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Volumn 9, Issue 5, 2014, Pages 658-668

The H3K27me3 demethylase UTX in normal development and disease

Author keywords

Cancer; Embryogenesis; H3K27; HOX; Kabuki; MLL2; RB; Reprogramming; SWI SNF; UTX

Indexed keywords

BRG1 PROTEIN; HISTONE; HISTONE DEMETHYLASE; HISTONE H3 LYSINE 27 TRIMETHYL; HISTONE LYSINE METHYLTRANSFERASE; HOX PROTEIN; METHYLTRANSFERASE; POLYCOMB GROUP PROTEIN; PROTEIN SWI; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR SNF; UBIQUITOUSLY TRANSCRIBED TETRATRICOPEPTIDE REPEAT X CHROMOSOME; UNCLASSIFIED DRUG; NUCLEAR PROTEIN; UTX PROTEIN, HUMAN;

EID: 84899801975     PISSN: 15592294     EISSN: 15592308     Source Type: Journal    
DOI: 10.4161/epi.28298     Document Type: Review
Times cited : (113)

References (97)
  • 1
    • 11144332565 scopus 로고    scopus 로고
    • Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
    • PMID:15620353
    • Shi Y, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA, Casero RA, Shi Y.Histone demethylation mediated by the nuclear amine oxidase homolog LSD1.Cell 2004; 119:941-53.PMID:15620353; http://dx.doi.org/10.1016/j.cell.2004.12.012.
    • (2004) Cell , vol.119 , pp. 941-953
    • Shi, Y.1    Lan, F.2    Matson, C.3    Mulligan, P.4    Whetstine, J.R.5    Cole, P.A.6    Casero, R.A.7    Shi, Y.8
  • 2
    • 84860215207 scopus 로고    scopus 로고
    • Molecular mechanisms and potential functions of histone demethylases
    • PMID:22473470
    • Kooistra SM, Helin K.Molecular mechanisms and potential functions of histone demethylases.Nat Rev Mol Cell Biol 2012; 13:297-311.PMID:22473470.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 297-311
    • Kooistra, S.M.1    Helin, K.2
  • 5
    • 35348993743 scopus 로고    scopus 로고
    • Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination
    • PMID:17761849
    • Lee MG, Villa R, Trojer P, Norman J, Yan KP, Reinberg D, Di Croce L, Shiekhattar R.Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.Science 2007; 318:447-50.PMID:17761849; http://dx.doi.org/10.1126/science.1149042.
    • (2007) Science , vol.318 , pp. 447-450
    • Lee, M.G.1    Villa, R.2    Trojer, P.3    Norman, J.4    Yan, K.P.5    Reinberg, D.6    Di Croce, L.7    Shiekhattar, R.8
  • 6
    • 34548644772 scopus 로고    scopus 로고
    • The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing
    • PMID:17825402
    • De Santa F, Totaro MG, Prosperini E, Notarbartolo S, Testa G, Natoli G.The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing.Cell 2007; 130:1083-94.PMID:17825402; http://dx.doi.org/10.1016/j.cell.2007.08.019.
    • (2007) Cell , vol.130 , pp. 1083-1094
    • de Santa, F.1    Totaro, M.G.2    Prosperini, E.3    Notarbartolo, S.4    Testa, G.5    Natoli, G.6
  • 7
    • 36749082438 scopus 로고    scopus 로고
    • Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases
    • PMID:18003914
    • Hong S, Cho YW, Yu LR, Yu H, Veenstra TD, Ge K.Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases.Proc Natl Acad Sci U S A 2007; 104:18439-44.PMID:18003914; http://dx.doi.org/10.1073/pnas.0707292104.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 18439-18444
    • Hong, S.1    Cho, Y.W.2    Yu, L.R.3    Yu, H.4    Veenstra, T.D.5    Ge, K.6
  • 8
    • 33847219608 scopus 로고    scopus 로고
    • Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth
    • PMID:17178841
    • Issaeva I, Zonis Y, Rozovskaia T, Orlovsky K, Croce CM, Nakamura T, Mazo A, Eisenbach L, Canaani E.Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth.Mol Cell Biol 2007; 27:1889-903.PMID:17178841; http://dx.doi.org/10.1128/MCB.01506-06.
    • (2007) Mol Cell Biol , vol.27 , pp. 1889-1903
    • Issaeva, I.1    Zonis, Y.2    Rozovskaia, T.3    Orlovsky, K.4    Croce, C.M.5    Nakamura, T.6    Mazo, A.7    Eisenbach, L.8    Canaani, E.9
  • 9
    • 34547122520 scopus 로고    scopus 로고
    • PTIP associates with MLL3- and MLL4- containing histone H3 lysine 4 methyltransferase complex
    • PMID:17500065
    • Cho YW, Hong T, Hong S, Guo H, Yu H, Kim D, Guszczynski T, Dressler GR, Copeland TD, Kalkum M, et al.PTIP associates with MLL3- and MLL4- containing histone H3 lysine 4 methyltransferase complex.J Biol Chem 2007; 282:20395-406.PMID:17500065; http://dx.doi.org/10.1074/jbc.M701574200.
    • (2007) J Biol Chem , vol.282 , pp. 20395-20406
    • Cho, Y.W.1    Hong, T.2    Hong, S.3    Guo, H.4    Yu, H.5    Kim, D.6    Guszczynski, T.7    Dressler, G.R.8    Copeland, T.D.9    Kalkum, M.10
  • 10
    • 78649263390 scopus 로고    scopus 로고
    • Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family memberdependent gene expression
    • PMID:21095589
    • Miller SA, Mohn SE, Weinmann AS.Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family memberdependent gene expression.Mol Cell 2010; 40:594-605.PMID:21095589; http://dx.doi.org/10.1016/j.molcel.2010.10.028.
    • (2010) Mol Cell , vol.40 , pp. 594-605
    • Miller, S.A.1    Mohn, S.E.2    Weinmann, A.S.3
  • 11
    • 84855957128 scopus 로고    scopus 로고
    • UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program
    • PMID:22192413
    • Lee S, Lee JW, Lee SK.UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program.Dev Cell 2012; 22:25-37.PMID:22192413; http://dx.doi.org/10.1016/j.devcel.2011.11.009.
    • (2012) Dev Cell , vol.22 , pp. 25-37
    • Lee, S.1    Lee, J.W.2    Lee, S.K.3
  • 13
    • 84866530722 scopus 로고    scopus 로고
    • UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity
    • PMID:22949634
    • Wang C, Lee JE, Cho YW, Xiao Y, Jin Q, Liu C, Ge K.UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity.Proc Natl Acad Sci U S A 2012; 109:15324-9.PMID:22949634; http://dx.doi.org/10.1073/pnas.1204166109.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 15324-15329
    • Wang, C.1    Lee, J.E.2    Cho, Y.W.3    Xiao, Y.4    Jin, Q.5    Liu, C.6    Ge, K.7
  • 14
    • 84866912634 scopus 로고    scopus 로고
    • UTX and UTY demonstrate histone demethylaseindependent function in mouse embryonic development
    • PMID:23028370
    • Shpargel KB, Sengoku T, Yokoyama S, Magnuson T.UTX and UTY demonstrate histone demethylaseindependent function in mouse embryonic development.PLoS Genet 2012; 8:e1002964.PMID:23028370; http://dx.doi.org/10.1371/journal.pgen.1002964.
    • (2012) PLoS Genet , vol.8
    • Shpargel, K.B.1    Sengoku, T.2    Yokoyama, S.3    Magnuson, T.4
  • 21
    • 0036830642 scopus 로고    scopus 로고
    • Role of histone H3 lysine 27 methylation in Polycomb-group silencing
    • PMID:12351676
    • Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P, Jones RS, Zhang Y.Role of histone H3 lysine 27 methylation in Polycomb-group silencing.Science 2002; 298:1039-43.PMID:12351676; http://dx.doi.org/10.1126/science.1076997.
    • (2002) Science , vol.298 , pp. 1039-1043
    • Cao, R.1    Wang, L.2    Wang, H.3    Xia, L.4    Erdjument-Bromage, H.5    Tempst, P.6    Jones, R.S.7    Zhang, Y.8
  • 22
    • 0037131523 scopus 로고    scopus 로고
    • Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites
    • PMID:12408863
    • Czermin B, Melfi R, McCabe D, Seitz V, Imhof A, Pirrotta V.Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites.Cell 2002; 111:185-96.PMID:12408863; http://dx.doi.org/10.1016/S0092-8674(02)00975-3.
    • (2002) Cell , vol.111 , pp. 185-196
    • Czermin, B.1    Melfi, R.2    McCabe, D.3    Seitz, V.4    Imhof, A.5    Pirrotta, V.6
  • 23
    • 0037111831 scopus 로고    scopus 로고
    • Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein
    • PMID:12435631
    • Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D.Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein.Genes Dev 2002; 16:2893-905.PMID:12435631; http://dx.doi.org/10.1101/gad.1035902.
    • (2002) Genes Dev , vol.16 , pp. 2893-2905
    • Kuzmichev, A.1    Nishioka, K.2    Erdjument-Bromage, H.3    Tempst, P.4    Reinberg, D.5
  • 25
    • 84861813539 scopus 로고    scopus 로고
    • Diverse ways to be specific: A novel Zn-binding domain confers substrate specificity to UTX/KDM6A histone H3 Lys 27 demethylase
    • PMID:22056667
    • Kim E, Song JJ.Diverse ways to be specific: a novel Zn-binding domain confers substrate specificity to UTX/KDM6A histone H3 Lys 27 demethylase.Genes Dev 2011; 25:2223-6.PMID:22056667; http://dx.doi.org/10.1101/gad.179473.111.
    • (2011) Genes Dev , vol.25 , pp. 2223-2226
    • Kim, E.1    Song, J.J.2
  • 26
    • 80455140217 scopus 로고    scopus 로고
    • Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A
    • PMID:22002947
    • Sengoku T, Yokoyama S.Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A.Genes Dev 2011; 25:2266-77.PMID:22002947; http://dx.doi.org/10.1101/gad.172296.111.
    • (2011) Genes Dev , vol.25 , pp. 2266-2277
    • Sengoku, T.1    Yokoyama, S.2
  • 27
    • 38549165276 scopus 로고    scopus 로고
    • Drosophila UTX is a histone H3 Lys27 demethylase that colocalizes with the elongating form of RNA polymerase II
    • PMID:18039863
    • Smith ER, Lee MG, Winter B, Droz NM, Eissenberg JC, Shiekhattar R, Shilatifard A.Drosophila UTX is a histone H3 Lys27 demethylase that colocalizes with the elongating form of RNA polymerase II.Mol Cell Biol 2008; 28:1041-6.PMID:18039863; http://dx.doi.org/10.1128/MCB.01504-07.
    • (2008) Mol Cell Biol , vol.28 , pp. 1041-1046
    • Smith, E.R.1    Lee, M.G.2    Winter, B.3    Droz, N.M.4    Eissenberg, J.C.5    Shiekhattar, R.6    Shilatifard, A.7
  • 28
    • 84863671360 scopus 로고    scopus 로고
    • The C.elegans H3K27 demethylase UTX-1 is essential for normal development, independent of its enzymatic activity
    • PMID:22570628
    • Vandamme J, Lettier G, Sidoli S, Di Schiavi E, Nørregaard Jensen O, Salcini AE.The C.elegans H3K27 demethylase UTX-1 is essential for normal development, independent of its enzymatic activity.PLoS Genet 2012; 8:e1002647.PMID:22570628; http://dx.doi.org/10.1371/journal.pgen.1002647.
    • (2012) PLoS Genet , vol.8
    • Vandamme, J.1    Lettier, G.2    Sidoli, S.3    Di Schiavi, E.4    Nørregaard, J.O.5    Salcini, A.E.6
  • 30
    • 84870490787 scopus 로고    scopus 로고
    • Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4
    • PMID:23166019
    • Herz HM, Mohan M, Garruss AS, Liang K, Takahashi YH, Mickey K, Voets O, Verrijzer CP, Shilatifard A.Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4.Genes Dev 2012; 26:2604-20.PMID:23166019; http://dx.doi.org/10.1101/gad.201327.112.
    • (2012) Genes Dev , vol.26 , pp. 2604-2620
    • Herz, H.M.1    Mohan, M.2    Garruss, A.S.3    Liang, K.4    Takahashi, Y.H.5    Mickey, K.6    Voets, O.7    Verrijzer, C.P.8    Shilatifard, A.9
  • 31
    • 84876452079 scopus 로고    scopus 로고
    • The Drosophila ortholog of MLL3 and MLL4, trithorax related, functions as a negative regulator of tissue growth
    • PMID:23459941
    • Kanda H, Nguyen A, Chen L, Okano H, Hariharan IK.The Drosophila ortholog of MLL3 and MLL4, trithorax related, functions as a negative regulator of tissue growth.Mol Cell Biol 2013; 33:1702-10.PMID:23459941; http://dx.doi.org/10.1128/MCB.01585-12.
    • (2013) Mol Cell Biol , vol.33 , pp. 1702-1710
    • Kanda, H.1    Nguyen, A.2    Chen, L.3    Okano, H.4    Hariharan, I.K.5
  • 32
    • 84886099830 scopus 로고    scopus 로고
    • Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer
    • PMID:24105274
    • Plass C, Pfister SM, Lindroth AM, Bogatyrova O, Claus R, Lichter P.Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer.Nat Rev Genet 2013; 14:765-80.PMID:24105274; http://dx.doi.org/10.1038/nrg3554.
    • (2013) Nat Rev Genet , vol.14 , pp. 765-780
    • Plass, C.1    Pfister, S.M.2    Lindroth, A.M.3    Bogatyrova, O.4    Claus, R.5    Lichter, P.6
  • 33
    • 0036847620 scopus 로고    scopus 로고
    • Function and selectivity of bromodomains in anchoring chromatinmodifying complexes to promoter nucleosomes
    • PMID:12419247
    • Hassan AH, Prochasson P, Neely KE, Galasinski SC, Chandy M, Carrozza MJ, Workman JL.Function and selectivity of bromodomains in anchoring chromatinmodifying complexes to promoter nucleosomes.Cell 2002; 111:369-79.PMID:12419247; http://dx.doi.org/10.1016/S0092-8674(02)01005-X
    • (2002) Cell , vol.111 , pp. 369-379
    • Hassan, A.H.1    Prochasson, P.2    Neely, K.E.3    Galasinski, S.C.4    Chandy, M.5    Carrozza, M.J.6    Workman, J.L.7
  • 34
    • 34548544648 scopus 로고    scopus 로고
    • Chromatin remodeling and cancer, Part II: ATP-dependent chromatin remodeling
    • PMID:17822959
    • Wang GG, Allis CD, Chi P.Chromatin remodeling and cancer, Part II: ATP-dependent chromatin remodeling.Trends Mol Med 2007; 13:373-80.PMID:17822959; http://dx.doi.org/10.1016/j.molmed.2007.07.004.
    • (2007) Trends Mol Med , vol.13 , pp. 373-380
    • Wang, G.G.1    Allis, C.D.2    Chi, P.3
  • 35
    • 0036076091 scopus 로고    scopus 로고
    • The T-box family
    • PMID:12093383
    • Wilson V, Conlon FL.The T-box family.Genome Biol 2002; 3:REVIEWS3008.PMID:12093383; http://dx.doi.org/10.1186/gb-2002-3-6-reviews3008.
    • (2002) Genome Biol , vol.3
    • Wilson, V.1    Conlon, F.L.2
  • 36
    • 67650383471 scopus 로고    scopus 로고
    • The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells
    • PMID:19448667
    • Naidu SR, Love IM, Imbalzano AN, Grossman SR, Androphy EJ.The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells.Oncogene 2009; 28:2492-501.PMID:19448667; http://dx.doi.org/10.1038/onc.2009.121.
    • (2009) Oncogene , vol.28 , pp. 2492-2501
    • Naidu, S.R.1    Love, I.M.2    Imbalzano, A.N.3    Grossman, S.R.4    Androphy, E.J.5
  • 37
    • 84864012602 scopus 로고    scopus 로고
    • Histone demethylase UTX and chromatin remodeler BRM bind directly to CBP and modulate acetylation of histone H3 lysine 27
    • PMID:22493065
    • Tie F, Banerjee R, Conrad PA, Scacheri PC, Harte PJ.Histone demethylase UTX and chromatin remodeler BRM bind directly to CBP and modulate acetylation of histone H3 lysine 27.Mol Cell Biol 2012; 32:2323-34.PMID:22493065; http://dx.doi.org/10.1128/MCB.06392-11.
    • (2012) Mol Cell Biol , vol.32 , pp. 2323-2334
    • Tie, F.1    Banerjee, R.2    Conrad, P.A.3    Scacheri, P.C.4    Harte, P.J.5
  • 38
    • 84884269699 scopus 로고    scopus 로고
    • The regulation of Hox gene expression during animal development
    • PMID:24046316
    • Mallo M, Alonso CR.The regulation of Hox gene expression during animal development.Development 2013; 140:3951-63.PMID:24046316; http://dx.doi.org/10.1242/dev.068346.
    • (2013) Development , vol.140 , pp. 3951-3963
    • Mallo, M.1    Alonso, C.R.2
  • 39
    • 77951605788 scopus 로고    scopus 로고
    • The Hox genes and their roles in oncogenesis
    • PMID:20357775
    • Shah N, Sukumar S.The Hox genes and their roles in oncogenesis.Nat Rev Cancer 2010; 10:361-71.PMID:20357775; http://dx.doi.org/10.1038/nrc2826.
    • (2010) Nat Rev Cancer , vol.10 , pp. 361-371
    • Shah, N.1    Sukumar, S.2
  • 40
    • 33646870495 scopus 로고    scopus 로고
    • Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions
    • PMID:16618801
    • Bracken AP, Dietrich N, Pasini D, Hansen KH, Helin K.Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions.Genes Dev 2006; 20:1123-36.PMID:16618801; http://dx.doi.org/10.1101/gad.381706.
    • (2006) Genes Dev , vol.20 , pp. 1123-1136
    • Bracken, A.P.1    Dietrich, N.2    Pasini, D.3    Hansen, K.H.4    Helin, K.5
  • 41
    • 76749139057 scopus 로고    scopus 로고
    • The histone demethylase UTX enables RB-dependent cell fate control
    • PMID:20123895
    • Wang JK, Tsai MC, Poulin G, Adler AS, Chen S, Liu H, Shi Y, Chang HY.The histone demethylase UTX enables RB-dependent cell fate control.Genes Dev 2010; 24:327-32.PMID:20123895; http://dx.doi.org/10.1101/gad.1882610.
    • (2010) Genes Dev , vol.24 , pp. 327-332
    • Wang, J.K.1    Tsai, M.C.2    Poulin, G.3    Adler, A.S.4    Chen, S.5    Liu, H.6    Shi, Y.7    Chang, H.Y.8
  • 42
    • 77955846599 scopus 로고    scopus 로고
    • The tumor suppressor Rb and its related Rbl2 genes are regulated by Utx histone demethylase
    • PMID:20650264
    • Terashima M, Ishimura A, Yoshida M, Suzuki Y, Sugano S, Suzuki T.The tumor suppressor Rb and its related Rbl2 genes are regulated by Utx histone demethylase.Biochem Biophys Res Commun 2010; 399:238-44.PMID:20650264; http://dx.doi.org/10.1016/j.bbrc.2010.07.061.
    • (2010) Biochem Biophys Res Commun , vol.399 , pp. 238-244
    • Terashima, M.1    Ishimura, A.2    Yoshida, M.3    Suzuki, Y.4    Sugano, S.5    Suzuki, T.6
  • 43
    • 79960484375 scopus 로고    scopus 로고
    • Gene silencing in X-chromosome inactivation: Advances in understanding facultative heterochromatin formation
    • PMID:21765457
    • Wutz A.Gene silencing in X-chromosome inactivation: advances in understanding facultative heterochromatin formation.Nat Rev Genet 2011; 12:542-53.PMID:21765457; http://dx.doi.org/10.1038/nrg3035.
    • (2011) Nat Rev Genet , vol.12 , pp. 542-553
    • Wutz, A.1
  • 44
    • 78751662908 scopus 로고    scopus 로고
    • The Polycomb complex PRC2 and its mark in life
    • PMID:21248841
    • Margueron R, Reinberg D.The Polycomb complex PRC2 and its mark in life.Nature 2011; 469:343-9.PMID:21248841; http://dx.doi.org/10.1038/nature09784.
    • (2011) Nature , vol.469 , pp. 343-349
    • Margueron, R.1    Reinberg, D.2
  • 46
    • 84878504294 scopus 로고    scopus 로고
    • Female bias in Rhox6 and 9 regulation by the histone demethylase KDM6A
    • PMID:23658530
    • Berletch JB, Deng X, Nguyen DK, Disteche CM.Female bias in Rhox6 and 9 regulation by the histone demethylase KDM6A.PLoS Genet 2013; 9:e1003489.PMID:23658530; http://dx.doi.org/10.1371/journal.pgen.1003489.
    • (2013) PLoS Genet , vol.9
    • Berletch, J.B.1    Deng, X.2    Nguyen, D.K.3    Disteche, C.M.4
  • 47
    • 43749094750 scopus 로고    scopus 로고
    • Sex-specific differences in expression of histone demethylases Utx and Uty in mouse brain and neurons
    • PMID:18434530;
    • Xu J, Deng X, Watkins R, Disteche CM.Sex-specific differences in expression of histone demethylases Utx and Uty in mouse brain and neurons.J Neurosci 2008; 28:4521-7.PMID:18434530; http://dx.doi.org/10.1523/JNEUROSCI.5382-07.2008.
    • (2008) J Neurosci , vol.28 , pp. 4521-4527
    • Xu, J.1    Deng, X.2    Watkins, R.3    Disteche, C.M.4
  • 48
    • 79958175738 scopus 로고    scopus 로고
    • Epigenomics of human embryonic stem cells and induced pluripotent stem cells: Insights into pluripotency and implications for disease
    • PMID:21658297
    • Rada-Iglesias A, Wysocka J.Epigenomics of human embryonic stem cells and induced pluripotent stem cells: insights into pluripotency and implications for disease.Genome Med 2011; 3:36.PMID:21658297; http://dx.doi.org/10.1186/gm252.
    • (2011) Genome Med , vol.3 , pp. 36
    • Rada-Iglesias, A.1    Wysocka, J.2
  • 49
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • PMID:16904174
    • Takahashi K, Yamanaka S.Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.Cell 2006; 126:663-76.PMID:16904174; http://dx.doi.org/10.1016/j.cell.2006.07.024.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 54
    • 84875722648 scopus 로고    scopus 로고
    • Utx is required for proper induction of ectoderm and mesoderm during differentiation of embryonic stem cells
    • PMID:23573229
    • Morales Torres C, Laugesen A, Helin K.Utx is required for proper induction of ectoderm and mesoderm during differentiation of embryonic stem cells.PLoS One 2013; 8:e60020.PMID:23573229; http://dx.doi.org/10.1371/journal.pone.0060020
    • (2013) PLoS One , vol.8
    • Morales, T.C.1    Laugesen, A.2    Helin, K.3
  • 55
    • 84872028638 scopus 로고    scopus 로고
    • Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway
    • PMID:22907667
    • Jiang W, Wang J, Zhang Y.Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway.Cell Res 2013; 23:122-30.PMID:22907667; http://dx.doi.org/10.1038/cr.2012.119.
    • (2013) Cell Res , vol.23 , pp. 122-130
    • Jiang, W.1    Wang, J.2    Zhang, Y.3
  • 56
    • 84880937390 scopus 로고    scopus 로고
    • The histone H3-K27 demethylase Utx regulates HOX gene expression in Drosophila in a temporally restricted manner
    • PMID:23900545
    • Copur Ö, Müller J.The histone H3-K27 demethylase Utx regulates HOX gene expression in Drosophila in a temporally restricted manner.Development 2013; 140:3478-85.PMID:23900545; http://dx.doi.org/10.1242/dev.097204.
    • (2013) Development , vol.140 , pp. 3478-3485
    • Copur, O.1    Müller, J.2
  • 57
    • 70849109045 scopus 로고    scopus 로고
    • Dual role for the methyltransferase G9a in the maintenance of beta-globin gene transcription in adult erythroid cells
    • PMID:19822740
    • Chaturvedi CP, Hosey AM, Palii C, Perez-Iratxeta C, Nakatani Y, Ranish JA, Dilworth FJ, Brand M.Dual role for the methyltransferase G9a in the maintenance of beta-globin gene transcription in adult erythroid cells.Proc Natl Acad Sci U S A 2009; 106:18303-8.PMID:19822740; http://dx.doi.org/10.1073/pnas.0906769106.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 18303-18308
    • Chaturvedi, C.P.1    Hosey, A.M.2    Palii, C.3    Perez-Iratxeta, C.4    Nakatani, Y.5    Ranish, J.A.6    Dilworth, F.J.7    Brand, M.8
  • 58
    • 84862777232 scopus 로고    scopus 로고
    • A functional role for the histone demethylase UTX in normal and malignant hematopoietic cells
    • 487-498+e3 PMID:22306297
    • Liu J, Mercher T, Scholl C, Brumme K, Gilliland DG, Zhu N.A functional role for the histone demethylase UTX in normal and malignant hematopoietic cells.Exp Hematol 2012; 40:487-98, e3.PMID:22306297; http://dx.doi.org/10.1016/j.exphem.2012.01.017.
    • (2012) Exp Hematol , vol.40
    • Liu, J.1    Mercher, T.2    Scholl, C.3    Brumme, K.4    Gilliland, D.G.5    Zhu, N.6
  • 59
    • 7544230144 scopus 로고    scopus 로고
    • The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation
    • PMID:15520282
    • Caretti G, Di Padova M, Micales B, Lyons GE, Sartorelli V.The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation.Genes Dev 2004; 18:2627-38.PMID:15520282; http://dx.doi.org/10.1101/gad.1241904.
    • (2004) Genes Dev , vol.18 , pp. 2627-2638
    • Caretti, G.1    Di Padova, M.2    Micales, B.3    Lyons, G.E.4    Sartorelli, V.5
  • 60
    • 84894262774 scopus 로고    scopus 로고
    • EZH2 and KDM6A act as an epigenetic switch to regulate mesenchymal stem cell lineage specification
    • PMID:24123378
    • Hemming S, Cakouros D, Isenmann S, Cooper L, Menicanin D, Zannettino A, Gronthos S.EZH2 and KDM6A act as an epigenetic switch to regulate mesenchymal stem cell lineage specification.Stem Cells 2014; 32:802-15.PMID:24123378; http://dx.doi.org/10.1002/stem.1573.
    • (2014) Stem Cells , vol.32 , pp. 802-815
    • Hemming, S.1    Cakouros, D.2    Isenmann, S.3    Cooper, L.4    Menicanin, D.5    Zannettino, A.6    Gronthos, S.7
  • 61
    • 68249128477 scopus 로고    scopus 로고
    • Epigenetic reprogramming during wound healing: Loss of polycomb-mediated silencing may enable upregulation of repair genes
    • PMID:19575012
    • Shaw T, Martin P.Epigenetic reprogramming during wound healing: loss of polycomb-mediated silencing may enable upregulation of repair genes.EMBO Rep 2009; 10:881-6.PMID:19575012; http://dx.doi.org/10.1038/embor.2009.102.
    • (2009) EMBO Rep , vol.10 , pp. 881-886
    • Shaw, T.1    Martin, P.2
  • 62
    • 81155139577 scopus 로고    scopus 로고
    • The H3K27 demethylase UTX-1 regulates C.elegans lifespan in a germline-independent, insulin-dependent manner
    • PMID:21834846
    • Maures TJ, Greer EL, Hauswirth AG, Brunet A.The H3K27 demethylase UTX-1 regulates C.elegans lifespan in a germline-independent, insulin-dependent manner.Aging Cell 2011; 10:980-90.PMID:21834846; http://dx.doi.org/10.1111/j.1474-9726.2011.00738.x
    • (2011) Aging Cell , vol.10 , pp. 980-990
    • Maures, T.J.1    Greer, E.L.2    Hauswirth, A.G.3    Brunet, A.4
  • 63
    • 79960936857 scopus 로고    scopus 로고
    • Histone demethylase UTX-1 regulates C.elegans life span by targeting the insulin/IGF-1 signaling pathway
    • PMID:21803287
    • Jin C, Li J, Green CD, Yu X, Tang X, Han D, Xian B, Wang D, Huang X, Cao X, et al.Histone demethylase UTX-1 regulates C.elegans life span by targeting the insulin/IGF-1 signaling pathway.Cell Metab 2011; 14:161-72.PMID:21803287; http://dx.doi.org/10.1016/j.cmet.2011.07.001.
    • (2011) Cell Metab , vol.14 , pp. 161-172
    • Jin, C.1    Li, J.2    Green, C.D.3    Yu, X.4    Tang, X.5    Han, D.6    Xian, B.7    Wang, D.8    Huang, X.9    Cao, X.10
  • 64
    • 0019850335 scopus 로고
    • Kabuki make-up syndrome: A syndrome of mental retardation, unusual facies, large and protruding ears, and postnatal growth deficiency
    • PMID:7277096
    • Niikawa N, Matsuura N, Fukushima Y, Ohsawa T, Kajii T.Kabuki make-up syndrome: a syndrome of mental retardation, unusual facies, large and protruding ears, and postnatal growth deficiency.J Pediatr 1981; 99:565-9.PMID:7277096; http://dx.doi.org/10.1016/S0022-3476(81)80255-7.
    • (1981) J Pediatr , vol.99 , pp. 565-569
    • Niikawa, N.1    Matsuura, N.2    Fukushima, Y.3    Ohsawa, T.4    Kajii, T.5
  • 70
    • 0042819645 scopus 로고    scopus 로고
    • Patient with Kabuki syndrome and acute leukemia
    • PMID:12949977
    • Scherer S, Theile U, Beyer V, Ferrari R, Kreck C, Rister M.Patient with Kabuki syndrome and acute leukemia.Am J Med Genet A 2003; 122A:76-9.PMID:12949977; http://dx.doi.org/10.1002/ajmg.a.20261.
    • (2003) Am J Med Genet A , vol.122 A , pp. 76-79
    • Scherer, S.1    Theile, U.2    Beyer, V.3    Ferrari, R.4    Kreck, C.5    Rister, M.6
  • 72
    • 15944401335 scopus 로고    scopus 로고
    • High incidence of malformation syndromes in a series of 1,073 children with cancer
    • PMID:15712196
    • Merks JH, Caron HN, Hennekam RC.High incidence of malformation syndromes in a series of 1,073 children with cancer.Am J Med Genet A 2005; 134A:132-43.PMID:15712196; http://dx.doi.org/10.1002/ajmg.a.30603.
    • (2005) Am J Med Genet A , vol.134 A , pp. 132-143
    • Merks, J.H.1    Caron, H.N.2    Hennekam, R.C.3
  • 74
    • 51449111084 scopus 로고    scopus 로고
    • Low-grade fibromyxoid sarcoma: Yet another malignancy associated with Kabuki syndrome
    • PMID:18541969
    • Shahdadpuri R, O'Meara A, O'Sullivan M, Reardon W.Low-grade fibromyxoid sarcoma: yet another malignancy associated with Kabuki syndrome.Clin Dysmorphol 2008; 17:199-202.PMID:18541969; http://dx.doi.org/10.1097/MCD.0b013e3282f5f4e3.
    • (2008) Clin Dysmorphol , vol.17 , pp. 199-202
    • Shahdadpuri, R.1    O'Meara, A.2    O'Sullivan, M.3    Reardon, W.4
  • 75
    • 84873084751 scopus 로고    scopus 로고
    • Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia
    • PMID:23263491
    • De Keersmaecker K, Atak ZK, Li N, Vicente C, Patchett S, Girardi T, Gianfelici V, Geerdens E, Clappier E, Porcu M, et al.Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia.Nat Genet 2013; 45:186-90.PMID:23263491; http://dx.doi.org/10.1038/ng.2508.
    • (2013) Nat Genet , vol.45 , pp. 186-190
    • de Keersmaecker, K.1    Atak, Z.K.2    Li, N.3    Vicente, C.4    Patchett, S.5    Girardi, T.6    Gianfelici, V.7    Geerdens, E.8    Clappier, E.9    Porcu, M.10
  • 77
    • 80052266351 scopus 로고    scopus 로고
    • Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder
    • PMID:21822268
    • Gui Y, Guo G, Huang Y, Hu X, Tang A, Gao S, Wu R, Chen C, Li X, Zhou L, et al.Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder.Nat Genet 2011; 43:875-8.PMID:21822268; http://dx.doi.org/10.1038/ng.907.
    • (2011) Nat Genet , vol.43 , pp. 875-878
    • Gui, Y.1    Guo, G.2    Huang, Y.3    Hu, X.4    Tang, A.5    Gao, S.6    Wu, R.7    Chen, C.8    Li, X.9    Zhou, L.10
  • 86
    • 80053135096 scopus 로고    scopus 로고
    • Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A
    • PMID:21828135
    • Jankowska AM, Makishima H, Tiu RV, Szpurka H, Huang Y, Traina F, Visconte V, Sugimoto Y, Prince C, O'Keefe C, et al.Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A.Blood 2011; 118:3932-41.PMID:21828135; http://dx.doi.org/10.1182/blood-2010-10-311019.
    • (2011) Blood , vol.118 , pp. 3932-3941
    • Jankowska, A.M.1    Makishima, H.2    Tiu, R.V.3    Szpurka, H.4    Huang, Y.5    Traina, F.6    Visconte, V.7    Sugimoto, Y.8    Prince, C.9    O'Keefe, C.10
  • 87
    • 0345700319 scopus 로고    scopus 로고
    • A human homolog of Additional sex combs, ADDITIONAL SEX COMBS-LIKE 1, maps to chromosome 20q11
    • PMID:12657473
    • Fisher CL, Berger J, Randazzo F, Brock HW.A human homolog of Additional sex combs, ADDITIONAL SEX COMBS-LIKE 1, maps to chromosome 20q11.Gene 2003; 306:115-26.PMID:12657473; http://dx.doi.org/10.1016/S0378-1119(03)00430-X88.
    • (2003) Gene , vol.306 , pp. 115-126
    • Fisher, C.L.1    Berger, J.2    Randazzo, F.3    Brock, H.W.4
  • 88
    • 77956189495 scopus 로고    scopus 로고
    • Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
    • PMID:20639862
    • Ito S, D'Alessio AC, Taranova OV, Hong K, Sowers LC, Zhang Y.Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification.Nature 2010; 466:1129-33.PMID:20639862; http://dx.doi.org/10.1038/nature09303.
    • (2010) Nature , vol.466 , pp. 1129-1133
    • Ito, S.1    D'Alessio, A.C.2    Taranova, O.V.3    Hong, K.4    Sowers, L.C.5    Zhang, Y.6
  • 91
    • 84859947197 scopus 로고    scopus 로고
    • Australian Pancreatic Cancer Genome Initiative.Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma
    • PMID:22421440
    • Mann KM, Ward JM, Yew CC, Kovochich A, Dawson DW, Black MA, Brett BT, Sheetz TE, Dupuy AJ, Chang DK, et al.; Australian Pancreatic Cancer Genome Initiative.Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma.Proc Natl Acad Sci U S A 2012; 109:5934-41.PMID:22421440; http://dx.doi.org/10.1073/pnas.1202490109.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 5934-5941
    • Mann, K.M.1    Ward, J.M.2    Yew, C.C.3    Kovochich, A.4    Dawson, D.W.5    Black, M.A.6    Brett, B.T.7    Sheetz, T.E.8    Dupuy, A.J.9    Chang, D.K.10
  • 93
    • 79958173697 scopus 로고    scopus 로고
    • Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: Towards understanding selectivity of inhibitors targeting oncogenic histone demethylases
    • PMID:21575637
    • Kristensen JB, Nielsen AL, Jørgensen L, Kristensen LH, Helgstrand C, Juknaite L, Kristensen JL, Kastrup JS, Clausen RP, Olsen L, et al.Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: towards understanding selectivity of inhibitors targeting oncogenic histone demethylases.FEBS Lett 2011; 585:1951-6.PMID:21575637; http://dx.doi.org/10.1016/j.febslet.2011.05.023.
    • (2011) FEBS Lett , vol.585 , pp. 1951-1956
    • Kristensen, J.B.1    Nielsen, A.L.2    Jørgensen, L.3    Kristensen, L.H.4    Helgstrand, C.5    Juknaite, L.6    Kristensen, J.L.7    Kastrup, J.S.8    Clausen, R.P.9    Olsen, L.10
  • 94
    • 65349129552 scopus 로고    scopus 로고
    • Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors
    • PMID:19359167
    • Hamada S, Kim TD, Suzuki T, Itoh Y, Tsumoto H, Nakagawa H, Janknecht R, Miyata N.Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors.Bioorg Med Chem Lett 2009; 19:2852-5.PMID:19359167; http://dx.doi.org/10.1016/j.bmcl.2009.03.098.
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 2852-2855
    • Hamada, S.1    Kim, T.D.2    Suzuki, T.3    Itoh, Y.4    Tsumoto, H.5    Nakagawa, H.6    Janknecht, R.7    Miyata, N.8
  • 95
    • 79959204866 scopus 로고    scopus 로고
    • A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases
    • PMID:21585201
    • Luo X, Liu Y, Kubicek S, Myllyharju J, Tumber A, Ng S, Che KH, Podoll J, Heightman TD, Oppermann U, et al.A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases.J Am Chem Soc 2011; 133:9451-6.PMID:21585201; http://dx.doi.org/10.1021/ja201597b
    • (2011) J Am Chem Soc , vol.133 , pp. 9451-9456
    • Luo, X.1    Liu, Y.2    Kubicek, S.3    Myllyharju, J.4    Tumber, A.5    Ng, S.6    Che, K.H.7    Podoll, J.8    Heightman, T.D.9    Oppermann, U.10


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