DNMT3A Arg882 mutation drives chronic myelomonocytic leukemia through disturbing gene expression/DNA methylation in hematopoietic cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 7, 2014, Pages 2620-2625

  Xu, Jie ^a   Wang, Yue Ying ^a   Dai, Yu Jun ^a   Zhang, Wu ^a   Zhang, Wei Na ^a   Xiong, Shu Min ^a   Gu, Zhao Hui ^b   Wang, Kan Kan ^a   Zeng, Rong ^c   Chen, Zhu ^a,b   Chen, Sai Juan ^a,b  

^a SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

^b Shanghai Jiao Tong University   (China)

^c INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

Epigenetic abnormality; Genomic variation; Leukemogenic effect

Indexed keywords

ACTIN; ARGININE; CYCLIN DEPENDENT KINASE 1; DNA METHYLTRANSFERASE 3A; TRANSCRIPTOME;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW TRANSPLANTATION; CELL CYCLE; CELL PROLIFERATION; CELL TRANSFORMATION; CHRONIC MYELOMONOCYTIC LEUKEMIA; CONTROLLED STUDY; DNA METHYLATION; DNA METHYLATION ASSAY; EPIGENETICS; GENE EXPRESSION; GENE MUTATION; HEMATOPOIESIS; HEMATOPOIETIC CELL; LEUKEMOGENESIS; MICROARRAY ANALYSIS; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RETROVIRUS; THROMBOCYTOSIS;

EPIGENETIC ABNORMALITY; GENOMIC VARIATION; LEUKEMOGENIC EFFECT;

ANIMALS; BLOTTING, WESTERN; CELL CYCLE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEMATOPOIETIC STEM CELLS; HUMANS; IMMUNOBLOTTING; IMMUNOPHENOTYPING; IMMUNOPRECIPITATION; LEUKEMIA, MYELOMONOCYTIC, CHRONIC; MASS SPECTROMETRY; MICE; MICE, INBRED BALB C; MICROARRAY ANALYSIS; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE;

EID: 84894303664     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1400150111     Document Type: Article

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