Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 36, 2008, Pages 13626-13631

  Steele, Andrew D ^a,d   Hutter, Gregor ^b   Jackson, Walker S ^a   Heppner, Frank L ^b,e   Borkowski, Andrew W ^a   King, Oliver D ^a,f   Raymond, Gregory J ^c   Aguzzi, Adriano ^b   Lindquist, Susan ^a  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^f BOSTON BIOMEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

HSF1; Neurodegeneration; Protein misfolding; Prp; Transmissible spongiform encephalopathy

Indexed keywords

HEAT SHOCK FACTOR 1; HEAT SHOCK PROTEIN; PRION PROTEIN; PROTEINASE K; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BEHAVIOR DISORDER; BIOACCUMULATION; CONTROLLED STUDY; HISTOPATHOLOGY; KNOCKOUT MOUSE; LIFESPAN; MOTOR PERFORMANCE; MOUSE; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; PRION; PRION DISEASE; PRIORITY JOURNAL; PROTEIN FUNCTION; SURVIVAL; VIRUS INFECTIVITY;

AGING; ANIMALS; BEHAVIOR, ANIMAL; DNA-BINDING PROTEINS; ENDOPEPTIDASE K; MICE; MICE, KNOCKOUT; PRION DISEASES; PRIONS; SURVIVAL RATE; TRANSCRIPTION FACTORS;

MUS;

EID: 51649130437     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0806319105     Document Type: Article

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