-
1
-
-
78649906060
-
DNMT3A mutations in acute myeloid leukemia
-
T.J. Ley, L. Ding, M.J. Walter, M.D. McLellan, T. Lamprecht, D.E. Larson, C. Kandoth, J.E. Payton, J. Baty, J. Welch, C.C. Harris, C.F. Lichti, R.R. Townsend, R.S. Fulton, D.J. Dooling, D.C. Koboldt, H. Schmidt, Q. Zhang, J.R. Osborne, L. Lin, M. O'Laughlin, J.F. McMichael, K.D. Delehaunty, S.D. McGrath, L.A. Fulton, V.J. Magrini, T.L. Vickery, J. Hundal, L.L. Cook, J.J. Conyers, G.W. Swift, J.P. Reed, P.A. Alldredge, T. Wylie, J. Walker, J. Kalicki, M.A. Watson, S. Heath, W.D. Shannon, N. Varghese, R. Nagarajan, P. Westervelt, M.H. Tomasson, D.C. Link, T.A. Graubert, J.F. DiPersio, E.R. Mardis, and R.K. Wilson DNMT3A mutations in acute myeloid leukemia N. Engl. J. Med. 363 2010 2424 2433
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 2424-2433
-
-
Ley, T.J.1
Ding, L.2
Walter, M.J.3
McLellan, M.D.4
Lamprecht, T.5
Larson, D.E.6
Kandoth, C.7
Payton, J.E.8
Baty, J.9
Welch, J.10
Harris, C.C.11
Lichti, C.F.12
Townsend, R.R.13
Fulton, R.S.14
Dooling, D.J.15
Koboldt, D.C.16
Schmidt, H.17
Zhang, Q.18
Osborne, J.R.19
Lin, L.20
O'Laughlin, M.21
McMichael, J.F.22
Delehaunty, K.D.23
McGrath, S.D.24
Fulton, L.A.25
Magrini, V.J.26
Vickery, T.L.27
Hundal, J.28
Cook, L.L.29
Conyers, J.J.30
Swift, G.W.31
Reed, J.P.32
Alldredge, P.A.33
Wylie, T.34
Walker, J.35
Kalicki, J.36
Watson, M.A.37
Heath, S.38
Shannon, W.D.39
Varghese, N.40
Nagarajan, R.41
Westervelt, P.42
Tomasson, M.H.43
Link, D.C.44
Graubert, T.A.45
Dipersio, J.F.46
Mardis, E.R.47
Wilson, R.K.48
more..
-
2
-
-
77954089584
-
Array-based genomic resequencing of human leukemia
-
Y. Yamashita, J. Yuan, I. Suetake, H. Suzuki, Y. Ishikawa, Y.L. Choi, T. Ueno, M. Soda, T. Hamada, H. Haruta, S. Takada, Y. Miyazaki, H. Kiyoi, E. Ito, T. Naoe, M. Tomonaga, M. Toyota, S. Tajima, A. Iwama, and H. Mano Array-based genomic resequencing of human leukemia Oncogene 29 2010 3723 3731
-
(2010)
Oncogene
, vol.29
, pp. 3723-3731
-
-
Yamashita, Y.1
Yuan, J.2
Suetake, I.3
Suzuki, H.4
Ishikawa, Y.5
Choi, Y.L.6
Ueno, T.7
Soda, M.8
Hamada, T.9
Haruta, H.10
Takada, S.11
Miyazaki, Y.12
Kiyoi, H.13
Ito, E.14
Naoe, T.15
Tomonaga, M.16
Toyota, M.17
Tajima, S.18
Iwama, A.19
Mano, H.20
more..
-
3
-
-
84863116398
-
Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia
-
G. Marcucci, K.H. Metzeler, S. Schwind, H. Becker, K. Maharry, K. Mrozek, M.D. Radmacher, J. Kohlschmidt, D. Nicolet, S.P. Whitman, Y.Z. Wu, B.L. Powell, T.H. Carter, J.E. Kolitz, M. Wetzler, A.J. Carroll, M.R. Baer, J.O. Moore, M.A. Caligiuri, R.A. Larson, and C.D. Bloomfield Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia J. Clin. Oncol. 30 2012 742 750
-
(2012)
J. Clin. Oncol.
, vol.30
, pp. 742-750
-
-
Marcucci, G.1
Metzeler, K.H.2
Schwind, S.3
Becker, H.4
Maharry, K.5
Mrozek, K.6
Radmacher, M.D.7
Kohlschmidt, J.8
Nicolet, D.9
Whitman, S.P.10
Wu, Y.Z.11
Powell, B.L.12
Carter, T.H.13
Kolitz, J.E.14
Wetzler, M.15
Carroll, A.J.16
Baer, M.R.17
Moore, J.O.18
Caligiuri, M.A.19
Larson, R.A.20
Bloomfield, C.D.21
more..
-
4
-
-
84862501737
-
Mutant DNMT3A: Teaming up to transform
-
C. Thiede Mutant DNMT3A: teaming up to transform Blood 119 2012 5615 5617
-
(2012)
Blood
, vol.119
, pp. 5615-5617
-
-
Thiede, C.1
-
5
-
-
79953176952
-
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
-
X.J. Yan, J. Xu, Z.H. Gu, C.M. Pan, G. Lu, Y. Shen, J.Y. Shi, Y.M. Zhu, L. Tang, X.W. Zhang, W.X. Liang, J.Q. Mi, H.D. Song, K.Q. Li, Z. Chen, and S.J. Chen Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia Nat. Genet. 43 2011 309 315
-
(2011)
Nat. Genet.
, vol.43
, pp. 309-315
-
-
Yan, X.J.1
Xu, J.2
Gu, Z.H.3
Pan, C.M.4
Lu, G.5
Shen, Y.6
Shi, J.Y.7
Zhu, Y.M.8
Tang, L.9
Zhang, X.W.10
Liang, W.X.11
Mi, J.Q.12
Song, H.D.13
Li, K.Q.14
Chen, Z.15
Chen, S.J.16
-
6
-
-
79960735923
-
Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemia
-
F. Thol, F. Damm, A. Ludeking, C. Winschel, K. Wagner, M. Morgan, H. Yun, G. Gohring, B. Schlegelberger, D. Hoelzer, M. Lubbert, L. Kanz, W. Fiedler, H. Kirchner, G. Heil, J. Krauter, A. Ganser, and M. Heuser Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemia J. Clin. Oncol. 29 2011 2889 2896
-
(2011)
J. Clin. Oncol.
, vol.29
, pp. 2889-2896
-
-
Thol, F.1
Damm, F.2
Ludeking, A.3
Winschel, C.4
Wagner, K.5
Morgan, M.6
Yun, H.7
Gohring, G.8
Schlegelberger, B.9
Hoelzer, D.10
Lubbert, M.11
Kanz, L.12
Fiedler, W.13
Kirchner, H.14
Heil, G.15
Krauter, J.16
Ganser, A.17
Heuser, M.18
-
7
-
-
84894303664
-
DNMT3A Arg882 mutation drives chronic myelomonocytic leukemia through disturbing gene expression/DNA methylation in hematopoietic cells
-
J. Xu, Y.Y. Wang, Y.J. Dai, W. Zhang, W.N. Zhang, S.M. Xiong, Z.H. Gu, K.K. Wang, R. Zeng, Z. Chen, and S.J. Chen DNMT3A Arg882 mutation drives chronic myelomonocytic leukemia through disturbing gene expression/DNA methylation in hematopoietic cells Proc. Natl. Acad. Sci. USA 111 2014 2620 2625
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 2620-2625
-
-
Xu, J.1
Wang, Y.Y.2
Dai, Y.J.3
Zhang, W.4
Zhang, W.N.5
Xiong, S.M.6
Gu, Z.H.7
Wang, K.K.8
Zeng, R.9
Chen, Z.10
Chen, S.J.11
-
8
-
-
84893437787
-
A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells
-
S.J. Kim, H. Zhao, S. Hardikar, A.K. Singh, M.A. Goodell, and T. Chen A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells Blood 122 2013 4086 4089
-
(2013)
Blood
, vol.122
, pp. 4086-4089
-
-
Kim, S.J.1
Zhao, H.2
Hardikar, S.3
Singh, A.K.4
Goodell, M.A.5
Chen, T.6
-
9
-
-
84898545028
-
The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers
-
D.A. Russler-Germain, D.H. Spencer, M.A. Young, T.L. Lamprecht, C.A. Miller, R. Fulton, M.R. Meyer, P. Erdmann-Gilmore, R.R. Townsend, R.K. Wilson, and T.J. Ley The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers Cancer Cell 25 2014 442 454
-
(2014)
Cancer Cell
, vol.25
, pp. 442-454
-
-
Russler-Germain, D.A.1
Spencer, D.H.2
Young, M.A.3
Lamprecht, T.L.4
Miller, C.A.5
Fulton, R.6
Meyer, M.R.7
Erdmann-Gilmore, P.8
Townsend, R.R.9
Wilson, R.K.10
Ley, T.J.11
-
10
-
-
0037099537
-
LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23)
-
R. Ono, T. Taki, T. Taketani, M. Taniwaki, H. Kobayashi, and Y. Hayashi LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23) Cancer Res. 62 2002 4075 4080
-
(2002)
Cancer Res.
, vol.62
, pp. 4075-4080
-
-
Ono, R.1
Taki, T.2
Taketani, T.3
Taniwaki, M.4
Kobayashi, H.5
Hayashi, Y.6
-
11
-
-
66149146320
-
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
-
M. Tahiliani, K.P. Koh, Y. Shen, W.A. Pastor, H. Bandukwala, Y. Brudno, S. Agarwal, L.M. Iyer, D.R. Liu, L. Aravind, and A. Rao Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1 Science 324 2009 930 935
-
(2009)
Science
, vol.324
, pp. 930-935
-
-
Tahiliani, M.1
Koh, K.P.2
Shen, Y.3
Pastor, W.A.4
Bandukwala, H.5
Brudno, Y.6
Agarwal, S.7
Iyer, L.M.8
Liu, D.R.9
Aravind, L.10
Rao, A.11
-
12
-
-
79956323623
-
Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation
-
G. Ficz, M.R. Branco, S. Seisenberger, F. Santos, F. Krueger, T.A. Hore, C.J. Marques, S. Andrews, and W. Reik Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation Nature 473 2011 398 402
-
(2011)
Nature
, vol.473
, pp. 398-402
-
-
Ficz, G.1
Branco, M.R.2
Seisenberger, S.3
Santos, F.4
Krueger, F.5
Hore, T.A.6
Marques, C.J.7
Andrews, S.8
Reik, W.9
-
13
-
-
79961125686
-
Tet1 and 5-hydroxymethylation: A genome-wide view in mouse embryonic stem cells
-
H. Wu, and Y. Zhang Tet1 and 5-hydroxymethylation: a genome-wide view in mouse embryonic stem cells Cell Cycle 10 2011 2428 2436
-
(2011)
Cell Cycle
, vol.10
, pp. 2428-2436
-
-
Wu, H.1
Zhang, Y.2
-
14
-
-
84863393263
-
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
-
J.P. Patel, M. Gonen, M.E. Figueroa, H. Fernandez, Z. Sun, J. Racevskis, P. Van Vlierberghe, I. Dolgalev, S. Thomas, O. Aminova, K. Huberman, J. Cheng, A. Viale, N.D. Socci, A. Heguy, A. Cherry, G. Vance, R.R. Higgins, R.P. Ketterling, R.E. Gallagher, M. Litzow, M.R. van den Brink, H.M. Lazarus, J.M. Rowe, S. Luger, A. Ferrando, E. Paietta, M.S. Tallman, A. Melnick, O. Abdel-Wahab, and R.L. Levine Prognostic relevance of integrated genetic profiling in acute myeloid leukemia N. Engl. J. Med. 366 2012 1079 1089
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 1079-1089
-
-
Patel, J.P.1
Gonen, M.2
Figueroa, M.E.3
Fernandez, H.4
Sun, Z.5
Racevskis, J.6
Van Vlierberghe, P.7
Dolgalev, I.8
Thomas, S.9
Aminova, O.10
Huberman, K.11
Cheng, J.12
Viale, A.13
Socci, N.D.14
Heguy, A.15
Cherry, A.16
Vance, G.17
Higgins, R.R.18
Ketterling, R.P.19
Gallagher, R.E.20
Litzow, M.21
Van Den Brink, M.R.22
Lazarus, H.M.23
Rowe, J.M.24
Luger, S.25
Ferrando, A.26
Paietta, E.27
Tallman, M.S.28
Melnick, A.29
Abdel-Wahab, O.30
Levine, R.L.31
more..
-
15
-
-
81555228423
-
Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia
-
Y. Shen, Y.M. Zhu, X. Fan, J.Y. Shi, Q.R. Wang, X.J. Yan, Z.H. Gu, Y.Y. Wang, B. Chen, C.L. Jiang, H. Yan, F.F. Chen, H.M. Chen, Z. Chen, J. Jin, and S.J. Chen Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia Blood 118 2011 5593 5603
-
(2011)
Blood
, vol.118
, pp. 5593-5603
-
-
Shen, Y.1
Zhu, Y.M.2
Fan, X.3
Shi, J.Y.4
Wang, Q.R.5
Yan, X.J.6
Gu, Z.H.7
Wang, Y.Y.8
Chen, B.9
Jiang, C.L.10
Yan, H.11
Chen, F.F.12
Chen, H.M.13
Chen, Z.14
Jin, J.15
Chen, S.J.16
-
16
-
-
79954428737
-
TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: A Cancer and Leukemia Group B study
-
K.H. Metzeler, K. Maharry, M.D. Radmacher, K. Mrozek, D. Margeson, H. Becker, J. Curfman, K.B. Holland, S. Schwind, S.P. Whitman, Y.Z. Wu, W. Blum, B.L. Powell, T.H. Carter, M. Wetzler, J.O. Moore, J.E. Kolitz, M.R. Baer, A.J. Carroll, R.A. Larson, M.A. Caligiuri, G. Marcucci, and C.D. Bloomfield TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: a Cancer and Leukemia Group B study J. Clin. Oncol. 29 2011 1373 1381
-
(2011)
J. Clin. Oncol.
, vol.29
, pp. 1373-1381
-
-
Metzeler, K.H.1
Maharry, K.2
Radmacher, M.D.3
Mrozek, K.4
Margeson, D.5
Becker, H.6
Curfman, J.7
Holland, K.B.8
Schwind, S.9
Whitman, S.P.10
Wu, Y.Z.11
Blum, W.12
Powell, B.L.13
Carter, T.H.14
Wetzler, M.15
Moore, J.O.16
Kolitz, J.E.17
Baer, M.R.18
Carroll, A.J.19
Larson, R.A.20
Caligiuri, M.A.21
Marcucci, G.22
Bloomfield, C.D.23
more..
-
17
-
-
80053620171
-
TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics
-
W.C. Chou, S.C. Chou, C.Y. Liu, C.Y. Chen, H.A. Hou, Y.Y. Kuo, M.C. Lee, B.S. Ko, J.L. Tang, M. Yao, W. Tsay, S.J. Wu, S.Y. Huang, S.C. Hsu, Y.C. Chen, Y.C. Chang, Y.Y. Kuo, K.T. Kuo, F.Y. Lee, M.C. Liu, C.W. Liu, M.H. Tseng, C.F. Huang, and H.F. Tien TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics Blood 118 2011 3803 3810
-
(2011)
Blood
, vol.118
, pp. 3803-3810
-
-
Chou, W.C.1
Chou, S.C.2
Liu, C.Y.3
Chen, C.Y.4
Hou, H.A.5
Kuo, Y.Y.6
Lee, M.C.7
Ko, B.S.8
Tang, J.L.9
Yao, M.10
Tsay, W.11
Wu, S.J.12
Huang, S.Y.13
Hsu, S.C.14
Chen, Y.C.15
Chang, Y.C.16
Kuo, Y.Y.17
Kuo, K.T.18
Lee, F.Y.19
Liu, M.C.20
Liu, C.W.21
Tseng, M.H.22
Huang, C.F.23
Tien, H.F.24
more..
-
18
-
-
78650175023
-
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
-
M. Ko, Y. Huang, A.M. Jankowska, U.J. Pape, M. Tahiliani, H.S. Bandukwala, J. An, E.D. Lamperti, K.P. Koh, R. Ganetzky, X.S. Liu, L. Aravind, S. Agarwal, J.P. Maciejewski, and A. Rao Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2 Nature 468 2010 839 843
-
(2010)
Nature
, vol.468
, pp. 839-843
-
-
Ko, M.1
Huang, Y.2
Jankowska, A.M.3
Pape, U.J.4
Tahiliani, M.5
Bandukwala, H.S.6
An, J.7
Lamperti, E.D.8
Koh, K.P.9
Ganetzky, R.10
Liu, X.S.11
Aravind, L.12
Agarwal, S.13
Maciejewski, J.P.14
Rao, A.15
-
19
-
-
78650019179
-
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
-
M.E. Figueroa, O. Abdel-Wahab, C. Lu, P.S. Ward, J. Patel, A. Shih, Y. Li, N. Bhagwat, A. Vasanthakumar, H.F. Fernandez, M.S. Tallman, Z. Sun, K. Wolniak, J.K. Peeters, W. Liu, S.E. Choe, V.R. Fantin, E. Paietta, B. Lowenberg, J.D. Licht, L.A. Godley, R. Delwel, P.J. Valk, C.B. Thompson, R.L. Levine, and A. Melnick Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation Cancer Cell 18 2010 553 567
-
(2010)
Cancer Cell
, vol.18
, pp. 553-567
-
-
Figueroa, M.E.1
Abdel-Wahab, O.2
Lu, C.3
Ward, P.S.4
Patel, J.5
Shih, A.6
Li, Y.7
Bhagwat, N.8
Vasanthakumar, A.9
Fernandez, H.F.10
Tallman, M.S.11
Sun, Z.12
Wolniak, K.13
Peeters, J.K.14
Liu, W.15
Choe, S.E.16
Fantin, V.R.17
Paietta, E.18
Lowenberg, B.19
Licht, J.D.20
Godley, L.A.21
Delwel, R.22
Valk, P.J.23
Thompson, C.B.24
Levine, R.L.25
Melnick, A.26
more..
-
20
-
-
79960064353
-
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
-
K. Moran-Crusio, L. Reavie, A. Shih, O. Abdel-Wahab, D. Ndiaye-Lobry, C. Lobry, M.E. Figueroa, A. Vasanthakumar, J. Patel, X. Zhao, F. Perna, S. Pandey, J. Madzo, C. Song, Q. Dai, C. He, S. Ibrahim, M. Beran, J. Zavadil, S.D. Nimer, A. Melnick, L.A. Godley, I. Aifantis, and R.L. Levine Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation Cancer Cell 20 2011 11 24
-
(2011)
Cancer Cell
, vol.20
, pp. 11-24
-
-
Moran-Crusio, K.1
Reavie, L.2
Shih, A.3
Abdel-Wahab, O.4
Ndiaye-Lobry, D.5
Lobry, C.6
Figueroa, M.E.7
Vasanthakumar, A.8
Patel, J.9
Zhao, X.10
Perna, F.11
Pandey, S.12
Madzo, J.13
Song, C.14
Dai, Q.15
He, C.16
Ibrahim, S.17
Beran, M.18
Zavadil, J.19
Nimer, S.D.20
Melnick, A.21
Godley, L.A.22
Aifantis, I.23
Levine, R.L.24
more..
-
21
-
-
80052284526
-
Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice
-
M. Ko, H.S. Bandukwala, J. An, E.D. Lamperti, E.C. Thompson, R. Hastie, A. Tsangaratou, K. Rajewsky, S.B. Koralov, and A. Rao Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice Proc. Natl. Acad. Sci. USA 108 2011 14566 14571
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 14566-14571
-
-
Ko, M.1
Bandukwala, H.S.2
An, J.3
Lamperti, E.D.4
Thompson, E.C.5
Hastie, R.6
Tsangaratou, A.7
Rajewsky, K.8
Koralov, S.B.9
Rao, A.10
-
22
-
-
79960062301
-
TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis
-
C. Quivoron, L. Couronne, V. Della Valle, C.K. Lopez, I. Plo, O. Wagner-Ballon, M. Do Cruzeiro, F. Delhommeau, B. Arnulf, M.H. Stern, L. Godley, P. Opolon, H. Tilly, E. Solary, Y. Duffourd, P. Dessen, H. Merle-Beral, F. Nguyen-Khac, M. Fontenay, W. Vainchenker, C. Bastard, T. Mercher, and O.A. Bernard TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis Cancer Cell 20 2011 25 38
-
(2011)
Cancer Cell
, vol.20
, pp. 25-38
-
-
Quivoron, C.1
Couronne, L.2
Della Valle, V.3
Lopez, C.K.4
Plo, I.5
Wagner-Ballon, O.6
Do Cruzeiro, M.7
Delhommeau, F.8
Arnulf, B.9
Stern, M.H.10
Godley, L.11
Opolon, P.12
Tilly, H.13
Solary, E.14
Duffourd, Y.15
Dessen, P.16
Merle-Beral, H.17
Nguyen-Khac, F.18
Fontenay, M.19
Vainchenker, W.20
Bastard, C.21
Mercher, T.22
Bernard, O.A.23
more..
-
23
-
-
77957759961
-
The prognostic significance of IDH1 mutations in younger adult patients with acute myeloid leukemia is dependent on FLT3/ITD status
-
C.L. Green, C.M. Evans, R.K. Hills, A.K. Burnett, D.C. Linch, and R.E. Gale The prognostic significance of IDH1 mutations in younger adult patients with acute myeloid leukemia is dependent on FLT3/ITD status Blood 116 2010 2779 2782
-
(2010)
Blood
, vol.116
, pp. 2779-2782
-
-
Green, C.L.1
Evans, C.M.2
Hills, R.K.3
Burnett, A.K.4
Linch, D.C.5
Gale, R.E.6
-
24
-
-
79960534917
-
The prognostic significance of IDH2 mutations in AML depends on the location of the mutation
-
C.L. Green, C.M. Evans, L. Zhao, R.K. Hills, A.K. Burnett, D.C. Linch, and R.E. Gale The prognostic significance of IDH2 mutations in AML depends on the location of the mutation Blood 118 2011 409 412
-
(2011)
Blood
, vol.118
, pp. 409-412
-
-
Green, C.L.1
Evans, C.M.2
Zhao, L.3
Hills, R.K.4
Burnett, A.K.5
Linch, D.C.6
Gale, R.E.7
-
25
-
-
72049125350
-
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
-
L. Dang, D.W. White, S. Gross, B.D. Bennett, M.A. Bittinger, E.M. Driggers, V.R. Fantin, H.G. Jang, S. Jin, M.C. Keenan, K.M. Marks, R.M. Prins, P.S. Ward, K.E. Yen, L.M. Liau, J.D. Rabinowitz, L.C. Cantley, C.B. Thompson, M.G. Vander Heiden, and S.M. Su Cancer-associated IDH1 mutations produce 2-hydroxyglutarate Nature 462 2009 739 744
-
(2009)
Nature
, vol.462
, pp. 739-744
-
-
Dang, L.1
White, D.W.2
Gross, S.3
Bennett, B.D.4
Bittinger, M.A.5
Driggers, E.M.6
Fantin, V.R.7
Jang, H.G.8
Jin, S.9
Keenan, M.C.10
Marks, K.M.11
Prins, R.M.12
Ward, P.S.13
Yen, K.E.14
Liau, L.M.15
Rabinowitz, J.D.16
Cantley, L.C.17
Thompson, C.B.18
Vander Heiden, M.G.19
Su, S.M.20
more..
-
26
-
-
77649305610
-
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
-
P.S. Ward, J. Patel, D.R. Wise, O. Abdel-Wahab, B.D. Bennett, H.A. Coller, J.R. Cross, V.R. Fantin, C.V. Hedvat, A.E. Perl, J.D. Rabinowitz, M. Carroll, S.M. Su, K.A. Sharp, R.L. Levine, and C.B. Thompson The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate Cancer Cell 17 2010 225 234
-
(2010)
Cancer Cell
, vol.17
, pp. 225-234
-
-
Ward, P.S.1
Patel, J.2
Wise, D.R.3
Abdel-Wahab, O.4
Bennett, B.D.5
Coller, H.A.6
Cross, J.R.7
Fantin, V.R.8
Hedvat, C.V.9
Perl, A.E.10
Rabinowitz, J.D.11
Carroll, M.12
Su, S.M.13
Sharp, K.A.14
Levine, R.L.15
Thompson, C.B.16
-
27
-
-
79955547561
-
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
-
R. Chowdhury, K.K. Yeoh, Y.M. Tian, L. Hillringhaus, E.A. Bagg, N.R. Rose, I.K. Leung, X.S. Li, E.C. Woon, M. Yang, M.A. McDonough, O.N. King, I.J. Clifton, R.J. Klose, T.D. Claridge, P.J. Ratcliffe, C.J. Schofield, and A. Kawamura The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases EMBO Rep. 12 2011 463 469
-
(2011)
EMBO Rep.
, vol.12
, pp. 463-469
-
-
Chowdhury, R.1
Yeoh, K.K.2
Tian, Y.M.3
Hillringhaus, L.4
Bagg, E.A.5
Rose, N.R.6
Leung, I.K.7
Li, X.S.8
Woon, E.C.9
Yang, M.10
McDonough, M.A.11
King, O.N.12
Clifton, I.J.13
Klose, R.J.14
Claridge, T.D.15
Ratcliffe, P.J.16
Schofield, C.J.17
Kawamura, A.18
-
28
-
-
84877632013
-
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells
-
D. Rohle, J. Popovici-Muller, N. Palaskas, S. Turcan, C. Grommes, C. Campos, J. Tsoi, O. Clark, B. Oldrini, E. Komisopoulou, K. Kunii, A. Pedraza, S. Schalm, L. Silverman, A. Miller, F. Wang, H. Yang, Y. Chen, A. Kernytsky, M.K. Rosenblum, W. Liu, S.A. Biller, S.M. Su, C.W. Brennan, T.A. Chan, T.G. Graeber, K.E. Yen, and I.K. Mellinghoff An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells Science 340 2013 626 630
-
(2013)
Science
, vol.340
, pp. 626-630
-
-
Rohle, D.1
Popovici-Muller, J.2
Palaskas, N.3
Turcan, S.4
Grommes, C.5
Campos, C.6
Tsoi, J.7
Clark, O.8
Oldrini, B.9
Komisopoulou, E.10
Kunii, K.11
Pedraza, A.12
Schalm, S.13
Silverman, L.14
Miller, A.15
Wang, F.16
Yang, H.17
Chen, Y.18
Kernytsky, A.19
Rosenblum, M.K.20
Liu, W.21
Biller, S.A.22
Su, S.M.23
Brennan, C.W.24
Chan, T.A.25
Graeber, T.G.26
Yen, K.E.27
Mellinghoff, I.K.28
more..
-
29
-
-
84877620952
-
Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation
-
F. Wang, J. Travins, B. DeLaBarre, V. Penard-Lacronique, S. Schalm, E. Hansen, K. Straley, A. Kernytsky, W. Liu, C. Gliser, H. Yang, S. Gross, E. Artin, V. Saada, E. Mylonas, C. Quivoron, J. Popovici-Muller, J.O. Saunders, F.G. Salituro, S. Yan, S. Murray, W. Wei, Y. Gao, L. Dang, M. Dorsch, S. Agresta, D.P. Schenkein, S.A. Biller, S.M. Su, S. de Botton, and K.E. Yen Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation Science 340 2013 622 626
-
(2013)
Science
, vol.340
, pp. 622-626
-
-
Wang, F.1
Travins, J.2
Delabarre, B.3
Penard-Lacronique, V.4
Schalm, S.5
Hansen, E.6
Straley, K.7
Kernytsky, A.8
Liu, W.9
Gliser, C.10
Yang, H.11
Gross, S.12
Artin, E.13
Saada, V.14
Mylonas, E.15
Quivoron, C.16
Popovici-Muller, J.17
Saunders, J.O.18
Salituro, F.G.19
Yan, S.20
Murray, S.21
Wei, W.22
Gao, Y.23
Dang, L.24
Dorsch, M.25
Agresta, S.26
Schenkein, D.P.27
Biller, S.A.28
Su, S.M.29
De Botton, S.30
Yen, K.E.31
more..
-
30
-
-
84896109877
-
Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance
-
L.M. Kats, M. Reschke, R. Taulli, O. Pozdnyakova, K. Burgess, P. Bhargava, K. Straley, R. Karnik, A. Meissner, D. Small, S.M. Su, K. Yen, J. Zhang, and P.P. Pandolfi Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance Cell Stem Cell 14 2014 329 341
-
(2014)
Cell Stem Cell
, vol.14
, pp. 329-341
-
-
Kats, L.M.1
Reschke, M.2
Taulli, R.3
Pozdnyakova, O.4
Burgess, K.5
Bhargava, P.6
Straley, K.7
Karnik, R.8
Meissner, A.9
Small, D.10
Su, S.M.11
Yen, K.12
Zhang, J.13
Pandolfi, P.P.14
-
31
-
-
85028119196
-
Clinical safety and activity in a phase i trial of AG-221, a first in class, potent inhibitor of the IDH2-mutant protein
-
(Abstract CT103)
-
M.T.E. Stein, D.A. Pollyea, I.W. Flinn, A.T. Fathi, R.M. Stone, R.L. Levine, S. Agresta, D. Schenkein, H. Yang, B. Fan, K. Yen, S. De Botton, Clinical safety and activity in a phase I trial of AG-221, a first in class, potent inhibitor of the IDH2-mutant protein, in patients with IDH2 mutant positive advanced hematologic malignancies (2014) (Abstract CT103).
-
(2014)
Patients with IDH2 Mutant Positive Advanced Hematologic Malignancies
-
-
Stein, M.T.E.1
Pollyea, D.A.2
Flinn, I.W.3
Fathi, A.T.4
Stone, R.M.5
Levine, R.L.6
Agresta, S.7
Schenkein, D.8
Yang, H.9
Fan, B.10
Yen, K.11
De Botton, S.12
-
32
-
-
33947513027
-
Regulation of histone methylation by demethylimination and demethylation
-
R.J. Klose, and Y. Zhang Regulation of histone methylation by demethylimination and demethylation Nat. Rev. Mol. Cell Biol. 8 2007 307 318
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 307-318
-
-
Klose, R.J.1
Zhang, Y.2
-
33
-
-
33646486601
-
Histone lysine demethylases and their impact on epigenetics
-
P. Trojer, and D. Reinberg Histone lysine demethylases and their impact on epigenetics Cell 125 2006 213 217
-
(2006)
Cell
, vol.125
, pp. 213-217
-
-
Trojer, P.1
Reinberg, D.2
-
34
-
-
35148867907
-
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development
-
K. Agger, P.A. Cloos, J. Christensen, D. Pasini, S. Rose, J. Rappsilber, I. Issaeva, E. Canaani, A.E. Salcini, and K. Helin UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development Nature 449 2007 731 734
-
(2007)
Nature
, vol.449
, pp. 731-734
-
-
Agger, K.1
Cloos, P.A.2
Christensen, J.3
Pasini, D.4
Rose, S.5
Rappsilber, J.6
Issaeva, I.7
Canaani, E.8
Salcini, A.E.9
Helin, K.10
-
35
-
-
34548644772
-
The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing
-
F. De Santa, M.G. Totaro, E. Prosperini, S. Notarbartolo, G. Testa, and G. Natoli The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing Cell 130 2007 1083 1094
-
(2007)
Cell
, vol.130
, pp. 1083-1094
-
-
De Santa, F.1
Totaro, M.G.2
Prosperini, E.3
Notarbartolo, S.4
Testa, G.5
Natoli, G.6
-
37
-
-
84855833698
-
Deletion of KDM6A, a histone demethylase interacting with MLL2, in three patients with Kabuki syndrome
-
D. Lederer, B. Grisart, M.C. Digilio, V. Benoit, M. Crespin, S.C. Ghariani, I. Maystadt, B. Dallapiccola, and C. Verellen-Dumoulin Deletion of KDM6A, a histone demethylase interacting with MLL2, in three patients with Kabuki syndrome Am. J. Hum. Genet. 90 2012 119 124
-
(2012)
Am. J. Hum. Genet.
, vol.90
, pp. 119-124
-
-
Lederer, D.1
Grisart, B.2
Digilio, M.C.3
Benoit, V.4
Crespin, M.5
Ghariani, S.C.6
Maystadt, I.7
Dallapiccola, B.8
Verellen-Dumoulin, C.9
-
38
-
-
67349203626
-
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
-
G. van Haaften, G.L. Dalgliesh, H. Davies, L. Chen, G. Bignell, C. Greenman, S. Edkins, C. Hardy, S. O'Meara, J. Teague, A. Butler, J. Hinton, C. Latimer, J. Andrews, S. Barthorpe, D. Beare, G. Buck, P.J. Campbell, J. Cole, S. Forbes, M. Jia, D. Jones, C.Y. Kok, C. Leroy, M.L. Lin, D.J. McBride, M. Maddison, S. Maquire, K. McLay, A. Menzies, T. Mironenko, L. Mulderrig, L. Mudie, E. Pleasance, R. Shepherd, R. Smith, L. Stebbings, P. Stephens, G. Tang, P.S. Tarpey, R. Turner, K. Turrell, J. Varian, S. West, S. Widaa, P. Wray, V.P. Collins, K. Ichimura, S. Law, J. Wong, S.T. Yuen, S.Y. Leung, G. Tonon, R.A. DePinho, Y.T. Tai, K.C. Anderson, R.J. Kahnoski, A. Massie, S.K. Khoo, B.T. Teh, M.R. Stratton, and P.A. Futreal Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer Nat. Genet. 41 2009 521 523
-
(2009)
Nat. Genet.
, vol.41
, pp. 521-523
-
-
Van Haaften, G.1
Dalgliesh, G.L.2
Davies, H.3
Chen, L.4
Bignell, G.5
Greenman, C.6
Edkins, S.7
Hardy, C.8
O'Meara, S.9
Teague, J.10
Butler, A.11
Hinton, J.12
Latimer, C.13
Andrews, J.14
Barthorpe, S.15
Beare, D.16
Buck, G.17
Campbell, P.J.18
Cole, J.19
Forbes, S.20
Jia, M.21
Jones, D.22
Kok, C.Y.23
Leroy, C.24
Lin, M.L.25
McBride, D.J.26
Maddison, M.27
Maquire, S.28
McLay, K.29
Menzies, A.30
Mironenko, T.31
Mulderrig, L.32
Mudie, L.33
Pleasance, E.34
Shepherd, R.35
Smith, R.36
Stebbings, L.37
Stephens, P.38
Tang, G.39
Tarpey, P.S.40
Turner, R.41
Turrell, K.42
Varian, J.43
West, S.44
Widaa, S.45
Wray, P.46
Collins, V.P.47
Ichimura, K.48
Law, S.49
Wong, J.50
Yuen, S.T.51
Leung, S.Y.52
Tonon, G.53
Depinho, R.A.54
Tai, Y.T.55
Anderson, K.C.56
Kahnoski, R.J.57
Massie, A.58
Khoo, S.K.59
Teh, B.T.60
Stratton, M.R.61
Futreal, P.A.62
more..
-
39
-
-
84873084751
-
Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia
-
K. De Keersmaecker, Z.K. Atak, N. Li, C. Vicente, S. Patchett, T. Girardi, V. Gianfelici, E. Geerdens, E. Clappier, M. Porcu, I. Lahortiga, R. Luca, J. Yan, G. Hulselmans, H. Vranckx, R. Vandepoel, B. Sweron, K. Jacobs, N. Mentens, I. Wlodarska, B. Cauwelier, J. Cloos, J. Soulier, A. Uyttebroeck, C. Bagni, B.A. Hassan, P. Vandenberghe, A.W. Johnson, S. Aerts, and J. Cools Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia Nat. Genet. 45 2013 186 190
-
(2013)
Nat. Genet.
, vol.45
, pp. 186-190
-
-
De Keersmaecker, K.1
Atak, Z.K.2
Li, N.3
Vicente, C.4
Patchett, S.5
Girardi, T.6
Gianfelici, V.7
Geerdens, E.8
Clappier, E.9
Porcu, M.10
Lahortiga, I.11
Luca, R.12
Yan, J.13
Hulselmans, G.14
Vranckx, H.15
Vandepoel, R.16
Sweron, B.17
Jacobs, K.18
Mentens, N.19
Wlodarska, I.20
Cauwelier, B.21
Cloos, J.22
Soulier, J.23
Uyttebroeck, A.24
Bagni, C.25
Hassan, B.A.26
Vandenberghe, P.27
Johnson, A.W.28
Aerts, S.29
Cools, J.30
more..
-
40
-
-
79951494668
-
Initial genome sequencing and analysis of multiple myeloma
-
M.A. Chapman, M.S. Lawrence, J.J. Keats, K. Cibulskis, C. Sougnez, A.C. Schinzel, C.L. Harview, J.P. Brunet, G.J. Ahmann, M. Adli, K.C. Anderson, K.G. Ardlie, D. Auclair, A. Baker, P.L. Bergsagel, B.E. Bernstein, Y. Drier, R. Fonseca, S.B. Gabriel, C.C. Hofmeister, S. Jagannath, A.J. Jakubowiak, A. Krishnan, J. Levy, T. Liefeld, S. Lonial, S. Mahan, B. Mfuko, S. Monti, L.M. Perkins, R. Onofrio, T.J. Pugh, S.V. Rajkumar, A.H. Ramos, D.S. Siegel, A. Sivachenko, A.K. Stewart, S. Trudel, R. Vij, D. Voet, W. Winckler, T. Zimmerman, J. Carpten, J. Trent, W.C. Hahn, L.A. Garraway, M. Meyerson, E.S. Lander, G. Getz, and T.R. Golub Initial genome sequencing and analysis of multiple myeloma Nature 471 2011 467 472
-
(2011)
Nature
, vol.471
, pp. 467-472
-
-
Chapman, M.A.1
Lawrence, M.S.2
Keats, J.J.3
Cibulskis, K.4
Sougnez, C.5
Schinzel, A.C.6
Harview, C.L.7
Brunet, J.P.8
Ahmann, G.J.9
Adli, M.10
Anderson, K.C.11
Ardlie, K.G.12
Auclair, D.13
Baker, A.14
Bergsagel, P.L.15
Bernstein, B.E.16
Drier, Y.17
Fonseca, R.18
Gabriel, S.B.19
Hofmeister, C.C.20
Jagannath, S.21
Jakubowiak, A.J.22
Krishnan, A.23
Levy, J.24
Liefeld, T.25
Lonial, S.26
Mahan, S.27
Mfuko, B.28
Monti, S.29
Perkins, L.M.30
Onofrio, R.31
Pugh, T.J.32
Rajkumar, S.V.33
Ramos, A.H.34
Siegel, D.S.35
Sivachenko, A.36
Stewart, A.K.37
Trudel, S.38
Vij, R.39
Voet, D.40
Winckler, W.41
Zimmerman, T.42
Carpten, J.43
Trent, J.44
Hahn, W.C.45
Garraway, L.A.46
Meyerson, M.47
Lander, E.S.48
Getz, G.49
Golub, T.R.50
more..
-
41
-
-
80052266351
-
Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder
-
Y. Gui, G. Guo, Y. Huang, X. Hu, A. Tang, S. Gao, R. Wu, C. Chen, X. Li, L. Zhou, M. He, Z. Li, X. Sun, W. Jia, J. Chen, S. Yang, F. Zhou, X. Zhao, S. Wan, R. Ye, C. Liang, Z. Liu, P. Huang, C. Liu, H. Jiang, Y. Wang, H. Zheng, L. Sun, X. Liu, Z. Jiang, D. Feng, J. Chen, S. Wu, J. Zou, Z. Zhang, R. Yang, J. Zhao, C. Xu, W. Yin, Z. Guan, J. Ye, H. Zhang, J. Li, K. Kristiansen, M.L. Nickerson, D. Theodorescu, Y. Li, X. Zhang, S. Li, J. Wang, H. Yang, J. Wang, and Z. Cai Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder Nat. Genet. 43 2011 875 878
-
(2011)
Nat. Genet.
, vol.43
, pp. 875-878
-
-
Gui, Y.1
Guo, G.2
Huang, Y.3
Hu, X.4
Tang, A.5
Gao, S.6
Wu, R.7
Chen, C.8
Li, X.9
Zhou, L.10
He, M.11
Li, Z.12
Sun, X.13
Jia, W.14
Chen, J.15
Yang, S.16
Zhou, F.17
Zhao, X.18
Wan, S.19
Ye, R.20
Liang, C.21
Liu, Z.22
Huang, P.23
Liu, C.24
Jiang, H.25
Wang, Y.26
Zheng, H.27
Sun, L.28
Liu, X.29
Jiang, Z.30
Feng, D.31
Chen, J.32
Wu, S.33
Zou, J.34
Zhang, Z.35
Yang, R.36
Zhao, J.37
Xu, C.38
Yin, W.39
Guan, Z.40
Ye, J.41
Zhang, H.42
Li, J.43
Kristiansen, K.44
Nickerson, M.L.45
Theodorescu, D.46
Li, Y.47
Zhang, X.48
Li, S.49
Wang, J.50
Yang, H.51
Wang, J.52
Cai, Z.53
more..
-
42
-
-
84864419974
-
Dissecting the genomic complexity underlying medulloblastoma
-
D.T. Jones, N. Jager, M. Kool, T. Zichner, B. Hutter, M. Sultan, Y.J. Cho, T.J. Pugh, V. Hovestadt, A.M. Stutz, T. Rausch, H.J. Warnatz, M. Ryzhova, S. Bender, D. Sturm, S. Pleier, H. Cin, E. Pfaff, L. Sieber, A. Wittmann, M. Remke, H. Witt, S. Hutter, T. Tzaridis, J. Weischenfeldt, B. Raeder, M. Avci, V. Amstislavskiy, M. Zapatka, U.D. Weber, Q. Wang, B. Lasitschka, C.C. Bartholomae, M. Schmidt, C. von Kalle, V. Ast, C. Lawerenz, J. Eils, R. Kabbe, V. Benes, P. van Sluis, J. Koster, R. Volckmann, D. Shih, M.J. Betts, R.B. Russell, S. Coco, G.P. Tonini, U. Schuller, V. Hans, N. Graf, Y.J. Kim, C. Monoranu, W. Roggendorf, A. Unterberg, C. Herold-Mende, T. Milde, A.E. Kulozik, A. von Deimling, O. Witt, E. Maass, J. Rossler, M. Ebinger, M.U. Schuhmann, M.C. Fruhwald, M. Hasselblatt, N. Jabado, S. Rutkowski, A.O. von Bueren, D. Williamson, S.C. Clifford, M.G. McCabe, V.P. Collins, S. Wolf, S. Wiemann, H. Lehrach, B. Brors, W. Scheurlen, J. Felsberg, G. Reifenberger, P.A. Northcott, M.D. Taylor, M. Meyerson, S.L. Pomeroy, M.L. Yaspo, J.O. Korbel, A. Korshunov, R. Eils, S.M. Pfister, and P. Lichter Dissecting the genomic complexity underlying medulloblastoma Nature 488 2012 100 105
-
(2012)
Nature
, vol.488
, pp. 100-105
-
-
Jones, D.T.1
Jager, N.2
Kool, M.3
Zichner, T.4
Hutter, B.5
Sultan, M.6
Cho, Y.J.7
Pugh, T.J.8
Hovestadt, V.9
Stutz, A.M.10
Rausch, T.11
Warnatz, H.J.12
Ryzhova, M.13
Bender, S.14
Sturm, D.15
Pleier, S.16
Cin, H.17
Pfaff, E.18
Sieber, L.19
Wittmann, A.20
Remke, M.21
Witt, H.22
Hutter, S.23
Tzaridis, T.24
Weischenfeldt, J.25
Raeder, B.26
Avci, M.27
Amstislavskiy, V.28
Zapatka, M.29
Weber, U.D.30
Wang, Q.31
Lasitschka, B.32
Bartholomae, C.C.33
Schmidt, M.34
Von Kalle, C.35
Ast, V.36
Lawerenz, C.37
Eils, J.38
Kabbe, R.39
Benes, V.40
Van Sluis, P.41
Koster, J.42
Volckmann, R.43
Shih, D.44
Betts, M.J.45
Russell, R.B.46
Coco, S.47
Tonini, G.P.48
Schuller, U.49
Hans, V.50
Graf, N.51
Kim, Y.J.52
Monoranu, C.53
Roggendorf, W.54
Unterberg, A.55
Herold-Mende, C.56
Milde, T.57
Kulozik, A.E.58
Von Deimling, A.59
Witt, O.60
Maass, E.61
Rossler, J.62
Ebinger, M.63
Schuhmann, M.U.64
Fruhwald, M.C.65
Hasselblatt, M.66
Jabado, N.67
Rutkowski, S.68
Von Bueren, A.O.69
Williamson, D.70
Clifford, S.C.71
McCabe, M.G.72
Collins, V.P.73
Wolf, S.74
Wiemann, S.75
Lehrach, H.76
Brors, B.77
Scheurlen, W.78
Felsberg, J.79
Reifenberger, G.80
Northcott, P.A.81
Taylor, M.D.82
Meyerson, M.83
Pomeroy, S.L.84
Yaspo, M.L.85
Korbel, J.O.86
Korshunov, A.87
Eils, R.88
Pfister, S.M.89
Lichter, P.90
more..
-
43
-
-
84864492215
-
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations
-
T.J. Pugh, S.D. Weeraratne, T.C. Archer, D.A. Pomeranz Krummel, D. Auclair, J. Bochicchio, M.O. Carneiro, S.L. Carter, K. Cibulskis, R.L. Erlich, H. Greulich, M.S. Lawrence, N.J. Lennon, A. McKenna, J. Meldrim, A.H. Ramos, M.G. Ross, C. Russ, E. Shefler, A. Sivachenko, B. Sogoloff, P. Stojanov, P. Tamayo, J.P. Mesirov, V. Amani, N. Teider, S. Sengupta, J.P. Francois, P.A. Northcott, M.D. Taylor, F. Yu, G.R. Crabtree, A.G. Kautzman, S.B. Gabriel, G. Getz, N. Jager, D.T. Jones, P. Lichter, S.M. Pfister, T.M. Roberts, M. Meyerson, S.L. Pomeroy, and Y.J. Cho Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations Nature 488 2012 106 110
-
(2012)
Nature
, vol.488
, pp. 106-110
-
-
Pugh, T.J.1
Weeraratne, S.D.2
Archer, T.C.3
Pomeranz Krummel, D.A.4
Auclair, D.5
Bochicchio, J.6
Carneiro, M.O.7
Carter, S.L.8
Cibulskis, K.9
Erlich, R.L.10
Greulich, H.11
Lawrence, M.S.12
Lennon, N.J.13
McKenna, A.14
Meldrim, J.15
Ramos, A.H.16
Ross, M.G.17
Russ, C.18
Shefler, E.19
Sivachenko, A.20
Sogoloff, B.21
Stojanov, P.22
Tamayo, P.23
Mesirov, J.P.24
Amani, V.25
Teider, N.26
Sengupta, S.27
Francois, J.P.28
Northcott, P.A.29
Taylor, M.D.30
Yu, F.31
Crabtree, G.R.32
Kautzman, A.G.33
Gabriel, S.B.34
Getz, G.35
Jager, N.36
Jones, D.T.37
Lichter, P.38
Pfister, S.M.39
Roberts, T.M.40
Meyerson, M.41
Pomeroy, S.L.42
Cho, Y.J.43
more..
-
44
-
-
75149188170
-
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
-
G.L. Dalgliesh, K. Furge, C. Greenman, L. Chen, G. Bignell, A. Butler, H. Davies, S. Edkins, C. Hardy, C. Latimer, J. Teague, J. Andrews, S. Barthorpe, D. Beare, G. Buck, P.J. Campbell, S. Forbes, M. Jia, D. Jones, H. Knott, C.Y. Kok, K.W. Lau, C. Leroy, M.L. Lin, D.J. McBride, M. Maddison, S. Maguire, K. McLay, A. Menzies, T. Mironenko, L. Mulderrig, L. Mudie, S. O'Meara, E. Pleasance, A. Rajasingham, R. Shepherd, R. Smith, L. Stebbings, P. Stephens, G. Tang, P.S. Tarpey, K. Turrell, K.J. Dykema, S.K. Khoo, D. Petillo, B. Wondergem, J. Anema, R.J. Kahnoski, B.T. Teh, M.R. Stratton, and P.A. Futreal Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes Nature 463 2010 360 363
-
(2010)
Nature
, vol.463
, pp. 360-363
-
-
Dalgliesh, G.L.1
Furge, K.2
Greenman, C.3
Chen, L.4
Bignell, G.5
Butler, A.6
Davies, H.7
Edkins, S.8
Hardy, C.9
Latimer, C.10
Teague, J.11
Andrews, J.12
Barthorpe, S.13
Beare, D.14
Buck, G.15
Campbell, P.J.16
Forbes, S.17
Jia, M.18
Jones, D.19
Knott, H.20
Kok, C.Y.21
Lau, K.W.22
Leroy, C.23
Lin, M.L.24
McBride, D.J.25
Maddison, M.26
Maguire, S.27
McLay, K.28
Menzies, A.29
Mironenko, T.30
Mulderrig, L.31
Mudie, L.32
O'Meara, S.33
Pleasance, E.34
Rajasingham, A.35
Shepherd, R.36
Smith, R.37
Stebbings, L.38
Stephens, P.39
Tang, G.40
Tarpey, P.S.41
Turrell, K.42
Dykema, K.J.43
Khoo, S.K.44
Petillo, D.45
Wondergem, B.46
Anema, J.47
Kahnoski, R.J.48
Teh, B.T.49
Stratton, M.R.50
Futreal, P.A.51
more..
-
45
-
-
84863723010
-
The mutational landscape of lethal castration-resistant prostate cancer
-
C.S. Grasso, Y.M. Wu, D.R. Robinson, X. Cao, S.M. Dhanasekaran, A.P. Khan, M.J. Quist, X. Jing, R.J. Lonigro, J.C. Brenner, I.A. Asangani, B. Ateeq, S.Y. Chun, J. Siddiqui, L. Sam, M. Anstett, R. Mehra, J.R. Prensner, N. Palanisamy, G.A. Ryslik, F. Vandin, B.J. Raphael, L.P. Kunju, D.R. Rhodes, K.J. Pienta, A.M. Chinnaiyan, and S.A. Tomlins The mutational landscape of lethal castration-resistant prostate cancer Nature 487 2012 239 243
-
(2012)
Nature
, vol.487
, pp. 239-243
-
-
Grasso, C.S.1
Wu, Y.M.2
Robinson, D.R.3
Cao, X.4
Dhanasekaran, S.M.5
Khan, A.P.6
Quist, M.J.7
Jing, X.8
Lonigro, R.J.9
Brenner, J.C.10
Asangani, I.A.11
Ateeq, B.12
Chun, S.Y.13
Siddiqui, J.14
Sam, L.15
Anstett, M.16
Mehra, R.17
Prensner, J.R.18
Palanisamy, N.19
Ryslik, G.A.20
Vandin, F.21
Raphael, B.J.22
Kunju, L.P.23
Rhodes, D.R.24
Pienta, K.J.25
Chinnaiyan, A.M.26
Tomlins, S.A.27
more..
-
46
-
-
84879689007
-
The mutational landscape of adenoid cystic carcinoma
-
A.S. Ho, K. Kannan, D.M. Roy, L.G. Morris, I. Ganly, N. Katabi, D. Ramaswami, L.A. Walsh, S. Eng, J.T. Huse, J. Zhang, I. Dolgalev, K. Huberman, A. Heguy, A. Viale, M. Drobnjak, M.A. Leversha, C.E. Rice, B. Singh, N.G. Iyer, C.R. Leemans, E. Bloemena, R.L. Ferris, R.R. Seethala, B.E. Gross, Y. Liang, R. Sinha, L. Peng, B.J. Raphael, S. Turcan, Y. Gong, N. Schultz, S. Kim, S. Chiosea, J.P. Shah, C. Sander, W. Lee, and T.A. Chan The mutational landscape of adenoid cystic carcinoma Nat. Genet. 45 2013 791 798
-
(2013)
Nat. Genet.
, vol.45
, pp. 791-798
-
-
Ho, A.S.1
Kannan, K.2
Roy, D.M.3
Morris, L.G.4
Ganly, I.5
Katabi, N.6
Ramaswami, D.7
Walsh, L.A.8
Eng, S.9
Huse, J.T.10
Zhang, J.11
Dolgalev, I.12
Huberman, K.13
Heguy, A.14
Viale, A.15
Drobnjak, M.16
Leversha, M.A.17
Rice, C.E.18
Singh, B.19
Iyer, N.G.20
Leemans, C.R.21
Bloemena, E.22
Ferris, R.L.23
Seethala, R.R.24
Gross, B.E.25
Liang, Y.26
Sinha, R.27
Peng, L.28
Raphael, B.J.29
Turcan, S.30
Gong, Y.31
Schultz, N.32
Kim, S.33
Chiosea, S.34
Shah, J.P.35
Sander, C.36
Lee, W.37
Chan, T.A.38
more..
-
47
-
-
84893786820
-
Advanced urothelial carcinoma: Next-generation sequencing reveals diverse genomic alterations and targets of therapy
-
J.S. Ross, K. Wang, R.N. Al-Rohil, T. Nazeer, C.E. Sheehan, G.A. Otto, J. He, G. Palmer, R. Yelensky, D. Lipson, S. Ali, S. Balasubramanian, J.A. Curran, L. Garcia, K. Mahoney, S.R. Downing, M. Hawryluk, V.A. Miller, and P.J. Stephens Advanced urothelial carcinoma: next-generation sequencing reveals diverse genomic alterations and targets of therapy Mod. Pathol. 27 2014 271 280
-
(2014)
Mod. Pathol.
, vol.27
, pp. 271-280
-
-
Ross, J.S.1
Wang, K.2
Al-Rohil, R.N.3
Nazeer, T.4
Sheehan, C.E.5
Otto, G.A.6
He, J.7
Palmer, G.8
Yelensky, R.9
Lipson, D.10
Ali, S.11
Balasubramanian, S.12
Curran, J.A.13
Garcia, L.14
Mahoney, K.15
Downing, S.R.16
Hawryluk, M.17
Miller, V.A.18
Stephens, P.J.19
-
48
-
-
84865120905
-
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response
-
L. Kruidenier, C.W. Chung, Z. Cheng, J. Liddle, K. Che, G. Joberty, M. Bantscheff, C. Bountra, A. Bridges, H. Diallo, D. Eberhard, S. Hutchinson, E. Jones, R. Katso, M. Leveridge, P.K. Mander, J. Mosley, C. Ramirez-Molina, P. Rowland, C.J. Schofield, R.J. Sheppard, J.E. Smith, C. Swales, R. Tanner, P. Thomas, A. Tumber, G. Drewes, U. Oppermann, D.J. Patel, K. Lee, and D.M. Wilson A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response Nature 488 2012 404 408
-
(2012)
Nature
, vol.488
, pp. 404-408
-
-
Kruidenier, L.1
Chung, C.W.2
Cheng, Z.3
Liddle, J.4
Che, K.5
Joberty, G.6
Bantscheff, M.7
Bountra, C.8
Bridges, A.9
Diallo, H.10
Eberhard, D.11
Hutchinson, S.12
Jones, E.13
Katso, R.14
Leveridge, M.15
Mander, P.K.16
Mosley, J.17
Ramirez-Molina, C.18
Rowland, P.19
Schofield, C.J.20
Sheppard, R.J.21
Smith, J.E.22
Swales, C.23
Tanner, R.24
Thomas, P.25
Tumber, A.26
Drewes, G.27
Oppermann, U.28
Patel, D.J.29
Lee, K.30
Wilson, D.M.31
more..
-
49
-
-
78751662908
-
The Polycomb complex PRC2 and its mark in life
-
R. Margueron, and D. Reinberg The Polycomb complex PRC2 and its mark in life Nature 469 2011 343 349
-
(2011)
Nature
, vol.469
, pp. 343-349
-
-
Margueron, R.1
Reinberg, D.2
-
50
-
-
0018240421
-
A gene complex controlling segmentation in Drosophila
-
E.B. Lewis A gene complex controlling segmentation in Drosophila Nature 276 1978 565 570
-
(1978)
Nature
, vol.276
, pp. 565-570
-
-
Lewis, E.B.1
-
51
-
-
75749124332
-
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
-
R.D. Morin, N.A. Johnson, T.M. Severson, A.J. Mungall, J. An, R. Goya, J.E. Paul, M. Boyle, B.W. Woolcock, F. Kuchenbauer, D. Yap, R.K. Humphries, O.L. Griffith, S. Shah, H. Zhu, M. Kimbara, P. Shashkin, J.F. Charlot, M. Tcherpakov, R. Corbett, A. Tam, R. Varhol, D. Smailus, M. Moksa, Y. Zhao, A. Delaney, H. Qian, I. Birol, J. Schein, R. Moore, R. Holt, D.E. Horsman, J.M. Connors, S. Jones, S. Aparicio, M. Hirst, R.D. Gascoyne, and M.A. Marra Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin Nat. Genet. 42 2010 181 185
-
(2010)
Nat. Genet.
, vol.42
, pp. 181-185
-
-
Morin, R.D.1
Johnson, N.A.2
Severson, T.M.3
Mungall, A.J.4
An, J.5
Goya, R.6
Paul, J.E.7
Boyle, M.8
Woolcock, B.W.9
Kuchenbauer, F.10
Yap, D.11
Humphries, R.K.12
Griffith, O.L.13
Shah, S.14
Zhu, H.15
Kimbara, M.16
Shashkin, P.17
Charlot, J.F.18
Tcherpakov, M.19
Corbett, R.20
Tam, A.21
Varhol, R.22
Smailus, D.23
Moksa, M.24
Zhao, Y.25
Delaney, A.26
Qian, H.27
Birol, I.28
Schein, J.29
Moore, R.30
Holt, R.31
Horsman, D.E.32
Connors, J.M.33
Jones, S.34
Aparicio, S.35
Hirst, M.36
Gascoyne, R.D.37
Marra, M.A.38
more..
-
52
-
-
78650454078
-
Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
-
C.J. Sneeringer, M.P. Scott, K.W. Kuntz, S.K. Knutson, R.M. Pollock, V.M. Richon, and R.A. Copeland Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas Proc. Natl. Acad. Sci. USA 107 2010 20980 20985
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 20980-20985
-
-
Sneeringer, C.J.1
Scott, M.P.2
Kuntz, K.W.3
Knutson, S.K.4
Pollock, R.M.5
Richon, V.M.6
Copeland, R.A.7
-
53
-
-
79952167230
-
Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
-
D.B. Yap, J. Chu, T. Berg, M. Schapira, S.W. Cheng, A. Moradian, R.D. Morin, A.J. Mungall, B. Meissner, M. Boyle, V.E. Marquez, M.A. Marra, R.D. Gascoyne, R.K. Humphries, C.H. Arrowsmith, G.B. Morin, and S.A. Aparicio Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation Blood 117 2011 2451 2459
-
(2011)
Blood
, vol.117
, pp. 2451-2459
-
-
Yap, D.B.1
Chu, J.2
Berg, T.3
Schapira, M.4
Cheng, S.W.5
Moradian, A.6
Morin, R.D.7
Mungall, A.J.8
Meissner, B.9
Boyle, M.10
Marquez, V.E.11
Marra, M.A.12
Gascoyne, R.D.13
Humphries, R.K.14
Arrowsmith, C.H.15
Morin, G.B.16
Aparicio, S.A.17
-
54
-
-
84866597616
-
A687V EZH2 is a gain-of-function mutation found in lymphoma patients
-
C.R. Majer, L. Jin, M.P. Scott, S.K. Knutson, K.W. Kuntz, H. Keilhack, J.J. Smith, M.P. Moyer, V.M. Richon, R.A. Copeland, and T.J. Wigle A687V EZH2 is a gain-of-function mutation found in lymphoma patients FEBS Lett. 586 2012 3448 3451
-
(2012)
FEBS Lett.
, vol.586
, pp. 3448-3451
-
-
Majer, C.R.1
Jin, L.2
Scott, M.P.3
Knutson, S.K.4
Kuntz, K.W.5
Keilhack, H.6
Smith, J.J.7
Moyer, M.P.8
Richon, V.M.9
Copeland, R.A.10
Wigle, T.J.11
-
55
-
-
84863165348
-
Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
-
M.T. McCabe, A.P. Graves, G. Ganji, E. Diaz, W.S. Halsey, Y. Jiang, K.N. Smitheman, H.M. Ott, M.B. Pappalardi, K.E. Allen, S.B. Chen, A. Della Pietra 3rd, E. Dul 3rd, A.M. Hughes, S.A. Gilbert, S.H. Thrall, P.J. Tummino, R.G. Kruger, M. Brandt, B. Schwartz, and C.L. Creasy Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27) Proc. Natl. Acad. Sci. USA 109 2012 2989 2994
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 2989-2994
-
-
McCabe, M.T.1
Graves, A.P.2
Ganji, G.3
Diaz, E.4
Halsey, W.S.5
Jiang, Y.6
Smitheman, K.N.7
Ott, H.M.8
Pappalardi, M.B.9
Allen, K.E.10
Chen, S.B.11
Della Pietra, A.12
Dul, E.13
Hughes, A.M.14
Gilbert, S.A.15
Thrall, S.H.16
Tummino, P.J.17
Kruger, R.G.18
Brandt, M.19
Schwartz, B.20
Creasy, C.L.21
more..
-
56
-
-
84877815031
-
EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation
-
W. Beguelin, R. Popovic, M. Teater, Y. Jiang, K.L. Bunting, M. Rosen, H. Shen, S.N. Yang, L. Wang, T. Ezponda, E. Martinez-Garcia, H. Zhang, Y. Zheng, S.K. Verma, M.T. McCabe, H.M. Ott, G.S. Van Aller, R.G. Kruger, Y. Liu, C.F. McHugh, D.W. Scott, Y.R. Chung, N. Kelleher, R. Shaknovich, C.L. Creasy, R.D. Gascoyne, K.K. Wong, L. Cerchietti, R.L. Levine, O. Abdel-Wahab, J.D. Licht, O. Elemento, and A.M. Melnick EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation Cancer Cell 23 2013 677 692
-
(2013)
Cancer Cell
, vol.23
, pp. 677-692
-
-
Beguelin, W.1
Popovic, R.2
Teater, M.3
Jiang, Y.4
Bunting, K.L.5
Rosen, M.6
Shen, H.7
Yang, S.N.8
Wang, L.9
Ezponda, T.10
Martinez-Garcia, E.11
Zhang, H.12
Zheng, Y.13
Verma, S.K.14
McCabe, M.T.15
Ott, H.M.16
Van Aller, G.S.17
Kruger, R.G.18
Liu, Y.19
McHugh, C.F.20
Scott, D.W.21
Chung, Y.R.22
Kelleher, N.23
Shaknovich, R.24
Creasy, C.L.25
Gascoyne, R.D.26
Wong, K.K.27
Cerchietti, L.28
Levine, R.L.29
Abdel-Wahab, O.30
Licht, J.D.31
Elemento, O.32
Melnick, A.M.33
more..
-
57
-
-
77955085750
-
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
-
T. Ernst, A.J. Chase, J. Score, C.E. Hidalgo-Curtis, C. Bryant, A.V. Jones, K. Waghorn, K. Zoi, F.M. Ross, A. Reiter, A. Hochhaus, H.G. Drexler, A. Duncombe, F. Cervantes, D. Oscier, J. Boultwood, F.H. Grand, and N.C. Cross Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders Nat. Genet. 42 2010 722 726
-
(2010)
Nat. Genet.
, vol.42
, pp. 722-726
-
-
Ernst, T.1
Chase, A.J.2
Score, J.3
Hidalgo-Curtis, C.E.4
Bryant, C.5
Jones, A.V.6
Waghorn, K.7
Zoi, K.8
Ross, F.M.9
Reiter, A.10
Hochhaus, A.11
Drexler, H.G.12
Duncombe, A.13
Cervantes, F.14
Oscier, D.15
Boultwood, J.16
Grand, F.H.17
Cross, N.C.18
-
58
-
-
84856747744
-
Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia
-
P. Ntziachristos, A. Tsirigos, P. Van Vlierberghe, J. Nedjic, T. Trimarchi, M.S. Flaherty, D. Ferres-Marco, V. da Ros, Z. Tang, J. Siegle, P. Asp, M. Hadler, I. Rigo, K. De Keersmaecker, J. Patel, T. Huynh, F. Utro, S. Poglio, J.B. Samon, E. Paietta, J. Racevskis, J.M. Rowe, R. Rabadan, R.L. Levine, S. Brown, F. Pflumio, M. Dominguez, A. Ferrando, and I. Aifantis Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia Nat. Med. 18 2012 298 301
-
(2012)
Nat. Med.
, vol.18
, pp. 298-301
-
-
Ntziachristos, P.1
Tsirigos, A.2
Van Vlierberghe, P.3
Nedjic, J.4
Trimarchi, T.5
Flaherty, M.S.6
Ferres-Marco, D.7
Da Ros, V.8
Tang, Z.9
Siegle, J.10
Asp, P.11
Hadler, M.12
Rigo, I.13
De Keersmaecker, K.14
Patel, J.15
Huynh, T.16
Utro, F.17
Poglio, S.18
Samon, J.B.19
Paietta, E.20
Racevskis, J.21
Rowe, J.M.22
Rabadan, R.23
Levine, R.L.24
Brown, S.25
Pflumio, F.26
Dominguez, M.27
Ferrando, A.28
Aifantis, I.29
more..
-
59
-
-
84862907593
-
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
-
J. Zhang, L. Ding, L. Holmfeldt, G. Wu, S.L. Heatley, D. Payne-Turner, J. Easton, X. Chen, J. Wang, M. Rusch, C. Lu, S.C. Chen, L. Wei, J.R. Collins-Underwood, J. Ma, K.G. Roberts, S.B. Pounds, A. Ulyanov, J. Becksfort, P. Gupta, R. Huether, R.W. Kriwacki, M. Parker, D.J. McGoldrick, D. Zhao, D. Alford, S. Espy, K.C. Bobba, G. Song, D. Pei, C. Cheng, S. Roberts, M.I. Barbato, D. Campana, E. Coustan-Smith, S.A. Shurtleff, S.C. Raimondi, M. Kleppe, J. Cools, K.A. Shimano, M.L. Hermiston, S. Doulatov, K. Eppert, E. Laurenti, F. Notta, J.E. Dick, G. Basso, S.P. Hunger, M.L. Loh, M. Devidas, B. Wood, S. Winter, K.P. Dunsmore, R.S. Fulton, L.L. Fulton, X. Hong, C.C. Harris, D.J. Dooling, K. Ochoa, K.J. Johnson, J.C. Obenauer, W.E. Evans, C.H. Pui, C.W. Naeve, T.J. Ley, E.R. Mardis, R.K. Wilson, J.R. Downing, and C.G. Mullighan The genetic basis of early T-cell precursor acute lymphoblastic leukaemia Nature 481 2012 157 163
-
(2012)
Nature
, vol.481
, pp. 157-163
-
-
Zhang, J.1
Ding, L.2
Holmfeldt, L.3
Wu, G.4
Heatley, S.L.5
Payne-Turner, D.6
Easton, J.7
Chen, X.8
Wang, J.9
Rusch, M.10
Lu, C.11
Chen, S.C.12
Wei, L.13
Collins-Underwood, J.R.14
Ma, J.15
Roberts, K.G.16
Pounds, S.B.17
Ulyanov, A.18
Becksfort, J.19
Gupta, P.20
Huether, R.21
Kriwacki, R.W.22
Parker, M.23
McGoldrick, D.J.24
Zhao, D.25
Alford, D.26
Espy, S.27
Bobba, K.C.28
Song, G.29
Pei, D.30
Cheng, C.31
Roberts, S.32
Barbato, M.I.33
Campana, D.34
Coustan-Smith, E.35
Shurtleff, S.A.36
Raimondi, S.C.37
Kleppe, M.38
Cools, J.39
Shimano, K.A.40
Hermiston, M.L.41
Doulatov, S.42
Eppert, K.43
Laurenti, E.44
Notta, F.45
Dick, J.E.46
Basso, G.47
Hunger, S.P.48
Loh, M.L.49
Devidas, M.50
Wood, B.51
Winter, S.52
Dunsmore, K.P.53
Fulton, R.S.54
Fulton, L.L.55
Hong, X.56
Harris, C.C.57
Dooling, D.J.58
Ochoa, K.59
Johnson, K.J.60
Obenauer, J.C.61
Evans, W.E.62
Pui, C.H.63
Naeve, C.W.64
Ley, T.J.65
Mardis, E.R.66
Wilson, R.K.67
Downing, J.R.68
Mullighan, C.G.69
more..
-
60
-
-
84859295400
-
A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia
-
C. Simon, J. Chagraoui, J. Krosl, P. Gendron, B. Wilhelm, S. Lemieux, G. Boucher, P. Chagnon, S. Drouin, R. Lambert, C. Rondeau, A. Bilodeau, S. Lavallee, M. Sauvageau, J. Hebert, and G. Sauvageau A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia Genes Dev. 26 2012 651 656
-
(2012)
Genes Dev.
, vol.26
, pp. 651-656
-
-
Simon, C.1
Chagraoui, J.2
Krosl, J.3
Gendron, P.4
Wilhelm, B.5
Lemieux, S.6
Boucher, G.7
Chagnon, P.8
Drouin, S.9
Lambert, R.10
Rondeau, C.11
Bilodeau, A.12
Lavallee, S.13
Sauvageau, M.14
Hebert, J.15
Sauvageau, G.16
-
61
-
-
79959794787
-
Clinical effect of point mutations in myelodysplastic syndromes
-
R. Bejar, K. Stevenson, O. Abdel-Wahab, N. Galili, B. Nilsson, G. Garcia-Manero, H. Kantarjian, A. Raza, R.L. Levine, D. Neuberg, and B.L. Ebert Clinical effect of point mutations in myelodysplastic syndromes N. Engl. J. Med. 364 2011 2496 2506
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 2496-2506
-
-
Bejar, R.1
Stevenson, K.2
Abdel-Wahab, O.3
Galili, N.4
Nilsson, B.5
Garcia-Manero, G.6
Kantarjian, H.7
Raza, A.8
Levine, R.L.9
Neuberg, D.10
Ebert, B.L.11
-
62
-
-
81055126771
-
EZH2 mutational status predicts poor survival in myelofibrosis
-
P. Guglielmelli, F. Biamonte, J. Score, C. Hidalgo-Curtis, F. Cervantes, M. Maffioli, T. Fanelli, T. Ernst, N. Winkelman, A.V. Jones, K. Zoi, A. Reiter, A. Duncombe, L. Villani, A. Bosi, G. Barosi, N.C. Cross, and A.M. Vannucchi EZH2 mutational status predicts poor survival in myelofibrosis Blood 118 2011 5227 5234
-
(2011)
Blood
, vol.118
, pp. 5227-5234
-
-
Guglielmelli, P.1
Biamonte, F.2
Score, J.3
Hidalgo-Curtis, C.4
Cervantes, F.5
Maffioli, M.6
Fanelli, T.7
Ernst, T.8
Winkelman, N.9
Jones, A.V.10
Zoi, K.11
Reiter, A.12
Duncombe, A.13
Villani, L.14
Bosi, A.15
Barosi, G.16
Cross, N.C.17
Vannucchi, A.M.18
-
63
-
-
79960227474
-
Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms
-
O. Abdel-Wahab, A. Pardanani, J. Patel, M. Wadleigh, T. Lasho, A. Heguy, M. Beran, D.G. Gilliland, R.L. Levine, and A. Tefferi Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms Leukemia 25 2011 1200 1202
-
(2011)
Leukemia
, vol.25
, pp. 1200-1202
-
-
Abdel-Wahab, O.1
Pardanani, A.2
Patel, J.3
Wadleigh, M.4
Lasho, T.5
Heguy, A.6
Beran, M.7
Gilliland, D.G.8
Levine, R.L.9
Tefferi, A.10
-
64
-
-
84866749552
-
Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes
-
R. Bejar, K.E. Stevenson, B.A. Caughey, O. Abdel-Wahab, D.P. Steensma, N. Galili, A. Raza, H. Kantarjian, R.L. Levine, D. Neuberg, G. Garcia-Manero, and B.L. Ebert Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes J. Clin. Oncol. 30 2012 3376 3382
-
(2012)
J. Clin. Oncol.
, vol.30
, pp. 3376-3382
-
-
Bejar, R.1
Stevenson, K.E.2
Caughey, B.A.3
Abdel-Wahab, O.4
Steensma, D.P.5
Galili, N.6
Raza, A.7
Kantarjian, H.8
Levine, R.L.9
Neuberg, D.10
Garcia-Manero, G.11
Ebert, B.L.12
-
65
-
-
84888083126
-
Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders
-
T. Muto, G. Sashida, M. Oshima, G.R. Wendt, M. Mochizuki-Kashio, Y. Nagata, M. Sanada, S. Miyagi, A. Saraya, A. Kamio, G. Nagae, C. Nakaseko, K. Yokote, K. Shimoda, H. Koseki, Y. Suzuki, S. Sugano, H. Aburatani, S. Ogawa, and A. Iwama Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders J. Exp. Med. 210 2013 2627 2639
-
(2013)
J. Exp. Med.
, vol.210
, pp. 2627-2639
-
-
Muto, T.1
Sashida, G.2
Oshima, M.3
Wendt, G.R.4
Mochizuki-Kashio, M.5
Nagata, Y.6
Sanada, M.7
Miyagi, S.8
Saraya, A.9
Kamio, A.10
Nagae, G.11
Nakaseko, C.12
Yokote, K.13
Shimoda, K.14
Koseki, H.15
Suzuki, Y.16
Sugano, S.17
Aburatani, H.18
Ogawa, S.19
Iwama, A.20
more..
-
66
-
-
84857042600
-
Mutations and deletions of the SUZ12 polycomb gene in myeloproliferative neoplasms
-
M. Brecqueville, N. Cervera, J. Adelaide, J. Rey, N. Carbuccia, M. Chaffanet, M.J. Mozziconacci, N. Vey, D. Birnbaum, V. Gelsi-Boyer, and A. Murati Mutations and deletions of the SUZ12 polycomb gene in myeloproliferative neoplasms Blood Cancer J. 1 2011 e33
-
(2011)
Blood Cancer J.
, vol.1
, pp. 33
-
-
Brecqueville, M.1
Cervera, N.2
Adelaide, J.3
Rey, J.4
Carbuccia, N.5
Chaffanet, M.6
Mozziconacci, M.J.7
Vey, N.8
Birnbaum, D.9
Gelsi-Boyer, V.10
Murati, A.11
-
67
-
-
84856596417
-
Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms
-
J. Score, C. Hidalgo-Curtis, A.V. Jones, N. Winkelmann, A. Skinner, D. Ward, K. Zoi, T. Ernst, F. Stegelmann, K. Dohner, A. Chase, and N.C. Cross Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms Blood 119 2012 1208 1213
-
(2012)
Blood
, vol.119
, pp. 1208-1213
-
-
Score, J.1
Hidalgo-Curtis, C.2
Jones, A.V.3
Winkelmann, N.4
Skinner, A.5
Ward, D.6
Zoi, K.7
Ernst, T.8
Stegelmann, F.9
Dohner, K.10
Chase, A.11
Cross, N.C.12
-
68
-
-
84865152223
-
ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression
-
O. Abdel-Wahab, M. Adli, L.M. LaFave, J. Gao, T. Hricik, A.H. Shih, S. Pandey, J.P. Patel, Y.R. Chung, R. Koche, F. Perna, X. Zhao, J.E. Taylor, C.Y. Park, M. Carroll, A. Melnick, S.D. Nimer, J.D. Jaffe, I. Aifantis, B.E. Bernstein, and R.L. Levine ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression Cancer Cell 22 2012 180 193
-
(2012)
Cancer Cell
, vol.22
, pp. 180-193
-
-
Abdel-Wahab, O.1
Adli, M.2
Lafave, L.M.3
Gao, J.4
Hricik, T.5
Shih, A.H.6
Pandey, S.7
Patel, J.P.8
Chung, Y.R.9
Koche, R.10
Perna, F.11
Zhao, X.12
Taylor, J.E.13
Park, C.Y.14
Carroll, M.15
Melnick, A.16
Nimer, S.D.17
Jaffe, J.D.18
Aifantis, I.19
Bernstein, B.E.20
Levine, R.L.21
more..
-
69
-
-
66849124925
-
Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia
-
V. Gelsi-Boyer, V. Trouplin, J. Adelaide, J. Bonansea, N. Cervera, N. Carbuccia, A. Lagarde, T. Prebet, M. Nezri, D. Sainty, S. Olschwang, L. Xerri, M. Chaffanet, M.J. Mozziconacci, N. Vey, and D. Birnbaum Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia Br. J. Haematol. 145 2009 788 800
-
(2009)
Br. J. Haematol.
, vol.145
, pp. 788-800
-
-
Gelsi-Boyer, V.1
Trouplin, V.2
Adelaide, J.3
Bonansea, J.4
Cervera, N.5
Carbuccia, N.6
Lagarde, A.7
Prebet, T.8
Nezri, M.9
Sainty, D.10
Olschwang, S.11
Xerri, L.12
Chaffanet, M.13
Mozziconacci, M.J.14
Vey, N.15
Birnbaum, D.16
-
70
-
-
84255176496
-
ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category
-
K.H. Metzeler, H. Becker, K. Maharry, M.D. Radmacher, J. Kohlschmidt, K. Mrozek, D. Nicolet, S.P. Whitman, Y.Z. Wu, S. Schwind, B.L. Powell, T.H. Carter, M. Wetzler, J.O. Moore, J.E. Kolitz, M.R. Baer, A.J. Carroll, R.A. Larson, M.A. Caligiuri, G. Marcucci, and C.D. Bloomfield ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category Blood 118 2011 6920 6929
-
(2011)
Blood
, vol.118
, pp. 6920-6929
-
-
Metzeler, K.H.1
Becker, H.2
Maharry, K.3
Radmacher, M.D.4
Kohlschmidt, J.5
Mrozek, K.6
Nicolet, D.7
Whitman, S.P.8
Wu, Y.Z.9
Schwind, S.10
Powell, B.L.11
Carter, T.H.12
Wetzler, M.13
Moore, J.O.14
Kolitz, J.E.15
Baer, M.R.16
Carroll, A.J.17
Larson, R.A.18
Caligiuri, M.A.19
Marcucci, G.20
Bloomfield, C.D.21
more..
-
71
-
-
79959317767
-
Prognostic significance of ASXL1 mutations in patients with myelodysplastic syndromes
-
F. Thol, I. Friesen, F. Damm, H. Yun, E.M. Weissinger, J. Krauter, K. Wagner, A. Chaturvedi, A. Sharma, M. Wichmann, G. Gohring, C. Schumann, G. Bug, O. Ottmann, W.K. Hofmann, B. Schlegelberger, M. Heuser, and A. Ganser Prognostic significance of ASXL1 mutations in patients with myelodysplastic syndromes J. Clin. Oncol. 29 2011 2499 2506
-
(2011)
J. Clin. Oncol.
, vol.29
, pp. 2499-2506
-
-
Thol, F.1
Friesen, I.2
Damm, F.3
Yun, H.4
Weissinger, E.M.5
Krauter, J.6
Wagner, K.7
Chaturvedi, A.8
Sharma, A.9
Wichmann, M.10
Gohring, G.11
Schumann, C.12
Bug, G.13
Ottmann, O.14
Hofmann, W.K.15
Schlegelberger, B.16
Heuser, M.17
Ganser, A.18
-
72
-
-
77952421834
-
Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia
-
J. Boultwood, J. Perry, A. Pellagatti, M. Fernandez-Mercado, C. Fernandez-Santamaria, M.J. Calasanz, M.J. Larrayoz, M. Garcia-Delgado, A. Giagounidis, L. Malcovati, M.G. Della Porta, M. Jadersten, S. Killick, E. Hellstrom-Lindberg, M. Cazzola, and J.S. Wainscoat Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia Leukemia 24 2010 1062 1065
-
(2010)
Leukemia
, vol.24
, pp. 1062-1065
-
-
Boultwood, J.1
Perry, J.2
Pellagatti, A.3
Fernandez-Mercado, M.4
Fernandez-Santamaria, C.5
Calasanz, M.J.6
Larrayoz, M.J.7
Garcia-Delgado, M.8
Giagounidis, A.9
Malcovati, L.10
Della Porta, M.G.11
Jadersten, M.12
Killick, S.13
Hellstrom-Lindberg, E.14
Cazzola, M.15
Wainscoat, J.S.16
-
73
-
-
80053135096
-
Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A
-
A.M. Jankowska, H. Makishima, R.V. Tiu, H. Szpurka, Y. Huang, F. Traina, V. Visconte, Y. Sugimoto, C. Prince, C. O'Keefe, E.D. Hsi, A. List, M.A. Sekeres, A. Rao, M.A. McDevitt, and J.P. Maciejewski Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A Blood 118 2011 3932 3941
-
(2011)
Blood
, vol.118
, pp. 3932-3941
-
-
Jankowska, A.M.1
Makishima, H.2
Tiu, R.V.3
Szpurka, H.4
Huang, Y.5
Traina, F.6
Visconte, V.7
Sugimoto, Y.8
Prince, C.9
O'Keefe, C.10
Hsi, E.D.11
List, A.12
Sekeres, M.A.13
Rao, A.14
McDevitt, M.A.15
Maciejewski, J.P.16
-
74
-
-
84888116023
-
Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo
-
O. Abdel-Wahab, J. Gao, M. Adli, A. Dey, T. Trimarchi, Y.R. Chung, C. Kuscu, T. Hricik, D. Ndiaye-Lobry, L.M. Lafave, R. Koche, A.H. Shih, O.A. Guryanova, E. Kim, S. Li, S. Pandey, J.Y. Shin, L. Telis, J. Liu, P.K. Bhatt, S. Monette, X. Zhao, C.E. Mason, C.Y. Park, B.E. Bernstein, I. Aifantis, and R.L. Levine Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo J. Exp. Med. 210 2013 2641 2659
-
(2013)
J. Exp. Med.
, vol.210
, pp. 2641-2659
-
-
Abdel-Wahab, O.1
Gao, J.2
Adli, M.3
Dey, A.4
Trimarchi, T.5
Chung, Y.R.6
Kuscu, C.7
Hricik, T.8
Ndiaye-Lobry, D.9
Lafave, L.M.10
Koche, R.11
Shih, A.H.12
Guryanova, O.A.13
Kim, E.14
Li, S.15
Pandey, S.16
Shin, J.Y.17
Telis, L.18
Liu, J.19
Bhatt, P.K.20
Monette, S.21
Zhao, X.22
Mason, C.E.23
Park, C.Y.24
Bernstein, B.E.25
Aifantis, I.26
Levine, R.L.27
more..
-
75
-
-
84866467141
-
Loss of the tumor suppressor BAP1 causes myeloid transformation
-
A. Dey, D. Seshasayee, R. Noubade, D.M. French, J. Liu, M.S. Chaurushiya, D.S. Kirkpatrick, V.C. Pham, J.R. Lill, C.E. Bakalarski, J. Wu, L. Phu, P. Katavolos, L.M. LaFave, O. Abdel-Wahab, Z. Modrusan, S. Seshagiri, K. Dong, Z. Lin, M. Balazs, R. Suriben, K. Newton, S. Hymowitz, G. Garcia-Manero, F. Martin, R.L. Levine, and V.M. Dixit Loss of the tumor suppressor BAP1 causes myeloid transformation Science 337 2012 1541 1546
-
(2012)
Science
, vol.337
, pp. 1541-1546
-
-
Dey, A.1
Seshasayee, D.2
Noubade, R.3
French, D.M.4
Liu, J.5
Chaurushiya, M.S.6
Kirkpatrick, D.S.7
Pham, V.C.8
Lill, J.R.9
Bakalarski, C.E.10
Wu, J.11
Phu, L.12
Katavolos, P.13
Lafave, L.M.14
Abdel-Wahab, O.15
Modrusan, Z.16
Seshagiri, S.17
Dong, K.18
Lin, Z.19
Balazs, M.20
Suriben, R.21
Newton, K.22
Hymowitz, S.23
Garcia-Manero, G.24
Martin, F.25
Levine, R.L.26
Dixit, V.M.27
more..
-
76
-
-
80052029516
-
Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
-
R.D. Morin, M. Mendez-Lago, A.J. Mungall, R. Goya, K.L. Mungall, R.D. Corbett, N.A. Johnson, T.M. Severson, R. Chiu, M. Field, S. Jackman, M. Krzywinski, D.W. Scott, D.L. Trinh, J. Tamura-Wells, S. Li, M.R. Firme, S. Rogic, M. Griffith, S. Chan, O. Yakovenko, I.M. Meyer, E.Y. Zhao, D. Smailus, M. Moksa, S. Chittaranjan, L. Rimsza, A. Brooks-Wilson, J.J. Spinelli, S. Ben-Neriah, B. Meissner, B. Woolcock, M. Boyle, H. McDonald, A. Tam, Y. Zhao, A. Delaney, T. Zeng, K. Tse, Y. Butterfield, I. Birol, R. Holt, J. Schein, D.E. Horsman, R. Moore, S.J. Jones, J.M. Connors, M. Hirst, R.D. Gascoyne, and M.A. Marra Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma Nature 476 2011 298 303
-
(2011)
Nature
, vol.476
, pp. 298-303
-
-
Morin, R.D.1
Mendez-Lago, M.2
Mungall, A.J.3
Goya, R.4
Mungall, K.L.5
Corbett, R.D.6
Johnson, N.A.7
Severson, T.M.8
Chiu, R.9
Field, M.10
Jackman, S.11
Krzywinski, M.12
Scott, D.W.13
Trinh, D.L.14
Tamura-Wells, J.15
Li, S.16
Firme, M.R.17
Rogic, S.18
Griffith, M.19
Chan, S.20
Yakovenko, O.21
Meyer, I.M.22
Zhao, E.Y.23
Smailus, D.24
Moksa, M.25
Chittaranjan, S.26
Rimsza, L.27
Brooks-Wilson, A.28
Spinelli, J.J.29
Ben-Neriah, S.30
Meissner, B.31
Woolcock, B.32
Boyle, M.33
McDonald, H.34
Tam, A.35
Zhao, Y.36
Delaney, A.37
Zeng, T.38
Tse, K.39
Butterfield, Y.40
Birol, I.41
Holt, R.42
Schein, J.43
Horsman, D.E.44
Moore, R.45
Jones, S.J.46
Connors, J.M.47
Hirst, M.48
Gascoyne, R.D.49
Marra, M.A.50
more..
-
77
-
-
33749993417
-
The consensus coding sequences of human breast and colorectal cancers
-
T. Sjoblom, S. Jones, L.D. Wood, D.W. Parsons, J. Lin, T.D. Barber, D. Mandelker, R.J. Leary, J. Ptak, N. Silliman, S. Szabo, P. Buckhaults, C. Farrell, P. Meeh, S.D. Markowitz, J. Willis, D. Dawson, J.K. Willson, A.F. Gazdar, J. Hartigan, L. Wu, C. Liu, G. Parmigiani, B.H. Park, K.E. Bachman, N. Papadopoulos, B. Vogelstein, K.W. Kinzler, and V.E. Velculescu The consensus coding sequences of human breast and colorectal cancers Science 314 2006 268 274
-
(2006)
Science
, vol.314
, pp. 268-274
-
-
Sjoblom, T.1
Jones, S.2
Wood, L.D.3
Parsons, D.W.4
Lin, J.5
Barber, T.D.6
Mandelker, D.7
Leary, R.J.8
Ptak, J.9
Silliman, N.10
Szabo, S.11
Buckhaults, P.12
Farrell, C.13
Meeh, P.14
Markowitz, S.D.15
Willis, J.16
Dawson, D.17
Willson, J.K.18
Gazdar, A.F.19
Hartigan, J.20
Wu, L.21
Liu, C.22
Parmigiani, G.23
Park, B.H.24
Bachman, K.E.25
Papadopoulos, N.26
Vogelstein, B.27
Kinzler, K.W.28
Velculescu, V.E.29
more..
-
78
-
-
84862777410
-
Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas
-
G. Wu, A. Broniscer, T.A. McEachron, C. Lu, B.S. Paugh, J. Becksfort, C. Qu, L. Ding, R. Huether, M. Parker, J. Zhang, A. Gajjar, M.A. Dyer, C.G. Mullighan, R.J. Gilbertson, E.R. Mardis, R.K. Wilson, J.R. Downing, D.W. Ellison, J. Zhang, and S.J. Baker Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas Nat. Genet. 44 2012 251 253
-
(2012)
Nat. Genet.
, vol.44
, pp. 251-253
-
-
Wu, G.1
Broniscer, A.2
McEachron, T.A.3
Lu, C.4
Paugh, B.S.5
Becksfort, J.6
Qu, C.7
Ding, L.8
Huether, R.9
Parker, M.10
Zhang, J.11
Gajjar, A.12
Dyer, M.A.13
Mullighan, C.G.14
Gilbertson, R.J.15
Mardis, E.R.16
Wilson, R.K.17
Downing, J.R.18
Ellison, D.W.19
Zhang, J.20
Baker, S.J.21
more..
-
79
-
-
84862777348
-
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
-
J. Schwartzentruber, A. Korshunov, X.Y. Liu, D.T. Jones, E. Pfaff, K. Jacob, D. Sturm, A.M. Fontebasso, D.A. Quang, M. Tonjes, V. Hovestadt, S. Albrecht, M. Kool, A. Nantel, C. Konermann, A. Lindroth, N. Jager, T. Rausch, M. Ryzhova, J.O. Korbel, T. Hielscher, P. Hauser, M. Garami, A. Klekner, L. Bognar, M. Ebinger, M.U. Schuhmann, W. Scheurlen, A. Pekrun, M.C. Fruhwald, W. Roggendorf, C. Kramm, M. Durken, J. Atkinson, P. Lepage, A. Montpetit, M. Zakrzewska, K. Zakrzewski, P.P. Liberski, Z. Dong, P. Siegel, A.E. Kulozik, M. Zapatka, A. Guha, D. Malkin, J. Felsberg, G. Reifenberger, A. von Deimling, K. Ichimura, V.P. Collins, H. Witt, T. Milde, O. Witt, C. Zhang, P. Castelo-Branco, P. Lichter, D. Faury, U. Tabori, C. Plass, J. Majewski, S.M. Pfister, and N. Jabado Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma Nature 482 2012 226 231
-
(2012)
Nature
, vol.482
, pp. 226-231
-
-
Schwartzentruber, J.1
Korshunov, A.2
Liu, X.Y.3
Jones, D.T.4
Pfaff, E.5
Jacob, K.6
Sturm, D.7
Fontebasso, A.M.8
Quang, D.A.9
Tonjes, M.10
Hovestadt, V.11
Albrecht, S.12
Kool, M.13
Nantel, A.14
Konermann, C.15
Lindroth, A.16
Jager, N.17
Rausch, T.18
Ryzhova, M.19
Korbel, J.O.20
Hielscher, T.21
Hauser, P.22
Garami, M.23
Klekner, A.24
Bognar, L.25
Ebinger, M.26
Schuhmann, M.U.27
Scheurlen, W.28
Pekrun, A.29
Fruhwald, M.C.30
Roggendorf, W.31
Kramm, C.32
Durken, M.33
Atkinson, J.34
Lepage, P.35
Montpetit, A.36
Zakrzewska, M.37
Zakrzewski, K.38
Liberski, P.P.39
Dong, Z.40
Siegel, P.41
Kulozik, A.E.42
Zapatka, M.43
Guha, A.44
Malkin, D.45
Felsberg, J.46
Reifenberger, G.47
Von Deimling, A.48
Ichimura, K.49
Collins, V.P.50
Witt, H.51
Milde, T.52
Witt, O.53
Zhang, C.54
Castelo-Branco, P.55
Lichter, P.56
Faury, D.57
Tabori, U.58
Plass, C.59
Majewski, J.60
Pfister, S.M.61
Jabado, N.62
more..
-
80
-
-
84880496479
-
Low frequency of H3.3 mutations and upregulated DAXX expression in MDS
-
Y. Attieh, Q.R. Geng, C.D. Dinardo, H. Zheng, Y. Jia, Z.H. Fang, I. Gañán-Gómez, H. Yang, Y. Wei, H. Kantarjian, and G. Garcia-Manero Low frequency of H3.3 mutations and upregulated DAXX expression in MDS Blood. 121 19 2013 4009 4011
-
(2013)
Blood.
, vol.121
, Issue.19
, pp. 4009-4011
-
-
Attieh, Y.1
Geng, Q.R.2
Dinardo, C.D.3
Zheng, H.4
Jia, Y.5
Fang, Z.H.6
Gañán-Gómez, I.7
Yang, H.8
Wei, Y.9
Kantarjian, H.10
Garcia-Manero, G.11
-
81
-
-
84874659208
-
H3.3 G34R mutations in pediatric primitive neuroectodermal tumors of central nervous system (CNS-PNET) and pediatric glioblastomas: Possible diagnostic and therapeutic implications?
-
M. Gessi, G.H. Gielen, J. Hammes, E. Dörner, A.Z. Mühlen, A. Waha, and T. Pietsch H3.3 G34R mutations in pediatric primitive neuroectodermal tumors of central nervous system (CNS-PNET) and pediatric glioblastomas: possible diagnostic and therapeutic implications? J Neurooncol. 112 1 2013 67 72
-
(2013)
J Neurooncol.
, vol.112
, Issue.1
, pp. 67-72
-
-
Gessi, M.1
Gielen, G.H.2
Hammes, J.3
Dörner, E.4
Mühlen, A.Z.5
Waha, A.6
Pietsch, T.7
-
82
-
-
84887619842
-
Exomic analysis of myxoid liposarcomas, synovial sarcomas, and osteosarcomas
-
C.G. Joseph, H. Hwang, Y. Jiao, L.D. Wood, I. Kinde, J. Wu, N. Mandahl, J. Luo, R.H. Hruban, L.A. Diaz Jr., T.C. He, B. Vogelstein, K.W. Kinzler, F. Mertens, and N. Papadopoulos Exomic analysis of myxoid liposarcomas, synovial sarcomas, and osteosarcomas Genes Chromosomes Cancer. 53 1 2014 15 24
-
(2014)
Genes Chromosomes Cancer.
, vol.53
, Issue.1
, pp. 15-24
-
-
Joseph, C.G.1
Hwang, H.2
Jiao, Y.3
Wood, L.D.4
Kinde, I.5
Wu, J.6
Mandahl, N.7
Luo, J.8
Hruban, R.H.9
Diaz, L.A.10
He, T.C.11
Vogelstein, B.12
Kinzler, K.W.13
Mertens, F.14
Papadopoulos, N.15
-
83
-
-
84867606428
-
Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma
-
D. Sturm, H. Witt, V. Hovestadt, D.A. Khuong-Quang, D.T. Jones, C. Konermann, E. Pfaff, M. Tonjes, M. Sill, S. Bender, M. Kool, M. Zapatka, N. Becker, M. Zucknick, T. Hielscher, X.Y. Liu, A.M. Fontebasso, M. Ryzhova, S. Albrecht, K. Jacob, M. Wolter, M. Ebinger, M.U. Schuhmann, T. van Meter, M.C. Fruhwald, H. Hauch, A. Pekrun, B. Radlwimmer, T. Niehues, G. von Komorowski, M. Durken, A.E. Kulozik, J. Madden, A. Donson, N.K. Foreman, R. Drissi, M. Fouladi, W. Scheurlen, A. von Deimling, C. Monoranu, W. Roggendorf, C. Herold-Mende, A. Unterberg, C.M. Kramm, J. Felsberg, C. Hartmann, B. Wiestler, W. Wick, T. Milde, O. Witt, A.M. Lindroth, J. Schwartzentruber, D. Faury, A. Fleming, M. Zakrzewska, P.P. Liberski, K. Zakrzewski, P. Hauser, M. Garami, A. Klekner, L. Bognar, S. Morrissy, F. Cavalli, M.D. Taylor, P. van Sluis, J. Koster, R. Versteeg, R. Volckmann, T. Mikkelsen, K. Aldape, G. Reifenberger, V.P. Collins, J. Majewski, A. Korshunov, P. Lichter, C. Plass, N. Jabado, and S.M. Pfister Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma Cancer Cell 22 2012 425 437
-
(2012)
Cancer Cell
, vol.22
, pp. 425-437
-
-
Sturm, D.1
Witt, H.2
Hovestadt, V.3
Khuong-Quang, D.A.4
Jones, D.T.5
Konermann, C.6
Pfaff, E.7
Tonjes, M.8
Sill, M.9
Bender, S.10
Kool, M.11
Zapatka, M.12
Becker, N.13
Zucknick, M.14
Hielscher, T.15
Liu, X.Y.16
Fontebasso, A.M.17
Ryzhova, M.18
Albrecht, S.19
Jacob, K.20
Wolter, M.21
Ebinger, M.22
Schuhmann, M.U.23
Van Meter, T.24
Fruhwald, M.C.25
Hauch, H.26
Pekrun, A.27
Radlwimmer, B.28
Niehues, T.29
Von Komorowski, G.30
Durken, M.31
Kulozik, A.E.32
Madden, J.33
Donson, A.34
Foreman, N.K.35
Drissi, R.36
Fouladi, M.37
Scheurlen, W.38
Von Deimling, A.39
Monoranu, C.40
Roggendorf, W.41
Herold-Mende, C.42
Unterberg, A.43
Kramm, C.M.44
Felsberg, J.45
Hartmann, C.46
Wiestler, B.47
Wick, W.48
Milde, T.49
Witt, O.50
Lindroth, A.M.51
Schwartzentruber, J.52
Faury, D.53
Fleming, A.54
Zakrzewska, M.55
Liberski, P.P.56
Zakrzewski, K.57
Hauser, P.58
Garami, M.59
Klekner, A.60
Bognar, L.61
Morrissy, S.62
Cavalli, F.63
Taylor, M.D.64
Van Sluis, P.65
Koster, J.66
Versteeg, R.67
Volckmann, R.68
Mikkelsen, T.69
Aldape, K.70
Reifenberger, G.71
Collins, V.P.72
Majewski, J.73
Korshunov, A.74
Lichter, P.75
Plass, C.76
Jabado, N.77
Pfister, S.M.78
more..
-
84
-
-
84877299145
-
The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression
-
K.M. Chan, D. Fang, H. Gan, R. Hashizume, C. Yu, M. Schroeder, N. Gupta, S. Mueller, C.D. James, R. Jenkins, J. Sarkaria, and Z. Zhang The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression Genes Dev. 27 2013 985 990
-
(2013)
Genes Dev.
, vol.27
, pp. 985-990
-
-
Chan, K.M.1
Fang, D.2
Gan, H.3
Hashizume, R.4
Yu, C.5
Schroeder, M.6
Gupta, N.7
Mueller, S.8
James, C.D.9
Jenkins, R.10
Sarkaria, J.11
Zhang, Z.12
-
85
-
-
84865863019
-
K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas
-
D.A. Khuong-Quang, P. Buczkowicz, P. Rakopoulos, X.Y. Liu, A.M. Fontebasso, E. Bouffet, U. Bartels, S. Albrecht, J. Schwartzentruber, L. Letourneau, M. Bourgey, G. Bourque, A. Montpetit, G. Bourret, P. Lepage, A. Fleming, P. Lichter, M. Kool, A. von Deimling, D. Sturm, A. Korshunov, D. Faury, D.T. Jones, J. Majewski, S.M. Pfister, N. Jabado, and C. Hawkins K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas Acta Neuropathol. 124 2012 439 447
-
(2012)
Acta Neuropathol.
, vol.124
, pp. 439-447
-
-
Khuong-Quang, D.A.1
Buczkowicz, P.2
Rakopoulos, P.3
Liu, X.Y.4
Fontebasso, A.M.5
Bouffet, E.6
Bartels, U.7
Albrecht, S.8
Schwartzentruber, J.9
Letourneau, L.10
Bourgey, M.11
Bourque, G.12
Montpetit, A.13
Bourret, G.14
Lepage, P.15
Fleming, A.16
Lichter, P.17
Kool, M.18
Von Deimling, A.19
Sturm, D.20
Korshunov, A.21
Faury, D.22
Jones, D.T.23
Majewski, J.24
Pfister, S.M.25
Jabado, N.26
Hawkins, C.27
more..
-
86
-
-
84877621282
-
Histone H3.3 mutations drive pediatric glioblastoma through upregulation of MYCN
-
L. Bjerke, A. Mackay, M. Nandhabalan, A. Burford, A. Jury, S. Popov, D.A. Bax, D. Carvalho, K.R. Taylor, M. Vinci, I. Bajrami, I.M. McGonnell, C.J. Lord, R.M. Reis, D. Hargrave, A. Ashworth, P. Workman, and C. Jones Histone H3.3 mutations drive pediatric glioblastoma through upregulation of MYCN Cancer Discov. 22 2013
-
(2013)
Cancer Discov.
, vol.22
-
-
Bjerke, L.1
Mackay, A.2
Nandhabalan, M.3
Burford, A.4
Jury, A.5
Popov, S.6
Bax, D.A.7
Carvalho, D.8
Taylor, K.R.9
Vinci, M.10
Bajrami, I.11
McGonnell, I.M.12
Lord, C.J.13
Reis, R.M.14
Hargrave, D.15
Ashworth, A.16
Workman, P.17
Jones, C.18
-
87
-
-
84887617868
-
Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas
-
S. Bender, Y. Tang, A.M. Lindroth, V. Hovestadt, D.T. Jones, M. Kool, M. Zapatka, P.A. Northcott, D. Sturm, W. Wang, B. Radlwimmer, J.W. Hojfeldt, N. Truffaux, D. Castel, S. Schubert, M. Ryzhova, H. Seker-Cin, J. Gronych, P.D. Johann, S. Stark, J. Meyer, T. Milde, M. Schuhmann, M. Ebinger, C.M. Monoranu, A. Ponnuswami, S. Chen, C. Jones, O. Witt, V.P. Collins, A. von Deimling, N. Jabado, S. Puget, J. Grill, K. Helin, A. Korshunov, P. Lichter, M. Monje, C. Plass, Y.J. Cho, and S.M. Pfister Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas Cancer Cell 24 2013 660 672
-
(2013)
Cancer Cell
, vol.24
, pp. 660-672
-
-
Bender, S.1
Tang, Y.2
Lindroth, A.M.3
Hovestadt, V.4
Jones, D.T.5
Kool, M.6
Zapatka, M.7
Northcott, P.A.8
Sturm, D.9
Wang, W.10
Radlwimmer, B.11
Hojfeldt, J.W.12
Truffaux, N.13
Castel, D.14
Schubert, S.15
Ryzhova, M.16
Seker-Cin, H.17
Gronych, J.18
Johann, P.D.19
Stark, S.20
Meyer, J.21
Milde, T.22
Schuhmann, M.23
Ebinger, M.24
Monoranu, C.M.25
Ponnuswami, A.26
Chen, S.27
Jones, C.28
Witt, O.29
Collins, V.P.30
Von Deimling, A.31
Jabado, N.32
Puget, S.33
Grill, J.34
Helin, K.35
Korshunov, A.36
Lichter, P.37
Monje, M.38
Plass, C.39
Cho, Y.J.40
Pfister, S.M.41
more..
-
88
-
-
84877785024
-
Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma
-
P.W. Lewis, M.M. Muller, M.S. Koletsky, F. Cordero, S. Lin, L.A. Banaszynski, B.A. Garcia, T.W. Muir, O.J. Becher, and C.D. Allis Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma Science 340 2013 857 861
-
(2013)
Science
, vol.340
, pp. 857-861
-
-
Lewis, P.W.1
Muller, M.M.2
Koletsky, M.S.3
Cordero, F.4
Lin, S.5
Banaszynski, L.A.6
Garcia, B.A.7
Muir, T.W.8
Becher, O.J.9
Allis, C.D.10
-
89
-
-
84883226328
-
A lesson learned from the H3.3K27M mutation found in pediatric glioma: A new approach to the study of the function of histone modifications in vivo?
-
K.M. Chan, J. Han, D. Fang, H. Gan, and Z. Zhang A lesson learned from the H3.3K27M mutation found in pediatric glioma: a new approach to the study of the function of histone modifications in vivo? Cell Cycle 12 2013 2546 2552
-
(2013)
Cell Cycle
, vol.12
, pp. 2546-2552
-
-
Chan, K.M.1
Han, J.2
Fang, D.3
Gan, H.4
Zhang, Z.5
-
90
-
-
61849102836
-
MLL5 governs hematopoiesis: A step closer
-
H. Liu, T.D. Westergard, and J.J. Hsieh MLL5 governs hematopoiesis: a step closer Blood 113 2009 1395 1396
-
(2009)
Blood
, vol.113
, pp. 1395-1396
-
-
Liu, H.1
Westergard, T.D.2
Hsieh, J.J.3
-
91
-
-
35548934558
-
MLL translocations, histone modifications and leukaemia stem-cell development
-
A.V. Krivtsov, and S.A. Armstrong MLL translocations, histone modifications and leukaemia stem-cell development Nat. Rev. Cancer 7 2007 823 833
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 823-833
-
-
Krivtsov, A.V.1
Armstrong, S.A.2
-
92
-
-
77955660663
-
Diverse somatic mutation patterns and pathway alterations in human cancers
-
Z. Kan, B.S. Jaiswal, J. Stinson, V. Janakiraman, D. Bhatt, H.M. Stern, P. Yue, P.M. Haverty, R. Bourgon, J. Zheng, M. Moorhead, S. Chaudhuri, L.P. Tomsho, B.A. Peters, K. Pujara, S. Cordes, D.P. Davis, V.E. Carlton, W. Yuan, L. Li, W. Wang, C. Eigenbrot, J.S. Kaminker, D.A. Eberhard, P. Waring, S.C. Schuster, Z. Modrusan, Z. Zhang, D. Stokoe, F.J. de Sauvage, M. Faham, and S. Seshagiri Diverse somatic mutation patterns and pathway alterations in human cancers Nature 466 2010 869 873
-
(2010)
Nature
, vol.466
, pp. 869-873
-
-
Kan, Z.1
Jaiswal, B.S.2
Stinson, J.3
Janakiraman, V.4
Bhatt, D.5
Stern, H.M.6
Yue, P.7
Haverty, P.M.8
Bourgon, R.9
Zheng, J.10
Moorhead, M.11
Chaudhuri, S.12
Tomsho, L.P.13
Peters, B.A.14
Pujara, K.15
Cordes, S.16
Davis, D.P.17
Carlton, V.E.18
Yuan, W.19
Li, L.20
Wang, W.21
Eigenbrot, C.22
Kaminker, J.S.23
Eberhard, D.A.24
Waring, P.25
Schuster, S.C.26
Modrusan, Z.27
Zhang, Z.28
Stokoe, D.29
De Sauvage, F.J.30
Faham, M.31
Seshagiri, S.32
more..
-
93
-
-
84898547095
-
Driver mutations of cancer epigenomes
-
D.M. Roy, L.A. Walsh, and T.A. Chan Driver mutations of cancer epigenomes Protein Cell 5 2014 265 296
-
(2014)
Protein Cell
, vol.5
, pp. 265-296
-
-
Roy, D.M.1
Walsh, L.A.2
Chan, T.A.3
-
94
-
-
84868157863
-
Epigenetic alterations in hematopoietic malignancies
-
Y.R. Chung, E. Schatoff, and O. Abdel-Wahab Epigenetic alterations in hematopoietic malignancies Int. J. Hematol. 96 2012 413 427
-
(2012)
Int. J. Hematol.
, vol.96
, pp. 413-427
-
-
Chung, Y.R.1
Schatoff, E.2
Abdel-Wahab, O.3
-
95
-
-
79960058024
-
Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor
-
S.R. Daigle, E.J. Olhava, C.A. Therkelsen, C.R. Majer, C.J. Sneeringer, J. Song, L.D. Johnston, M.P. Scott, J.J. Smith, Y. Xiao, L. Jin, K.W. Kuntz, R. Chesworth, M.P. Moyer, K.M. Bernt, J.C. Tseng, A.L. Kung, S.A. Armstrong, R.A. Copeland, V.M. Richon, and R.M. Pollock Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor Cancer Cell 20 2012 53 65
-
(2012)
Cancer Cell
, vol.20
, pp. 53-65
-
-
Daigle, S.R.1
Olhava, E.J.2
Therkelsen, C.A.3
Majer, C.R.4
Sneeringer, C.J.5
Song, J.6
Johnston, L.D.7
Scott, M.P.8
Smith, J.J.9
Xiao, Y.10
Jin, L.11
Kuntz, K.W.12
Chesworth, R.13
Moyer, M.P.14
Bernt, K.M.15
Tseng, J.C.16
Kung, A.L.17
Armstrong, S.A.18
Copeland, R.A.19
Richon, V.M.20
Pollock, R.M.21
more..
-
96
-
-
79954552505
-
The super elongation complex (SEC) and MLL in development and disease
-
E. Smith, C. Lin, and A. Shilatifard The super elongation complex (SEC) and MLL in development and disease Genes Dev. 25 2011 661 672
-
(2011)
Genes Dev.
, vol.25
, pp. 661-672
-
-
Smith, E.1
Lin, C.2
Shilatifard, A.3
-
97
-
-
80052955256
-
BET bromodomain inhibition as a therapeutic strategy to target c-Myc
-
J.E. Delmore, G.C. Issa, M.E. Lemieux, P.B. Rahl, J. Shi, H.M. Jacobs, E. Kastritis, T. Gilpatrick, R.M. Paranal, J. Qi, M. Chesi, A.C. Schinzel, M.R. McKeown, T.P. Heffernan, C.R. Vakoc, P.L. Bergsagel, I.M. Ghobrial, P.G. Richardson, R.A. Young, W.C. Hahn, K.C. Anderson, A.L. Kung, J.E. Bradner, and C.S. Mitsiades BET bromodomain inhibition as a therapeutic strategy to target c-Myc Cell 146 2011 904 917
-
(2011)
Cell
, vol.146
, pp. 904-917
-
-
Delmore, J.E.1
Issa, G.C.2
Lemieux, M.E.3
Rahl, P.B.4
Shi, J.5
Jacobs, H.M.6
Kastritis, E.7
Gilpatrick, T.8
Paranal, R.M.9
Qi, J.10
Chesi, M.11
Schinzel, A.C.12
McKeown, M.R.13
Heffernan, T.P.14
Vakoc, C.R.15
Bergsagel, P.L.16
Ghobrial, I.M.17
Richardson, P.G.18
Young, R.A.19
Hahn, W.C.20
Anderson, K.C.21
Kung, A.L.22
Bradner, J.E.23
Mitsiades, C.S.24
more..
-
98
-
-
78650806593
-
Suppression of inflammation by a synthetic histone mimic
-
E. Nicodeme, K.L. Jeffrey, U. Schaefer, S. Beinke, S. Dewell, C.W. Chung, R. Chandwani, I. Marazzi, P. Wilson, H. Coste, J. White, J. Kirilovsky, C.M. Rice, J.M. Lora, R.K. Prinjha, K. Lee, and A. Tarakhovsky Suppression of inflammation by a synthetic histone mimic Nature 468 2010 1119 1123
-
(2010)
Nature
, vol.468
, pp. 1119-1123
-
-
Nicodeme, E.1
Jeffrey, K.L.2
Schaefer, U.3
Beinke, S.4
Dewell, S.5
Chung, C.W.6
Chandwani, R.7
Marazzi, I.8
Wilson, P.9
Coste, H.10
White, J.11
Kirilovsky, J.12
Rice, C.M.13
Lora, J.M.14
Prinjha, R.K.15
Lee, K.16
Tarakhovsky, A.17
-
99
-
-
80054984945
-
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
-
M.A. Dawson, R.K. Prinjha, A. Dittmann, G. Giotopoulos, M. Bantscheff, W.I. Chan, S.C. Robson, C.W. Chung, C. Hopf, M.M. Savitski, C. Huthmacher, E. Gudgin, D. Lugo, S. Beinke, T.D. Chapman, E.J. Roberts, P.E. Soden, K.R. Auger, O. Mirguet, K. Doehner, R. Delwel, A.K. Burnett, P. Jeffrey, G. Drewes, K. Lee, B.J. Huntly, and T. Kouzarides Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia Nature 478 2011 529 533
-
(2011)
Nature
, vol.478
, pp. 529-533
-
-
Dawson, M.A.1
Prinjha, R.K.2
Dittmann, A.3
Giotopoulos, G.4
Bantscheff, M.5
Chan, W.I.6
Robson, S.C.7
Chung, C.W.8
Hopf, C.9
Savitski, M.M.10
Huthmacher, C.11
Gudgin, E.12
Lugo, D.13
Beinke, S.14
Chapman, T.D.15
Roberts, E.J.16
Soden, P.E.17
Auger, K.R.18
Mirguet, O.19
Doehner, K.20
Delwel, R.21
Burnett, A.K.22
Jeffrey, P.23
Drewes, G.24
Lee, K.25
Huntly, B.J.26
Kouzarides, T.27
more..
-
100
-
-
78650847770
-
Selective inhibition of BET bromodomains
-
P. Filippakopoulos, J. Qi, S. Picaud, Y. Shen, W.B. Smith, O. Fedorov, E.M. Morse, T. Keates, T.T. Hickman, I. Felletar, M. Philpott, S. Munro, M.R. McKeown, Y. Wang, A.L. Christie, N. West, M.J. Cameron, B. Schwartz, T.D. Heightman, N. La Thangue, C.A. French, O. Wiest, A.L. Kung, S. Knapp, and J.E. Bradner Selective inhibition of BET bromodomains Nature 468 2010 1067 1073
-
(2010)
Nature
, vol.468
, pp. 1067-1073
-
-
Filippakopoulos, P.1
Qi, J.2
Picaud, S.3
Shen, Y.4
Smith, W.B.5
Fedorov, O.6
Morse, E.M.7
Keates, T.8
Hickman, T.T.9
Felletar, I.10
Philpott, M.11
Munro, S.12
McKeown, M.R.13
Wang, Y.14
Christie, A.L.15
West, N.16
Cameron, M.J.17
Schwartz, B.18
Heightman, T.D.19
La Thangue, N.20
French, C.A.21
Wiest, O.22
Kung, A.L.23
Knapp, S.24
Bradner, J.E.25
more..
-
101
-
-
80055000824
-
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
-
J. Zuber, J. Shi, E. Wang, A.R. Rappaport, H. Herrmann, E.A. Sison, D. Magoon, J. Qi, K. Blatt, M. Wunderlich, M.J. Taylor, C. Johns, A. Chicas, J.C. Mulloy, S.C. Kogan, P. Brown, P. Valent, J.E. Bradner, S.W. Lowe, and C.R. Vakoc RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia Nature 478 2011 524 528
-
(2011)
Nature
, vol.478
, pp. 524-528
-
-
Zuber, J.1
Shi, J.2
Wang, E.3
Rappaport, A.R.4
Herrmann, H.5
Sison, E.A.6
Magoon, D.7
Qi, J.8
Blatt, K.9
Wunderlich, M.10
Taylor, M.J.11
Johns, C.12
Chicas, A.13
Mulloy, J.C.14
Kogan, S.C.15
Brown, P.16
Valent, P.17
Bradner, J.E.18
Lowe, S.W.19
Vakoc, C.R.20
more..
-
102
-
-
84895815322
-
Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma
-
J. Okosun, C. Bodor, J. Wang, S. Araf, C.Y. Yang, C. Pan, S. Boller, D. Cittaro, M. Bozek, S. Iqbal, J. Matthews, D. Wrench, J. Marzec, K. Tawana, N. Popov, C. O'Riain, D. O'Shea, E. Carlotti, A. Davies, C.H. Lawrie, A. Matolcsy, M. Calaminici, A. Norton, R.J. Byers, C. Mein, E. Stupka, T.A. Lister, G. Lenz, S. Montoto, J.G. Gribben, Y. Fan, R. Grosschedl, C. Chelala, and J. Fitzgibbon Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma Nat. Genet. 46 2014 176 181
-
(2014)
Nat. Genet.
, vol.46
, pp. 176-181
-
-
Okosun, J.1
Bodor, C.2
Wang, J.3
Araf, S.4
Yang, C.Y.5
Pan, C.6
Boller, S.7
Cittaro, D.8
Bozek, M.9
Iqbal, S.10
Matthews, J.11
Wrench, D.12
Marzec, J.13
Tawana, K.14
Popov, N.15
O'Riain, C.16
O'Shea, D.17
Carlotti, E.18
Davies, A.19
Lawrie, C.H.20
Matolcsy, A.21
Calaminici, M.22
Norton, A.23
Byers, R.J.24
Mein, C.25
Stupka, E.26
Lister, T.A.27
Lenz, G.28
Montoto, S.29
Gribben, J.G.30
Fan, Y.31
Grosschedl, R.32
Chelala, C.33
Fitzgibbon, J.34
more..
-
103
-
-
80052269038
-
Analysis of the coding genome of diffuse large B-cell lymphoma
-
L. Pasqualucci, V. Trifonov, G. Fabbri, J. Ma, D. Rossi, A. Chiarenza, V.A. Wells, A. Grunn, M. Messina, O. Elliot, J. Chan, G. Bhagat, A. Chadburn, G. Gaidano, C.G. Mullighan, R. Rabadan, and R. Dalla-Favera Analysis of the coding genome of diffuse large B-cell lymphoma Nat. Genet. 43 2011 830 837
-
(2011)
Nat. Genet.
, vol.43
, pp. 830-837
-
-
Pasqualucci, L.1
Trifonov, V.2
Fabbri, G.3
Ma, J.4
Rossi, D.5
Chiarenza, A.6
Wells, V.A.7
Grunn, A.8
Messina, M.9
Elliot, O.10
Chan, J.11
Bhagat, G.12
Chadburn, A.13
Gaidano, G.14
Mullighan, C.G.15
Rabadan, R.16
Dalla-Favera, R.17
-
105
-
-
84862976633
-
Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators
-
A. Fujimoto, Y. Totoki, T. Abe, K.A. Boroevich, F. Hosoda, H.H. Nguyen, M. Aoki, N. Hosono, M. Kubo, F. Miya, Y. Arai, H. Takahashi, T. Shirakihara, M. Nagasaki, T. Shibuya, K. Nakano, K. Watanabe-Makino, H. Tanaka, H. Nakamura, J. Kusuda, H. Ojima, K. Shimada, T. Okusaka, M. Ueno, Y. Shigekawa, Y. Kawakami, K. Arihiro, H. Ohdan, K. Gotoh, O. Ishikawa, S. Ariizumi, M. Yamamoto, T. Yamada, K. Chayama, T. Kosuge, H. Yamaue, N. Kamatani, S. Miyano, H. Nakagama, Y. Nakamura, T. Tsunoda, T. Shibata, and H. Nakagawa Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators Nat. Genet. 44 2012 760 764
-
(2012)
Nat. Genet.
, vol.44
, pp. 760-764
-
-
Fujimoto, A.1
Totoki, Y.2
Abe, T.3
Boroevich, K.A.4
Hosoda, F.5
Nguyen, H.H.6
Aoki, M.7
Hosono, N.8
Kubo, M.9
Miya, F.10
Arai, Y.11
Takahashi, H.12
Shirakihara, T.13
Nagasaki, M.14
Shibuya, T.15
Nakano, K.16
Watanabe-Makino, K.17
Tanaka, H.18
Nakamura, H.19
Kusuda, J.20
Ojima, H.21
Shimada, K.22
Okusaka, T.23
Ueno, M.24
Shigekawa, Y.25
Kawakami, Y.26
Arihiro, K.27
Ohdan, H.28
Gotoh, K.29
Ishikawa, O.30
Ariizumi, S.31
Yamamoto, M.32
Yamada, T.33
Chayama, K.34
Kosuge, T.35
Yamaue, H.36
Kamatani, N.37
Miyano, S.38
Nakagama, H.39
Nakamura, Y.40
Tsunoda, T.41
Shibata, T.42
Nakagawa, H.43
more..
-
106
-
-
84861581233
-
Exome sequencing of liver fluke-associated cholangiocarcinoma
-
C.K. Ong, C. Subimerb, C. Pairojkul, S. Wongkham, I. Cutcutache, W. Yu, J.R. McPherson, G.E. Allen, C.C. Ng, B.H. Wong, S.S. Myint, V. Rajasegaran, H.L. Heng, A. Gan, Z.J. Zang, Y. Wu, J. Wu, M.H. Lee, D. Huang, P. Ong, W. Chan-on, Y. Cao, C.N. Qian, K.H. Lim, A. Ooi, K. Dykema, K. Furge, V. Kukongviriyapan, B. Sripa, C. Wongkham, P. Yongvanit, P.A. Futreal, V. Bhudhisawasdi, S. Rozen, P. Tan, and B.T. Teh Exome sequencing of liver fluke-associated cholangiocarcinoma Nat. Genet. 44 2012 690 693
-
(2012)
Nat. Genet.
, vol.44
, pp. 690-693
-
-
Ong, C.K.1
Subimerb, C.2
Pairojkul, C.3
Wongkham, S.4
Cutcutache, I.5
Yu, W.6
McPherson, J.R.7
Allen, G.E.8
Ng, C.C.9
Wong, B.H.10
Myint, S.S.11
Rajasegaran, V.12
Heng, H.L.13
Gan, A.14
Zang, Z.J.15
Wu, Y.16
Wu, J.17
Lee, M.H.18
Huang, D.19
Ong, P.20
Chan-On, W.21
Cao, Y.22
Qian, C.N.23
Lim, K.H.24
Ooi, A.25
Dykema, K.26
Furge, K.27
Kukongviriyapan, V.28
Sripa, B.29
Wongkham, C.30
Yongvanit, P.31
Futreal, P.A.32
Bhudhisawasdi, V.33
Rozen, S.34
Tan, P.35
Teh, B.T.36
more..
-
107
-
-
84860327480
-
Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes
-
Z.J. Zang, I. Cutcutache, S.L. Poon, S.L. Zhang, J.R. McPherson, J. Tao, V. Rajasegaran, H.L. Heng, N. Deng, A. Gan, K.H. Lim, C.K. Ong, D. Huang, S.Y. Chin, I.B. Tan, C.C. Ng, W. Yu, Y. Wu, M. Lee, J. Wu, D. Poh, W.K. Wan, S.Y. Rha, J. So, M. Salto-Tellez, K.G. Yeoh, W.K. Wong, Y.J. Zhu, P.A. Futreal, B. Pang, Y. Ruan, A.M. Hillmer, D. Bertrand, N. Nagarajan, S. Rozen, B.T. Teh, and P. Tan Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes Nat. Genet. 44 2012 570 574
-
(2012)
Nat. Genet.
, vol.44
, pp. 570-574
-
-
Zang, Z.J.1
Cutcutache, I.2
Poon, S.L.3
Zhang, S.L.4
McPherson, J.R.5
Tao, J.6
Rajasegaran, V.7
Heng, H.L.8
Deng, N.9
Gan, A.10
Lim, K.H.11
Ong, C.K.12
Huang, D.13
Chin, S.Y.14
Tan, I.B.15
Ng, C.C.16
Yu, W.17
Wu, Y.18
Lee, M.19
Wu, J.20
Poh, D.21
Wan, W.K.22
Rha, S.Y.23
So, J.24
Salto-Tellez, M.25
Yeoh, K.G.26
Wong, W.K.27
Zhu, Y.J.28
Futreal, P.A.29
Pang, B.30
Ruan, Y.31
Hillmer, A.M.32
Bertrand, D.33
Nagarajan, N.34
Rozen, S.35
Teh, B.T.36
Tan, P.37
more..
-
108
-
-
0037028488
-
MLL3, a new human member of the TRX/MLL gene family, maps to 7q36, a chromosome region frequently deleted in myeloid leukaemia
-
M. Ruault, M.E. Brun, M. Ventura, G. Roizes, and A. De Sario MLL3, a new human member of the TRX/MLL gene family, maps to 7q36, a chromosome region frequently deleted in myeloid leukaemia Gene 284 2002 73 81
-
(2002)
Gene
, vol.284
, pp. 73-81
-
-
Ruault, M.1
Brun, M.E.2
Ventura, M.3
Roizes, G.4
De Sario, A.5
-
109
-
-
84874426603
-
Exome sequencing identifies an MLL3 gene germ line mutation in a pedigree of colorectal cancer and acute myeloid leukemia
-
W.D. Li, Q.R. Li, S.N. Xu, F.J. Wei, Z.J. Ye, J.K. Cheng, and J.P. Chen Exome sequencing identifies an MLL3 gene germ line mutation in a pedigree of colorectal cancer and acute myeloid leukemia Blood 121 2013 1478 1479
-
(2013)
Blood
, vol.121
, pp. 1478-1479
-
-
Li, W.D.1
Li, Q.R.2
Xu, S.N.3
Wei, F.J.4
Ye, Z.J.5
Cheng, J.K.6
Chen, J.P.7
-
110
-
-
80051618706
-
Frequent alteration of MLL3 frameshift mutations in microsatellite deficient colorectal cancer
-
Y. Watanabe, R.J. Castoro, H.S. Kim, B. North, R. Oikawa, T. Hiraishi, S.S. Ahmed, W. Chung, M.Y. Cho, M. Toyota, F. Itoh, M.R. Estecio, L. Shen, J. Jelinek, and J.P. Issa Frequent alteration of MLL3 frameshift mutations in microsatellite deficient colorectal cancer PLoS One 6 2011 e23320
-
(2011)
PLoS One
, vol.6
, pp. 23320
-
-
Watanabe, Y.1
Castoro, R.J.2
Kim, H.S.3
North, B.4
Oikawa, R.5
Hiraishi, T.6
Ahmed, S.S.7
Chung, W.8
Cho, M.Y.9
Toyota, M.10
Itoh, F.11
Estecio, M.R.12
Shen, L.13
Jelinek, J.14
Issa, J.P.15
-
111
-
-
80051665475
-
Somatic mutations of the mixed-lineage leukemia 3 (MLL3) gene in primary breast cancers
-
X.X. Wang, L. Fu, X. Li, X. Wu, Z. Zhu, L. Fu, and J.T. Dong Somatic mutations of the mixed-lineage leukemia 3 (MLL3) gene in primary breast cancers Pathol. Oncol. Res. 17 2011 429 433
-
(2011)
Pathol. Oncol. Res.
, vol.17
, pp. 429-433
-
-
Wang, X.X.1
Fu, L.2
Li, X.3
Wu, X.4
Zhu, Z.5
Fu, L.6
Dong, J.T.7
-
112
-
-
84900420439
-
MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia
-
Y.L. Chong Chen, Amy R. Rappaport, Thomas Kitzing, Nikolaus Schultz, Zhen Zhao, Aditya S. Shroff, Ross A. Dickins, Christopher R. Vakoc, James E. Bradner, Wendy Stock, Michelle M. LeBeau, Kevin M. Shannon, Scott Kogan, Johannes Zuber, and Scott W. Lowe MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia Cancer Cell 25 2014 1 14
-
(2014)
Cancer Cell
, vol.25
, pp. 1-14
-
-
Chong Chen, Y.L.1
Rappaport, A.R.2
Kitzing, T.3
Schultz, N.4
Zhao, Z.5
Shroff, A.S.6
Dickins, R.A.7
Vakoc, C.R.8
Bradner, J.E.9
Stock, W.10
Lebeau, M.M.11
Shannon, K.M.12
Kogan, S.13
Zuber, J.14
Lowe, S.W.15
-
113
-
-
0032212243
-
The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts
-
M. Chesi, E. Nardini, R.S. Lim, K.D. Smith, W.M. Kuehl, and P.L. Bergsagel The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts Blood 92 1998 3025 3034
-
(1998)
Blood
, vol.92
, pp. 3025-3034
-
-
Chesi, M.1
Nardini, E.2
Lim, R.S.3
Smith, K.D.4
Kuehl, W.M.5
Bergsagel, P.L.6
-
114
-
-
81355133161
-
NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming
-
A.J. Kuo, P. Cheung, K. Chen, B.M. Zee, M. Kioi, J. Lauring, Y. Xi, B.H. Park, X. Shi, B.A. Garcia, W. Li, and O. Gozani NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming Mol. Cell 44 2011 609 620
-
(2011)
Mol. Cell
, vol.44
, pp. 609-620
-
-
Kuo, A.J.1
Cheung, P.2
Chen, K.3
Zee, B.M.4
Kioi, M.5
Lauring, J.6
Xi, Y.7
Park, B.H.8
Shi, X.9
Garcia, B.A.10
Li, W.11
Gozani, O.12
-
115
-
-
84887108791
-
Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia
-
J.D. Jaffe, Y. Wang, H.M. Chan, J. Zhang, R. Huether, G.V. Kryukov, H.E. Bhang, J.E. Taylor, M. Hu, N.P. Englund, F. Yan, Z. Wang, E. Robert McDonald 3rd, L. Wei, J. Ma, J. Easton, Z. Yu, R. deBeaumount, V. Gibaja, K. Venkatesan, R. Schlegel, W.R. Sellers, N. Keen, J. Liu, G. Caponigro, J. Barretina, V.G. Cooke, C. Mullighan, S.A. Carr, J.R. Downing, L.A. Garraway, and F. Stegmeier Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia Nat. Genet. 45 2013 1386 1391
-
(2013)
Nat. Genet.
, vol.45
, pp. 1386-1391
-
-
Jaffe, J.D.1
Wang, Y.2
Chan, H.M.3
Zhang, J.4
Huether, R.5
Kryukov, G.V.6
Bhang, H.E.7
Taylor, J.E.8
Hu, M.9
Englund, N.P.10
Yan, F.11
Wang, Z.12
-
116
-
-
84891861309
-
Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies
-
J.A. Oyer, X. Huang, Y. Zheng, J. Shim, T. Ezponda, Z. Carpenter, M. Allegretta, C.I. Okot-Kotber, J.P. Patel, A. Melnick, R.L. Levine, A. Ferrando, A.D. Mackerell Jr., N.L. Kelleher, J.D. Licht, and R. Popovic Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies Leukemia 28 2014 198 201
-
(2014)
Leukemia
, vol.28
, pp. 198-201
-
-
Oyer, J.A.1
Huang, X.2
Zheng, Y.3
Shim, J.4
Ezponda, T.5
Carpenter, Z.6
Allegretta, M.7
Okot-Kotber, C.I.8
Patel, J.P.9
Melnick, A.10
Levine, R.L.11
Ferrando, A.12
Mackerell, A.D.13
Kelleher, N.L.14
Licht, J.D.15
Popovic, R.16
-
117
-
-
84907418637
-
Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia
-
B.G. Mar, L.B. Bullinger, K.M. McLean, P.V. Grauman, M.H. Harris, K. Stevenson, D.S. Neuberg, A.U. Sinha, S.E. Sallan, L.B. Silverman, A.L. Kung, L. Lo Nigro, B.L. Ebert, and S.A. Armstrong Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia Nat. Commun. 5 2014 3469
-
(2014)
Nat. Commun.
, vol.5
, pp. 3469
-
-
Mar, B.G.1
Bullinger, L.B.2
McLean, K.M.3
Grauman, P.V.4
Harris, M.H.5
Stevenson, K.6
Neuberg, D.S.7
Sinha, A.U.8
Sallan, S.E.9
Silverman, L.B.10
Kung, A.L.11
Lo Nigro, L.12
Ebert, B.L.13
Armstrong, S.A.14
-
118
-
-
0035957953
-
CREB-binding protein and p300 in transcriptional regulation
-
N. Vo, and R.H. Goodman CREB-binding protein and p300 in transcriptional regulation J. Biol. Chem. 276 2001 13505 13508
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 13505-13508
-
-
Vo, N.1
Goodman, R.H.2
-
119
-
-
0034141972
-
CREB-binding protein and p300: Molecular integrators of hematopoietic transcription
-
G.A. Blobel CREB-binding protein and p300: molecular integrators of hematopoietic transcription Blood 95 2000 745 755
-
(2000)
Blood
, vol.95
, pp. 745-755
-
-
Blobel, G.A.1
-
120
-
-
84866851740
-
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
-
M. Peifer, L. Fernandez-Cuesta, M.L. Sos, J. George, D. Seidel, L.H. Kasper, D. Plenker, F. Leenders, R. Sun, T. Zander, R. Menon, M. Koker, I. Dahmen, C. Muller, V. Di Cerbo, H.U. Schildhaus, J. Altmuller, I. Baessmann, C. Becker, B. de Wilde, J. Vandesompele, D. Bohm, S. Ansen, F. Gabler, I. Wilkening, S. Heynck, J.M. Heuckmann, X. Lu, S.L. Carter, K. Cibulskis, S. Banerji, G. Getz, K.S. Park, D. Rauh, C. Grutter, M. Fischer, L. Pasqualucci, G. Wright, Z. Wainer, P. Russell, I. Petersen, Y. Chen, E. Stoelben, C. Ludwig, P. Schnabel, H. Hoffmann, T. Muley, M. Brockmann, W. Engel-Riedel, L.A. Muscarella, V.M. Fazio, H. Groen, W. Timens, H. Sietsma, E. Thunnissen, E. Smit, D.A. Heideman, P.J. Snijders, F. Cappuzzo, C. Ligorio, S. Damiani, J. Field, S. Solberg, O.T. Brustugun, M. Lund-Iversen, J. Sanger, J.H. Clement, A. Soltermann, H. Moch, W. Weder, B. Solomon, J.C. Soria, P. Validire, B. Besse, E. Brambilla, C. Brambilla, S. Lantuejoul, P. Lorimier, P.M. Schneider, M. Hallek, W. Pao, M. Meyerson, J. Sage, J. Shendure, R. Schneider, R. Buttner, J. Wolf, P. Nurnberg, S. Perner, L.C. Heukamp, P.K. Brindle, S. Haas, and R.K. Thomas Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer Nat. Genet. 44 2012 1104 1110
-
(2012)
Nat. Genet.
, vol.44
, pp. 1104-1110
-
-
Peifer, M.1
Fernandez-Cuesta, L.2
Sos, M.L.3
George, J.4
Seidel, D.5
Kasper, L.H.6
Plenker, D.7
Leenders, F.8
Sun, R.9
Zander, T.10
Menon, R.11
Koker, M.12
Dahmen, I.13
Muller, C.14
Di Cerbo, V.15
Schildhaus, H.U.16
Altmuller, J.17
Baessmann, I.18
Becker, C.19
De Wilde, B.20
Vandesompele, J.21
Bohm, D.22
Ansen, S.23
Gabler, F.24
Wilkening, I.25
Heynck, S.26
Heuckmann, J.M.27
Lu, X.28
Carter, S.L.29
Cibulskis, K.30
Banerji, S.31
Getz, G.32
Park, K.S.33
Rauh, D.34
Grutter, C.35
Fischer, M.36
Pasqualucci, L.37
Wright, G.38
Wainer, Z.39
Russell, P.40
Petersen, I.41
Chen, Y.42
Stoelben, E.43
Ludwig, C.44
Schnabel, P.45
Hoffmann, H.46
Muley, T.47
Brockmann, M.48
Engel-Riedel, W.49
Muscarella, L.A.50
Fazio, V.M.51
Groen, H.52
Timens, W.53
Sietsma, H.54
Thunnissen, E.55
Smit, E.56
Heideman, D.A.57
Snijders, P.J.58
Cappuzzo, F.59
Ligorio, C.60
Damiani, S.61
Field, J.62
Solberg, S.63
Brustugun, O.T.64
Lund-Iversen, M.65
Sanger, J.66
Clement, J.H.67
Soltermann, A.68
Moch, H.69
Weder, W.70
Solomon, B.71
Soria, J.C.72
Validire, P.73
Besse, B.74
Brambilla, E.75
Brambilla, C.76
Lantuejoul, S.77
Lorimier, P.78
Schneider, P.M.79
Hallek, M.80
Pao, W.81
Meyerson, M.82
Sage, J.83
Shendure, J.84
Schneider, R.85
Buttner, R.86
Wolf, J.87
Nurnberg, P.88
Perner, S.89
Heukamp, L.C.90
Brindle, P.K.91
Haas, S.92
Thomas, R.K.93
more..
-
121
-
-
79952381408
-
CREBBP mutations in relapsed acute lymphoblastic leukaemia
-
C.G. Mullighan, J. Zhang, L.H. Kasper, S. Lerach, D. Payne-Turner, L.A. Phillips, S.L. Heatley, L. Holmfeldt, J.R. Collins-Underwood, J. Ma, K.H. Buetow, C.H. Pui, S.D. Baker, P.K. Brindle, and J.R. Downing CREBBP mutations in relapsed acute lymphoblastic leukaemia Nature 471 2011 235 239
-
(2011)
Nature
, vol.471
, pp. 235-239
-
-
Mullighan, C.G.1
Zhang, J.2
Kasper, L.H.3
Lerach, S.4
Payne-Turner, D.5
Phillips, L.A.6
Heatley, S.L.7
Holmfeldt, L.8
Collins-Underwood, J.R.9
Ma, J.10
Buetow, K.H.11
Pui, C.H.12
Baker, S.D.13
Brindle, P.K.14
Downing, J.R.15
-
122
-
-
79952430906
-
Inactivating mutations of acetyltransferase genes in B-cell lymphoma
-
L. Pasqualucci, D. Dominguez-Sola, A. Chiarenza, G. Fabbri, A. Grunn, V. Trifonov, L.H. Kasper, S. Lerach, H. Tang, J. Ma, D. Rossi, A. Chadburn, V.V. Murty, C.G. Mullighan, G. Gaidano, R. Rabadan, P.K. Brindle, and R. Dalla-Favera Inactivating mutations of acetyltransferase genes in B-cell lymphoma Nature 471 2011 189 195
-
(2011)
Nature
, vol.471
, pp. 189-195
-
-
Pasqualucci, L.1
Dominguez-Sola, D.2
Chiarenza, A.3
Fabbri, G.4
Grunn, A.5
Trifonov, V.6
Kasper, L.H.7
Lerach, S.8
Tang, H.9
Ma, J.10
Rossi, D.11
Chadburn, A.12
Murty, V.V.13
Mullighan, C.G.14
Gaidano, G.15
Rabadan, R.16
Brindle, P.K.17
Dalla-Favera, R.18
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