Combined inhibition of PI3Kβ and PI3Kγ reduces fat mass by enhancing α-MSH-dependent sympathetic drive

Science Signaling

Volumn 7, Issue 352, 2014, Pages

  Perino, Alessia ^a,g   Beretta, Martina ^a,b   Kilić, Ana ^c   Ghigo, Alessandra ^a   Carnevale, Daniela ^d,e   Repetto, Ivan Enrico ^a   Braccini, Laura ^a   Longo, Dario ^a   Liebig Gonglach, Michaela ^c   Zaglia, Tania ^f   Iacobucci, Roberta ^e   Mongillo, Marco ^f   Wetzker, Reinhard ^b   Bauer, Michael ^b   Aime, Silvio ^a   Vercelli, Alessandro ^a   Lembo, Giuseppe ^d,e   Pfeifer, Alexander ^c   Hirsch, Emilio ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b JENA UNIVERSITY HOSPITAL   (Germany)

^c UNIVERSITY OF BONN   (Germany)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

^e IRCCS NEUROMED   (Italy)

^f VENETIAN INSTITUTE OF MOLECULAR MEDICINE   (Italy)

^g EPFL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

5 (6 QUINOXALINYLMETHYLENE) 2,4 THIAZOLIDINEDIONE; ALPHA INTERMEDIN; MELANOCORTIN 4 RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; TGX 221; UNCLASSIFIED DRUG; CYCLIC AMP; PHOSPHATIDYLINOSITOL 3 KINASE;

3T3 CELL LINE; ADRENERGIC SYSTEM; ANIMAL CELL; APPETITE; ARTICLE; BODY FAT; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; ENERGY EXPENDITURE; FAT MASS; FEMALE; LIPOLYSIS; MALE; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; NORADRENALIN RELEASE; OBESITY; WEIGHT REDUCTION; WHITE ADIPOSE TISSUE; ADIPOSE TISSUE; ANATOMY AND HISTOLOGY; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; ENERGY METABOLISM; ENZYMOLOGY; FEEDBACK SYSTEM; FLUORESCENT ANTIBODY TECHNIQUE; GENE TARGETING; GROWTH, DEVELOPMENT AND AGING; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN SITU HYBRIDIZATION; METABOLISM; NONPARAMETRIC TEST; PATHOPHYSIOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WHITE ADIPOCYTE;

MUS;

3T3 CELLS; ADIPOCYTES, WHITE; ADIPOSE TISSUE; ALPHA-MSH; ANIMALS; BLOTTING, WESTERN; CYCLIC AMP; ENERGY METABOLISM; FEEDBACK, PHYSIOLOGICAL; FLUORESCENT ANTIBODY TECHNIQUE; GENE KNOCK-IN TECHNIQUES; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN SITU HYBRIDIZATION; LIPOLYSIS; MICE; OBESITY; PHOSPHATIDYLINOSITOL 3-KINASES; REAL-TIME POLYMERASE CHAIN REACTION; STATISTICS, NONPARAMETRIC; SYMPATHETIC NERVOUS SYSTEM;

EID: 84911954749     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2005485     Document Type: Article

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