-
4
-
-
0141819143
-
An age-induced switch to a hyper-recombinational state
-
McMurray M.A., Gottschling D.E. An age-induced switch to a hyper-recombinational state. Science 2003, 301:1908-1911.
-
(2003)
Science
, vol.301
, pp. 1908-1911
-
-
McMurray, M.A.1
Gottschling, D.E.2
-
5
-
-
67549136242
-
Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect
-
Veatch J.R., McMurray M.A., Nelson Z.W., Gottschling D.E. Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect. Cell 2009, 137:1247-1258.
-
(2009)
Cell
, vol.137
, pp. 1247-1258
-
-
Veatch, J.R.1
McMurray, M.A.2
Nelson, Z.W.3
Gottschling, D.E.4
-
6
-
-
34249873947
-
Translocation of proteins into mitochondria
-
Neupert W., Herrmann J.M. Translocation of proteins into mitochondria. Annu Rev Biochem 2007, 76:723-749.
-
(2007)
Annu Rev Biochem
, vol.76
, pp. 723-749
-
-
Neupert, W.1
Herrmann, J.M.2
-
7
-
-
84864296714
-
The role of mitochondria in cellular iron-sulfur protein biogenesis and iron metabolism
-
Lill R., Hoffmann B., Molik S., Pierik A.J., Rietzschel N., Stehling O., Uzarska M.A., Webert H., Wilbrecht C., Mühlenhoff U. The role of mitochondria in cellular iron-sulfur protein biogenesis and iron metabolism. Biochim Biophys Acta 2012, 1823:1491-1508.
-
(2012)
Biochim Biophys Acta
, vol.1823
, pp. 1491-1508
-
-
Lill, R.1
Hoffmann, B.2
Molik, S.3
Pierik, A.J.4
Rietzschel, N.5
Stehling, O.6
Uzarska, M.A.7
Webert, H.8
Wilbrecht, C.9
Mühlenhoff, U.10
-
8
-
-
83655212423
-
Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes
-
Netz D.J.A., Stith C.M., Stümpfig M., Köpf G., Vogel D., Genau H.M., Stodola J.L., Lill R., Burgers P.M.J., Pierik A.J. Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes. Nat Chem Biol 2012, 8:125-132.
-
(2012)
Nat Chem Biol
, vol.8
, pp. 125-132
-
-
Netz, D.J.A.1
Stith, C.M.2
Stümpfig, M.3
Köpf, G.4
Vogel, D.5
Genau, H.M.6
Stodola, J.L.7
Lill, R.8
Burgers, P.M.J.9
Pierik, A.J.10
-
9
-
-
84857029886
-
Iron-sulphur clusters in nucleic acid processing enzymes
-
White M.F., Dillingham M.S. Iron-sulphur clusters in nucleic acid processing enzymes. Curr Opin Struct Biol 2012, 22:94-100.
-
(2012)
Curr Opin Struct Biol
, vol.22
, pp. 94-100
-
-
White, M.F.1
Dillingham, M.S.2
-
10
-
-
84871011474
-
An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast
-
Hughes A.L., Gottschling D.E. An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast. Nature 2012, 492:261-265.
-
(2012)
Nature
, vol.492
, pp. 261-265
-
-
Hughes, A.L.1
Gottschling, D.E.2
-
11
-
-
0242585476
-
Asymmetric inheritance of oxidatively damaged proteins during cytokinesis in Saccharomyces cerevisiae: a Sir2p dependent mechanism
-
Aguilaniu H., Gustafsson L., Rigoulet M., Nyström T. Asymmetric inheritance of oxidatively damaged proteins during cytokinesis in Saccharomyces cerevisiae: a Sir2p dependent mechanism. Science 2003, 299:1751-1753.
-
(2003)
Science
, vol.299
, pp. 1751-1753
-
-
Aguilaniu, H.1
Gustafsson, L.2
Rigoulet, M.3
Nyström, T.4
-
12
-
-
34948846000
-
Accelerated aging and failure to segregate damaged proteins in Sir2 mutants can be suppressed by overproducing the protein aggregation-remodeling factor Hsp104p
-
Erjavek N., Larsson L., Grantham J., Nyström T. Accelerated aging and failure to segregate damaged proteins in Sir2 mutants can be suppressed by overproducing the protein aggregation-remodeling factor Hsp104p. Genes Dev 2007, 21:2410-2421.
-
(2007)
Genes Dev
, vol.21
, pp. 2410-2421
-
-
Erjavek, N.1
Larsson, L.2
Grantham, J.3
Nyström, T.4
-
13
-
-
74549184412
-
The polarisome is required for segregation and retrograde transport of protein aggregates
-
Liu B., Larsson L., Caballero A., Hao X., Öling D., Grantham J., Nyström T. The polarisome is required for segregation and retrograde transport of protein aggregates. Cell 2010, 140:257-267.
-
(2010)
Cell
, vol.140
, pp. 257-267
-
-
Liu, B.1
Larsson, L.2
Caballero, A.3
Hao, X.4
Öling, D.5
Grantham, J.6
Nyström, T.7
-
14
-
-
34547410267
-
Sir2p-dependent cytoskeleton formation and mitotic segregation of damaged proteins-a process regulating the antioxidant capacity of yeast daughter cells
-
Erjavek N., Nyström T. Sir2p-dependent cytoskeleton formation and mitotic segregation of damaged proteins-a process regulating the antioxidant capacity of yeast daughter cells. Proc Natl Acad Sci U S A 2007, 26:10877-10881.
-
(2007)
Proc Natl Acad Sci U S A
, vol.26
, pp. 10877-10881
-
-
Erjavek, N.1
Nyström, T.2
-
15
-
-
67649268322
-
Accumulation of overoxidized peroxiredoxin III in aged rat liver mitochondria
-
Musicco C., Capelli V., Pesce V., Timperio A.M., Calvani M., Mosconi L., Zolla L., Cantatore P., Gadaleta M.N. Accumulation of overoxidized peroxiredoxin III in aged rat liver mitochondria. Biochim Biophys Acta 2009, 1787:890-896.
-
(2009)
Biochim Biophys Acta
, vol.1787
, pp. 890-896
-
-
Musicco, C.1
Capelli, V.2
Pesce, V.3
Timperio, A.M.4
Calvani, M.5
Mosconi, L.6
Zolla, L.7
Cantatore, P.8
Gadaleta, M.N.9
-
16
-
-
80052217019
-
Life span extension and H(2)O(2) resistance elicited by caloric restriction require the peroxiredoxin Tsa1 in Saccharomyces cerevisiae
-
Molin M., Yang J., Hanzén S., Toledano M.B., Labarre J., Nyström T. Life span extension and H(2)O(2) resistance elicited by caloric restriction require the peroxiredoxin Tsa1 in Saccharomyces cerevisiae. Mol Cell 2011, 43:823-833.
-
(2011)
Mol Cell
, vol.43
, pp. 823-833
-
-
Molin, M.1
Yang, J.2
Hanzén, S.3
Toledano, M.B.4
Labarre, J.5
Nyström, T.6
-
17
-
-
84866490309
-
Peroxiredoxins, gerontogenes linking aging to genome instability and cancer
-
Nyström T., Yang J., Molin M. Peroxiredoxins, gerontogenes linking aging to genome instability and cancer. Genes Dev 2012, 26:2001-2008.
-
(2012)
Genes Dev
, vol.26
, pp. 2001-2008
-
-
Nyström, T.1
Yang, J.2
Molin, M.3
-
18
-
-
0031459980
-
Extrachromosomal rDNA circles-a cause of aging in yeast
-
Sinclair D.A., Guarente L. Extrachromosomal rDNA circles-a cause of aging in yeast. Cell 1997, 91:1033-1042.
-
(1997)
Cell
, vol.91
, pp. 1033-1042
-
-
Sinclair, D.A.1
Guarente, L.2
-
19
-
-
49649106438
-
A mechanism for asymmetric segregation of age during yeast budding
-
Shcheprova Z., Baldi S., Frei S.B., Gonnet G., Barral Y. A mechanism for asymmetric segregation of age during yeast budding. Nature 2008, 454:728-734.
-
(2008)
Nature
, vol.454
, pp. 728-734
-
-
Shcheprova, Z.1
Baldi, S.2
Frei, S.B.3
Gonnet, G.4
Barral, Y.5
-
20
-
-
79151480523
-
Nuclear geometry and rapid mitosis ensure asymmetric episome segregation in yeast
-
Gehlen L.R., Nagai S., Shimada K., Meister P., Taddei A., Gasser S.M. Nuclear geometry and rapid mitosis ensure asymmetric episome segregation in yeast. Curr Biol 2011, 21:25-33.
-
(2011)
Curr Biol
, vol.21
, pp. 25-33
-
-
Gehlen, L.R.1
Nagai, S.2
Shimada, K.3
Meister, P.4
Taddei, A.5
Gasser, S.M.6
-
21
-
-
84875976775
-
A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan
-
Kwan E.X., Foss E.J., Tsuchiyama S., Alvino G.M., Kruglyak L., Kaeberlein M., Raghuraman M.K., Brewer B.J., Kennedy B.K., Bedalov A. A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan. PLoS Genet 2013, 9:e1003329.
-
(2013)
PLoS Genet
, vol.9
-
-
Kwan, E.X.1
Foss, E.J.2
Tsuchiyama, S.3
Alvino, G.M.4
Kruglyak, L.5
Kaeberlein, M.6
Raghuraman, M.K.7
Brewer, B.J.8
Kennedy, B.K.9
Bedalov, A.10
-
22
-
-
84864019027
-
Molecular phenotyping of aging in single yeast cells using a novel microfluidic device
-
Xie Z., Zhang Y., Zou K., Brandman O., Luo C., Ouyang Q., Li H. Molecular phenotyping of aging in single yeast cells using a novel microfluidic device. Aging Cell 2012, 11:599-606.
-
(2012)
Aging Cell
, vol.11
, pp. 599-606
-
-
Xie, Z.1
Zhang, Y.2
Zou, K.3
Brandman, O.4
Luo, C.5
Ouyang, Q.6
Li, H.7
-
23
-
-
84859463277
-
Whole lifespan microscopic observation of budding yeast aging through a microfluidic dissection platform
-
Lee S.S., Avalos Vizcarra I., Huberts D.H.E.W., Lee L.P., Heinemann M. Whole lifespan microscopic observation of budding yeast aging through a microfluidic dissection platform. Proc Natl Acad Sci U S A 2012, 109:4916-4920.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 4916-4920
-
-
Lee, S.S.1
Avalos Vizcarra, I.2
Huberts, D.H.E.W.3
Lee, L.P.4
Heinemann, M.5
-
24
-
-
77951020823
-
The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1
-
Heeren G., Rinnerthaler M., Laun P., von Seyerl P., Kössler S., Klinger H., Hager M., Bogengruber E., Jarolim S., Simon-Nobbe B., et al. The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1. Aging 2009, 13:622-636.
-
(2009)
Aging
, vol.13
, pp. 622-636
-
-
Heeren, G.1
Rinnerthaler, M.2
Laun, P.3
von Seyerl, P.4
Kössler, S.5
Klinger, H.6
Hager, M.7
Bogengruber, E.8
Jarolim, S.9
Simon-Nobbe, B.10
-
25
-
-
79955501271
-
Absence of mitochondrial translation control proteins extend life span by activating sirtuin-dependent silencing
-
Caballero A., Ugidos A., Liu B., Öling D., Molin M., Kvint K., Hao X., Mignat C., Nachin L., Molin M., Nyström T. Absence of mitochondrial translation control proteins extend life span by activating sirtuin-dependent silencing. Mol Cell 2011, 42:390-400.
-
(2011)
Mol Cell
, vol.42
, pp. 390-400
-
-
Caballero, A.1
Ugidos, A.2
Liu, B.3
Öling, D.4
Molin, M.5
Kvint, K.6
Hao, X.7
Mignat, C.8
Nachin, L.9
Molin, M.10
Nyström, T.11
-
26
-
-
79955512116
-
The search for nonconventional mitochondrial determinants of aging
-
Chen X.J. The search for nonconventional mitochondrial determinants of aging. Mol Cell 2011, 42:271-273.
-
(2011)
Mol Cell
, vol.42
, pp. 271-273
-
-
Chen, X.J.1
-
27
-
-
70349782312
-
Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain
-
Copeland J.M., Cho J., Lo T., Hur J.H., Bahadorani S., Arabyan T., Rabie J., Soh J., Walker D.W. Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain. Curr Biol 2009, 19:1591-1598.
-
(2009)
Curr Biol
, vol.19
, pp. 1591-1598
-
-
Copeland, J.M.1
Cho, J.2
Lo, T.3
Hur, J.H.4
Bahadorani, S.5
Arabyan, T.6
Rabie, J.7
Soh, J.8
Walker, D.W.9
-
28
-
-
0037147103
-
Rates of behavior and aging specified by mitochondrial function during development
-
Dillin A., Hsu A.L., Arantes-Oliveira N., Lehrer-Graiwer J., Hsin H., Fraser A.G., Kamath R.S., Ahringer J., Kenyon C. Rates of behavior and aging specified by mitochondrial function during development. Science 2002, 298:2398-2401.
-
(2002)
Science
, vol.298
, pp. 2398-2401
-
-
Dillin, A.1
Hsu, A.L.2
Arantes-Oliveira, N.3
Lehrer-Graiwer, J.4
Hsin, H.5
Fraser, A.G.6
Kamath, R.S.7
Ahringer, J.8
Kenyon, C.9
-
29
-
-
0037228016
-
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
-
Lee S.S., Lee R.Y., Fraser A.G., Kamath R.S., Ahringer J., Ruvkun G. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet 2003, 33:40-48.
-
(2003)
Nat Genet
, vol.33
, pp. 40-48
-
-
Lee, S.S.1
Lee, R.Y.2
Fraser, A.G.3
Kamath, R.S.4
Ahringer, J.5
Ruvkun, G.6
-
30
-
-
0035515923
-
Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans
-
Feng J., Bussière F., Hekimi S. Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. Dev Cell 2001, 1:633-644.
-
(2001)
Dev Cell
, vol.1
, pp. 633-644
-
-
Feng, J.1
Bussière, F.2
Hekimi, S.3
-
31
-
-
78650944949
-
The cell-non-autonomous nature of electron transport chain-mediated longevity
-
Durieux J., Wolff S., Dillin A. The cell-non-autonomous nature of electron transport chain-mediated longevity. Cell 2011, 144:79-91.
-
(2011)
Cell
, vol.144
, pp. 79-91
-
-
Durieux, J.1
Wolff, S.2
Dillin, A.3
-
32
-
-
84878138385
-
Mitonuclear protein imbalance as a conserved longevity mechanism
-
Houtkooper R.H., Mouchiroud L., Ryu D., Moullan N., Katsyuba E., Knott G., Williams R.W., Auwerx J. Mitonuclear protein imbalance as a conserved longevity mechanism. Nature 2013, 497:451-457.
-
(2013)
Nature
, vol.497
, pp. 451-457
-
-
Houtkooper, R.H.1
Mouchiroud, L.2
Ryu, D.3
Moullan, N.4
Katsyuba, E.5
Knott, G.6
Williams, R.W.7
Auwerx, J.8
-
33
-
-
84879343155
-
XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity
-
Taylor R.C., Dillin A. XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity. Cell 2013, 153:1435-1447.
-
(2013)
Cell
, vol.153
, pp. 1435-1447
-
-
Taylor, R.C.1
Dillin, A.2
-
34
-
-
70349266064
-
Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
-
Ben-Zvi A., Miller E.A., Morimoto R.I. Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging. Proc Natl Acad Sci U S A 2009, 106:14914-14919.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 14914-14919
-
-
Ben-Zvi, A.1
Miller, E.A.2
Morimoto, R.I.3
-
35
-
-
43449138491
-
Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans
-
Steinkraus K.A., Smith E.D., Davis C., Carr D., Pendergrass W.R., Sutphin G.L., Kennedy B.K., Kaeberlein M. Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans. Aging Cell 2008, 7:394-404.
-
(2008)
Aging Cell
, vol.7
, pp. 394-404
-
-
Steinkraus, K.A.1
Smith, E.D.2
Davis, C.3
Carr, D.4
Pendergrass, W.R.5
Sutphin, G.L.6
Kennedy, B.K.7
Kaeberlein, M.8
-
36
-
-
0030659557
-
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
-
Ogg S., Paradis S., Gottlieb S., Patterson G.I., Lee L., Tissenbaum H.A., Ruvkun G. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 1997, 389:994-999.
-
(1997)
Nature
, vol.389
, pp. 994-999
-
-
Ogg, S.1
Paradis, S.2
Gottlieb, S.3
Patterson, G.I.4
Lee, L.5
Tissenbaum, H.A.6
Ruvkun, G.7
-
37
-
-
0030657540
-
Daf-16: an HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
-
Lin K., Dorman J.B., Rodan A., Kenyon C. daf-16: an HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 1997, 278:1319-1322.
-
(1997)
Science
, vol.278
, pp. 1319-1322
-
-
Lin, K.1
Dorman, J.B.2
Rodan, A.3
Kenyon, C.4
-
38
-
-
44049095652
-
Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons
-
Prahlad V., Cornelius T., Morimoto R.I. Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons. Science 2008, 320:811-814.
-
(2008)
Science
, vol.320
, pp. 811-814
-
-
Prahlad, V.1
Cornelius, T.2
Morimoto, R.I.3
-
39
-
-
84878873702
-
Regulation of organismal proteostasis by transcellular chaperone signaling
-
van Oosten-Hawle P., Porter R.S., Morimoto R.I. Regulation of organismal proteostasis by transcellular chaperone signaling. Cell 2013, 153:1366-1378.
-
(2013)
Cell
, vol.153
, pp. 1366-1378
-
-
van Oosten-Hawle, P.1
Porter, R.S.2
Morimoto, R.I.3
-
40
-
-
80855138775
-
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
-
Baker D.J., Wijshake T., Tchkonia T., LeBrasseur N.K., Childs B.G., van de Sluis B., Kirkland J.L., van Deursen J.M. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 2011, 479:232-236.
-
(2011)
Nature
, vol.479
, pp. 232-236
-
-
Baker, D.J.1
Wijshake, T.2
Tchkonia, T.3
LeBrasseur, N.K.4
Childs, B.G.5
van de Sluis, B.6
Kirkland, J.L.7
van Deursen, J.M.8
|