Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state

Science

Volumn 341, Issue 6143, 2013, Pages

  Santagata, Sandro ^a,b,c   Mendillo, Marc L ^c,d   Tang, Yun Chi ^d,g   Subramanian, Aravind ^e   Perley, Casey C ^c,d   Roche, Stéphane P ^f   Wong, Bang ^e   Narayan, Rajiv ^e   Kwon, Hyoungtae ^c,d   Koeva, Martina ^c,d   Amon, Angelika ^d   Golub, Todd R ^e   Porco, John A ^f   Whitesell, Luke ^c   Lindquist, Susan ^c,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^f Boston University   (United States)

^g SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID TRANSFER RNA LIGASE; ANISOMYCIN; ANTINEOPLASTIC AGENT; CEPHAELINE; EMETINE; GREEN FLUORESCENT PROTEIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK TRANSCRIPTION FACTOR 1; INITIATION FACTOR; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; POLYPEPTIDE; PROTEASOME; QUERCETIN; RNA POLYMERASE II; ROHINITIB; SHORT HAIRPIN RNA; THIOREDOXIN INTERACTING PROTEIN; TRIPTOLIDE; UNCLASSIFIED DRUG; BENZOFURAN DERIVATIVE; DNA BINDING PROTEIN; HEAT SHOCK TRANSCRIPTION FACTOR; ROCAGLAMIDE; TRANSCRIPTION FACTOR;

BIOCHEMISTRY; CANCER; CELL ORGANELLE; GENE EXPRESSION; HEAT SHOCK; LESION; PROTEIN; TUMOR;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; BIOMASS; BREAST ADENOCARCINOMA; CANCER CELL; CANCER MODEL; CELL PROLIFERATION; CHROMOSOMAL INSTABILITY; COMPETITIVE INHIBITION; DNA BINDING MOTIF; DNA DETERMINATION; ENERGY METABOLISM; GENE EXPRESSION; GENETIC DATABASE; GENETIC SCREENING; GLUCOSE TRANSPORT; HEAT SHOCK RESPONSE; HELA CELL; HIGH THROUGHPUT SCREENING; HOUSEKEEPING GENE; HUMAN; LEUKEMIA CELL; MICROSATELLITE INSTABILITY; MYELOID LEUKEMIA; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN SYNTHESIS; RIBOSOME; RIBOSOME SUBUNIT; RNA PROCESSING; SARCOMA; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION REGULATION; TRANSLATION INITIATION; UPREGULATION; WILD TYPE; ANIMAL; BIOSYNTHESIS; CANCER TRANSPLANTATION; CELL STRAIN 3T3; CELL TRANSFORMATION; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MOUSE; NEOPLASM; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZOFURANS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; DNA-BINDING PROTEINS; ENERGY METABOLISM; GENE EXPRESSION REGULATION, NEOPLASTIC; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MICE; NEOPLASM TRANSPLANTATION; NEOPLASMS; NIH 3T3 CELLS; PROTEIN BIOSYNTHESIS; RIBOSOMES; TRANSCRIPTION FACTORS;

MLCS; MLOWN;

EID: 84880438841     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1238303     Document Type: Article

References (45)

1. D. Ruggero, P. P. Pandolfi, Nat. Rev. Cancer 3, 179-192 (2003). doi: 10.1038/nrc1015; pmid: 12612653
2. J. C. Chan et al., Sci. Signal. 4, ra56 (2011). doi: 10.1126/scisignal. 2001754; pmid: 21878679
3. R. J. White, Nat. Rev. Mol. Cell Biol. 6, 69-78 (2005). doi: 10.1038/nrm1551; pmid: 15688068
4. K. M. Hannan et al., Mol. Cell. Biol. 23, 8862-8877 (2003). doi: 10.1128/MCB.23.23.8862-8877.2003; pmid: 14612424
5. D. Silvera, S. C. Formenti, R. J. Schneider, Nat. Rev. Cancer 10, 254-266 (2010). doi: 10.1038/nrc2824; pmid: 20332778
6. P. P. Roux, I. Topisirovic, Cold Spring Harb. Perspect. Biol. 4, a012252 (2012). doi: 10.1101/cshperspect.a012252; pmid: 22888049
7. F. U. Hartl, M. Hayer-Hartl, Science 295, 1852-1858 (2002). doi: 10.1126/science.1068408; pmid: 11884745
8. M. L. Mendillo et al., Cell 150, 549-562 (2012). doi: 10.1016/j.cell.2012.06.031; pmid: 22863008
9. L. Whitesell, S. Lindquist, Expert Opin. Ther. Targets 13, 469-478 (2009). doi: 10.1517/14728220902832697; pmid: 19335068
10. M. E. Bordeleau et al., J. Clin. Invest. 118, 2651-2660 (2008). pmid: 18551192
11. J. M. Chambers et al., Org. Lett. 15, 1406-1409 (2013). doi: 10.1021/ol400401d; pmid: 23461621
12. C. M. Rodrigo, R. Cencic, S. P. Roche, J. Pelletier, J. A. Porco Jr., J. Med. Chem. 55, 558-562 (2012). doi: 10.1021/jm201263k; pmid: 22128783
13. S. P. Roche, R. Cencic, J. Pelletier, J. A. Porco Jr., Angew. Chem. Int. Ed. Engl. 49, 6533-6538 (2010). doi: 10.1002/anie.201003212; pmid: 20687060
14. X. Jin, D. Moskophidis, N. F. Mivechi, Cell Metab. 14, 91-103 (2011). doi: 10.1016/j.cmet.2011.03.025; pmid: 21723507
15. C. Dai, L. Whitesell, A. B. Rogers, S. Lindquist, Cell 130, 1005-1018 (2007). doi: 10.1016/j.cell.2007.07.020; pmid: 17889646
16. H. Parikh et al., PLoS Med. 4, e158 (2007). doi: 10.1371/journal.pmed. 0040158; pmid: 17472435
17. C. A. Stoltzman et al., Proc. Natl. Acad. Sci. U.S.A. 105, 6912-6917 (2008). doi: 10.1073/pnas.0712199105; pmid: 18458340
18. S. Y. Kim, H. W. Suh, J. W. Chung, S. R. Yoon, I. Choi, Cell. Mol. Immunol. 4, 345-351 (2007). pmid: 17976314
19. C. Dai et al., J. Clin. Invest. 122, 3742-3754 (2012). doi: 10.1172/JCI62727; pmid: 22945628
20. Y. C. Tang, B. R. Williams, J. J. Siegel, A. Amon, Cell 144, 499-512 (2011). doi: 10.1016/j.cell.2011.01.017; pmid: 21315436
21. B. R. Williams et al., Science 322, 703-709 (2008). doi: 10.1126/science.1160058; pmid: 18974345
22. S. Santagata et al., Proc. Natl. Acad. Sci. U.S.A. 108, 18378-18383 (2011). doi: 10.1073/pnas.1115031108; pmid: 22042860
23. F. Fang, R. Chang, L. Yang, Cancer 118, 1782-1794 (2012). doi: 10.1002/cncr.26482; pmid: 22009757
24. L. Alinari et al., Clin. Cancer Res. 18, 4600-4611 (2012). doi: 10.1158/1078-0432.CCR-12-0839; pmid: 22791882
25. R. Cencic et al., PLoS ONE 4, e5223 (2009). doi: 10.1371/journal.pone. 0005223; pmid: 19401772
26. D. M. Lucas et al., Blood 113, 4656-4666 (2009). doi: 10.1182/blood-2008-09-175430; pmid: 19190247
27. M. Okabe et al., Leuk. Res. 19, 933-943 (1995). doi: 10.1016/0145- 2126(95)00039-9; pmid: 8632663
28. L. Meng, V. L. Gabai, M. Y. Sherman, Oncogene 29, 5204-5213 (2010). doi: 10.1038/onc.2010.277; pmid: 20622894
29. S. Santagata et al., ACS Chem. Biol. 7, 340-349 (2012). doi: 10.1021/cb200353m; pmid: 22050377
30. K. L. Scott et al., Cancer Cell 20, 92-103 (2011). doi: 10.1016/j.ccr.2011.05.025; pmid: 21741599
31. V. L. Gabai et al., Mol. Cell. Biol. 32, 929-940 (2012). doi: 10.1128/MCB.05921-11; pmid: 22215620
32. S. D. Westerheide, J. Anckar, S. M. Stevens Jr., L. Sistonen, R. I. Morimoto, Science 323, 1063-1066 (2009). doi: 10.1126/science.1165946; pmid: 19229036
33. O. Brandman et al., Cell 151, 1042-1054 (2012). doi: 10.1016/j.cell.2012. 10.044; pmid: 23178123
34. J. S. Hahn, Z. Hu, D. J. Thiele, V. R. Iyer, Mol. Cell. Biol. 24, 5249-5256 (2004). doi: 10.1128/MCB.24.12.5249-5256.2004; pmid: 15169889
35. A. L. Hsu, C. T. Murphy, C. Kenyon, Science 300, 1142-1145 (2003). doi: 10.1126/science.1083701; pmid: 12750521
36. S. D. Chou, T. Prince, J. Gong, S. K. Calderwood, PLoS ONE 7, e39679 (2012). doi: 10.1371/journal.pone.0039679; pmid: 22768106
37. S. M. Hensen et al., Cell Stress Chaperones 17, 743-755 (2012). doi: 10.1007/s12192-012-0347-1; pmid: 22797943
38. T. Peng, T. R. Golub, D. M. Sabatini, Mol. Cell. Biol. 22, 5575-5584 (2002). doi: 10.1128/MCB.22.15.5575-5584.2002; pmid: 12101249
39. L. Whitesell, S. Santagata, N. U. Lin, Curr. Mol. Med. 12, 1108-1124 (2012). doi: 10.2174/156652412803306657; pmid: 22804235
40. N. L. Solimini, J. Luo, S. J. Elledge, Cell 130, 986-988 (2007). doi: 10.1016/j.cell.2007.09.007; pmid: 17889643
41. J. Lamb et al., Science 313, 1929-1935 (2006). doi: 10.1126/science. 1132939; pmid: 17008526
42. A. Subramanian et al., Proc. Natl. Acad. Sci. U.S.A. 102, 15545-15550 (2005). doi: 10.1073/pnas.0506580102; pmid: 16199517
43. D. Peck et al., Genome Biol. 7, R61 (2006). doi: 10.1186/gb-2006-7-7-r61; pmid: 16859521
44. T. A. Ince et al., Cancer Cell 12, 160-170 (2007). doi: 10.1016/j.ccr.2007.06.013; pmid: 17692807
45. T. J. Turbyville et al., J. Nat. Prod. 69, 178-184 (2006). doi: 10.1021/np058095b; pmid: 16499313