi R, Nishio T, Nakai D, Nomura H, Unno M, Suzuki M, Naitoh T, Matsuno S, Yawo H 1999 Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J Biol Chem 274:17159-17163
7. Cattori V, Hagenbuch B, Hagenbuch N, Stieger B, Ha R, Winterhalter KE, Meier PJ 2000 Identification of organic anion transporting polypeptide 4 (Oatp4) as a major fulllength isoform of the liver-specific transporter-1 (rlst-1) in rat liver. FEBS Lett 474:242-245
8. König J, Cui Y, Nies AT, Keppler D 2000 A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. Am J Physiol 278: G156-G164
9. König J, Cui Y, Nies AT, Keppler D 2000 Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. J Biol Chem 275:23161-23168
10. Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA, Gocayne JD, Amanatides P, Ballew RM, Huson DH, Wortman JR, Zhang Q, Kodira CD, Zheng XH, Chen L, Skupski M, Subramanian G, Thomas PD, Zhang J, Gabor Miklos GL, Nelson C, Broder S, Clark AG, Nadeau J, McKusick VA, Zinder N, Levine AJ, Roberts RJ, Simon M, Slayman C, Hunkapiller M, Bolanos R, Delcher A, Dew I, Fasulo D, Flanigan M, Florea L, Halpern A, Hannenhalli S, Kravitz S, Levy S, Mobarry C, Reinert K, Remington K, Abu-Threideh J, Beasley E, Biddick K, Bonazzi V, Brandon R, Cargill M, Chandramouliswaran I, Charlab R, Chaturvedi K, Deng Z, Di Francesco V, Dunn P, Eilbeck K, Evangelista C, Gabrielian AE, Gan W, Ge W, Gong F, Gu Z, Guan P, Heiman TJ, Higgins ME, Ji RR, Ke Z, Ketchum KA, Lai Z, Lei Y, Li Z, Li J, Liang Y, Lin X, Lu F, Merkulov GV, Milshina N, Moore HM, Naik AK, Narayan VA, Neelam B, Nusskern D, Rusch DB, Salzberg S, Shao W, Shue B, Sun J, Wang Z, Wang A, Wang X, Wang J, Wei M, Wides R, Xiao C, Yan C, et al. 2001 The sequence of the human genome. Science 291:1304-1351
11. Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, Funke R, Gage D, Harris K, Heaford A, Howland J, Kann L, Lehoczky J, LeVine R, McEwan P, McKernan K, Meldrim J, Mesirov JP, Miranda C, Morris W, Naylor J, Raymond C, Rosetti M, Santos R, Sheridan A, Sougnez C, Stange-Thomann N, Stojanovic N, Subramanian A, Wyman D, Rogers J, Sulston J, Ainscough R, Beck S, Bentley D, Burton J, Clee C, Carter N, Coulson A, Deadman R, Deloukas P, Dunham A, Dunham I, Durbin R, French L, Grafham D, Gregory S, Hubbard T, Humphray S, Hunt A, Jones M, Lloyd C, McMurray A, Matthews L, Mercer S, Milne S, Mullikin JC, Mungall A, Plumb R, Ross M, Shownkeen R, Sims S, Waterston RH, Wilson RK, Hillier LW, McPherson JD, Marra MA, Mardis ER, Fulton LA, Chinwalla AT, Pepin KH, Gish WR, Chissoe SL, Wendl MC, Delehaunty KD, Miner TL, Delehaunty A, Kramer JB, Cook LL, Fulton RS, Johnson DL, Minx PJ, Clifton SW, Hawkins T, Branscomb E, Predki P, Richardson P, Wenning S, Slezak T, Doggett N, Cheng JF, Olsen A, Lucas S, Elkin C, Uberbacher E, Frazier M, et al. 2001 Initial sequencing and analysis of the human genome. Nature 409:860-921
12. Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A 2000 Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun 273:251-260
13. Hagenbuch B, Meier PJ 1996 Sinusoidal (basolateral) bile salt uptake systems of hepatocytes. Semin Liver Dis 16:129-136
14. Kullak-Ublick GA, Hagenbuch B, Stieger B, Schteingart CD, Hofmann AF, Wolkoff AW, Meier PJ 1995 Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology 109:1274-1282
15. Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang W-P, Kirchgessner TG 1999 A novel human hepatic organic anion transporting polypeptide (OATP2). J Biol Chem 274:37161-37168
16. Lu R, Kanai N, Bao Y, Schuster VL 1996 Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA (HPGT). J Clin Invest 98:1142-1149
17. van Montfoort JE, Hagenbuch B, Fattinger K, Müller M, Groothuis GMM, Meijer DKF, Meier PJ 1999 Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations. J Pharmacol Exp Ther 291:147-152
18. Gao B, Hagenbuch B, Kullak-Ublick GA, Benke D, Aguzzi A, Meier PJ 2000 Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier. J Pharmacol Exp Ther 294:73-79
19. Friesema EC, Docter R, Moerings EP, Stieger B, Hagenbuch B, Meier PJ, Krenning EP, Hennemann G, Visser TJ 1999 Identification of thyroid hormone transporters. Biochem Biophys Res Commun 254:497-501
20. Bossuyt X, Muller M, Hagenbuch B, Meier PJ 1996 Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver. J Pharmacol Exp Ther 276:891-896
21. Saito H, Masuda S, Inui K 1996 Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney. J Biol Chem 271:20719-20725
22. Sekine T, Watanabe N, Hosoyamada M, Kanai Y, Endou H 1997 Expression cloning and characterization of a novel multispecific organic anion transporter. J Biol Chem 272:18526-18529
23. Hennemann G, Docter R, Fritschy JM, De Jong M, Krenning EP, Visser TJ 2001 Plasma membrane transport of thyroid hormones and its role in thyroid hormone metabolism and bioavailability. Endocr Rev 22:451-476
24. Cai S-Y, Wang W, Soroka CJ, Ballatori N, Boyer JL 2001 Molecular and functional characterization of a novel hepatic organic anion transporting polypeptide (OATP) from a primitive vertebrate. Hepatology 34:A1208
25. Goncalves E, Lakshmanan M, Pontecorvi A, Robbins J 1990 Thyroid hormone transport in a human glioma cell line. Mol Cell Endocrinol 69:157-165
26. Bianco AC, Salvatore D, Gereben B, Berry MJ, Larsen PR 2002 Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev 23:38-89
27. Gharbi-Chini J, Torresani J 1981 Thyroid hormone binding to plasma membrane preparations: studies in different thyroid states and tissues. J Endocrinol Invest 4:177-183
28. Mendis-Handagama SM, Ariyaratne HB 2001 Differentiation of the adult Leydig cell population in the postnatal testis. Biol Reprod 65:660-671
29. Manna PR, Poy P, Clark BJ, Stocco DM, Huhtaniemi IT 2001 Interaction of thyroid hormone and steroidogenic acute regulatory (StAR) protein in the regulation of murine Leydig cell steroidogenesis. J Steroid Biochem Mol Biol 76:167-177
30. Abe T, Kakyo M, Sakagami H, Tokui T, Nishio T, Tanemoto M, Nomura H, Hebert SC, Masuno S, Kondo H, Yawo H 1998 Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2. J Biol Chem 273:22395-22401
31. 35S]sulfobromophthalein of high specific activity. Anal Biochem 179:72-74
32. +/taurocholate cotransporting polypeptide (Ntcp) in rat liver. Gastroenterology 107:1781-1787
33. Shi S, Key M, Kalra KL 1991 Antigen retrieval from formalin-fixed, paraffin-embedded tissue: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J Histochem Cytochem 39:741-748
34. Hagenbuch B, Scharschmidt BF, Meier PJ 1996 Effect of antisense oligonucleotides on the expression of hepatocellular bile acid and organic anion uptake systems in Xenopus laevis oocytes. Biochem J 316:901-904
35. Eckhardt U, Schroeder A, Stieger B, Höchli M, Landmann L, Tynes R, Meier PJ, Hagenbuch B 1999 Polyspecific substrate uptake by the hepatic organic anion tranporter oatp1 in stably transfected CHO cells. Am J Physiol 276:G1037-G1042
36. Palermo DP, DeGraaf ME, Marotti KR, Rehberg E, Post LE 1991 Production of analytical quantities of recombinant proteins in Chinese hamster ovary cells using sodium butyrate to elevate gene expression. J Biotechnol 19:35-48
37. Rost B 1996 PHD: predicting one-dimensional protein structure by profile-based neural networks. Methods Enzymol 266:525-539
38. Devereux J, Haeberli P, Smithies O 1984 A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res 12:387-395
39. Page RDM 1996 TreeView: an application to display phylogenetic trees on personal computers. Comput Appl Biosci 12:357-358