Modulation of the Maladaptive Stress Response to Manage Diseases of Protein Folding

PLoS Biology

Volumn 12, Issue 11, 2014, Pages

  Roth, Daniela Martino ^a   Hutt, Darren M ^a   Tong, Jiansong ^a   Bouchecareilh, Marion ^a   Wang, Ning ^b   Seeley, Theo ^a   Dekkers, Johanna F ^c   Beekman, Jeffrey M ^c   Garza, Dan ^d   Drew, Lawrence ^d   Masliah, Eliezer ^e   Morimoto, Richard I ^b   Balch, William E ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d Proteostasis Therapeutics Inc   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; HEAT SHOCK PROTEIN 40; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HEAT SHOCK TRANSCRIPTION FACTOR 1; PROTEIN P23; ALKYLATING AGENT; CFTR PROTEIN, HUMAN; DITERPENE; DNA BINDING PROTEIN; EPOXIDE; HEAT SHOCK TRANSCRIPTION FACTOR; ISOMERASE; PHENANTHRENE DERIVATIVE; PROSTAGLANDIN E SYNTHASE; TRANSCRIPTION FACTOR; TRIPTOLIDE;

ALPHA 1 ANTITRYPSIN DEFICIENCY; ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CAENORHABDITIS ELEGANS; CELL LINE; CONTROLLED STUDY; CYSTIC FIBROSIS; CYTOSOL; DISEASE COURSE; DISEASE EXACERBATION; DOWN REGULATION; EPITHELIUM; GAIN OF FUNCTION MUTATION; GENE SILENCING; HEAT SHOCK RESPONSE; HUMAN; HUMAN CELL; HUMAN TISSUE; LOSS OF FUNCTION MUTATION; MOUSE; NIEMANN PICK DISEASE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STRUCTURE; ANIMAL; CYTOPLASM; GENETICS; METABOLISM; PHYSIOLOGICAL STRESS; PRECLINICAL STUDY; PROTEOSTASIS DEFICIENCY; RESPIRATORY TRACT MUCOSA; TRANSGENIC MOUSE;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; CAENORHABDITIS ELEGANS; CELL LINE; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DITERPENES; DNA-BINDING PROTEINS; DRUG EVALUATION, PRECLINICAL; EPOXY COMPOUNDS; GENE SILENCING; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; MICE, TRANSGENIC; ORGANOIDS; PHENANTHRENES; PROTEIN FOLDING; PROTEOSTASIS DEFICIENCIES; RESPIRATORY MUCOSA; STRESS, PHYSIOLOGICAL; TRANSCRIPTION FACTORS;

EID: 84912572110     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1001998     Document Type: Article

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