Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics

Clinical Pharmacology and Therapeutics

Volumn 79, Issue 3, 2006, Pages 186-196

  Katz, David A ^a   Carr, Robert ^a   Grimm, David R ^a   Xiong, Hao ^a   Holley Shanks, Rhonda ^a   Mueller, Toby ^a   Leake, Brenda ^a   Wang, Qiang ^a   Han, Lixin ^a   Wang, Perry G ^a   Edeki, Timi ^a   Sahelijo, Leonardo ^a   Doan, Thao ^a   Allen, Andrew ^a   Spear, Brian B ^a   Kim, Richard B ^a  

^a R48B/AP6C 6 ^*

Author keywords

[No Author keywords available]

Indexed keywords

ATRASENTAN; CARRIER PROTEIN; CYTOCHROME P450 3A5; ENDOTHELIN A RECEPTOR; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 2B15; GLUCURONOSYLTRANSFERASE 2B4; ORGANIC ANION TRANSPORTER 2; ORGANIC CATION TRANSPORTER 2; UNCLASSIFIED DRUG;

ADULT; ANALYSIS OF COVARIANCE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EXPOSURE; ENZYME ACTIVITY; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; HELA CELL; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IN VITRO STUDY; IN VIVO STUDY; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; STEADY STATE;

ADULT; ALLELES; CARRIER PROTEINS; FEMALE; GENOTYPE; HELA CELLS; HUMANS; MALE; MIDDLE AGED; ORGANIC ANION TRANSPORTERS; PHENOTYPE; PYRROLIDINES; TRANSFECTION;

EID: 33644543341     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clpt.2005.11.003     Document Type: Article

References (31)

1. T. Abe, M. Kakyo, T. Tokui, R. Nakagomi, T. Nishio, D. Nakai Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1 J Biol Chem 274 1999 17159 17163
2. Y. Cui, J. König, I. Leier, U. Buchholz, D. Keppler Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6 J Biol Chem 276 2001 9626 9630
3. B. Hsiang, Y. Zhu, Z. Wang, Y. Wu, V. Sasseville, W. Yang A novel human hepatic organic anion transporting polypeptide (OATP2) J Biol Chem 274 1999 37161 37168
4. J. König, Y. Cui, A. Nies, D. Keppler Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide J Biol Chem 275 2000 23161 23168
5. I. Tamai, J.-I. Nezu, H. Uchino, Y. Sai, A. Oku, M. Shimane Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family Biochem Biophys Res Comm 273 2000 251 260
6. R. Tirona, B. Leake, A. Wolkoff, R. Kim Human organic anion transporting protein-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation J Pharmacol Exp Ther 304 2003 223 228
7. T. Nozawa, M. Nakajima, I. Tamai, K. Noda, J.-I. Nezu, Y. Sai Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9) allele frequencies in the Japanese population and functional analysis J Pharmacol Exp Ther 302 2002 804 813
8. C. Michalski, Y. Cui, A. Nies, A. Nuessler, P. Neuhaus, U. Zanger A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter J Biol Chem 277 2002 43058 43063
9. Y. Nishizato, I. Ieiri, H. Suzuki, M. Kimura, K. Kawabata, T. Hirota Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes consequences for pravastatin pharmacokinetics Clin Pharmacol Ther 73 2003 554 565
10. M. Niemi, E. Schaeffeler, T. Lang, M. Fromm, M. Neuvonen, C. Kyrklund High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1) Pharmacogenetics 14 2004 429 440
11. J. Mwinyi, A. Johne, S. Bauer, I. Roots, T. Gerloff Evidence for inverse effects of OATP-C (SLC21A6) *5 and *1b haplotypes on pravastatin kinetics Clin Pharmacol Ther 75 2004 415 421
12. G. Kullak-Ublick, M. Ismair, B. Stieger, L. Landmann, R. Huber, F. Pizzagalli Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver Gastroenterology 120 2001 525 533
13. A. Treiber, R. Schneiter, S. Delahaye, M. Clozel Inhibition of organic anion transporting polypeptide-mediated hepatic uptake is the major determinant in the pharmacokinetic interaction between bosentan and cyclosporin A in the rat J Pharmacol Exp Ther 308 2004 1121 1129
14. M. Cvetkovic, B. Leake, M. Fromm, G. Wilkinson, R. Kim OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine Drug Metab Dispos 27 1999 866 871
15. P.G. Wang, J. Wei, M. Chang, T. El-Shourbagy High-throughput determination of atrasentan in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry Biomed Chromatogr 19 2005 663 670
16. S. Hoffmeyer, O. Burk, O. von Richter, H. Arnold, J. Brockmöller, A. Johne Functional polymorphisms of the human multidrug-resistance gene multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo Proc Natl Acad Sci U S A 97 2000 3473 3478
17. R. Kim, B. Leake, E. Choo, G. Dresser, S. Kubba, U. Schwarz Identification of functionally variant MDR1 alleles among European Americans and African Americans Clin Pharmacol Ther 70 2001 189 199
18. P. Kuehl, J. Zhang, Y. Lin, J. Lamba, M. Assem, J. Schuetz Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression Nat Genet 27 2001 383 391
19. M. Leabman, C. Huang, M. Kawamoto, S. Johns, D. Stryke, T. Ferrin Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function Pharmacogenetics 12 2002 395 405
20. R. Tirona, B. Leake, G. Merino, R. Kim Polymorphisms in OATP-C J Biol Chem 276 2001 35669 35675
21. P. Bosma, J. Chowdhury, C. Bakker, S. Gantla, A. deBoer, B. Oostra The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome New Engl J Med 333 1995 1171 1175
22. M. Riedy, J.-Y. Wang, A. Miller, A. Buckler, J. Hall, M. Guida Genomic organization of the UGT2b gene cluster on human chromosome 4q13 Pharmacogenetics 10 2000 251 260
23. É. Lévesque, M. Beaulieu, D. Hum, A. Bélanger Characterization and substrate specificity of UGT2B4 (E458) a UDP-glucuronosyltransferase encoded by a polymorphic gene Pharmacogenetics 9 1999 207 216
24. D. Katz Method of haplotyping and kit therefor inventor; Abbott Laboratories, assignee US patent US20030027150 A1 2003 Feb 6
25. H. Xiong, J. Jankowski, E. Ashbrenner, Y. Chiu, M. Mendoza, P. Wang Effect of rifampin (RIF) on the pharmacokinetics (PK) of atrasentan (ABT-627, ATN) [abstract] J Clin Oncol 22 2004 4728
26. K. Letschert, D. Keppler, J. König Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8) Pharmacogenetics 14 2004 453 464
27. Y. Shitara, T. Itoh, H. Sato, A.P. Li, Y. Sugiyama Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A J Pharmacol Exp Ther 304 2003 610 616
28. D. Schneck, B. Birmingham, J. Zalikowski, P. Mitchell, Y. Wang, P. Martin The effect of gemfibrozil on the pharmacokinetics of rosuvastatin Clin Pharmacol Ther 75 2004 455 463
29. S. Simonson, A. Raza, P. Martin, P. Mitchell, J. Jarcho, C. Brown Rosuvastatin pharmacokinetics in heart transplant recipients administered an antirejection regimen including cyclosporine Clin Pharmacol Ther 76 2004 167 177
30. T. Nozawa, S. Sugiura, M. Nakajima, A. Goto, T. Yokoi, J.-I. Nezu Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate implications for understanding troglitazone hepatotoxicity Drug Metab Dispos 32 2004 291 294
31. D. Katz, D. Grimm, R. Carr, H. Xiong, R. Holley-Shanks, T. Mueller Pharmacogenetic meta-analysis suggests that atrasentan is an organic anion transport protein C substrate [abstract] Clin Pharmacol Ther 75 2004 P94