A687V EZH2 is a gain-of-function mutation found in lymphoma patients

FEBS Letters

Volumn 586, Issue 19, 2012, Pages 3448-3451

  Majer, Christina R ^a   Jin, Lei ^a   Scott, Margaret Porter ^a   Knutson, Sarah K ^a   Kuntz, Kevin W ^a   Keilhack, Heike ^a   Smith, Jesse J ^a   Moyer, Mikel P ^a   Richon, Victoria M ^a   Copeland, Robert A ^a   Wigle, Tim J ^a  

^a EPIZYME INC   (United States)

Author keywords

EZH2; Gain of function mutation; Genetically altered enzyme; H3K27; Histone Methyltransferase; Hypertrimethylation; Lymphoma

Indexed keywords

TRANSCRIPTION FACTOR EZH2;

ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; EZH2 GENE; GAIN OF FUNCTION MUTATION; GENE; HETEROZYGOSITY; HUMAN; HUMAN CELL; LYMPHOMA CELL; NONHODGKIN LYMPHOMA; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN METHYLATION; WILD TYPE;

HETEROZYGOTE; HISTONES; HUMANS; KINETICS; LYMPHOMA, NON-HODGKIN; METHYLATION; MODELS, MOLECULAR; MUTANT PROTEINS; NEOPLASM PROTEINS; POINT MUTATION; POLYCOMB REPRESSIVE COMPLEX 2; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS;

EID: 84866597616     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.07.066     Document Type: Article

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